AU597462B2 - Sustained release growth hormone compositions for parenteral administration and their use - Google Patents
Sustained release growth hormone compositions for parenteral administration and their use Download PDFInfo
- Publication number
- AU597462B2 AU597462B2 AU10170/88A AU1017088A AU597462B2 AU 597462 B2 AU597462 B2 AU 597462B2 AU 10170/88 A AU10170/88 A AU 10170/88A AU 1017088 A AU1017088 A AU 1017088A AU 597462 B2 AU597462 B2 AU 597462B2
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- Australia
- Prior art keywords
- biologically active
- growth hormone
- sorbitan
- weight basis
- water
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- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- 229910001651 emery Inorganic materials 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 229940013317 fish oils Drugs 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000007970 homogeneous dispersion Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000003581 hormone blood level Effects 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 229940059904 light mineral oil Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 235000010408 potassium alginate Nutrition 0.000 description 1
- 239000000737 potassium alginate Substances 0.000 description 1
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 229950000975 salicylanilide Drugs 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical class [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- LLKGTXLYJMUQJX-UHFFFAOYSA-M sodium;3-[2-carboxyethyl(dodecyl)amino]propanoate Chemical compound [Na+].CCCCCCCCCCCCN(CCC(O)=O)CCC([O-])=O LLKGTXLYJMUQJX-UHFFFAOYSA-M 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Closures For Containers (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/002,536 US4857506A (en) | 1987-01-12 | 1987-01-12 | Sustained release growth hormone compositions for parenteral administration and their use |
| US002536 | 1995-08-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU1017088A AU1017088A (en) | 1988-07-14 |
| AU597462B2 true AU597462B2 (en) | 1990-05-31 |
Family
ID=21701224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU10170/88A Ceased AU597462B2 (en) | 1987-01-12 | 1988-01-11 | Sustained release growth hormone compositions for parenteral administration and their use |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4857506A (esLanguage) |
| EP (1) | EP0278103B1 (esLanguage) |
| JP (1) | JPS63258425A (esLanguage) |
| AT (1) | ATE81781T1 (esLanguage) |
| AU (1) | AU597462B2 (esLanguage) |
| CA (1) | CA1318587C (esLanguage) |
| DE (1) | DE3782420T2 (esLanguage) |
| DK (1) | DK10088A (esLanguage) |
| ES (1) | ES2052542T3 (esLanguage) |
| FI (1) | FI880101A7 (esLanguage) |
| GR (1) | GR3006124T3 (esLanguage) |
| HU (1) | HU197992B (esLanguage) |
| IL (1) | IL84907A0 (esLanguage) |
| NZ (1) | NZ223010A (esLanguage) |
| ZA (1) | ZA88152B (esLanguage) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5763394A (en) * | 1988-04-15 | 1998-06-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| US5981485A (en) * | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| WO1990008537A1 (en) * | 1989-02-06 | 1990-08-09 | Abbott Laboratories | Pharmaceutical compositions for oral administration |
| US5232704A (en) * | 1990-12-19 | 1993-08-03 | G. D. Searle & Co. | Sustained release, bilayer buoyant dosage form |
| YU87892A (sh) * | 1991-10-01 | 1995-12-04 | Eli Lilly And Company Lilly Corporate Center | Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu |
| IL103275A0 (en) * | 1991-10-01 | 1993-02-21 | Lilly Co Eli | Injectable extended release formulations and methods |
| AU3125193A (en) * | 1991-12-05 | 1993-06-28 | Pitman-Moore, Inc. | A carbohydrate glass matrix for the sustained release of a therapeutic agent |
| US5342612A (en) * | 1991-12-20 | 1994-08-30 | American Cyanamid Company | Compositions for the treatment of mammalian diseases |
| DE4206732A1 (de) * | 1992-03-04 | 1993-09-09 | Goldschmidt Ag Th | Fluessige, lagerstabile, multiple emulsion des typs o/w/o |
| US5426096A (en) * | 1992-03-18 | 1995-06-20 | Soenksen; Peter | Use of human growth hormone |
| US5643867A (en) * | 1992-08-26 | 1997-07-01 | Celtrix Pharmaceuticals, Inc. | Method for treating catabolic conditions |
| DE4322174A1 (de) * | 1993-07-03 | 1995-01-12 | Goldschmidt Ag Th | Flüssige oder pastöse, lagerstabile, multiple Emulsion des Typs W·1·/O/W·2· |
| SE9303068D0 (sv) * | 1993-09-21 | 1993-09-21 | Kabi Pharmacia Ab | New use |
| ZA949350B (en) | 1994-01-25 | 1996-05-24 | Upjohn Co | Aqueous prolonged release formulation |
| GB9410092D0 (en) * | 1994-05-19 | 1994-07-06 | Kelco Int Ltd | Emulsion, method and use |
| US5589177A (en) * | 1994-12-06 | 1996-12-31 | Helene Curtis, Inc. | Rinse-off water-in-oil-in-water compositions |
| US6528483B2 (en) | 1995-06-07 | 2003-03-04 | André Beaulieu | Method of producing concentrated non-buffered solutions of fibronectin |
| US5821220A (en) * | 1995-06-07 | 1998-10-13 | Andre Beaulieu | Method of producing concentrated non-buffered solutions of fibronectin |
| FR2742354B1 (fr) * | 1995-12-15 | 1998-01-23 | Oreal | Emulsion e/h/e stable contenant un actif cosmetique et/ou dermatologique sensible a l'eau |
| GB9626865D0 (en) * | 1996-12-24 | 1997-02-12 | Cyanamid Websters Pty Limited | Veterinary vaccines |
| ZA9711731B (en) * | 1996-12-31 | 1998-07-01 | Monsanto Co | Aqueous glycerol formulations of somatotropin |
| KR19990071255A (ko) | 1998-02-28 | 1999-09-15 | 성재갑 | 소마토트로핀과 비타민의 합제 조성물 |
| GB9827600D0 (en) | 1998-12-15 | 1999-02-10 | De Beers Ind Diamond | Abrasive product |
| WO2001062296A2 (en) * | 2000-02-24 | 2001-08-30 | Monsanto Technology Llc | Non-aqueous injectable formulations for extended release of somatotropin |
| AU2001271491A1 (en) * | 2000-06-26 | 2002-01-08 | Monsanto Technology Llc | Non-aqueous surfactant-containing formulations for extended release of somatotropin |
| US6664234B1 (en) * | 2000-06-30 | 2003-12-16 | Monsanto Technology Llc | Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin |
| CZ2003808A3 (cs) * | 2000-09-20 | 2003-08-13 | Nycomed Pharma As | Způsob výroby prostředku ve formě kapalné emulse |
| FR2852247A1 (fr) * | 2003-03-11 | 2004-09-17 | Centre Nat Rech Scient | Utilisation de ligands peptidiques de recepteurs de la membrane plasmique et de leurs analogues pour moduler l'activite des mitochondries |
| TWI380815B (zh) * | 2009-12-02 | 2013-01-01 | Univ Nat Pingtung Sci & Tech | 一種應用於甲殼綱生物性腺發展之緩釋藥劑 |
| TWI400064B (zh) * | 2009-12-08 | 2013-07-01 | Univ Nat Pingtung Sci & Tech | 一種蝦類生物的注射方法 |
| EP2805965A1 (en) | 2009-12-21 | 2014-11-26 | Ambrx, Inc. | Modified porcine somatotropin polypeptides and their uses |
| CN102753573A (zh) | 2009-12-21 | 2012-10-24 | Ambrx公司 | 经过修饰的牛促生长素多肽和其用途 |
| WO2017199008A1 (en) * | 2016-05-16 | 2017-11-23 | The University Of Birmingham | Emulsion |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4823785A (en) * | 1984-10-04 | 1986-04-10 | Monsanto Technology Llc | Pharmaceutical compositions of polypeptides in oil |
| AU6170086A (en) * | 1985-08-23 | 1987-02-26 | Eli Lilly And Company | Injectable sustained release formulation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4521409A (en) * | 1983-10-03 | 1985-06-04 | Cornell Research Foundation, Inc. | Use of growth hormone to enhance ruminant mammary development |
| EP0140255B1 (en) * | 1983-10-14 | 1991-05-15 | Sumitomo Pharmaceuticals Company, Limited | Sustained-release injections |
| EP0193917A3 (en) * | 1985-03-06 | 1987-09-23 | American Cyanamid Company | Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration |
-
1987
- 1987-01-12 US US07/002,536 patent/US4857506A/en not_active Expired - Lifetime
- 1987-12-21 NZ NZ223010A patent/NZ223010A/en unknown
- 1987-12-22 AT AT87119008T patent/ATE81781T1/de active
- 1987-12-22 IL IL84907A patent/IL84907A0/xx unknown
- 1987-12-22 ES ES87119008T patent/ES2052542T3/es not_active Expired - Lifetime
- 1987-12-22 EP EP87119008A patent/EP0278103B1/en not_active Expired - Lifetime
- 1987-12-22 DE DE8787119008T patent/DE3782420T2/de not_active Expired - Fee Related
-
1988
- 1988-01-08 CA CA000556088A patent/CA1318587C/en not_active Expired - Fee Related
- 1988-01-11 JP JP63002658A patent/JPS63258425A/ja active Pending
- 1988-01-11 FI FI880101A patent/FI880101A7/fi not_active Application Discontinuation
- 1988-01-11 AU AU10170/88A patent/AU597462B2/en not_active Ceased
- 1988-01-11 ZA ZA880152A patent/ZA88152B/xx unknown
- 1988-01-11 DK DK010088A patent/DK10088A/da not_active Application Discontinuation
- 1988-01-11 HU HU8882A patent/HU197992B/hu unknown
-
1992
- 1992-11-02 GR GR920400980T patent/GR3006124T3/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4823785A (en) * | 1984-10-04 | 1986-04-10 | Monsanto Technology Llc | Pharmaceutical compositions of polypeptides in oil |
| AU6170086A (en) * | 1985-08-23 | 1987-02-26 | Eli Lilly And Company | Injectable sustained release formulation |
Also Published As
| Publication number | Publication date |
|---|---|
| DK10088D0 (da) | 1988-01-11 |
| ZA88152B (en) | 1988-06-28 |
| IL84907A0 (en) | 1988-06-30 |
| JPS63258425A (ja) | 1988-10-25 |
| NZ223010A (en) | 1990-11-27 |
| GR3006124T3 (esLanguage) | 1993-06-21 |
| EP0278103A2 (en) | 1988-08-17 |
| US4857506A (en) | 1989-08-15 |
| FI880101A0 (fi) | 1988-01-11 |
| AU1017088A (en) | 1988-07-14 |
| FI880101L (fi) | 1988-07-13 |
| EP0278103B1 (en) | 1992-10-28 |
| DE3782420T2 (de) | 1993-03-11 |
| HU197992B (en) | 1989-07-28 |
| HUT46233A (en) | 1988-10-28 |
| DK10088A (da) | 1988-07-13 |
| DE3782420D1 (de) | 1992-12-03 |
| CA1318587C (en) | 1993-06-01 |
| FI880101A7 (fi) | 1988-07-13 |
| EP0278103A3 (en) | 1990-04-04 |
| ATE81781T1 (de) | 1992-11-15 |
| ES2052542T3 (es) | 1994-07-16 |
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