AU743609B2 - Use of cholinesterase inhibitors to treat disorders of attention - Google Patents
Use of cholinesterase inhibitors to treat disorders of attention Download PDFInfo
- Publication number
- AU743609B2 AU743609B2 AU73215/98A AU7321598A AU743609B2 AU 743609 B2 AU743609 B2 AU 743609B2 AU 73215/98 A AU73215/98 A AU 73215/98A AU 7321598 A AU7321598 A AU 7321598A AU 743609 B2 AU743609 B2 AU 743609B2
- Authority
- AU
- Australia
- Prior art keywords
- indanon
- compound
- benzyl
- methylpiperidine
- dimethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 238000000034 method Methods 0.000 claims abstract description 52
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 36
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- 125000001424 substituent group Chemical group 0.000 claims description 28
- 238000011282 treatment Methods 0.000 claims description 28
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 22
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- 241000282414 Homo sapiens Species 0.000 claims description 19
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 18
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- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3983297P | 1997-03-03 | 1997-03-03 | |
| US60/039832 | 1997-03-03 | ||
| PCT/IB1998/000508 WO1998039000A1 (en) | 1997-03-03 | 1998-03-03 | Use of cholinesterase inhibitors to treat disorders of attention |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU7321598A AU7321598A (en) | 1998-09-22 |
| AU743609B2 true AU743609B2 (en) | 2002-01-31 |
Family
ID=21907565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU73215/98A Ceased AU743609B2 (en) | 1997-03-03 | 1998-03-03 | Use of cholinesterase inhibitors to treat disorders of attention |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6455544B1 (enExample) |
| EP (1) | EP0971713B1 (enExample) |
| JP (1) | JP4095676B2 (enExample) |
| AT (1) | ATE241358T1 (enExample) |
| AU (1) | AU743609B2 (enExample) |
| CA (1) | CA2282654C (enExample) |
| DE (1) | DE69815090T2 (enExample) |
| DK (1) | DK0971713T3 (enExample) |
| ES (1) | ES2200313T3 (enExample) |
| NZ (1) | NZ337515A (enExample) |
| PT (1) | PT971713E (enExample) |
| WO (1) | WO1998039000A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
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| PT971713E (pt) * | 1997-03-03 | 2003-09-30 | Eisai Co Ltd | Utilizacao de inibidores da colinesterase para tratamento de desordens da atencao |
| GB9716879D0 (en) * | 1997-08-08 | 1997-10-15 | Shire Int Licensing Bv | Treatment of attention deficit disorders |
| US6429207B1 (en) | 1997-11-21 | 2002-08-06 | Nps Pharmaceuticals, Inc. | Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases |
| EP1764101A1 (en) * | 2000-03-03 | 2007-03-21 | Eisai R&D Management Co., Ltd. | Use of a cholinesterase inhibitor for the treatment of dementia and cognitive impairments |
| US20030153598A1 (en) * | 2000-07-25 | 2003-08-14 | Raymond Pratt | Methods for treating Parkinson's disease with cholinesterase inhibitors |
| US20060183776A9 (en) * | 2000-03-03 | 2006-08-17 | Eisai Co., Ltd. | Liquid dosage formulations of donepezil |
| DK1311272T3 (da) | 2000-03-03 | 2007-02-26 | Eisai R&D Man Co Ltd | Hidtil ukendte fremgangsmåder hvor der anvendes cholinesteraseinhibitorer |
| JP2006516948A (ja) * | 2000-11-14 | 2006-07-13 | ニュー リバー ファーマシューティカルズ インコーポレイテッド | 硫酸アバカビルを含有する新規な薬剤化合物および同化合物の製造ならびに使用方法 |
| US20070053976A1 (en) * | 2002-05-17 | 2007-03-08 | Eisai R & D Management Co., Ltd. | Novel combination of drugs as antidepressant |
| WO2004034963A2 (en) * | 2002-05-17 | 2004-04-29 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
| US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| ES2329356T3 (es) | 2002-06-12 | 2009-11-25 | Chemocentryx, Inc. | Derivados de piperazina 1-arilo-4-sustituidos utilizados como antagonistas de ccr1 para el tratamiento de enfermedades inflamatorias e inmunitarias. |
| US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US20050232990A1 (en) * | 2003-12-31 | 2005-10-20 | Garth Boehm | Donepezil formulations |
| JP4845873B2 (ja) * | 2004-03-03 | 2011-12-28 | ケモセントリックス インコーポレーティッド | 二環式および架橋した窒素複素環 |
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US7795438B2 (en) | 2004-04-28 | 2010-09-14 | Eisai R&D Management Co., Ltd | Processes for producing 1-benzyl-4-[(5,6-dimethoxy-1indanon)-2-yl]methylpiperidine and hydrochloride |
| WO2006036936A2 (en) * | 2004-09-27 | 2006-04-06 | Bridge Pharma, Inc. | The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents |
| WO2006037047A2 (en) * | 2004-09-27 | 2006-04-06 | Bridge Pharma, Inc. | The r-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents |
| WO2006050359A2 (en) | 2004-11-02 | 2006-05-11 | Northwestern University | Pyridazine compounds and methods |
| KR20070097590A (ko) | 2005-01-25 | 2007-10-04 | 에픽스 델라웨어, 인코포레이티드 | 치환된 아릴아민 화합물 및 5―ｈｔ6 조절제로서의 이의용도 |
| ME01224B (me) * | 2005-04-04 | 2013-06-20 | Eisai R&D Man Co Ltd | Jedinjenja dihidropiridina za liječenje neurodegenerativnih bolesti i demencije |
| AU2006300492B2 (en) * | 2005-10-14 | 2011-08-25 | Eisai R & D Management Co., Ltd. | Process for producing 1-benzyl-4-[(5,6-dimethoxy-1indanon)-2-yl]methylpiperidine or hydrochloride thereof |
| EP1960357A2 (en) * | 2005-11-14 | 2008-08-27 | Medichem S.A. | Synthesis and preparations of intermediates and polymorphs thereof useful for the preparation of donepezil hydrochloride |
| CA2650711A1 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
| CA2655809C (en) * | 2006-07-21 | 2013-10-01 | Bridge Pharma, Inc. | Dermal anesthetic compounds |
| KR101408488B1 (ko) * | 2006-12-01 | 2014-06-17 | 닛토덴코 가부시키가이샤 | 도네페질 함유 접착 제제의 경시적인 변색을 억제하는 방법 |
| CN101573115B (zh) * | 2006-12-01 | 2012-06-06 | 日东电工株式会社 | 抑制含有多奈哌齐的贴剂着色的方法、及降低多奈哌齐类似物的生成量的方法 |
| JP2010520154A (ja) * | 2007-03-05 | 2010-06-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経変性疾患のためのａｍｐａレセプターアンタゴニストおよびｎｍｄａレセプターアンタゴニスト |
| WO2008139984A1 (en) * | 2007-04-26 | 2008-11-20 | Eisai R & D Management Co., Ltd. | Cinnamide compounds for dementia |
| KR100914691B1 (ko) * | 2007-08-10 | 2009-08-28 | 주식회사유한양행 | 도네페질 또는 그의 제조용 중간체의 제조방법 |
| EP2279739B2 (en) * | 2008-05-30 | 2018-02-28 | Nitto Denko Corporation | Donepezil-containing patch preparation and packaging thereof |
| BRPI0912099A2 (pt) * | 2008-05-30 | 2015-10-06 | Eisai R&D Man Co Ltd | preparação percutaneamente absorvível |
| EA037187B1 (ru) | 2010-02-09 | 2021-02-17 | Дзе Джонс Хопкинс Юниверсити | Способ и композиция для лечения когнитивного расстройства |
| EP2642998B1 (en) | 2010-11-24 | 2020-09-16 | The Trustees of Columbia University in the City of New York | A non-retinoid rbp4 antagonist for treatment of age-related macular degeneration and stargardt disease |
| WO2013166037A1 (en) | 2012-05-01 | 2013-11-07 | The Trustees Of Columbia University In The City Of New York | Non-retinoid antagonists for treatment of eye disorders |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| WO2014151936A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles, their preparation and use |
| EP2968303B1 (en) | 2013-03-14 | 2018-07-04 | The Trustees of Columbia University in the City of New York | Octahydrocyclopentapyrroles, their preparation and use |
| US10273243B2 (en) | 2013-03-14 | 2019-04-30 | The Trustees Of Columbia University In The City Of New York | 4-phenylpiperidines, their preparation and use |
| WO2014151959A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
| JP6433482B2 (ja) | 2013-03-15 | 2018-12-05 | エージンバイオ， インコーポレイテッド | 認知機能を改善するための方法および組成物 |
| US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| WO2015168286A1 (en) | 2014-04-30 | 2015-11-05 | The Trustees Of Columbia University In The City Of New York | Substituted 4-phenylpiperidines, their preparaiton and use |
| KR101732776B1 (ko) * | 2014-10-08 | 2017-05-04 | 영남대학교 산학협력단 | 신규한 인데노 피리디니움 유도체 화합물 및 이의 제조방법 |
| AU2016268096B2 (en) | 2015-05-22 | 2021-04-01 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4895841A (en) * | 1987-06-22 | 1990-01-23 | Eisai Co., Ltd. | Cyclic amine compounds with activity against acetylcholinesterase |
| WO1997046527A1 (en) * | 1996-06-07 | 1997-12-11 | Eisai Co., Ltd. | Polymorphs of donepezil hydrochloride and process for production |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5064858A (en) * | 1988-08-17 | 1991-11-12 | Spectrum Pharmaceutical Corporation | Protected complex of procaine for the treatment of symptoms from narcotics addiction, tinnitus and Alzheimer's disease |
| CA2222713C (en) * | 1995-07-14 | 2003-04-22 | Andrew John Mcglashan Richards | Composition comprising d-threo-methylphenidate and another drug |
| PT971713E (pt) * | 1997-03-03 | 2003-09-30 | Eisai Co Ltd | Utilizacao de inibidores da colinesterase para tratamento de desordens da atencao |
-
1998
- 1998-03-03 PT PT98905121T patent/PT971713E/pt unknown
- 1998-03-03 WO PCT/IB1998/000508 patent/WO1998039000A1/en not_active Ceased
- 1998-03-03 DK DK98905121T patent/DK0971713T3/da active
- 1998-03-03 NZ NZ337515A patent/NZ337515A/en not_active IP Right Cessation
- 1998-03-03 JP JP53831598A patent/JP4095676B2/ja not_active Expired - Lifetime
- 1998-03-03 ES ES98905121T patent/ES2200313T3/es not_active Expired - Lifetime
- 1998-03-03 DE DE69815090T patent/DE69815090T2/de not_active Expired - Lifetime
- 1998-03-03 CA CA002282654A patent/CA2282654C/en not_active Expired - Fee Related
- 1998-03-03 AU AU73215/98A patent/AU743609B2/en not_active Ceased
- 1998-03-03 US US09/033,880 patent/US6455544B1/en not_active Expired - Lifetime
- 1998-03-03 EP EP98905121A patent/EP0971713B1/en not_active Expired - Lifetime
- 1998-03-03 AT AT98905121T patent/ATE241358T1/de active
-
2002
- 2002-09-24 US US10/253,731 patent/US7105540B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4895841A (en) * | 1987-06-22 | 1990-01-23 | Eisai Co., Ltd. | Cyclic amine compounds with activity against acetylcholinesterase |
| WO1997046527A1 (en) * | 1996-06-07 | 1997-12-11 | Eisai Co., Ltd. | Polymorphs of donepezil hydrochloride and process for production |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2200313T3 (es) | 2004-03-01 |
| CA2282654C (en) | 2009-02-03 |
| US20030055040A1 (en) | 2003-03-20 |
| WO1998039000A1 (en) | 1998-09-11 |
| ATE241358T1 (de) | 2003-06-15 |
| DK0971713T3 (da) | 2003-09-22 |
| PT971713E (pt) | 2003-09-30 |
| DE69815090D1 (de) | 2003-07-03 |
| NZ337515A (en) | 2002-07-26 |
| EP0971713A1 (en) | 2000-01-19 |
| JP2001515480A (ja) | 2001-09-18 |
| DE69815090T2 (de) | 2004-02-19 |
| US6455544B1 (en) | 2002-09-24 |
| JP4095676B2 (ja) | 2008-06-04 |
| CA2282654A1 (en) | 1998-09-11 |
| US7105540B2 (en) | 2006-09-12 |
| EP0971713B1 (en) | 2003-05-28 |
| AU7321598A (en) | 1998-09-22 |
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| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: EISAI CO., LTD. Free format text: THE FORMER OWNER WAS: EISAI CO., LTD., SHARON L. ROGERS |
|
| FGA | Letters patent sealed or granted (standard patent) |