ES2181805T3 - Compuestos quimicos. - Google Patents
Compuestos quimicos.Info
- Publication number
- ES2181805T3 ES2181805T3 ES95941214T ES95941214T ES2181805T3 ES 2181805 T3 ES2181805 T3 ES 2181805T3 ES 95941214 T ES95941214 T ES 95941214T ES 95941214 T ES95941214 T ES 95941214T ES 2181805 T3 ES2181805 T3 ES 2181805T3
- Authority
- ES
- Spain
- Prior art keywords
- enzyme
- invested
- interaction
- muted
- therapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 4
- 108090000790 Enzymes Proteins 0.000 abstract 4
- 230000003993 interaction Effects 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 238000010913 antigen-directed enzyme pro-drug therapy Methods 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 239000006225 natural substrate Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Nanotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9426192.2A GB9426192D0 (en) | 1994-12-23 | 1994-12-23 | Chemical compounds |
| GBGB9516810.0A GB9516810D0 (en) | 1995-08-16 | 1995-08-16 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2181805T3 true ES2181805T3 (es) | 2003-03-01 |
Family
ID=26306259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95941214T Expired - Lifetime ES2181805T3 (es) | 1994-12-23 | 1995-12-21 | Compuestos quimicos. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5985281A (enExample) |
| EP (1) | EP0806964B1 (enExample) |
| JP (1) | JP3805365B2 (enExample) |
| KR (1) | KR100270650B1 (enExample) |
| CN (1) | CN1095677C (enExample) |
| AT (1) | ATE222124T1 (enExample) |
| AU (1) | AU701916B2 (enExample) |
| BR (1) | BR9510490B1 (enExample) |
| CA (1) | CA2205091A1 (enExample) |
| CZ (1) | CZ195297A3 (enExample) |
| DE (1) | DE69527805T2 (enExample) |
| ES (1) | ES2181805T3 (enExample) |
| FI (1) | FI972683L (enExample) |
| HU (1) | HUT77450A (enExample) |
| IL (1) | IL116511A0 (enExample) |
| MX (1) | MX9704575A (enExample) |
| NO (1) | NO972882L (enExample) |
| NZ (1) | NZ297529A (enExample) |
| PL (1) | PL184031B1 (enExample) |
| RU (1) | RU2189251C2 (enExample) |
| SK (1) | SK80997A3 (enExample) |
| TR (1) | TR199501654A2 (enExample) |
| WO (1) | WO1996020011A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9610050A (pt) * | 1995-08-16 | 1999-10-13 | Zeneca Ltd | Conjugado,sitemas de dois componentes combinados destinados a uso em um hospedeiro, compostos ou um sal destes famaceuticamente aceitavel,enzima,sequencia de polinucleotìdeos e de02 nucleotìdeos,vetor, célula hospedeira,processos de producão de uma enzima e de um conjugado e de tratamento de célulasneoplásticas em um hospedeiro,composicão farmaceutica e plasmìdeo |
| TW406454B (en) | 1996-10-10 | 2000-09-21 | Berg Tech Inc | High density connector and method of manufacture |
| AU6000698A (en) * | 1997-02-14 | 1998-09-08 | Zeneca Limited | Proteins |
| GB9703201D0 (en) * | 1997-02-15 | 1997-04-02 | Zeneca Ltd | Chemical compounds |
| GB9709421D0 (en) * | 1997-05-10 | 1997-07-02 | Zeneca Ltd | Chemical compounds |
| ATE499115T1 (de) * | 1998-09-18 | 2011-03-15 | Immunomedics Inc | Antikörper verwiesene enzymprodrugtherapie mit glukuronidase |
| US6361774B1 (en) | 1999-09-17 | 2002-03-26 | Immunomedics, Inc. | Methods and compositions for increasing the target-specific toxicity of a chemotherapy drug |
| US20040117863A1 (en) * | 1998-09-18 | 2004-06-17 | Edge Michael D. | Transgenically produced fusion proteins |
| KR20020073127A (ko) * | 1999-09-17 | 2002-09-19 | 겐자임 트랜스제닉스 코포레이션 | 형질전환에 의하여 생성된 융합 단백질 |
| WO2002064093A2 (en) | 2001-02-15 | 2002-08-22 | King Pharmaceuticals, Inc. | Stabilized pharmaceutical and thyroid hormone compositions and method of preparation |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| BR0316643A (pt) * | 2002-11-27 | 2005-10-11 | Gtc Biotherapeutics Inc | Anticorpos modificados estavelmente produzidos no leite e método de produzir os mesmos |
| US20080019905A9 (en) * | 2005-02-18 | 2008-01-24 | Strome Scott E | Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection |
| EP1945666B1 (en) * | 2005-10-21 | 2013-03-27 | GTC Biotherapeutics, Inc. | Antibodies with enhanced antibody-dependent cellular cytoxicity activity, methods of their production and use |
| WO2007149827A2 (en) * | 2006-06-20 | 2007-12-27 | Janssen Pharmaceutica, N.V. | Method for modulating the pharmacokinetics and metabolism of a therapeutic agent |
| US20080031866A1 (en) * | 2006-06-20 | 2008-02-07 | Eichenbaum Gary M | Method for modulating the pharmacokinetics and metabolism of a therapeutic agent |
| CN101511774B (zh) * | 2006-10-03 | 2015-05-13 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性的芥子气类化合物及其相关化合物的前药 |
| GB0709333D0 (en) * | 2007-05-15 | 2007-06-20 | Smart Targeting Ltd | Binding protein |
| EP2279003A4 (en) * | 2008-05-01 | 2013-04-03 | Gtc Biotherapeutics Inc | ANTI-CD137 ANTIBODY AS A MEANS FOR THE TREATMENT OF INFLAMMATORY DISEASES |
| US10745492B1 (en) | 2019-04-03 | 2020-08-18 | Ark Diagnostics, Inc. | Antibodies to symmetrically dimethylated arginine analytes and use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8705477D0 (en) * | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| US4975278A (en) * | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| US5632990A (en) * | 1988-04-22 | 1997-05-27 | Cancer Research Campaign Tech. Ltd. | Treatment for tumors comprising conjugated antibody A5B7 and a prodrug |
| GB8809616D0 (en) * | 1988-04-22 | 1988-05-25 | Cancer Res Campaign Tech | Further improvements relating to drug delivery systems |
| ES2075893T3 (es) * | 1989-01-23 | 1995-10-16 | Akzo Nobel Nv | Activacion in vivo especifica de sede de farmacos terapeuticos. |
| US5433955A (en) * | 1989-01-23 | 1995-07-18 | Akzo N.V. | Site specific in vivo activation of therapeutic drugs |
| EP0625205A1 (en) * | 1992-01-30 | 1994-11-23 | Genzyme Limited | Chiral synthesis with modified enzymes |
| GB9323429D0 (en) * | 1993-11-12 | 1994-01-05 | Wellcome Found | Therapy |
| US5389537A (en) * | 1994-01-21 | 1995-02-14 | Wisconsin Alumni Research Foundation | Nuclease having altered specificity |
-
1995
- 1995-12-21 RU RU97112396/14A patent/RU2189251C2/ru not_active IP Right Cessation
- 1995-12-21 JP JP52028496A patent/JP3805365B2/ja not_active Expired - Fee Related
- 1995-12-21 FI FI972683A patent/FI972683L/fi unknown
- 1995-12-21 BR BRPI9510490-9A patent/BR9510490B1/pt not_active IP Right Cessation
- 1995-12-21 NZ NZ297529A patent/NZ297529A/xx not_active IP Right Cessation
- 1995-12-21 US US08/860,882 patent/US5985281A/en not_active Expired - Lifetime
- 1995-12-21 CA CA002205091A patent/CA2205091A1/en not_active Abandoned
- 1995-12-21 DE DE69527805T patent/DE69527805T2/de not_active Expired - Lifetime
- 1995-12-21 HU HU9702280A patent/HUT77450A/hu unknown
- 1995-12-21 ES ES95941214T patent/ES2181805T3/es not_active Expired - Lifetime
- 1995-12-21 WO PCT/GB1995/002991 patent/WO1996020011A1/en not_active Ceased
- 1995-12-21 CN CN95196986A patent/CN1095677C/zh not_active Expired - Fee Related
- 1995-12-21 EP EP95941214A patent/EP0806964B1/en not_active Expired - Lifetime
- 1995-12-21 PL PL95320964A patent/PL184031B1/pl not_active IP Right Cessation
- 1995-12-21 KR KR1019970704250A patent/KR100270650B1/ko not_active Expired - Fee Related
- 1995-12-21 AU AU42697/96A patent/AU701916B2/en not_active Ceased
- 1995-12-21 SK SK809-97A patent/SK80997A3/sk unknown
- 1995-12-21 AT AT95941214T patent/ATE222124T1/de not_active IP Right Cessation
- 1995-12-21 CZ CZ971952A patent/CZ195297A3/cs unknown
- 1995-12-21 MX MX9704575A patent/MX9704575A/es not_active IP Right Cessation
- 1995-12-22 IL IL11651195A patent/IL116511A0/xx not_active IP Right Cessation
- 1995-12-22 TR TR95/01654A patent/TR199501654A2/xx unknown
-
1997
- 1997-06-20 NO NO972882A patent/NO972882L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO972882L (no) | 1997-08-19 |
| TR199501654A2 (tr) | 1996-07-21 |
| NZ297529A (en) | 1999-07-29 |
| FI972683A0 (fi) | 1997-06-19 |
| FI972683A7 (fi) | 1997-06-19 |
| CA2205091A1 (en) | 1996-07-04 |
| BR9510490B1 (pt) | 2010-10-05 |
| MX9704575A (es) | 1997-10-31 |
| NO972882D0 (no) | 1997-06-20 |
| DE69527805T2 (de) | 2003-04-24 |
| TR199501654A3 (enExample) | 1996-07-21 |
| WO1996020011A1 (en) | 1996-07-04 |
| KR100270650B1 (ko) | 2000-11-01 |
| PL320964A1 (en) | 1997-11-24 |
| ATE222124T1 (de) | 2002-08-15 |
| CZ195297A3 (en) | 1997-12-17 |
| RU2189251C2 (ru) | 2002-09-20 |
| DE69527805D1 (de) | 2002-09-19 |
| HUT77450A (hu) | 1998-04-28 |
| FI972683L (fi) | 1997-06-19 |
| JPH10511547A (ja) | 1998-11-10 |
| US5985281A (en) | 1999-11-16 |
| CN1095677C (zh) | 2002-12-11 |
| JP3805365B2 (ja) | 2006-08-02 |
| AU701916B2 (en) | 1999-02-11 |
| CN1171054A (zh) | 1998-01-21 |
| EP0806964A1 (en) | 1997-11-19 |
| IL116511A0 (en) | 1996-07-23 |
| PL184031B1 (pl) | 2002-08-30 |
| BR9510490A (pt) | 1998-01-13 |
| EP0806964B1 (en) | 2002-08-14 |
| AU4269796A (en) | 1996-07-19 |
| SK80997A3 (en) | 1998-02-04 |
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