AU667146B2 - Inhibitors of HIV protease useful for the treatment of AIDS - Google Patents

Inhibitors of HIV protease useful for the treatment of AIDS

Info

Publication number
AU667146B2
AU667146B2 AU52528/93A AU5252893A AU667146B2 AU 667146 B2 AU667146 B2 AU 667146B2 AU 52528/93 A AU52528/93 A AU 52528/93A AU 5252893 A AU5252893 A AU 5252893A AU 667146 B2 AU667146 B2 AU 667146B2
Authority
AU
Australia
Prior art keywords
aids
hiv protease
inhibitors
treatment
protease useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU52528/93A
Other languages
English (en)
Other versions
AU5252893A (en
Inventor
Louis Nickolaus Jungheim
Timothy Alan Shepherd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/134,329 external-priority patent/US5733906A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU5252893A publication Critical patent/AU5252893A/en
Application granted granted Critical
Publication of AU667146B2 publication Critical patent/AU667146B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AU52528/93A 1992-12-22 1993-12-20 Inhibitors of HIV protease useful for the treatment of AIDS Ceased AU667146B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99525692A 1992-12-22 1992-12-22
US995256 1992-12-22
US08/134,329 US5733906A (en) 1993-10-12 1993-10-12 Inhibitors of HIV Protease useful for the treatment of Aids
US134329 2002-04-29

Publications (2)

Publication Number Publication Date
AU5252893A AU5252893A (en) 1994-07-07
AU667146B2 true AU667146B2 (en) 1996-03-07

Family

ID=26832220

Family Applications (1)

Application Number Title Priority Date Filing Date
AU52528/93A Ceased AU667146B2 (en) 1992-12-22 1993-12-20 Inhibitors of HIV protease useful for the treatment of AIDS

Country Status (21)

Country Link
US (1) US5905077A (OSRAM)
EP (1) EP0604185B1 (OSRAM)
JP (1) JPH06271534A (OSRAM)
KR (1) KR940014337A (OSRAM)
CN (1) CN1044117C (OSRAM)
AT (1) ATE178055T1 (OSRAM)
AU (1) AU667146B2 (OSRAM)
BR (1) BR9305162A (OSRAM)
CA (1) CA2112042A1 (OSRAM)
CZ (1) CZ281493A3 (OSRAM)
DE (1) DE69324120T2 (OSRAM)
ES (1) ES2132201T3 (OSRAM)
FI (1) FI935778A7 (OSRAM)
HU (1) HUT69693A (OSRAM)
IL (1) IL108092A (OSRAM)
MX (1) MX9308016A (OSRAM)
MY (1) MY131388A (OSRAM)
NO (1) NO934719L (OSRAM)
NZ (1) NZ250491A (OSRAM)
PL (1) PL301581A1 (OSRAM)
TW (1) TW262468B (OSRAM)

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Publication number Priority date Publication date Assignee Title
USH1649H (en) 1987-07-31 1997-05-06 Barrish; Joel C. HIV protease inhibitor combinations
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
CA2130754C (en) 1992-03-11 2005-02-08 Damian W. Grobelny Amine derivatives of oxo- and hydroxy-substituted hydrocarbons
US5484926A (en) 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5461154A (en) * 1994-02-02 1995-10-24 Eli Lilly And Company Intermediate and process for making
TW472047B (en) * 1994-02-04 2002-01-11 Merck & Co Inc Process for making HIV protease inhibitors
ES2116029T3 (es) * 1994-11-04 1998-07-01 Yamakawa Chemical Ind Procedimiento para preparar derivados de piperazina opticamente activos e intermedios para prepararlos.
DE69616446T2 (de) * 1995-02-03 2002-05-16 Kaneka Corp., Osaka Verfahren zur herstellung von alpha-haloketonen, alpha-halohydrinen und epoxiden
US5618937A (en) * 1995-03-15 1997-04-08 Merck & Co., Inc. Process to make HIV protease inhibitor from (2S)-4-picolyl-2-piperazine-t-butylcarboxamide
US6222043B1 (en) 1995-06-30 2001-04-24 Japan Energy Corporation Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof
CA2179935C (en) * 1995-06-30 2010-09-07 Ryohei Kato Novel dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof
DE69637770D1 (de) * 1995-09-26 2009-01-15 Agouron Pharma Verfahren zur herstellung von amidderivaten und ihren zwischenverbindungen
US6133461A (en) 1995-09-26 2000-10-17 Japan Tobacco Inc. Process for producing amide derivatives and intermediates therefor
ATE377006T1 (de) * 1995-11-28 2007-11-15 Cephalon Inc Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer
US5962725A (en) 1996-09-05 1999-10-05 Agouron Pharmaceuticals, Inc. Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir
EP0900566A4 (en) 1996-12-27 2001-04-25 Japan Energy Corp NEW TRIPEPTIDE COMPOUNDS AND MEDICINES AGAINST AIDS
JP4006058B2 (ja) 1997-03-11 2007-11-14 第一三共株式会社 多臓器不全予防及び／又は治療剤
WO1998041230A1 (en) 1997-03-14 1998-09-24 Snow Brand Milk Products Co., Ltd. Preventive and/or therapeutic agent for cachexia
US6538006B1 (en) * 1998-07-08 2003-03-25 Pharmacia Corporation Retroviral protease inhibitors
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
HRP990246A2 (en) * 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
BR9917082A (pt) 1998-12-24 2001-11-06 Du Pont Pharm Co Compostos inibidores da produção de proteìnas a"beta", método de tratamento de disfunções neurológicas associadas com a produção de "beta"-amilóide, composição farmacêutica e, método de inibição da atividade de y-secretase
US6960576B2 (en) * 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
WO2001027108A1 (en) 1999-10-08 2001-04-19 Bristol-Myers Squibb Pharma Company AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
JP2003523345A (ja) 2000-02-17 2003-08-05 ブリストル−マイヤーズ スクイブ ファーマ カンパニー Ａβタンパク質産生の阻害剤としてのスクシノイルアミノ炭素環および複素環
US6495540B2 (en) 2000-03-28 2002-12-17 Bristol - Myers Squibb Pharma Company Lactams as inhibitors of A-β protein production
AU2001253108A1 (en) 2000-04-03 2001-10-15 Bristol-Myers Squibb Pharma Company Cyclic lactams as inhibitors of a-beta protein production
WO2001074783A1 (en) * 2000-04-03 2001-10-11 Dupont Pharmaceuticals Company Cyclic lactams as inhibitors of a βετα protein production
US20100009966A1 (en) * 2001-04-11 2010-01-14 Bristol-Myers Squibb Pharma Company Substituted lactams as inhibitors of abeta protein production
CA2404273A1 (en) 2000-04-11 2001-10-18 Bristol-Myers Squibb Pharma Company Substituted lactams as inhibitors of a.beta. protein production
AU2001261728A1 (en) * 2000-05-17 2001-11-26 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
CN1386118A (zh) * 2000-06-01 2002-12-18 布里斯托尔-迈尔斯斯奎布药品公司 作为Aβ蛋白产生抑制剂的被环状琥珀酸酯取代的内酰胺类化合物
GB0028483D0 (en) * 2000-11-22 2001-01-10 Hoffmann La Roche Hydroxyethylamine HIV protease inhibitors
JPWO2002064553A1 (ja) * 2001-02-14 2004-06-10 呉羽化学工業株式会社 ハロゲノアルコール誘導体の製造方法
US20090062256A1 (en) * 2001-06-01 2009-03-05 Bristol-Myers Squibb Pharma Company LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
GB0123467D0 (en) 2001-09-28 2001-11-21 Hoffmann La Roche Carbocyclic HIV Protease inhibitors
KR101155335B1 (ko) * 2005-01-07 2012-06-11 엘지전자 주식회사 이동통신 단말기의 멀티미디어 메시지 동작방법
WO2007015805A1 (en) 2005-07-20 2007-02-08 Eli Lilly And Company 1-amino linked compounds
CN101508664B (zh) * 2009-02-25 2012-08-22 江阴希迪医药科技有限公司 N-苄氧羰基-3-氨基-1-氯-4-苯硫基-2-丁醇合成方法
SG186820A1 (en) 2010-07-02 2013-02-28 Gilead Sciences Inc Napht- 2 -ylacetic acid derivatives to treat aids
BR112012033689A2 (pt) 2010-07-02 2019-09-24 Gilead Sciences Inc derivados de ácido 2-quinolinil-acético como compostos de hiv antivirais
ES2615734T3 (es) 2011-04-21 2017-06-08 Gilead Sciences, Inc. Compuestos de benzotiazol y su uso farmacéutico
US9376392B2 (en) 2012-01-04 2016-06-28 Gilead Sciences, Inc. 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS
US9284323B2 (en) 2012-01-04 2016-03-15 Gilead Sciences, Inc. Naphthalene acetic acid derivatives against HIV infection
MX2014005002A (es) 2012-04-20 2014-07-09 Gilead Sciences Inc Derivados de acido benzotiazol-6-il acetico y su uso para tratar una infeccion por vih.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008701A1 (en) * 1990-11-19 1992-05-29 Monsanto Company Retroviral protease inhibitors
EP0526009A1 (en) * 1991-07-10 1993-02-03 Eli Lilly And Company Inhibitors of hiv protease useful for the treatment of aids
WO1993013066A1 (en) * 1991-12-20 1993-07-08 Syntex (U.S.A.) Inc. Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors

Family Cites Families (8)

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US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
IL89900A0 (en) * 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
CA1340588C (en) 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
EP0361341A3 (en) * 1988-09-28 1991-07-03 Miles Inc. Therapeutics for aids based on inhibitors of hiv protease
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
CS35692A3 (en) * 1991-02-08 1992-09-16 Sankyo Co Novel beta-amino-alpha-hydroxycarboxylic acids and pharmaceuticalcompositions comprising thereof
US5430041A (en) * 1991-05-10 1995-07-04 Hoffmann-La Roche Inc. Amino acid derivatives having antiviral activity
US5312820A (en) * 1992-07-17 1994-05-17 Merck & Co., Inc. Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008701A1 (en) * 1990-11-19 1992-05-29 Monsanto Company Retroviral protease inhibitors
EP0526009A1 (en) * 1991-07-10 1993-02-03 Eli Lilly And Company Inhibitors of hiv protease useful for the treatment of aids
WO1993013066A1 (en) * 1991-12-20 1993-07-08 Syntex (U.S.A.) Inc. Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors

Also Published As

Publication number Publication date
EP0604185A1 (en) 1994-06-29
PL301581A1 (en) 1994-06-27
CA2112042A1 (en) 1994-06-23
NO934719D0 (no) 1993-12-20
EP0604185B1 (en) 1999-03-24
BR9305162A (pt) 1994-11-01
NZ250491A (en) 1995-08-28
ATE178055T1 (de) 1999-04-15
DE69324120D1 (de) 1999-04-29
HUT69693A (en) 1995-09-28
NO934719L (no) 1994-06-23
US5905077A (en) 1999-05-18
AU5252893A (en) 1994-07-07
CN1044117C (zh) 1999-07-14
JPH06271534A (ja) 1994-09-27
MX9308016A (es) 1994-08-31
FI935778A0 (fi) 1993-12-21
CZ281493A3 (en) 1994-07-13
MY131388A (en) 2007-08-30
IL108092A0 (en) 1994-04-12
IL108092A (en) 1998-06-15
TW262468B (OSRAM) 1995-11-11
KR940014337A (ko) 1994-07-18
CN1094399A (zh) 1994-11-02
DE69324120T2 (de) 1999-11-25
FI935778A7 (fi) 1994-06-23
ES2132201T3 (es) 1999-08-16

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired