AU574246B2 - Homodisaccharide hypoglycemic agents - Google Patents

Homodisaccharide hypoglycemic agents

Info

Publication number
AU574246B2
AU574246B2 AU50810/85A AU5081085A AU574246B2 AU 574246 B2 AU574246 B2 AU 574246B2 AU 50810/85 A AU50810/85 A AU 50810/85A AU 5081085 A AU5081085 A AU 5081085A AU 574246 B2 AU574246 B2 AU 574246B2
Authority
AU
Australia
Prior art keywords
homodisaccharide
hypoglycemic agents
homonojirimycin
protected
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU50810/85A
Other languages
English (en)
Other versions
AU5081085A (en
Inventor
Paul S. Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of AU5081085A publication Critical patent/AU5081085A/en
Application granted granted Critical
Publication of AU574246B2 publication Critical patent/AU574246B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Luminescent Compositions (AREA)
AU50810/85A 1984-12-18 1985-12-05 Homodisaccharide hypoglycemic agents Ceased AU574246B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US683127 1984-12-18
US06/683,127 US4634765A (en) 1984-12-18 1984-12-18 Homodisaccharide hypoglycemic agents

Publications (2)

Publication Number Publication Date
AU5081085A AU5081085A (en) 1986-06-26
AU574246B2 true AU574246B2 (en) 1988-06-30

Family

ID=24742682

Family Applications (1)

Application Number Title Priority Date Filing Date
AU50810/85A Ceased AU574246B2 (en) 1984-12-18 1985-12-05 Homodisaccharide hypoglycemic agents

Country Status (20)

Country Link
US (1) US4634765A (OSRAM)
EP (1) EP0186103B1 (OSRAM)
JP (1) JPS61158994A (OSRAM)
KR (1) KR900005607B1 (OSRAM)
CN (1) CN1016784B (OSRAM)
AT (1) ATE62249T1 (OSRAM)
AU (1) AU574246B2 (OSRAM)
CA (1) CA1240989A (OSRAM)
DE (1) DE3582420D1 (OSRAM)
DK (1) DK587085A (OSRAM)
ES (1) ES8706164A1 (OSRAM)
FI (1) FI80707C (OSRAM)
GR (1) GR853032B (OSRAM)
HU (1) HU194263B (OSRAM)
IE (1) IE58186B1 (OSRAM)
NO (1) NO162387B (OSRAM)
NZ (1) NZ214570A (OSRAM)
PH (1) PH23660A (OSRAM)
PT (1) PT81689B (OSRAM)
ZA (1) ZA859573B (OSRAM)

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GB2181729B (en) * 1985-10-12 1990-04-04 Nippon Shinyaku Co Ltd Glucosylmoranoline derivatives and production thereof
JPS62242692A (ja) * 1986-04-15 1987-10-23 Nippon Shinyaku Co Ltd モラノリン誘導体の製造法
EP0344383A1 (en) * 1988-06-02 1989-12-06 Merrell Dow Pharmaceuticals Inc. Novel alpha-Glucosidase inhibitors
EP0345104B1 (en) * 1988-06-02 1995-11-02 Merrell Dow Pharmaceuticals Inc. Novel Alpha-glucosidase inhibitors
US4880917A (en) * 1988-07-01 1989-11-14 Merrell Dow Pharmaceuticals Inc. Process for hydrolyzing 2,6-dideoxy-2,6-iminoheptononitrile derivatives using trifluoroacetic acid and dinitrogen tetroxide
US4908439A (en) * 1988-09-16 1990-03-13 Merrell Dow Pharmaceuticals Inc. Synthesis of intermediate useful in the preparation of nojirimycin and related compounds
US5227479A (en) * 1989-12-20 1993-07-13 Merrell Dow Pharmaceuticals Inc. Process for the preparation of nojirimycin and related compounds
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
ES2363230T3 (es) * 1997-04-15 2011-07-27 Csir Métodos no terapéuticos para suprimir el apetito.
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
US6462197B2 (en) 2000-03-31 2002-10-08 Board Of Trustees Of Michigan State University Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines
GB2363985B (en) * 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
AU2005308575A1 (en) * 2004-11-23 2006-06-01 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia
PL2027137T3 (pl) 2005-06-08 2015-08-31 Amicus Therapeutics Inc Oczyszczanie imino- i aminocukrów
JP2008543784A (ja) * 2005-06-08 2008-12-04 アミカス セラピューティックス インコーポレイテッド 結晶性糖組成物および作製方法
WO2006133448A1 (en) * 2005-06-08 2006-12-14 Amicus Therapeutics, Inc. Stabilization of triflated compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
ES2371393T3 (es) 2007-03-12 2011-12-30 Zadec Aps Extracto antidiabético de rooibos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
WO2011145022A1 (en) 2010-05-21 2011-11-24 Pfizer Inc. 2-phenyl benzoylamides
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN102462726B (zh) * 2010-11-04 2016-03-09 中国医学科学院药物研究所 白树总生物碱及多羟基生物碱化合物的提取、分离及用途
US20130345392A1 (en) 2011-03-04 2013-12-26 Pfizer Inc Edn3-like peptides and uses thereof
EP2712362A4 (en) * 2011-05-13 2014-12-24 Glycom As MANUFACTURE OF LACTO-N-TETRAOSE
MY188344A (en) 2012-03-09 2021-12-01 Biotropics Malaysia Berhad Extract formulations of rhodamnia cinerea and uses thereof
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
EP4424697A3 (en) 2013-06-05 2024-12-25 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
CA2959208C (en) 2014-08-29 2023-09-19 Tes Pharma S.R.L. Pyrimidine derivatives and their use as inhibitors of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN104530150A (zh) * 2015-01-14 2015-04-22 佛山市赛维斯医药科技有限公司 含胺基苯和双葡萄糖苷结构化合物、其制备方法和用途
AU2017342083A1 (en) 2016-10-14 2019-04-11 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
IT201700078102A1 (it) 2017-07-11 2019-01-11 Dipharma Francis Srl Sintesi di un azazucchero e suoi intermedi
CN108828121B (zh) * 2018-06-14 2020-06-05 华润三九医药股份有限公司 一种白树药材中α-高野尻霉素的含量检测方法
JP7638868B2 (ja) 2018-11-20 2025-03-04 ティエエッセ ファルマ ソチエタ レスポンサビリタ リミタータ α－アミノ－β－カルボキシムコン酸セミアルデヒドデカルボキシラーゼ阻害剤
US11248001B2 (en) 2019-01-18 2022-02-15 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels
US4328233A (en) * 1978-11-06 1982-05-04 Bayer Aktiengesellschaft α-Glucosidase inhibiting 2-hydroxymethyl-3,4,5-trihydroxy-piperidines
US4348402A (en) * 1979-10-19 1982-09-07 Bayer Aktiengesellschaft 2-Hydroxyalkyl-3,4,5-trihydroxy-piperidine compounds, their production and their medicinal use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
GB2064527B (en) * 1979-12-08 1984-05-02 Nippon Shinyaku Co Ltd Moranoline derivatives and process for preparation thereof
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels
US4328233A (en) * 1978-11-06 1982-05-04 Bayer Aktiengesellschaft α-Glucosidase inhibiting 2-hydroxymethyl-3,4,5-trihydroxy-piperidines
US4348402A (en) * 1979-10-19 1982-09-07 Bayer Aktiengesellschaft 2-Hydroxyalkyl-3,4,5-trihydroxy-piperidine compounds, their production and their medicinal use

Also Published As

Publication number Publication date
FI854944A0 (fi) 1985-12-13
IE58186B1 (en) 1993-07-28
NZ214570A (en) 1988-03-30
HU194263B (en) 1988-01-28
KR860004921A (ko) 1986-07-16
NO855087L (no) 1986-06-19
PT81689B (pt) 1987-11-30
HUT40137A (en) 1986-11-28
PH23660A (en) 1989-09-27
JPS61158994A (ja) 1986-07-18
DK587085D0 (da) 1985-12-17
DK587085A (da) 1986-06-19
US4634765A (en) 1987-01-06
CA1240989A (en) 1988-08-23
EP0186103A3 (en) 1988-02-03
ES8706164A1 (es) 1987-06-01
ZA859573B (en) 1986-08-27
JPH0565519B2 (OSRAM) 1993-09-17
NO162387B (no) 1989-09-11
FI80707C (fi) 1990-07-10
CN1016784B (zh) 1992-05-27
KR900005607B1 (ko) 1990-07-31
GR853032B (OSRAM) 1986-04-18
AU5081085A (en) 1986-06-26
EP0186103B1 (en) 1991-04-03
FI854944L (fi) 1986-06-19
ES550060A0 (es) 1987-06-01
FI80707B (fi) 1990-03-30
EP0186103A2 (en) 1986-07-02
IE853179L (en) 1986-06-18
ATE62249T1 (de) 1991-04-15
CN85109548A (zh) 1986-07-09
PT81689A (en) 1986-01-01
DE3582420D1 (de) 1991-05-08

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired