AU581190B2 - 1H-imidazo``4,5-c``quinolines and 1H-imidazo``4,5-c`` quinolin-4-amines - Google Patents

1H-imidazo``4,5-c``quinolines and 1H-imidazo``4,5-c`` quinolin-4-amines

Info

Publication number
AU581190B2
AU581190B2 AU35402/84A AU3540284A AU581190B2 AU 581190 B2 AU581190 B2 AU 581190B2 AU 35402/84 A AU35402/84 A AU 35402/84A AU 3540284 A AU3540284 A AU 3540284A AU 581190 B2 AU581190 B2 AU 581190B2
Authority
AU
Australia
Prior art keywords
carbon atoms
alkyl
imidazo
phenyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired, expires
Application number
AU35402/84A
Other languages
English (en)
Other versions
AU3540284A (en
Inventor
John Franklin Gerster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wirra IP Pty Ltd
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of AU3540284A publication Critical patent/AU3540284A/en
Application granted granted Critical
Publication of AU581190B2 publication Critical patent/AU581190B2/en
Assigned to WIRRA IP PTY LIMITED reassignment WIRRA IP PTY LIMITED Alteration of Name(s) in Register under S187 Assignors: RIKER LABORATORIES, INC.
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Physical Water Treatments (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Alarm Systems (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Lubricants (AREA)
  • Luminescent Compositions (AREA)
AU35402/84A 1983-11-18 1984-11-14 1H-imidazo``4,5-c``quinolines and 1H-imidazo``4,5-c`` quinolin-4-amines Expired AU581190B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55315783A 1983-11-18 1983-11-18
US55315883A 1983-11-18 1983-11-18
US553158 1983-11-18
US553157 1983-11-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU29911/89A Division AU611997B2 (en) 1983-11-18 1989-02-14 3,4 amino quinolines and 4 amino 3 nitroquinolines

Publications (2)

Publication Number Publication Date
AU3540284A AU3540284A (en) 1985-05-23
AU581190B2 true AU581190B2 (en) 1989-02-16

Family

ID=27070262

Family Applications (2)

Application Number Title Priority Date Filing Date
AU35402/84A Expired AU581190B2 (en) 1983-11-18 1984-11-14 1H-imidazo``4,5-c``quinolines and 1H-imidazo``4,5-c`` quinolin-4-amines
AU29911/89A Expired AU611997B2 (en) 1983-11-18 1989-02-14 3,4 amino quinolines and 4 amino 3 nitroquinolines

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU29911/89A Expired AU611997B2 (en) 1983-11-18 1989-02-14 3,4 amino quinolines and 4 amino 3 nitroquinolines

Country Status (15)

Country Link
EP (2) EP0310950B1 (enExample)
JP (1) JPS60123488A (enExample)
KR (1) KR900005657B1 (enExample)
AT (2) ATE49763T1 (enExample)
AU (2) AU581190B2 (enExample)
CA (1) CA1271477A (enExample)
DE (3) DE3486043T2 (enExample)
DK (6) DK164280C (enExample)
ES (1) ES8603477A1 (enExample)
IE (1) IE57874B1 (enExample)
IL (2) IL84537A (enExample)
NL (2) NL980043I1 (enExample)
NO (7) NO163819C (enExample)
NZ (1) NZ210228A (enExample)
PH (1) PH22338A (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU615260B2 (en) * 1988-02-16 1991-09-26 Shionogi & Co., Ltd. 2-substituted carbonylimidazo(4,5-c) quinolines
AU630921B2 (en) * 1989-02-27 1992-11-12 Riker Laboratories, Inc. 1h-imidazo(4,5-c)quinolin-4-amines
AU658621B2 (en) * 1991-03-01 1995-04-27 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo(4,5-c)quinolin-4-amines

Families Citing this family (71)

* Cited by examiner, † Cited by third party
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CA1306260C (en) 1985-10-18 1992-08-11 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives
US4942168A (en) * 1987-07-13 1990-07-17 Hoechst-Roussel Pharmaceuticals Inc. Hydroxyquinoline amines, and method of enhancing memory in mammals
EP0361489A3 (en) * 1988-09-30 1991-06-12 Chugai Seiyaku Kabushiki Kaisha Novel 3,4-diaminoquinoline and pyridine compounds
US4994468A (en) * 1989-03-07 1991-02-19 Kyowa Hakko Kogyo Co., Ltd. Imidazoquinolone derivatives
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
CA2021338C (en) * 1989-07-18 1996-07-16 Fumio Suzuki Imidazoquinolone derivatives
US4988815A (en) * 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
FR2654021B1 (fr) * 1989-11-07 1992-02-28 Simond Jacques Procede de vitrification de cendres volantes et dispositif pour sa mise en óoeuvre.
GB8928281D0 (en) * 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
DE69122427T2 (de) * 1990-06-01 1997-03-06 Kyowa Hakko Kogyo Kk Imidazonaphthyridinderivate
US5266575A (en) * 1991-11-06 1993-11-30 Minnesota Mining And Manufacturing Company 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
IL105325A (en) * 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
US5395937A (en) * 1993-01-29 1995-03-07 Minnesota Mining And Manufacturing Company Process for preparing quinoline amines
US5693811A (en) * 1996-06-21 1997-12-02 Minnesota Mining And Manufacturing Company Process for preparing tetrahdroimidazoquinolinamines
US6069149A (en) * 1997-01-09 2000-05-30 Terumo Kabushiki Kaisha Amide derivatives and intermediates for the synthesis thereof
JPH10298181A (ja) * 1997-04-25 1998-11-10 Sumitomo Pharmaceut Co Ltd タイプ２ヘルパーｔ細胞選択的免疫応答抑制剤
JP2000119271A (ja) * 1998-08-12 2000-04-25 Hokuriku Seiyaku Co Ltd １ｈ―イミダゾピリジン誘導体
UA74852C2 (en) * 2000-12-08 2006-02-15 3M Innovative Properties Co Urea-substituted imidazoquinoline ethers
EP1438295B1 (en) * 2001-10-23 2012-08-15 Merck Serono SA Azole derivatives and pharmaceutical compositions containing them
GB0211649D0 (en) * 2002-05-21 2002-07-03 Novartis Ag Organic compounds
MXPA05000893A (es) 2002-07-23 2005-09-30 Biogal Gyogyszergyar Preparacion de 1h-imidazo[4,5-c]quinolin-4-aminas a traves de compuestos intermedios 1h-imidazo [4,5-c] quinolin-4-ftalimida.
IL166307A0 (en) 2002-07-26 2006-01-15 Preparation of 1h-imidazoÄ4,5-cÜquinolin-4-amines via novel 1h-imidazoÄ4,5-cÜquinolin-4-cyano and 1h-imidazo Ä4,5-cÜquinolin-4-cyano and 1h-imidazoÄ4,5-cÜquinolin-4-carboxamide intermediates
WO2005018556A2 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Hydroxylamine substituted imidazo-containing compounds
RU2006105101A (ru) * 2003-08-27 2007-10-10 3М Инновейтив Пропертиз Компани (US) Арилокси и арилалкиленокси замещенные имидазохинолины
WO2005023190A2 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for cd5+ b cell lymphoma
WO2005033049A2 (en) 2003-10-01 2005-04-14 Taro Pharmaceuticals U.S.A., Inc. METHOD OF PREPARING 4-AMINO-1H-IMIDAZO(4,5-c)QUINOLINES AND ACID ADDITION SALTS THEREOF
US8871782B2 (en) * 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
ITMI20032121A1 (it) * 2003-11-04 2005-05-05 Dinamite Dipharma Spa In Forma Abbr Eviata Dipharm Procedimento per la preparazione di imiquimod e suoi intermedi
CA2545774A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
US8598192B2 (en) 2003-11-14 2013-12-03 3M Innovative Properties Company Hydroxylamine substituted imidazoquinolines
AR046781A1 (es) 2003-11-25 2005-12-21 3M Innovative Properties Co Derivados de imidazoquinolinas. composiciones farmaceuticas.
WO2005066170A1 (en) 2003-12-29 2005-07-21 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
CA2551399A1 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
AU2005228150A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
EP1831226B1 (en) 2004-12-30 2012-08-08 3M Innovative Properties Company Chiral tetracyclic compounds inducing interferon biosynthesis
AU2005326708C1 (en) 2004-12-30 2012-08-30 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
AU2006210392A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune response modifiers
CA2597587A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
US7943636B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company 1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2006107853A2 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
CA2620182A1 (en) 2005-08-22 2007-03-01 Dennis A. Carson Tlr agonists
US8846697B2 (en) 2006-05-31 2014-09-30 The Regents Of The University Of California Purine analogs
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
EP2510946B1 (en) 2007-02-07 2015-08-05 The Regents of The University of California Conjugates of synthetic tlr agonists and uses therefor
EP2009002A1 (en) * 2007-06-21 2008-12-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) New process for the manufacture of 1H-imidazo [4,5-c]-quinoline ring systems
WO2010088924A1 (en) 2009-02-06 2010-08-12 Telormedix Sa Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
KR20110117705A (ko) 2009-02-11 2011-10-27 더 리전트 오브 더 유니버시티 오브 캘리포니아 톨-유사 수용체 조정제 및 질병의 치료
DK2606047T3 (en) 2010-08-17 2017-03-27 3M Innovative Properties Co COMPOSITIONS AND FORMULATIONS WITH LIPIDIZED IMMUNE RESPONSE-MODIFIING COMPOUND AND PROCEDURES THEREOF
US8728486B2 (en) 2011-05-18 2014-05-20 University Of Kansas Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds
CA2850932A1 (en) 2011-10-04 2013-04-11 Janus Biotherapeutics, Inc. Novel imidazole quinoline-based immune system modulators
BR122021012629B1 (pt) 2013-02-01 2022-06-07 Wellstat Therapeutics Corporation Compostos de amina, composição compreendendo os referidos compostos e usos dos mesmos
AR095604A1 (es) 2013-03-15 2015-10-28 Syngenta Participations Ag Derivados de imidazopiridina útiles como microbicidas
ES2538880B1 (es) * 2013-12-24 2016-09-08 Laboratorios Viñas S.A. Un procedimiento para obtener 4-amino-1-isobutil-1H-imidazo[4,5-c]quinoleína
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US11697851B2 (en) 2016-05-24 2023-07-11 The Regents Of The University Of California Early ovarian cancer detection diagnostic test based on mRNA isoforms
TWI674261B (zh) 2017-02-17 2019-10-11 美商英能腫瘤免疫股份有限公司 Nlrp3 調節劑
CN108794467A (zh) 2017-04-27 2018-11-13 博笛生物科技有限公司 2-氨基-喹啉衍生物
FI3641771T3 (fi) 2017-06-23 2026-08-11 Birdie Biopharmaceuticals Inc Farmaseuttisia koostumuksia
FR3113287B1 (fr) 2020-08-07 2023-06-23 Phv Pharma Procédé industriel de synthèse de l’imiquimod à partir de la quinolèine-2,4-diol applicable à son utilisation pharmaceutique
BR112023011284A2 (pt) 2020-12-09 2024-02-06 Wellstat Therapeutics Corp Composto de imidazoquinolina com atividade anti-inflamatória, antifúngica, antiparasítica e antineoplásica

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3700674A (en) * 1969-04-30 1972-10-24 American Cyanamid Co 4-alkylamino-3-nitroquinolines
RO86850B (ro) * 1982-05-03 1985-05-31 Eli Lilly And Company Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU615260B2 (en) * 1988-02-16 1991-09-26 Shionogi & Co., Ltd. 2-substituted carbonylimidazo(4,5-c) quinolines
AU630921B2 (en) * 1989-02-27 1992-11-12 Riker Laboratories, Inc. 1h-imidazo(4,5-c)quinolin-4-amines
AU658621B2 (en) * 1991-03-01 1995-04-27 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo(4,5-c)quinolin-4-amines

Also Published As

Publication number Publication date
NO844565L (no) 1985-05-20
NO169437C (no) 1992-06-24
NO1999015I1 (no) 1999-07-08
CA1271477A (en) 1990-07-10
NO890825L (no) 1985-05-20
DK542684A (da) 1985-05-19
NO163819C (no) 1990-08-01
NO890826L (no) 1985-05-20
DK136091D0 (da) 1991-07-16
AU611997B2 (en) 1991-06-27
ES537677A0 (es) 1985-12-16
ATE84525T1 (de) 1993-01-15
NO165146C (no) 1991-01-02
DK164451C (da) 1992-11-09
EP0145340B1 (en) 1990-01-24
NO890826D0 (no) 1989-02-27
DK135991A (da) 1991-07-16
DK136091A (da) 1991-07-16
IL84537A0 (en) 1988-04-29
DK164455B (da) 1992-06-29
NO163819B (no) 1990-04-17
AU2991189A (en) 1989-06-15
IE57874B1 (en) 1993-05-05
DK135791D0 (da) 1991-07-16
NO890822L (no) 1985-05-20
EP0145340A2 (en) 1985-06-19
IL84537A (en) 1990-12-23
NO168705B (no) 1991-12-16
DK164452C (da) 1992-11-09
EP0310950B1 (en) 1993-01-13
EP0310950A1 (en) 1989-04-12
DE3486043D1 (de) 1993-02-25
KR850003890A (ko) 1985-06-29
DE3481124D1 (de) 1990-03-01
AU3540284A (en) 1985-05-23
DK164280C (da) 1992-11-30
DK164280B (da) 1992-06-01
NL980041I2 (nl) 1999-07-01
NO169437B (no) 1992-03-16
NO165147C (no) 1991-01-02
NO890823D0 (no) 1989-02-27
PH22338A (en) 1988-08-12
NO890823L (no) 1985-05-20
NO890825D0 (no) 1989-02-27
ATE49763T1 (de) 1990-02-15
NO168705C (no) 1992-03-25
NO165146B (no) 1990-09-24
KR900005657B1 (ko) 1990-08-03
DK164452B (da) 1992-06-29
EP0145340A3 (en) 1986-06-11
DK135891A (da) 1991-07-16
NL980043I1 (nl) 1999-02-01
DK136191D0 (da) 1991-07-16
DK135891D0 (da) 1991-07-16
NO890824D0 (no) 1989-02-27
NO890822D0 (no) 1989-02-27
IE842952L (en) 1985-05-18
DK164455C (da) 1992-11-16
DK165921B (da) 1993-02-08
NZ210228A (en) 1989-01-27
DK542684D0 (da) 1984-11-15
JPH0586391B2 (enExample) 1993-12-10
DK164451B (da) 1992-06-29
NO165145B (no) 1990-09-24
DK136191A (da) 1991-07-16
DK165921C (da) 1993-06-28
DE19975027I2 (de) 2000-09-21
ES8603477A1 (es) 1985-12-16
DK135991D0 (da) 1991-07-16
DK135791A (da) 1991-07-16
NO165147B (no) 1990-09-24
NO890824L (no) 1985-05-20
JPS60123488A (ja) 1985-07-02
DE3486043T2 (de) 1993-06-03
DK169179B1 (da) 1994-09-05
NL980041I1 (nl) 1999-02-01
NO165145C (no) 1991-01-02

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AU3540284A (en) 1H-imidazo``4,5-c``quinolines and 1H-imidazo``4,5-c`` quinolin-4-amines