CA2336201A1 - Compositions and methods for inhibiting bone resorption - Google Patents

Compositions and methods for inhibiting bone resorption Download PDF

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Publication number
CA2336201A1
CA2336201A1 CA002336201A CA2336201A CA2336201A1 CA 2336201 A1 CA2336201 A1 CA 2336201A1 CA 002336201 A CA002336201 A CA 002336201A CA 2336201 A CA2336201 A CA 2336201A CA 2336201 A1 CA2336201 A1 CA 2336201A1
Authority
CA
Canada
Prior art keywords
geranylgeranyl
nitrogen
group
pharmaceutical composition
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002336201A
Other languages
English (en)
French (fr)
Inventor
Alfred A. Reszka
Edward M. Scolnick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9817172.1A external-priority patent/GB9817172D0/en
Priority claimed from GBGB9822330.8A external-priority patent/GB9822330D0/en
Application filed by Individual filed Critical Individual
Publication of CA2336201A1 publication Critical patent/CA2336201A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002336201A 1998-06-24 1999-06-21 Compositions and methods for inhibiting bone resorption Abandoned CA2336201A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US9040198P 1998-06-24 1998-06-24
US60/090,401 1998-06-24
US9291998P 1998-07-15 1998-07-15
US60/092,919 1998-07-15
GBGB9817172.1A GB9817172D0 (en) 1998-08-06 1998-08-06 Compositions and methods for inhibiting bone resorption
GB9822330.8 1998-10-13
GBGB9822330.8A GB9822330D0 (en) 1998-10-13 1998-10-13 Compositions and methods for inhibiting bone resorption
GB9817172.1 1998-10-13
PCT/US1999/013967 WO1999067809A1 (en) 1998-06-24 1999-06-21 Compositions and methods for inhibiting bone resorption

Publications (1)

Publication Number Publication Date
CA2336201A1 true CA2336201A1 (en) 1999-12-29

Family

ID=27451815

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002336201A Abandoned CA2336201A1 (en) 1998-06-24 1999-06-21 Compositions and methods for inhibiting bone resorption

Country Status (6)

Country Link
US (2) US6432931B1 (enExample)
EP (1) EP1088333A4 (enExample)
JP (1) JP2002519305A (enExample)
AU (1) AU757104B2 (enExample)
CA (1) CA2336201A1 (enExample)
WO (1) WO1999067809A1 (enExample)

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WO2002078689A1 (en) 2001-03-30 2002-10-10 The Nisshin Oillio, Ltd. Bone metabolism improving agents
EP1446009A2 (en) * 2001-11-08 2004-08-18 Merck & Co., Inc. Compounds useful in the treatment of anthrax
NZ532994A (en) * 2001-12-21 2008-05-30 Procter & Gamble Method for the treatment of bone disorders using a bisphosphonate regimen, risedronate in particular
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
HUP0600680A3 (en) * 2001-12-24 2008-04-28 Teva Pharma Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
KR20140021045A (ko) * 2002-05-10 2014-02-19 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
ES2530791T3 (es) * 2002-12-20 2015-03-05 Hoffmann La Roche Formulación de ibandronato de altas dosis
JP4463274B2 (ja) * 2003-06-27 2010-05-19 明 小谷 ビスホスホネート錯体
JP4738007B2 (ja) * 2005-02-04 2011-08-03 久光製薬株式会社 骨粗鬆症治療用外用剤
PT1855674E (pt) 2005-03-02 2014-10-08 Merck Canada Inc Composição para a inibição de catepsina k
US7704656B2 (en) * 2005-03-23 2010-04-27 Xerox Corporation Photoconductive imaging member
DE602006005597D1 (de) * 2005-12-27 2009-04-23 Ipca Lab Ltd Verbesserter Herstellungsprozess von 4-Amino-Hydroxybutyliden-1,1-bisphosphonischer Säure und ihrer Salze
US8974801B2 (en) * 2006-12-21 2015-03-10 Amphastar Pharmaceuticals Inc. Long term sustained release pharmaceutical composition containing aqueous suspension of bisphosphonate
US20080164004A1 (en) * 2007-01-08 2008-07-10 Anastasia Kolesnichenko Method and system of electromagnetic stirring for continuous casting of medium and high carbon steels
US8882740B2 (en) * 2009-12-23 2014-11-11 Stryker Trauma Gmbh Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
AU2012319143A1 (en) * 2011-10-04 2014-04-17 Coyote Pharmaceuticals, Inc. Geranylgeranylacetone derivatives
US20130085283A1 (en) * 2011-10-04 2013-04-04 Coyote Pharmaceuticals, Inc. Geranylgeranylacetone derivatives
JP2015514686A (ja) 2012-02-29 2015-05-21 コヨーテ・ファーマシューティカルズ・インコーポレイテッドＣｏｙｏｔｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｇｇａ及びそのｇｇａ誘導体組成物並びにこれらを含む麻痺状態を含めた神経変性疾患を治療する方法
WO2014055440A1 (en) * 2012-10-01 2014-04-10 Coyote Pharmaceuticals, Inc. Preparation of gga and derivatives thereof and their co-crystallization with urea or thiourea
US9119808B1 (en) 2012-10-08 2015-09-01 Coyote Pharmaceuticals, Inc. Treating neurodegenerative diseases with GGA or a derivative thereof
WO2014101049A1 (en) 2012-12-27 2014-07-03 Kimberly-Clark Worldwide, Inc. Water soluble essential oils and their use
WO2014101051A1 (en) 2012-12-27 2014-07-03 Kimberly-Clark Worldwide, Inc. Water soluble farnesol analogs and their use
WO2014151697A1 (en) * 2013-03-15 2014-09-25 Coyote Pharmaceuticals, Inc. Therapeutic uses for geranylgeranyl acetone and derivatives thereof
WO2014151719A1 (en) * 2013-03-15 2014-09-25 Coyote Pharmaceuticals, Inc. Sublingual formulations including geranylgeranylacetone and geranylgeranylacetone derivatives
KR102363895B1 (ko) * 2020-03-02 2022-02-17 영남대학교 산학협력단 염증 질환 또는 면역 질환의 예방 또는 치료용 약학적 조성물

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US4444784A (en) 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
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Also Published As

Publication number Publication date
AU757104B2 (en) 2003-01-30
US6432931B1 (en) 2002-08-13
WO1999067809A1 (en) 1999-12-29
EP1088333A1 (en) 2001-04-04
US6699850B2 (en) 2004-03-02
EP1088333A4 (en) 2005-08-10
WO1999067809A9 (en) 2001-03-22
AU4702599A (en) 2000-01-10
US20020082244A1 (en) 2002-06-27
JP2002519305A (ja) 2002-07-02

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued