AU701916B2 - Chemical compounds - Google Patents

Chemical compounds Download PDF

Info

Publication number
AU701916B2
AU701916B2 AU42697/96A AU4269796A AU701916B2 AU 701916 B2 AU701916 B2 AU 701916B2 AU 42697/96 A AU42697/96 A AU 42697/96A AU 4269796 A AU4269796 A AU 4269796A AU 701916 B2 AU701916 B2 AU 701916B2
Authority
AU
Australia
Prior art keywords
enzyme
dna
prodrug
cells
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU42697/96A
Other languages
English (en)
Other versions
AU4269796A (en
Inventor
David Charles Blakey
Francis Thomas Boyle
David Huw Davies
Hendrikus Johannes Eggelte
David William Heaton
John Frederick Hennam
Laurent Francois Andre Hennequin
Peter Robert Marsham
Brian Robert Rabin
Anthony Michael Slater
Antonio Tarragona-Fiol
Christopher John Taylorson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
London Biotechnology Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26306259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU701916(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9426192.2A external-priority patent/GB9426192D0/en
Priority claimed from GBGB9516810.0A external-priority patent/GB9516810D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of AU4269796A publication Critical patent/AU4269796A/en
Application granted granted Critical
Publication of AU701916B2 publication Critical patent/AU701916B2/en
Assigned to ASTRAZENECA AB reassignment ASTRAZENECA AB Alteration of Name(s) in Register under S187 Assignors: ZENECA LIMITED
Assigned to LONDON BIOTECHNOLOGY LIMITED reassignment LONDON BIOTECHNOLOGY LIMITED Alteration of Name(s) in Register under S187 Assignors: ASTRAZENECA AB
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
AU42697/96A 1994-12-23 1995-12-21 Chemical compounds Ceased AU701916B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9426192 1994-12-23
GBGB9426192.2A GB9426192D0 (en) 1994-12-23 1994-12-23 Chemical compounds
GBGB9516810.0A GB9516810D0 (en) 1995-08-16 1995-08-16 Chemical compounds
GB9516810 1995-08-16
PCT/GB1995/002991 WO1996020011A1 (en) 1994-12-23 1995-12-21 Chemical compounds

Publications (2)

Publication Number Publication Date
AU4269796A AU4269796A (en) 1996-07-19
AU701916B2 true AU701916B2 (en) 1999-02-11

Family

ID=26306259

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42697/96A Ceased AU701916B2 (en) 1994-12-23 1995-12-21 Chemical compounds

Country Status (23)

