AU608268B2 - Nasal solutions - Google Patents
Nasal solutions Download PDFInfo
- Publication number
- AU608268B2 AU608268B2 AU82955/87A AU8295587A AU608268B2 AU 608268 B2 AU608268 B2 AU 608268B2 AU 82955/87 A AU82955/87 A AU 82955/87A AU 8295587 A AU8295587 A AU 8295587A AU 608268 B2 AU608268 B2 AU 608268B2
- Authority
- AU
- Australia
- Prior art keywords
- human calcitonin
- methyl cellulose
- effective amount
- pharmaceutical composition
- viscosity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 101000741445 Homo sapiens Calcitonin Proteins 0.000 claims abstract description 29
- 229940045644 human calcitonin Drugs 0.000 claims abstract description 28
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 23
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000008135 aqueous vehicle Substances 0.000 claims abstract description 5
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 4
- 229920000642 polymer Polymers 0.000 claims description 21
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- 229920000609 methyl cellulose Polymers 0.000 claims description 12
- 235000010981 methylcellulose Nutrition 0.000 claims description 12
- 239000001923 methylcellulose Substances 0.000 claims description 12
- 239000008365 aqueous carrier Substances 0.000 claims description 11
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 11
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- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- QBSJHOGDIUQWTH-UHFFFAOYSA-N dihydrolanosterol Natural products CC(C)CCCC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 QBSJHOGDIUQWTH-UHFFFAOYSA-N 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 208000027720 dry mucous membrane Diseases 0.000 description 1
- VSHJAJRPRRNBEK-LMVCGNDWSA-N eel calcitonin Chemical compound C([C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CS)[C@@H](C)O)C(C)C)CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C1=CN=CN1 VSHJAJRPRRNBEK-LMVCGNDWSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 229920013819 hydroxyethyl ethylcellulose Polymers 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 description 1
- 229940058690 lanosterol Drugs 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 229940037525 nasal preparations Drugs 0.000 description 1
- 229940100656 nasal solution Drugs 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000000199 parathyroid hormone Substances 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010988 polyoxyethylene sorbitan tristearate Nutrition 0.000 description 1
- 239000001816 polyoxyethylene sorbitan tristearate Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 235000011078 sorbitan tristearate Nutrition 0.000 description 1
- 239000001589 sorbitan tristearate Substances 0.000 description 1
- 229960004129 sorbitan tristearate Drugs 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH520086 | 1986-12-23 | ||
| CH5200/86 | 1986-12-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU8295587A AU8295587A (en) | 1988-06-23 |
| AU608268B2 true AU608268B2 (en) | 1991-03-28 |
Family
ID=4289609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU82955/87A Ceased AU608268B2 (en) | 1986-12-23 | 1987-12-22 | Nasal solutions |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0277462B1 (esLanguage) |
| JP (1) | JPS63166832A (esLanguage) |
| AT (1) | ATE75404T1 (esLanguage) |
| AU (1) | AU608268B2 (esLanguage) |
| CA (1) | CA1322330C (esLanguage) |
| DE (1) | DE3778682D1 (esLanguage) |
| DK (1) | DK166714B1 (esLanguage) |
| ES (1) | ES2032303T3 (esLanguage) |
| GR (1) | GR3004585T3 (esLanguage) |
| IL (1) | IL84861A (esLanguage) |
| MY (1) | MY102411A (esLanguage) |
| NZ (1) | NZ223005A (esLanguage) |
| PH (1) | PH24802A (esLanguage) |
| PT (1) | PT86436B (esLanguage) |
| ZA (1) | ZA879593B (esLanguage) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5026825A (en) * | 1988-09-08 | 1991-06-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Intranasal calcitonin formulations |
| AU638128B2 (en) * | 1990-04-10 | 1993-06-17 | University Of Melbourne, The | Calcitonin gene related peptide for the treatment of undescended testicles |
| WO1991015246A1 (en) * | 1990-04-10 | 1991-10-17 | The University Of Melbourne | Calcitonin gene related peptide for the treatment of undescended testicles |
| JP3179538B2 (ja) * | 1990-12-11 | 2001-06-25 | ノバルティス アクチエンゲゼルシャフト | 安定なヒトカルシトニンの水性溶液 |
| GB9108634D0 (en) * | 1991-04-23 | 1991-06-12 | Ciba Geigy | Pharmaceutical compositions |
| WO1995033474A1 (en) * | 1994-06-03 | 1995-12-14 | Tsumura & Co. | Medicinal composition |
| NZ505919A (en) * | 1998-01-30 | 2002-10-25 | Novartis Consumer Health S | Nasal solutions |
| TWI243687B (en) | 1998-04-21 | 2005-11-21 | Teijin Ltd | Pharmaceutical composition for application to mucosa |
| AR026073A1 (es) | 1999-10-20 | 2002-12-26 | Nycomed Gmbh | Composicion farmaceutica acuosa que contiene ciclesonida |
| JP2002154989A (ja) * | 2000-11-14 | 2002-05-28 | Lion Corp | 眼科用組成物、及び生体粘膜への薬物の滞留性向上組成物 |
| GB2423711B (en) * | 2005-10-24 | 2007-02-14 | Fortune Apex Dev Ltd | Method for preparing a pharmaceutical composition with enhanced mucoadhesion |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2312260A1 (fr) * | 1975-05-26 | 1976-12-24 | Ciba Geigy Ag | Preparations a base de calcitonine, a action prolongee |
| EP0115627A1 (en) * | 1982-12-29 | 1984-08-15 | Armour Pharmaceutical Company | Enhancement of intranasal absorption of calcitonin by formulation with surfactants |
| GB2142335A (en) * | 1983-06-27 | 1985-01-16 | Ciba Geigy Ag | Human calcitonin 2 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8514090D0 (en) * | 1985-06-04 | 1985-07-10 | Sandoz Ltd | Organic compounds |
| JPS61267528A (ja) * | 1984-11-26 | 1986-11-27 | Yamanouchi Pharmaceut Co Ltd | 吸収促進剤を含有するカルシトニン経鼻剤 |
| DE3500268A1 (de) * | 1985-01-05 | 1986-07-10 | Hoechst Ag, 6230 Frankfurt | Praeparate mit verzoegerter wirkung, verfahren zu deren herstellung sowie entsprechende mittel zur human- bzw. veterinaermedizinischen anwendung |
| JPS61194034A (ja) * | 1985-02-25 | 1986-08-28 | Teijin Ltd | 経鼻投与用粉末状組成物 |
-
1987
- 1987-12-03 MY MYPI87003149A patent/MY102411A/en unknown
- 1987-12-17 IL IL84861A patent/IL84861A/xx unknown
- 1987-12-18 EP EP87810769A patent/EP0277462B1/de not_active Expired - Lifetime
- 1987-12-18 ES ES198787810769T patent/ES2032303T3/es not_active Expired - Lifetime
- 1987-12-18 DE DE8787810769T patent/DE3778682D1/de not_active Expired - Lifetime
- 1987-12-18 AT AT87810769T patent/ATE75404T1/de not_active IP Right Cessation
- 1987-12-21 CA CA000554944A patent/CA1322330C/en not_active Expired - Fee Related
- 1987-12-21 NZ NZ223005A patent/NZ223005A/xx unknown
- 1987-12-22 AU AU82955/87A patent/AU608268B2/en not_active Ceased
- 1987-12-22 PT PT86436A patent/PT86436B/pt not_active IP Right Cessation
- 1987-12-22 ZA ZA879593A patent/ZA879593B/xx unknown
- 1987-12-22 PH PH36277A patent/PH24802A/en unknown
- 1987-12-22 DK DK676987A patent/DK166714B1/da not_active IP Right Cessation
- 1987-12-22 JP JP62323061A patent/JPS63166832A/ja active Pending
-
1992
- 1992-05-13 GR GR920400684T patent/GR3004585T3/el unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2312260A1 (fr) * | 1975-05-26 | 1976-12-24 | Ciba Geigy Ag | Preparations a base de calcitonine, a action prolongee |
| EP0115627A1 (en) * | 1982-12-29 | 1984-08-15 | Armour Pharmaceutical Company | Enhancement of intranasal absorption of calcitonin by formulation with surfactants |
| GB2142335A (en) * | 1983-06-27 | 1985-01-16 | Ciba Geigy Ag | Human calcitonin 2 |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA879593B (en) | 1988-06-22 |
| EP0277462A1 (de) | 1988-08-10 |
| CA1322330C (en) | 1993-09-21 |
| AU8295587A (en) | 1988-06-23 |
| DE3778682D1 (de) | 1992-06-04 |
| DK676987D0 (da) | 1987-12-22 |
| ATE75404T1 (de) | 1992-05-15 |
| JPS63166832A (ja) | 1988-07-11 |
| GR3004585T3 (esLanguage) | 1993-04-28 |
| NZ223005A (en) | 1990-07-26 |
| IL84861A (en) | 1992-09-06 |
| MY102411A (en) | 1992-06-17 |
| EP0277462B1 (de) | 1992-04-29 |
| PH24802A (en) | 1990-10-30 |
| PT86436A (en) | 1988-01-01 |
| DK676987A (da) | 1988-06-24 |
| DK166714B1 (da) | 1993-07-05 |
| PT86436B (pt) | 1990-11-20 |
| ES2032303T3 (es) | 1993-02-01 |
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