AU583793B2 - Phenylquinolinecarboxylic acids and derivatives as antitumor agents - Google Patents
Phenylquinolinecarboxylic acids and derivatives as antitumor agentsInfo
- Publication number
- AU583793B2 AU583793B2 AU30852/84A AU3085284A AU583793B2 AU 583793 B2 AU583793 B2 AU 583793B2 AU 30852/84 A AU30852/84 A AU 30852/84A AU 3085284 A AU3085284 A AU 3085284A AU 583793 B2 AU583793 B2 AU 583793B2
- Authority
- AU
- Australia
- Prior art keywords
- derivatives
- antitumor agents
- phenylquinolinecarboxylic
- acids
- phenylquinolinecarboxylic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- JIPUGCBCIYYRSB-UHFFFAOYSA-N 3-phenylquinoline-2-carboxylic acid Chemical class OC(=O)C1=NC2=CC=CC=C2C=C1C1=CC=CC=C1 JIPUGCBCIYYRSB-UHFFFAOYSA-N 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51631983A | 1983-07-22 | 1983-07-22 | |
| US516319 | 1983-07-22 | ||
| US60510484A | 1984-04-30 | 1984-04-30 | |
| US605104 | 1984-04-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU3085284A AU3085284A (en) | 1985-01-24 |
| AU583793B2 true AU583793B2 (en) | 1989-05-11 |
Family
ID=27058797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU30852/84A Ceased AU583793B2 (en) | 1983-07-22 | 1984-07-19 | Phenylquinolinecarboxylic acids and derivatives as antitumor agents |
Country Status (16)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU610469B2 (en) * | 1988-04-26 | 1991-05-16 | Du Pont Pharmaceuticals Company | 4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889862A (en) * | 1986-08-28 | 1989-12-26 | E. I. Du Pont De Nemours And Company | Freeze-dried pharmaceutical compositions of phenylquinoline carboxylic acids |
| HUT55742A (en) * | 1987-12-28 | 1991-06-28 | Dowelanco | Process for producing (phenoxy-phenoxy)-propionate derivatives and theyr new intermediates |
| US4968702A (en) * | 1989-01-17 | 1990-11-06 | American Cyanamid Company | Substituted quinolinecarboxylic acids |
| US4918077A (en) * | 1989-01-25 | 1990-04-17 | E. I. Du Pont De Nemours & Co., Inc. | 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents |
| DE3905339A1 (de) * | 1989-02-22 | 1990-09-06 | Basf Ag | Chinolin-4-carbonsaeurederivate und deren verwendung |
| US5393891A (en) * | 1993-06-08 | 1995-02-28 | The Du Pont Merck Pharmaceutical Company | Immunoassay reagents and methods for detecting brequinar and analogs |
| TW448160B (en) * | 1993-12-28 | 2001-08-01 | Merck & Co Inc | Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
| EA008136B1 (ru) * | 1997-05-28 | 2007-04-27 | Авентис Фармасьютикалз Инк. | ХИНОЛИНОВЫЕ И ХИНОКСАЛИНОВЫЕ СОЕДИНЕНИЯ, ИНГИБИРУЮЩИЕ ТИРОЗИНКИНАЗЫ ТРОМБОЦИТАРНОГО ФАКТОРА РОСТА И/ИЛИ p56 |
| EP0924209B1 (en) * | 1997-12-19 | 2003-05-02 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
| JPWO2004002484A1 (ja) * | 2002-06-26 | 2005-10-27 | 協和醗酵工業株式会社 | ホスホジエステラーゼ阻害剤 |
| TW200804288A (en) * | 2005-12-12 | 2008-01-16 | Astrazeneca Ab | Alkylsulphonamide quinolines |
| US8232310B2 (en) | 2006-12-29 | 2012-07-31 | Georgetown University | Targeting of EWS-FLI1 as anti-tumor therapy |
| US9290449B2 (en) | 2012-04-12 | 2016-03-22 | Georgetown University | Methods and compositions for treating Ewings sarcoma family of tumors |
| RU2016114498A (ru) | 2013-10-24 | 2017-11-29 | Джорджтаун Юниверсити | Способы и композиции для лечения раковых заболеваний |
| KR20160079123A (ko) | 2013-11-22 | 2016-07-05 | 젠자임 코포레이션 | 신경변성 질병을 치료하기 위한 신규한 방법 |