Country Link
US (1) US5985281A (enExample)
EP (1) EP0806964B1 (enExample)
JP (1) JP3805365B2 (enExample)
KR (1) KR100270650B1 (enExample)
CN (1) CN1095677C (enExample)
AT (1) ATE222124T1 (enExample)
AU (1) AU701916B2 (enExample)
BR (1) BR9510490B1 (enExample)
CA (1) CA2205091A1 (enExample)
CZ (1) CZ195297A3 (enExample)
DE (1) DE69527805T2 (enExample)
ES (1) ES2181805T3 (enExample)
FI (1) FI972683A7 (enExample)
HU (1) HUT77450A (enExample)
IL (1) IL116511A0 (enExample)
MX (1) MX9704575A (enExample)
NO (1) NO972882L (enExample)
NZ (1) NZ297529A (enExample)
PL (1) PL184031B1 (enExample)
RU (1) RU2189251C2 (enExample)
SK (1) SK80997A3 (enExample)
TR (1) TR199501654A2 (enExample)
WO (1) WO1996020011A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1193278A (zh) 1995-08-16 1998-09-16 曾尼卡有限公司 化合物
SG71046A1 (en) 1996-10-10 2000-03-21 Connector Systems Tech Nv High density connector and method of manufacture
AU6000698A (en) * 1997-02-14 1998-09-08 Zeneca Limited Proteins
GB9703201D0 (en) * 1997-02-15 1997-04-02 Zeneca Ltd Chemical compounds
GB9709421D0 (en) * 1997-05-10 1997-07-02 Zeneca Ltd Chemical compounds
WO2000016808A2 (en) * 1998-09-18 2000-03-30 Immunomedics, Inc. Antibody directed enzyme prodrug therapy (edept) with glucoronidase
US20040117863A1 (en) * 1998-09-18 2004-06-17 Edge Michael D. Transgenically produced fusion proteins
US6361774B1 (en) 1999-09-17 2002-03-26 Immunomedics, Inc. Methods and compositions for increasing the target-specific toxicity of a chemotherapy drug
MXPA02002769A (es) * 1999-09-17 2005-07-01 Gtc Biotherapeutics Inc Proteinas de fusion producidas transgenicamente.
CA2438641A1 (en) 2001-02-15 2002-08-22 King Pharmaceuticals, Inc. Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
CA2506629A1 (en) * 2002-11-27 2004-06-17 Gtc Biotherapeutics, Inc. Modified antibodies stably produced in milk and methods of producing same
US20080019905A9 (en) * 2005-02-18 2008-01-24 Strome Scott E Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection
CN101484470B (zh) * 2005-10-21 2014-07-23 阿伊沃生物制剂有限公司 具有增强的抗体依赖性细胞毒性活性的抗体及其生产方法和用途
EP2037954A4 (en) * 2006-06-20 2011-09-14 Janssen Pharmaceutica Nv METHOD FOR MODULATING PHARMACOKINETICS AND METABOLISM OF THERAPEUTIC USE
US20080031866A1 (en) * 2006-06-20 2008-02-07 Eichenbaum Gary M Method for modulating the pharmacokinetics and metabolism of a therapeutic agent
WO2008041059A1 (en) 2006-10-03 2008-04-10 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of mustards and related compounds with very high skin penetration rates
GB0709333D0 (en) * 2007-05-15 2007-06-20 Smart Targeting Ltd Binding protein
EP2279003A4 (en) * 2008-05-01 2013-04-03 Gtc Biotherapeutics Inc ANTI-CD137 ANTIBODY AS A MEANS FOR THE TREATMENT OF INFLAMMATORY DISEASES
US10745492B1 (en) * 2019-04-03 2020-08-18 Ark Diagnostics, Inc. Antibodies to symmetrically dimethylated arginine analytes and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8705477D0 (en) * 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
US4975278A (en) * 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
GB8809616D0 (en) * 1988-04-22 1988-05-25 Cancer Res Campaign Tech Further improvements relating to drug delivery systems
US5632990A (en) * 1988-04-22 1997-05-27 Cancer Research Campaign Tech. Ltd. Treatment for tumors comprising conjugated antibody A5B7 and a prodrug
JP3273608B2 (ja) * 1989-01-23 2002-04-08 アクゾ・エヌ・ヴエー 治療薬の部位特異的インビボ活性化
US5433955A (en) * 1989-01-23 1995-07-18 Akzo N.V. Site specific in vivo activation of therapeutic drugs
CA2127126A1 (en) * 1992-01-30 1993-08-05 Helen M. Wilks Chiral synthesis with modified enzymes
GB9323429D0 (en) * 1993-11-12 1994-01-05 Wellcome Found Therapy
US5389537A (en) * 1994-01-21 1995-02-14 Wisconsin Alumni Research Foundation Nuclease having altered specificity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BOSSLET ET AL. CANCER RES. APR 1994 54:2151-59 *

Also Published As

Publication number Publication date
CZ195297A3 (en) 1997-12-17
US5985281A (en) 1999-11-16
WO1996020011A1 (en) 1996-07-04
JPH10511547A (ja) 1998-11-10
ATE222124T1 (de) 2002-08-15
FI972683A0 (fi) 1997-06-19
PL184031B1 (pl) 2002-08-30
MX9704575A (es) 1997-10-31
TR199501654A3 (enExample) 1996-07-21
HUT77450A (hu) 1998-04-28
BR9510490B1 (pt) 2010-10-05
RU2189251C2 (ru) 2002-09-20
DE69527805T2 (de) 2003-04-24
JP3805365B2 (ja) 2006-08-02
ES2181805T3 (es) 2003-03-01
NO972882L (no) 1997-08-19
FI972683L (fi) 1997-06-19
KR100270650B1 (ko) 2000-11-01
PL320964A1 (en) 1997-11-24
IL116511A0 (en) 1996-07-23
EP0806964B1 (en) 2002-08-14
SK80997A3 (en) 1998-02-04
DE69527805D1 (de) 2002-09-19
AU4269796A (en) 1996-07-19
CN1095677C (zh) 2002-12-11
CN1171054A (zh) 1998-01-21
NZ297529A (en) 1999-07-29
CA2205091A1 (en) 1996-07-04
FI972683A7 (fi) 1997-06-19
NO972882D0 (no) 1997-06-20
EP0806964A1 (en) 1997-11-19
TR199501654A2 (tr) 1996-07-21
BR9510490A (pt) 1998-01-13

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Legal Events

Date Code Title Description
PC Assignment registered

Owner name: ASTRAZENECA AB

Free format text: FORMER OWNER WAS: ZENECA LIMITED

PC Assignment registered

Owner name: LONDON BIOTECHNOLOGY LIMITED

Free format text: FORMER OWNER WAS: ASTRAZENECA AB