KR100270650B1 - 돌연변이된 숙주효소를 이용한 항체-지시된 효소 전구약제 치료 - Google Patents

돌연변이된 숙주효소를 이용한 항체-지시된 효소 전구약제 치료 Download PDF

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KR100270650B1
KR100270650B1 KR1019970704250A KR19970704250A KR100270650B1 KR 100270650 B1 KR100270650 B1 KR 100270650B1 KR 1019970704250 A KR1019970704250 A KR 1019970704250A KR 19970704250 A KR19970704250 A KR 19970704250A KR 100270650 B1 KR100270650 B1 KR 100270650B1
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South Korea
Prior art keywords
enzyme
dna
minutes
cells
pcr
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Expired - Fee Related
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KR1019970704250A
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English (en)
Korean (ko)
Inventor
존 테일러슨 크리스토퍼
요한네스 에겔테 헨드리쿠스
타라고나-피올 안토니오
로버트 라빈 브라이언
토마스 보일 프랜시스
프레더릭 헨남 존
찰스 블레이키 데이빗
로버트 마르샴 피터
윌리엄 히튼 데이빗
휴 데이비스 데이빗
마이클 슬레이터 앤소니
프랑소와 앙드레 에네퀸 로렝
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돈 리사 로얄
제네카 리미티드
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26306259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100270650(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9426192.2A external-priority patent/GB9426192D0/en
Priority claimed from GBGB9516810.0A external-priority patent/GB9516810D0/en
Application filed by 돈 리사 로얄, 제네카 리미티드 filed Critical 돈 리사 로얄
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Nanotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
KR1019970704250A 1994-12-23 1995-12-21 돌연변이된 숙주효소를 이용한 항체-지시된 효소 전구약제 치료 Expired - Fee Related KR100270650B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9426192.2 1994-12-23
GBGB9426192.2A GB9426192D0 (en) 1994-12-23 1994-12-23 Chemical compounds
GBGB9516810.0A GB9516810D0 (en) 1995-08-16 1995-08-16 Chemical compounds
GB9516810.0 1995-08-16
PCT/GB1995/002991 WO1996020011A1 (en) 1994-12-23 1995-12-21 Chemical compounds

Publications (1)

Publication Number Publication Date
KR100270650B1 true KR100270650B1 (ko) 2000-11-01

Family

ID=26306259

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970704250A Expired - Fee Related KR100270650B1 (ko) 1994-12-23 1995-12-21 돌연변이된 숙주효소를 이용한 항체-지시된 효소 전구약제 치료

Country Status (23)

Country Link
US (1) US5985281A (enExample)
EP (1) EP0806964B1 (enExample)
JP (1) JP3805365B2 (enExample)
KR (1) KR100270650B1 (enExample)
CN (1) CN1095677C (enExample)
AT (1) ATE222124T1 (enExample)
AU (1) AU701916B2 (enExample)
BR (1) BR9510490B1 (enExample)
CA (1) CA2205091A1 (enExample)
CZ (1) CZ195297A3 (enExample)
DE (1) DE69527805T2 (enExample)
ES (1) ES2181805T3 (enExample)
FI (1) FI972683L (enExample)
HU (1) HUT77450A (enExample)
IL (1) IL116511A0 (enExample)
MX (1) MX9704575A (enExample)
NO (1) NO972882L (enExample)
NZ (1) NZ297529A (enExample)
PL (1) PL184031B1 (enExample)
RU (1) RU2189251C2 (enExample)
SK (1) SK80997A3 (enExample)
TR (1) TR199501654A2 (enExample)
WO (1) WO1996020011A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9610050A (pt) * 1995-08-16 1999-10-13 Zeneca Ltd Conjugado,sitemas de dois componentes combinados destinados a uso em um hospedeiro, compostos ou um sal destes famaceuticamente aceitavel,enzima,sequencia de polinucleotìdeos e de02 nucleotìdeos,vetor, célula hospedeira,processos de producão de uma enzima e de um conjugado e de tratamento de célulasneoplásticas em um hospedeiro,composicão farmaceutica e plasmìdeo
TW406454B (en) 1996-10-10 2000-09-21 Berg Tech Inc High density connector and method of manufacture
AU6000698A (en) * 1997-02-14 1998-09-08 Zeneca Limited Proteins
GB9703201D0 (en) * 1997-02-15 1997-04-02 Zeneca Ltd Chemical compounds
GB9709421D0 (en) * 1997-05-10 1997-07-02 Zeneca Ltd Chemical compounds
ATE499115T1 (de) * 1998-09-18 2011-03-15 Immunomedics Inc Antikörper verwiesene enzymprodrugtherapie mit glukuronidase
US6361774B1 (en) 1999-09-17 2002-03-26 Immunomedics, Inc. Methods and compositions for increasing the target-specific toxicity of a chemotherapy drug
US20040117863A1 (en) * 1998-09-18 2004-06-17 Edge Michael D. Transgenically produced fusion proteins
KR20020073127A (ko) * 1999-09-17 2002-09-19 겐자임 트랜스제닉스 코포레이션 형질전환에 의하여 생성된 융합 단백질
WO2002064093A2 (en) 2001-02-15 2002-08-22 King Pharmaceuticals, Inc. Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
BR0316643A (pt) * 2002-11-27 2005-10-11 Gtc Biotherapeutics Inc Anticorpos modificados estavelmente produzidos no leite e método de produzir os mesmos
US20080019905A9 (en) * 2005-02-18 2008-01-24 Strome Scott E Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection
EP1945666B1 (en) * 2005-10-21 2013-03-27 GTC Biotherapeutics, Inc. Antibodies with enhanced antibody-dependent cellular cytoxicity activity, methods of their production and use
WO2007149827A2 (en) * 2006-06-20 2007-12-27 Janssen Pharmaceutica, N.V. Method for modulating the pharmacokinetics and metabolism of a therapeutic agent
US20080031866A1 (en) * 2006-06-20 2008-02-07 Eichenbaum Gary M Method for modulating the pharmacokinetics and metabolism of a therapeutic agent
CN101511774B (zh) * 2006-10-03 2015-05-13 于崇曦 具有快速皮肤穿透速度的带正电荷的水溶性的芥子气类化合物及其相关化合物的前药
GB0709333D0 (en) * 2007-05-15 2007-06-20 Smart Targeting Ltd Binding protein
EP2279003A4 (en) * 2008-05-01 2013-04-03 Gtc Biotherapeutics Inc ANTI-CD137 ANTIBODY AS A MEANS FOR THE TREATMENT OF INFLAMMATORY DISEASES
US10745492B1 (en) 2019-04-03 2020-08-18 Ark Diagnostics, Inc. Antibodies to symmetrically dimethylated arginine analytes and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8705477D0 (en) * 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
US4975278A (en) * 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US5632990A (en) * 1988-04-22 1997-05-27 Cancer Research Campaign Tech. Ltd. Treatment for tumors comprising conjugated antibody A5B7 and a prodrug
GB8809616D0 (en) * 1988-04-22 1988-05-25 Cancer Res Campaign Tech Further improvements relating to drug delivery systems
ES2075893T3 (es) * 1989-01-23 1995-10-16 Akzo Nobel Nv Activacion in vivo especifica de sede de farmacos terapeuticos.
US5433955A (en) * 1989-01-23 1995-07-18 Akzo N.V. Site specific in vivo activation of therapeutic drugs
EP0625205A1 (en) * 1992-01-30 1994-11-23 Genzyme Limited Chiral synthesis with modified enzymes
GB9323429D0 (en) * 1993-11-12 1994-01-05 Wellcome Found Therapy
US5389537A (en) * 1994-01-21 1995-02-14 Wisconsin Alumni Research Foundation Nuclease having altered specificity

Also Published As

Publication number Publication date
NO972882L (no) 1997-08-19
TR199501654A2 (tr) 1996-07-21
NZ297529A (en) 1999-07-29
FI972683A0 (fi) 1997-06-19
FI972683A7 (fi) 1997-06-19
CA2205091A1 (en) 1996-07-04
BR9510490B1 (pt) 2010-10-05
MX9704575A (es) 1997-10-31
NO972882D0 (no) 1997-06-20
DE69527805T2 (de) 2003-04-24
TR199501654A3 (enExample) 1996-07-21
WO1996020011A1 (en) 1996-07-04
PL320964A1 (en) 1997-11-24
ATE222124T1 (de) 2002-08-15
CZ195297A3 (en) 1997-12-17
RU2189251C2 (ru) 2002-09-20
DE69527805D1 (de) 2002-09-19
HUT77450A (hu) 1998-04-28
FI972683L (fi) 1997-06-19
JPH10511547A (ja) 1998-11-10
US5985281A (en) 1999-11-16
CN1095677C (zh) 2002-12-11
JP3805365B2 (ja) 2006-08-02
AU701916B2 (en) 1999-02-11
ES2181805T3 (es) 2003-03-01
CN1171054A (zh) 1998-01-21
EP0806964A1 (en) 1997-11-19
IL116511A0 (en) 1996-07-23
PL184031B1 (pl) 2002-08-30
BR9510490A (pt) 1998-01-13
EP0806964B1 (en) 2002-08-14
AU4269796A (en) 1996-07-19
SK80997A3 (en) 1998-02-04

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