AU742945B2 - Carboxylic acids and derivatives thereof and pharmaceutical compositions contai ning them - Google Patents

Carboxylic acids and derivatives thereof and pharmaceutical compositions contai ning them Download PDF

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Publication number
AU742945B2
AU742945B2 AU79947/98A AU7994798A AU742945B2 AU 742945 B2 AU742945 B2 AU 742945B2 AU 79947/98 A AU79947/98 A AU 79947/98A AU 7994798 A AU7994798 A AU 7994798A AU 742945 B2 AU742945 B2 AU 742945B2
Authority
AU
Australia
Prior art keywords
compound
acid
compounds
substituted
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU79947/98A
Other languages
English (en)
Other versions
AU7994798A (en
Inventor
Jacob Bar-Tana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syndromex Ltd
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Publication of AU7994798A publication Critical patent/AU7994798A/en
Application granted granted Critical
Publication of AU742945B2 publication Critical patent/AU742945B2/en
Priority to AU34363/02A priority Critical patent/AU780162B2/en
Assigned to SYNDROMEX LTD. reassignment SYNDROMEX LTD. Alteration of Name(s) in Register under S187 Assignors: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/602—Dicarboxylic acid esters having at least two carbon-to-carbon double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU79947/98A 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions contai ning them Ceased AU742945B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU34363/02A AU780162B2 (en) 1997-01-07 2002-04-16 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11997197A IL119971A (en) 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
IL119971 1997-01-07
PCT/IL1997/000427 WO1998030530A1 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU34363/02A Division AU780162B2 (en) 1997-01-07 2002-04-16 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
AU7994798A AU7994798A (en) 1998-08-03
AU742945B2 true AU742945B2 (en) 2002-01-17

Family

ID=11069666

Family Applications (1)

Application Number Title Priority Date Filing Date
AU79947/98A Ceased AU742945B2 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions contai ning them

Country Status (10)

Country Link
US (3) US6284903B1 (enExample)
EP (2) EP2112134B1 (enExample)
JP (2) JP2001507713A (enExample)
KR (2) KR100806928B1 (enExample)
AT (1) ATE431816T1 (enExample)
AU (1) AU742945B2 (enExample)
CA (1) CA2277075C (enExample)
DE (1) DE69739415D1 (enExample)
IL (1) IL119971A (enExample)
WO (1) WO1998030530A1 (enExample)

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US6814962B1 (en) * 1994-06-02 2004-11-09 Aventis Pharma S.A. Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
IL121165A0 (en) 1997-06-26 1997-11-20 Yissum Res Dev Co Pharmaceutical compositions containing carboxylic acids and derivatives thereof
US6459003B1 (en) 1999-04-01 2002-10-01 Esperion Therapeutics, Inc. Ether compounds
US7304093B2 (en) 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
CN1962596A (zh) 2000-10-11 2007-05-16 埃斯佩里安医疗公司 用于控制胆固醇以及相关用途的酮化合物以及组合物
JP2004531459A (ja) 2000-10-11 2004-10-14 エスペリオン セラピューティクス，インコーポレイテッド コレステロールマネージメント用スルホキシドおよびビススルホキシド化合物ならびに組成物および関連する使用
WO2002030884A2 (en) 2000-10-11 2002-04-18 Esperion Therapeutics, Inc. Sulfide and disulfide compounds and compositions for cholesterol management and related uses
MXPA03003021A (es) 2000-10-11 2003-07-14 Esperion Therapeutics Inc Compuestos de eter y composiciones para el control del colesterol y usos relacionados.
US7335689B2 (en) 2003-01-23 2008-02-26 Esperion Therapeutics, Inc. Dihydroxyl compounds and compositions for cholesterol management and related uses
US7705177B2 (en) 2003-12-24 2010-04-27 Esperion Therapuetics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US20090018199A1 (en) * 2003-12-30 2009-01-15 Syndrome X Ltd. Methods of Administering 3, 3, 14, 14 Tetramethyl Hexadecane 1, 16 Dioic Acid
WO2007016525A2 (en) 2005-07-29 2007-02-08 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
PT2118074E (pt) 2007-02-01 2014-03-20 Resverlogix Corp Compostos para a prevenção e tratamento de doenças cardiovasculares
IL181577A0 (en) * 2007-02-26 2007-07-04 Jacob Bar Tana Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders
EP2431043A1 (en) 2007-05-23 2012-03-21 Amcol International Corporation Cholesterol-interacting layered phyllosilicates for suppressing gastrointestinal cholesterol absorption
US8114995B2 (en) 2008-06-26 2012-02-14 Resverlogix Corp. Methods of preparing quinazolinone derivatives
ES2542835T3 (es) 2009-01-08 2015-08-12 Resverlogix Corporation Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares
NZ617779A (en) 2009-03-18 2015-08-28 Resverlogix Corp Novel anti-inflammatory agents
US9757368B2 (en) 2009-04-22 2017-09-12 Resverlogix Corp. Anti-inflammatory agents
KR101660578B1 (ko) 2009-09-03 2016-09-27 화이자 백신스 엘엘씨 Ｐｃｓｋ９ 백신
JP2013537240A (ja) 2010-09-20 2013-09-30 カリウス セラピューティクス エスエー 糖尿病および脂質異常症の処置のための方法および組成物
WO2012131504A1 (en) 2011-03-02 2012-10-04 Pfizer Inc. Pcsk9 vaccine
PT2773354T (pt) 2011-11-01 2019-07-17 Resverlogix Corp Formulações orais de libertação imediata para quinazolinonas substituídas
EP2787986B1 (en) 2011-12-08 2017-10-18 Syndromex Ltd. Deuterated tetramethyl dioic acids, compositions comprising them and uses thereof
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
JP2016507496A (ja) 2012-12-21 2016-03-10 ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． ブロモドメイン阻害剤としての新規複素環式化合物
EP3104877B1 (en) 2014-02-11 2020-01-22 The USA, as represented by The Secretary, Department of Health and Human Services Pcsk9 vaccine and methods of using the same
CN114984016A (zh) 2015-03-13 2022-09-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法
MX392182B (es) 2015-03-13 2025-03-21 Esperion Therapeutics Inc Combinaciones de dosis fija y formulaciones que comprenden ácido 8-hidroxi-2,2,14,14 tetrametilpentadecanodioico (etc1002) y ezetimiba y métodos para tratar o reducir el riesgo de enfermedad cardiovascular.
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
CN107118098B (zh) * 2016-02-25 2020-07-14 中国科学院上海药物研究所 一类脂肪酸类化合物、其制备方法及其用途
CN109195595A (zh) * 2016-06-02 2019-01-11 塞多麦克斯有限公司 使用α，α-取代的长链两亲性羧酸盐的糖尿病治疗方案
US10512624B2 (en) 2016-11-30 2019-12-24 Syndromex Ltd. Long-chain amphipathic dicarboxylic acids for treatment of diabetes type-1
CN112437765A (zh) 2019-06-21 2021-03-02 艾斯柏伦治疗公司 贝派地酸的盐形式及其使用方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268082A (en) 1969-08-08 1972-03-22 Orsymonde Improvements in or relating to bis-(carboxy-alkylene-thio)-decanes
US3773946A (en) * 1969-09-02 1973-11-20 Parke Davis & Co Triglyceride-lowering compositions and methods
US3930024A (en) * 1969-09-02 1975-12-30 Parke Davis & Co Pharmaceutical compositions and methods
BE755550A (fr) * 1969-09-02 1971-02-01 Parke Davis & Co Acides alcanedioiques, leurs sels et leurs esters abaissant la teneur en triglycerides du serum sanguin
FR2288516A2 (fr) * 1974-10-21 1976-05-21 Orsymonde Nouveaux bis-(carboxyalcoylene-thio)-1,10 decanes et leurs derives
IL64542A0 (en) * 1981-12-15 1982-03-31 Yissum Res Dev Co Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them
DE3423166A1 (de) * 1984-06-22 1986-01-02 Epis S.A., Zug Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US4634975A (en) * 1984-09-17 1987-01-06 Progressive Dynamics, Inc. Method and apparatus for producing electromagnetic surveillance fields
JPS61171417A (ja) * 1985-01-23 1986-08-02 Wakunaga Seiyaku Kk 抗糖尿病剤
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3634356A1 (de) * 1986-10-08 1988-04-21 Epis Sa Arzneimittel enthaltend alpha-halogenierte dicarbonsaeuren
DE4224670A1 (de) * 1992-07-25 1994-01-27 Boehringer Mannheim Gmbh Verwendung von â,w-Dicarbonsäuren als Fibrinogensenker
US5648387A (en) 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
JP2003001549A (ja) * 2001-06-26 2003-01-08 Howa Mach Ltd 光電式刃具折れ検知装置

Also Published As

Publication number Publication date
KR20070026888A (ko) 2007-03-08
EP2112134B1 (en) 2013-10-30
EP0988274A1 (en) 2000-03-29
ATE431816T1 (de) 2009-06-15
DE69739415D1 (de) 2009-07-02
JP5479857B2 (ja) 2014-04-23
IL119971A (en) 2003-02-12
JP2001507713A (ja) 2001-06-12
US6800772B2 (en) 2004-10-05
CA2277075C (en) 2010-06-22
EP2112134A1 (en) 2009-10-28
US6284903B1 (en) 2001-09-04
KR100806927B1 (ko) 2008-02-22
IL119971A0 (en) 1997-04-15
JP2010077141A (ja) 2010-04-08
AU7994798A (en) 1998-08-03
KR100806928B1 (ko) 2008-02-22
US20040132818A1 (en) 2004-07-08
KR20000069934A (ko) 2000-11-25
WO1998030530A1 (en) 1998-07-16
EP0988274A4 (en) 2000-10-18
EP0988274B1 (en) 2009-05-20
CA2277075A1 (en) 1998-07-16
US20020049345A1 (en) 2002-04-25

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: SYNDROMEX LTD.

Free format text: FORMER OWNER WAS: YISSUM RESEARCH DEVELOPMENT CO. OF THE HEBREW UNIVERSITY OF JERUSALEM