| EA032644B1 (ru) | 2014-10-09 | 2019-06-28 | Онктернал Терапьютикс, Инк. | Производные индолинона и их применение |
| CN109219594B (zh) | 2016-03-31 | 2022-10-11 | 英克特诺治疗公司 | 吲哚啉类似物及其用途 |
| CN114569606B (zh) | 2016-07-29 | 2024-04-19 | 英克特诺治疗公司 | 吲哚啉酮化合物的用途 |
| KR20220132538A (ko) * | 2019-12-26 | 2022-09-30 | 오하이오 스테이트 이노베이션 파운데이션 | 디하이드로오로테이트 데하이드로게나제를 억제하는 방법 및 조성물 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2579420A (en) * | 1950-04-18 | 1951-12-18 | Gen Aniline & Film Corp | Method for producing 6-halo-8-hydroxycinchoninic acids |
| US2888346A (en) * | 1955-08-22 | 1959-05-26 | Gen Aniline & Film Corp | Ultra-violet absorbing compounds |
-
1984
- 1984-07-19 CA CA000459263A patent/CA1288436C/en not_active Expired - Lifetime
- 1984-07-19 EP EP84108523A patent/EP0133244B1/en not_active Expired - Lifetime
- 1984-07-19 DE DE8484108523T patent/DE3483704D1/de not_active Expired - Lifetime
- 1984-07-19 AU AU30852/84A patent/AU583793B2/en not_active Ceased
- 1984-07-20 GR GR75386A patent/GR82234B/el unknown
- 1984-07-20 SU SU843776940A patent/SU1393314A3/ru active
- 1984-07-20 DK DK358784A patent/DK358784A/da not_active Application Discontinuation
- 1984-07-20 NO NO842969A patent/NO167510C/no unknown
- 1984-07-20 IE IE1873/84A patent/IE57627B1/en not_active IP Right Cessation
- 1984-07-20 IL IL72471A patent/IL72471A/xx not_active IP Right Cessation
- 1984-07-20 NZ NZ208966A patent/NZ208966A/en unknown
- 1984-07-20 PT PT78960A patent/PT78960B/pt not_active IP Right Cessation
- 1984-07-20 ES ES534509A patent/ES534509A0/es active Granted
- 1984-07-20 FI FI842928A patent/FI86987C/fi not_active IP Right Cessation
- 1984-07-20 HU HU842824A patent/HU194832B/hu not_active IP Right Cessation
-
1986
- 1986-01-06 SU SU864000869A patent/SU1452480A3/ru active
-
1995
- 1995-09-07 HK HK142395A patent/HK142395A/en not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2579420A (en) * | 1950-04-18 | 1951-12-18 | Gen Aniline & Film Corp | Method for producing 6-halo-8-hydroxycinchoninic acids |
| US2888346A (en) * | 1955-08-22 | 1959-05-26 | Gen Aniline & Film Corp | Ultra-violet absorbing compounds |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU610469B2 (en) * | 1988-04-26 | 1991-05-16 | Du Pont Pharmaceuticals Company | 4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| SU1393314A3 (ru) | 1988-04-30 |
| FI842928L (fi) | 1985-01-23 |
| DK358784A (da) | 1985-01-23 |
| ES8507498A1 (es) | 1985-09-01 |
| IL72471A (en) | 1988-11-15 |
| IE57627B1 (en) | 1993-02-10 |
| NO167510B (no) | 1991-08-05 |
| NZ208966A (en) | 1986-12-05 |
| IL72471A0 (en) | 1984-11-30 |
| NO167510C (no) | 1991-11-13 |
| EP0133244B1 (en) | 1990-12-05 |
| EP0133244A3 (en) | 1985-12-11 |
| FI86987C (fi) | 1992-11-10 |
| DK358784D0 (da) | 1984-07-20 |
| EP0133244A2 (en) | 1985-02-20 |
| HU194832B (en) | 1988-03-28 |
| PT78960B (en) | 1986-10-20 |
| FI842928A0 (fi) | 1984-07-20 |
| IE841873L (en) | 1985-01-22 |
| FI86987B (fi) | 1992-07-31 |
| HUT35248A (en) | 1985-06-28 |
| ES534509A0 (es) | 1985-09-01 |
| SU1452480A3 (ru) | 1989-01-15 |
| DE3483704D1 (de) | 1991-01-17 |
| GR82234B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-12-13 |
| CA1288436C (en) | 1991-09-03 |
| HK142395A (en) | 1995-09-15 |
| AU3085284A (en) | 1985-01-24 |
| NO842969L (no) | 1985-01-23 |
| PT78960A (en) | 1984-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |