NO163819C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 1h-imidazo(4,5-c)kinolin og derivater derav. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 1h-imidazo(4,5-c)kinolin og derivater derav.

Info

Publication number
NO163819C
NO163819C NO844565A NO844565A NO163819C NO 163819 C NO163819 C NO 163819C NO 844565 A NO844565 A NO 844565A NO 844565 A NO844565 A NO 844565A NO 163819 C NO163819 C NO 163819C
Authority
NO
Norway
Prior art keywords
imidazo
carbon atoms
quinoline
derivatives
preparation
Prior art date
Application number
NO844565A
Other languages
English (en)
Norwegian (no)
Other versions
NO163819B (no
NO844565L (no
Inventor
John Franklin Gerster
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of NO844565L publication Critical patent/NO844565L/no
Priority to NO890826A priority Critical patent/NO168705C/no
Priority to NO890822A priority patent/NO165145C/no
Priority to NO890825A priority patent/NO169437C/no
Priority to NO890824A priority patent/NO165147C/no
Priority to NO890823A priority patent/NO165146C/no
Publication of NO163819B publication Critical patent/NO163819B/no
Publication of NO163819C publication Critical patent/NO163819C/no
Priority to NO1999015C priority patent/NO1999015I1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Water Treatments (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Alarm Systems (AREA)
  • Lubricants (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Luminescent Compositions (AREA)
NO844565A 1983-11-18 1984-11-15 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1h-imidazo(4,5-c)kinolin og derivater derav. NO163819C (no)

Priority Applications (6)

Application Number Priority Date Filing Date Title
NO890826A NO168705C (no) 1983-11-18 1989-02-27 3-nitro-kinoliner.
NO890822A NO165145C (no) 1983-11-18 1989-02-27 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1h-imidazo-(4,5-c)-kinolin-4-aminderivater.
NO890825A NO169437C (no) 1983-11-18 1989-02-27 3-amino-kinoliner.
NO890824A NO165147C (no) 1983-11-18 1989-02-27 1h-imidazo(4,5-c)-kinolin-5-oxydforbindelser.
NO890823A NO165146C (no) 1983-11-18 1989-02-27 1h-imidazo-(4,5-c)-kinolin-4-klorforbindelser.
NO1999015C NO1999015I1 (no) 1983-11-18 1999-07-08 Imiquimod

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55315883A 1983-11-18 1983-11-18
US55315783A 1983-11-18 1983-11-18

Publications (3)

Publication Number Publication Date
NO844565L NO844565L (no) 1985-05-20
NO163819B NO163819B (no) 1990-04-17
NO163819C true NO163819C (no) 1990-08-01

Family

ID=27070262

Family Applications (7)

Application Number Title Priority Date Filing Date
NO844565A NO163819C (no) 1983-11-18 1984-11-15 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1h-imidazo(4,5-c)kinolin og derivater derav.
NO890824A NO165147C (no) 1983-11-18 1989-02-27 1h-imidazo(4,5-c)-kinolin-5-oxydforbindelser.
NO890826A NO168705C (no) 1983-11-18 1989-02-27 3-nitro-kinoliner.
NO890822A NO165145C (no) 1983-11-18 1989-02-27 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1h-imidazo-(4,5-c)-kinolin-4-aminderivater.
NO890823A NO165146C (no) 1983-11-18 1989-02-27 1h-imidazo-(4,5-c)-kinolin-4-klorforbindelser.
NO890825A NO169437C (no) 1983-11-18 1989-02-27 3-amino-kinoliner.
NO1999015C NO1999015I1 (no) 1983-11-18 1999-07-08 Imiquimod

Family Applications After (6)

Application Number Title Priority Date Filing Date
NO890824A NO165147C (no) 1983-11-18 1989-02-27 1h-imidazo(4,5-c)-kinolin-5-oxydforbindelser.
NO890826A NO168705C (no) 1983-11-18 1989-02-27 3-nitro-kinoliner.
NO890822A NO165145C (no) 1983-11-18 1989-02-27 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1h-imidazo-(4,5-c)-kinolin-4-aminderivater.
NO890823A NO165146C (no) 1983-11-18 1989-02-27 1h-imidazo-(4,5-c)-kinolin-4-klorforbindelser.
NO890825A NO169437C (no) 1983-11-18 1989-02-27 3-amino-kinoliner.
NO1999015C NO1999015I1 (no) 1983-11-18 1999-07-08 Imiquimod

Country Status (15)

Country Link
EP (2) EP0145340B1 (enExample)
JP (1) JPS60123488A (enExample)
KR (1) KR900005657B1 (enExample)
AT (2) ATE49763T1 (enExample)
AU (2) AU581190B2 (enExample)
CA (1) CA1271477A (enExample)
DE (3) DE19975027I2 (enExample)
DK (6) DK164280C (enExample)
ES (1) ES8603477A1 (enExample)
IE (1) IE57874B1 (enExample)
IL (2) IL84537A (enExample)
NL (2) NL980041I2 (enExample)
NO (7) NO163819C (enExample)
NZ (1) NZ210228A (enExample)
PH (1) PH22338A (enExample)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1306260C (en) 1985-10-18 1992-08-11 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives
US4942168A (en) * 1987-07-13 1990-07-17 Hoechst-Roussel Pharmaceuticals Inc. Hydroxyquinoline amines, and method of enhancing memory in mammals
CA1335996C (en) * 1988-02-16 1995-06-20 Susumu Takada 2-substituted carbonylimidazo¬4,5-c|quinolines
EP0361489A3 (en) * 1988-09-30 1991-06-12 Chugai Seiyaku Kabushiki Kaisha Novel 3,4-diaminoquinoline and pyridine compounds
ES2094141T3 (es) * 1989-02-27 1997-01-16 Riker Laboratories Inc 1h-imidazo(4,5-c)quinolin-4-aminas como antivirales.
US4994468A (en) * 1989-03-07 1991-02-19 Kyowa Hakko Kogyo Co., Ltd. Imidazoquinolone derivatives
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
JP2988692B2 (ja) * 1989-07-18 1999-12-13 協和醗酵工業株式会社 イミダゾキノロン誘導体
US4988815A (en) * 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
FR2654021B1 (fr) * 1989-11-07 1992-02-28 Simond Jacques Procede de vitrification de cendres volantes et dispositif pour sa mise en óoeuvre.
GB8928281D0 (en) * 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
DE69122427T2 (de) * 1990-06-01 1997-03-06 Kyowa Hakko Kogyo Kk Imidazonaphthyridinderivate
ES2131070T3 (es) * 1991-03-01 1999-07-16 Minnesota Mining & Mfg 1h-imidazo(4,5-c)quinolin-4-aminas sustituidas en posicion 1 y sustituidas en posicion 2.
US5266575A (en) * 1991-11-06 1993-11-30 Minnesota Mining And Manufacturing Company 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
IL105325A (en) * 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
US5395937A (en) * 1993-01-29 1995-03-07 Minnesota Mining And Manufacturing Company Process for preparing quinoline amines
US5693811A (en) * 1996-06-21 1997-12-02 Minnesota Mining And Manufacturing Company Process for preparing tetrahdroimidazoquinolinamines
EP0894797A4 (en) * 1997-01-09 2001-08-16 Terumo Corp NEW AMID DERIVATIVES AND INTERMEDIATES ON YOUR SYNTHESIS
JPH10298181A (ja) * 1997-04-25 1998-11-10 Sumitomo Pharmaceut Co Ltd タイプ２ヘルパーｔ細胞選択的免疫応答抑制剤
JP2000119271A (ja) 1998-08-12 2000-04-25 Hokuriku Seiyaku Co Ltd １ｈ―イミダゾピリジン誘導体
UA75622C2 (en) * 2000-12-08 2006-05-15 3M Innovative Properties Co Aryl ether substituted imidazoquinolines, pharmaceutical composition based thereon
AU2002359291C1 (en) * 2001-10-23 2008-11-20 Merck Serono Sa Azole derivatives and pharmaceutical compositions containing them
GB0211649D0 (en) * 2002-05-21 2002-07-03 Novartis Ag Organic compounds
JP2006502121A (ja) 2002-07-23 2006-01-19 テバ ジョジセルジャール レースベニュタールシャシャーグ １Ｈ−イミダゾ［４，５−ｃ］キノリン−４−フタルイミド中間体を介する１Ｈ−イミダゾ−［４，５−ｃ］キノリン−４−アミンの調製
AU2003254221A1 (en) 2002-07-26 2004-02-16 Biogal Gyogyszergyar Rt. Preparation of 1h-imidazo (4,5-c) quinolin-4-amines via novel 1h-imidazo (4,5-c) quinolin-4-cyano and 1h-imidazo (4,5-c) quinolin-4-carboxamide intermediates
WO2005018556A2 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Hydroxylamine substituted imidazo-containing compounds
PH12006500401A1 (en) 2003-08-27 2005-03-10 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
EP1660026A4 (en) 2003-09-05 2008-07-16 3M Innovative Properties Co TREATMENT FOR CD5 + B CELL LYMPHOMA
US7687628B2 (en) 2003-10-01 2010-03-30 Taro Pharmaceuticals U.S.A., Inc. Method of preparing 4-amino-1H-imidazo(4,5-c)quinolines and acid addition salts thereof
EP1673087B1 (en) 2003-10-03 2015-05-13 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
ITMI20032121A1 (it) * 2003-11-04 2005-05-05 Dinamite Dipharma Spa In Forma Abbr Eviata Dipharm Procedimento per la preparazione di imiquimod e suoi intermedi
WO2005048945A2 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
EP1685129A4 (en) 2003-11-14 2008-10-22 3M Innovative Properties Co OXIMSUBSTITUTED IMIDAZORING CONNECTIONS
CA2547020C (en) 2003-11-25 2014-03-25 3M Innovative Properties Company 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
US8802853B2 (en) 2003-12-29 2014-08-12 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
WO2005066169A2 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
AU2005228150A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
AU2005322898B2 (en) 2004-12-30 2011-11-24 3M Innovative Properties Company Chiral fused (1,2)imidazo(4,5-c) ring compounds
JP5313502B2 (ja) 2004-12-30 2013-10-09 スリーエム イノベイティブ プロパティズ カンパニー 置換キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
CA2597092A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
CA2597587A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
EP1863814A1 (en) 2005-04-01 2007-12-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
EP1869043A2 (en) 2005-04-01 2007-12-26 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
ES2577514T3 (es) 2005-08-22 2016-07-15 The Regents Of The University Of California Antagonistas de TLR
EP2029597A4 (en) 2006-05-31 2011-11-23 Univ California purine analogs
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
EP2510946B1 (en) 2007-02-07 2015-08-05 The Regents of The University of California Conjugates of synthetic tlr agonists and uses therefor
EP2009002A1 (en) * 2007-06-21 2008-12-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) New process for the manufacture of 1H-imidazo [4,5-c]-quinoline ring systems
WO2010088924A1 (en) 2009-02-06 2010-08-12 Telormedix Sa Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
BRPI1008383A2 (pt) 2009-02-11 2016-02-23 Univ California composto, composição farmacêutica, método para prevenir, inibir ou tratar uma condição, e, uso de um composto
EP3222621B1 (en) 2010-08-17 2023-03-08 3M Innovative Properties Company Lipidated immune response modifier compound and its medical use
US8728486B2 (en) 2011-05-18 2014-05-20 University Of Kansas Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds
US9873694B2 (en) 2011-10-04 2018-01-23 Janus Biotherapeutics, Inc. Imidazole quinoline-based immune system modulators
CA3217159A1 (en) * 2013-02-01 2014-08-07 Wellstat Therapeutics Corporation Substituted quinazolin-4-amine compounds and pharmaceutical compositions thereof having anti-inflammatory, antifungal, antiparasitic and anticancer activity
KR20150127085A (ko) * 2013-03-15 2015-11-16 신젠타 파티서페이션즈 아게 살균 활성인 이미다조피리딘 유도체
ES2538880B1 (es) * 2013-12-24 2016-09-08 Laboratorios Viñas S.A. Un procedimiento para obtener 4-amino-1-isobutil-1H-imidazo[4,5-c]quinoleína
US10548985B2 (en) 2014-01-10 2020-02-04 Birdie Biopharmaceuticals, Inc. Compounds and compositions for treating EGFR expressing tumors
CA2954446A1 (en) 2014-07-09 2016-01-14 Shanghai Birdie Biotech, Inc. Anti-pd-l1 combinations for treating tumors
JP6873980B2 (ja) * 2015-09-14 2021-05-19 ファイザー・インク ＬＲＲＫ２阻害薬としての新規のイミダゾ［４，５−ｃ］キノリンおよびイミダゾ［４，５−ｃ］［１，５］ナフチリジン誘導体
CN115252792A (zh) 2016-01-07 2022-11-01 博笛生物科技有限公司 用于治疗肿瘤的抗-egfr组合
CN106943596A (zh) 2016-01-07 2017-07-14 博笛生物科技（北京）有限公司 用于治疗肿瘤的抗-cd20组合
AU2017252640A1 (en) 2016-04-19 2018-12-06 Innate Tumor Immunity, Inc. NLRP3 modulators
WO2017184735A1 (en) * 2016-04-19 2017-10-26 Ifm Therapeutics, Inc Nlrp3 modulators
US11697851B2 (en) 2016-05-24 2023-07-11 The Regents Of The University Of California Early ovarian cancer detection diagnostic test based on mRNA isoforms
TWI674261B (zh) 2017-02-17 2019-10-11 美商英能腫瘤免疫股份有限公司 Nlrp3 調節劑
CN108794467A (zh) 2017-04-27 2018-11-13 博笛生物科技有限公司 2-氨基-喹啉衍生物
CA3067268A1 (en) 2017-06-23 2018-12-27 Birdie Biopharmaceuticals, Inc. Crystalline resiquimod monosulfate anhydrate and its preparation and uses
FR3113287B1 (fr) 2020-08-07 2023-06-23 Phv Pharma Procédé industriel de synthèse de l’imiquimod à partir de la quinolèine-2,4-diol applicable à son utilisation pharmaceutique
CN116528875A (zh) * 2020-12-09 2023-08-01 维尔斯达医疗公司 具有抗炎、抗真菌、抗寄生虫和抗癌活性的咪唑并喹啉化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3700674A (en) * 1969-04-30 1972-10-24 American Cyanamid Co 4-alkylamino-3-nitroquinolines
ZA832938B (en) * 1982-05-03 1984-12-24 Lilly Co Eli 2-phenylimidazo(4,5-c)pyridines

Also Published As

Publication number Publication date
DE3486043D1 (de) 1993-02-25
NO165145C (no) 1991-01-02
DK164455B (da) 1992-06-29
DK135891A (da) 1991-07-16
NO165146B (no) 1990-09-24
DE3486043T2 (de) 1993-06-03
NL980043I1 (nl) 1999-02-01
PH22338A (en) 1988-08-12
DK165921B (da) 1993-02-08
NO163819B (no) 1990-04-17
NO890826L (no) 1985-05-20
DK164280B (da) 1992-06-01
DK135991A (da) 1991-07-16
DK164455C (da) 1992-11-16
EP0145340B1 (en) 1990-01-24
NZ210228A (en) 1989-01-27
NO168705B (no) 1991-12-16
NO890826D0 (no) 1989-02-27
IL84537A0 (en) 1988-04-29
EP0310950B1 (en) 1993-01-13
ES537677A0 (es) 1985-12-16
DK164452B (da) 1992-06-29
KR900005657B1 (ko) 1990-08-03
NO844565L (no) 1985-05-20
DK169179B1 (da) 1994-09-05
NO890823L (no) 1985-05-20
NO890823D0 (no) 1989-02-27
NO890822D0 (no) 1989-02-27
DK135791A (da) 1991-07-16
NO165147C (no) 1991-01-02
NO1999015I1 (no) 1999-07-08
IL84537A (en) 1990-12-23
JPH0586391B2 (enExample) 1993-12-10
NO168705C (no) 1992-03-25
NL980041I1 (nl) 1999-02-01
IE842952L (en) 1985-05-18
DK542684D0 (da) 1984-11-15
NO890825D0 (no) 1989-02-27
ES8603477A1 (es) 1985-12-16
DK135891D0 (da) 1991-07-16
AU3540284A (en) 1985-05-23
NO165146C (no) 1991-01-02
DK164451B (da) 1992-06-29
IE57874B1 (en) 1993-05-05
AU2991189A (en) 1989-06-15
ATE84525T1 (de) 1993-01-15
DK136191A (da) 1991-07-16
DK136191D0 (da) 1991-07-16
DE19975027I2 (de) 2000-09-21
NO890825L (no) 1985-05-20
DK165921C (da) 1993-06-28
DK136091D0 (da) 1991-07-16
JPS60123488A (ja) 1985-07-02
EP0145340A3 (en) 1986-06-11
DK135791D0 (da) 1991-07-16
CA1271477A (en) 1990-07-10
AU611997B2 (en) 1991-06-27
KR850003890A (ko) 1985-06-29
DK542684A (da) 1985-05-19
ATE49763T1 (de) 1990-02-15
DK164451C (da) 1992-11-09
AU581190B2 (en) 1989-02-16
NO165147B (no) 1990-09-24
DK135991D0 (da) 1991-07-16
NO165145B (no) 1990-09-24
DK164452C (da) 1992-11-09
EP0145340A2 (en) 1985-06-19
NO890824L (no) 1985-05-20
NL980041I2 (nl) 1999-07-01
NO890824D0 (no) 1989-02-27
DE3481124D1 (de) 1990-03-01
EP0310950A1 (en) 1989-04-12
DK164280C (da) 1992-11-30
NO890822L (no) 1985-05-20
NO169437B (no) 1992-03-16
NO169437C (no) 1992-06-24
DK136091A (da) 1991-07-16

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Publication Publication Date Title
NO163819C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1h-imidazo(4,5-c)kinolin og derivater derav.

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