AU742198B2 - Cocoa extract compounds and methods for making and using the same - Google Patents

Cocoa extract compounds and methods for making and using the same Download PDF

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Publication number
AU742198B2
AU742198B2 AU33674/97A AU3367497A AU742198B2 AU 742198 B2 AU742198 B2 AU 742198B2 AU 33674/97 A AU33674/97 A AU 33674/97A AU 3367497 A AU3367497 A AU 3367497A AU 742198 B2 AU742198 B2 AU 742198B2
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AU
Australia
Prior art keywords
sugar
hydrogen
unit
group
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU33674/97A
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English (en)
Other versions
AU3367497A (en
Inventor
Margaret M. Buck
Giovanni G. Cipolla
John F. Hammerstone Jr.
Craig A. Mcclelland
Jeff A. Mundt
Laurie S. Post
Leo J. Romanczyk Jr.
Harold H. Schmitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mars Inc
Original Assignee
Mars Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1996/004497 external-priority patent/WO1997036597A1/en
Application filed by Mars Inc filed Critical Mars Inc
Publication of AU3367497A publication Critical patent/AU3367497A/en
Priority to AU83649/01A priority Critical patent/AU783239B2/en
Application granted granted Critical
Publication of AU742198B2 publication Critical patent/AU742198B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
AU33674/97A 1996-04-02 1997-04-02 Cocoa extract compounds and methods for making and using the same Expired AU742198B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU83649/01A AU783239B2 (en) 1996-04-02 2001-10-26 Cocoa extract compounds and methods for making and using the same

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63166196A 1996-04-02 1996-04-02
AU57116/96 1996-04-02
US08/631661 1996-04-02
PCT/US1996/004497 WO1997036597A1 (en) 1996-04-02 1996-04-02 Cocoa extract compounds and methods for making and using the same
PCT/US1997/005693 WO1997036497A2 (en) 1996-04-02 1997-04-02 Cocoa extract compounds and methods for making and using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU83649/01A Division AU783239B2 (en) 1996-04-02 2001-10-26 Cocoa extract compounds and methods for making and using the same

Publications (2)

Publication Number Publication Date
AU3367497A AU3367497A (en) 1997-10-22
AU742198B2 true AU742198B2 (en) 2001-12-20

Family

ID=26790948

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33674/97A Expired AU742198B2 (en) 1996-04-02 1997-04-02 Cocoa extract compounds and methods for making and using the same

Country Status (9)

Country Link
EP (2) EP1015006A4 (cg-RX-API-DMAC7.html)
JP (2) JP2000506901A (cg-RX-API-DMAC7.html)
CN (1) CN1159019C (cg-RX-API-DMAC7.html)
AU (1) AU742198B2 (cg-RX-API-DMAC7.html)
BR (1) BR9710955A (cg-RX-API-DMAC7.html)
CA (1) CA2250792C (cg-RX-API-DMAC7.html)
PL (1) PL329325A1 (cg-RX-API-DMAC7.html)
RU (1) RU2010111103A (cg-RX-API-DMAC7.html)
WO (1) WO1997036497A2 (cg-RX-API-DMAC7.html)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696485B1 (en) 1996-04-02 2004-02-24 Mars, Incorporated Procyanidin and cyclo-oxygenase modulator compositions
US7968140B2 (en) 1997-09-08 2011-06-28 Mars, Incorporated Chocolates and chocolate liquor having an enhanced polyphenol content
US6312753B1 (en) * 1996-09-06 2001-11-06 Mars, Incorporated Cocoa components, edible products having enriched polyphenol content, methods of making same and medical uses
US6207842B1 (en) * 1997-10-09 2001-03-27 Mars Incorporated Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
CA2322860C (en) * 1998-03-12 2010-10-19 Mars, Incorporated Products containing polyphenol(s) and l-arginine to stimulate nitric oxide production
US8507018B2 (en) 1998-03-12 2013-08-13 Mars, Incorporated Products containing polyphenol(s) and L-arginine and methods of use thereof
US6805883B2 (en) 1998-03-12 2004-10-19 Mars, Incorporated Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide
AU2004200273B2 (en) * 1998-03-12 2008-02-07 Mars, Incorporated Products Containing Polyphenol(s) and L-Arginine to stimulate nitric oxide production
US7011856B2 (en) * 1998-08-05 2006-03-14 Amino Up Chemical Co., Ltd. Composition for the treatment of symptoms and conditions associated with aging
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
WO2000054792A1 (en) * 1999-03-17 2000-09-21 Morinaga & Co., Ltd. Drugs, foods, drinks and feeds containing cocoa component
JP3260134B2 (ja) 1999-10-08 2002-02-25 信孝 鈴木 月経困難症、子宮内膜症の治療薬
JP2003527418A (ja) * 2000-03-22 2003-09-16 マーズ インコーポレイテッド アセチルサリチル酸と併用したカカオプロシアニジンの抗血小板療法としての使用
RU2303373C2 (ru) * 2000-04-14 2007-07-27 Марс, Инкорпорейтед Композиции и способы улучшения состояния сосудистой системы
US6627232B1 (en) * 2000-06-09 2003-09-30 Mars Incorporated Method for extracting cocoa procyanidins
DE10037983B4 (de) 2000-08-03 2006-04-13 Stefan Zikeli Polymerzusammensetzung und daraus hergestellter Formkörper mit einem Gehalt an Alkaloid
FR2812873B1 (fr) 2000-08-11 2003-08-01 Barry Callebaut France Procede de production de polyphenols a partir de feves de cacao
JP4763139B2 (ja) * 2001-02-21 2011-08-31 株式会社アミノアップ化学 新規な多価フェノール重合体及びその用途
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
US7108868B2 (en) * 2002-03-22 2006-09-19 Unigen Pharmaceuticals, Inc. Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia
US7972632B2 (en) 2003-02-28 2011-07-05 Unigen Pharmaceuticals, Inc. Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors
US7514107B2 (en) * 2002-03-21 2009-04-07 Mars, Incorporated Treatment of diseases involving defective gap junctional communication
FR2838055B1 (fr) * 2002-04-05 2006-06-09 Cep Nouvelle utilisation d'un extrait de cacao et les compositions cosmetiques et/ou dermatologiques a cet effet
US8034387B2 (en) 2002-04-30 2011-10-11 Unigen, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments
ATE438393T1 (de) 2002-04-30 2009-08-15 Unigen Pharmaceuticals Inc Formulierung eines gemisches aus flavonoiden und flavanen mit freiem b ring als therapeutisches mittel
US8945518B2 (en) 2002-04-30 2015-02-03 Unigen, Inc. Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions
KR20030097398A (ko) * 2002-06-21 2003-12-31 이노천 양념육용 폴리페놀을 함유한 소스
CA2521429A1 (en) 2003-04-04 2004-10-21 Unigen Pharmaceuticals, Inc. Formulation of dual cycloxygenase (cox) and lipoxygenase (lox) inhibitors for mammal skin care
TWI279231B (en) * 2003-10-02 2007-04-21 Asahi Breweries Ltd Neutralization agent of vacuolization toxin
US20050245601A1 (en) * 2003-10-10 2005-11-03 Mars, Incorporated Treatment of diseases involving ErbB2 kinase overexpression
CN1938015A (zh) 2004-01-28 2007-03-28 马尔斯公司 A型矢车菊苷配基的组合物和使用方法
EP1852430B1 (en) * 2005-02-25 2019-07-03 Nagasaki University Method of producing proanthocyanidin oligomer
JP4681363B2 (ja) * 2005-03-04 2011-05-11 美智士 谷 悪性腫瘍治療剤及びそれを含む飲食品
JP4942953B2 (ja) * 2005-06-30 2012-05-30 サントリーホールディングス株式会社 プロシアニジンの分析方法
KR100761248B1 (ko) 2006-10-12 2007-10-04 주식회사 유니젠 대나무 및 황금 추출물을 유효성분으로 함유하는 아토피성피부염 치료를 위한 조성물
ES2401926T3 (es) 2006-11-17 2013-04-25 Barry Callebaut Ag Método para la producción de un producto de cacao soluble a partir de cacao en polvo
US8609174B2 (en) 2006-11-17 2013-12-17 Barry Callebaut Ag Method for producing a soluble cocoa product from cocoa powder
GB0724716D0 (en) 2007-12-19 2008-01-30 Barry Callebaut Ag Process
GB0801119D0 (en) 2008-01-22 2008-02-27 Barry Callebaut Ag Composition
FR2927811B1 (fr) * 2008-02-27 2010-09-10 Unither Dev Colorant pharmaceutique extrait de cranberry concentre en proanthocyanidines a.
JP5462491B2 (ja) * 2009-01-21 2014-04-02 株式会社 エフェクト プロアントシアニジン三量体
EP2414509B1 (en) 2009-04-03 2015-09-23 DianaPlantSciences S.A.S. Production and extraction of procyanidins from plant cell cultures
JP5569716B2 (ja) * 2009-06-23 2014-08-13 独立行政法人国立循環器病研究センター レクチン様酸化ｌｄｌ受容体阻害用医薬品
US20120323016A1 (en) * 2009-12-17 2012-12-20 National University Of Singapore Method of preparing derivatives/oligomers of epicatechin and applications thereof
MX2012010225A (es) 2010-03-05 2012-10-01 Mars Inc Composiciones y bebidas apetecibles con extracto de cacao.
WO2012047817A1 (en) 2010-10-04 2012-04-12 Dianaplantsciences, Inc. Production and extraction of procyanidins from plant cells cultures
CN103338636A (zh) * 2010-12-07 2013-10-02 好时公司 影响脂肪酸摄取和代谢及炎性介质产生的化合物和从可可产品中分离所述化合物的方法
AU2012214104C1 (en) * 2011-02-08 2017-08-03 Poly Gain Pte Ltd Sugar extracts
HK1202384A1 (en) * 2012-02-16 2015-10-02 株式会社鎌田 Filter containing built-in capsule, cigarette provided with filter and cigarette substitute provide with filter
ITTV20120064A1 (it) * 2012-04-19 2013-10-20 R I Group Srl Estratto per trattamento delle cefalee primitive
CN103113384B (zh) * 2013-02-27 2015-05-20 安徽农业大学 一种名为茯砖素b的儿茶素类衍生物及其制备方法和应用
WO2016046375A1 (en) * 2014-09-25 2016-03-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) Theobroma cacao extract for use in the treatment or prevention of receptor tyrosine kinases related disorders
TW201733605A (zh) * 2016-02-29 2017-10-01 明治股份有限公司 可可水萃物、含它之飲食品、可可萃取物之製造方法、及多酚之萃取方法
EP3747276B1 (en) 2019-06-04 2024-11-06 ODC Lizenz AG Cocoa-based frozen desserts and methods of their manufacture

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166861A (en) * 1976-03-23 1979-09-04 Inverni Della Beffa S.P.A. Pharmacologically active polyphenolic substances
EP0657169A1 (en) * 1993-12-06 1995-06-14 The Nikka Whisky Distilling Co., Ltd. Fruit polyphenol; process for production thereof; and antioxidant, hypotensive agent, antimutagenic agent, antiallergic agent and anticariogenic agent, each comprising said polyphenol

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1584725A (cg-RX-API-DMAC7.html) * 1968-01-30 1970-01-02
JPS6011912B2 (ja) * 1981-07-30 1985-03-28 日本新薬株式会社 タンニン
JPS58154571A (ja) * 1982-03-08 1983-09-14 Nippon Shinyaku Co Ltd 新規タンニン
JPS6116982A (ja) * 1984-07-03 1986-01-24 Kikkoman Corp 抗酸化剤
NL8403748A (nl) * 1984-12-10 1986-07-01 Zaan Cacaofab Bv Cacaopoeder.
US4698360B1 (en) * 1985-04-09 1997-11-04 D Investigations Pharmacologiq Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
GB8518289D0 (en) * 1985-07-19 1985-08-29 Inverni Della Beffa Spa Obtaining proanthocyanidine a2
JPS6425726A (en) * 1987-04-24 1989-01-27 Yuutoku Yakuhin Kogyo Kk Agent for eliminating active oxygen free radical
FR2618675B1 (fr) * 1987-07-30 1990-03-23 Bonnaure Mallet Martine Composition pharmaceutique destinee au traitement des maladies parodontales comportant a titre de principe actif, au moins un monomere et/ou oligomere procyanidolique
US5650432A (en) * 1995-03-24 1997-07-22 Jlb, Inc. Method of treating or preventing non-viral microbial infection
FR2706478B1 (fr) * 1993-06-14 1995-09-08 Ovi Sa Compositions de dérivés phénoliques, leur préparation et leurs applications comme anti-oxydants.
US5554645A (en) * 1994-10-03 1996-09-10 Mars, Incorporated Antineoplastic cocoa extracts and methods for making and using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166861A (en) * 1976-03-23 1979-09-04 Inverni Della Beffa S.P.A. Pharmacologically active polyphenolic substances
EP0657169A1 (en) * 1993-12-06 1995-06-14 The Nikka Whisky Distilling Co., Ltd. Fruit polyphenol; process for production thereof; and antioxidant, hypotensive agent, antimutagenic agent, antiallergic agent and anticariogenic agent, each comprising said polyphenol

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CZOCHANKSA ET AL J. CHEM. SOC. 198,(10), 2278-2286 *

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HK1020881A1 (en) 2000-05-26
AU3367497A (en) 1997-10-22
JP2000506901A (ja) 2000-06-06
BR9710955A (pt) 2001-03-13
EP1015006A4 (en) 2003-09-24
WO1997036497A3 (en) 1997-12-24
JP2011006427A (ja) 2011-01-13
CN1159019C (zh) 2004-07-28
CA2250792A1 (en) 1997-10-09
CA2250792C (en) 2011-09-13
WO1997036497A2 (en) 1997-10-09
PL329325A1 (en) 1999-03-29
EP1015006A2 (en) 2000-07-05
EP2110134A1 (en) 2009-10-21
RU2010111103A (ru) 2011-09-27
CN1221344A (zh) 1999-06-30

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