PT81689B - Processo para a preparacao de agentes hipoglicemicos homodissacarios, designadamente, glicosidos da 2,6-imino-2,6-didesoxi-d-glicero-1-gulo-heptidol (homonojirimicina) - Google Patents

Processo para a preparacao de agentes hipoglicemicos homodissacarios, designadamente, glicosidos da 2,6-imino-2,6-didesoxi-d-glicero-1-gulo-heptidol (homonojirimicina)

Info

Publication number
PT81689B
PT81689B PT81689A PT8168985A PT81689B PT 81689 B PT81689 B PT 81689B PT 81689 A PT81689 A PT 81689A PT 8168985 A PT8168985 A PT 8168985A PT 81689 B PT81689 B PT 81689B
Authority
PT
Portugal
Prior art keywords
glycosides
homonojyrymicine
heptidol
dimenson
glycero
Prior art date
Application number
PT81689A
Other languages
English (en)
Other versions
PT81689A (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of PT81689A publication Critical patent/PT81689A/pt
Publication of PT81689B publication Critical patent/PT81689B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Luminescent Compositions (AREA)
PT81689A 1984-12-18 1985-12-16 Processo para a preparacao de agentes hipoglicemicos homodissacarios, designadamente, glicosidos da 2,6-imino-2,6-didesoxi-d-glicero-1-gulo-heptidol (homonojirimicina) PT81689B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/683,127 US4634765A (en) 1984-12-18 1984-12-18 Homodisaccharide hypoglycemic agents

Publications (2)

Publication Number Publication Date
PT81689A PT81689A (en) 1986-01-01
PT81689B true PT81689B (pt) 1987-11-30

Family

ID=24742682

Family Applications (1)

Application Number Title Priority Date Filing Date
PT81689A PT81689B (pt) 1984-12-18 1985-12-16 Processo para a preparacao de agentes hipoglicemicos homodissacarios, designadamente, glicosidos da 2,6-imino-2,6-didesoxi-d-glicero-1-gulo-heptidol (homonojirimicina)

Country Status (20)

Country Link
US (1) US4634765A (pt)
EP (1) EP0186103B1 (pt)
JP (1) JPS61158994A (pt)
KR (1) KR900005607B1 (pt)
CN (1) CN1016784B (pt)
AT (1) ATE62249T1 (pt)
AU (1) AU574246B2 (pt)
CA (1) CA1240989A (pt)
DE (1) DE3582420D1 (pt)
DK (1) DK587085A (pt)
ES (1) ES8706164A1 (pt)
FI (1) FI80707C (pt)
GR (1) GR853032B (pt)
HU (1) HU194263B (pt)
IE (1) IE58186B1 (pt)
NO (1) NO162387B (pt)
NZ (1) NZ214570A (pt)
PH (1) PH23660A (pt)
PT (1) PT81689B (pt)
ZA (1) ZA859573B (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2181729B (en) * 1985-10-12 1990-04-04 Nippon Shinyaku Co Ltd Glucosylmoranoline derivatives and production thereof
JPS62242692A (ja) * 1986-04-15 1987-10-23 Nippon Shinyaku Co Ltd モラノリン誘導体の製造法
EP0344383A1 (en) * 1988-06-02 1989-12-06 Merrell Dow Pharmaceuticals Inc. Novel alpha-Glucosidase inhibitors
EP0345104B1 (en) * 1988-06-02 1995-11-02 Merrell Dow Pharmaceuticals Inc. Novel Alpha-glucosidase inhibitors
US4880917A (en) * 1988-07-01 1989-11-14 Merrell Dow Pharmaceuticals Inc. Process for hydrolyzing 2,6-dideoxy-2,6-iminoheptononitrile derivatives using trifluoroacetic acid and dinitrogen tetroxide
US4908439A (en) * 1988-09-16 1990-03-13 Merrell Dow Pharmaceuticals Inc. Synthesis of intermediate useful in the preparation of nojirimycin and related compounds
US5227479A (en) * 1989-12-20 1993-07-13 Merrell Dow Pharmaceuticals Inc. Process for the preparation of nojirimycin and related compounds
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
NZ525021A (en) * 1997-04-15 2004-05-28 Csir Pharmaceutical compositions having appetite suppressant activity
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
WO2001074776A1 (en) 2000-03-31 2001-10-11 Michigan State University Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines
GB2363985B (en) * 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
KR20070084455A (ko) * 2004-11-23 2007-08-24 워너-램버트 캄파니 엘엘씨 지질혈증 치료용 ｈｍｇ ｃｏ-ａ 환원효소 억제제로서의7-(2ｈ-피라졸-3-일)-3,5-디히드록시-헵탄산 유도체
BRPI0613224A2 (pt) * 2005-06-08 2010-12-28 Amicus Therapeutics Inc método para estabilizar um açúcar triflatado, método para aumentar o rendimento da reação de um produto de açúcar e composição de açúcar triflatado estabilizada
EP2027137B1 (en) * 2005-06-08 2015-02-18 Amicus Therapeutics, Inc. Imino and amino sugar purification
JP2008543784A (ja) * 2005-06-08 2008-12-04 アミカス セラピューティックス インコーポレイテッド 結晶性糖組成物および作製方法
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
ATE518544T1 (de) 2007-03-12 2011-08-15 Zadec Aps Rotbusch-extrakt gegen diabetes
EP2170930B3 (en) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
JP2013528172A (ja) 2010-05-21 2013-07-08 ファイザー・インク ２−フェニルベンゾイルアミド
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN102462726B (zh) * 2010-11-04 2016-03-09 中国医学科学院药物研究所 白树总生物碱及多羟基生物碱化合物的提取、分离及用途
WO2012120414A2 (en) 2011-03-04 2012-09-13 Pfizer Inc. Edn3-like peptides and uses thereof
CN103703012A (zh) * 2011-05-13 2014-04-02 格礼卡姆股份公司 乳糖-n-四糖的制造
US20150050371A1 (en) 2012-03-09 2015-02-19 Biotropics Malaysia Berhad Extract Formulations of Rhodamnia Cinerea And Uses Thereof
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016516804A (ja) 2013-04-17 2016-06-09 ファイザー・インク 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
AU2015308350B2 (en) 2014-08-29 2020-03-05 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN104530150A (zh) * 2015-01-14 2015-04-22 佛山市赛维斯医药科技有限公司 含胺基苯和双葡萄糖苷结构化合物、其制备方法和用途
WO2018069532A1 (en) 2016-10-14 2018-04-19 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
IT201700078102A1 (it) 2017-07-11 2019-01-11 Dipharma Francis Srl Sintesi di un azazucchero e suoi intermedi
CN108828121B (zh) * 2018-06-14 2020-06-05 华润三九医药股份有限公司 一种白树药材中α-高野尻霉素的含量检测方法
CN113302189A (zh) 2018-11-20 2021-08-24 Tes制药有限责任公司 α-氨基-β-羧基己二烯二酸半醛去羧酶的抑制剂
EP3911648A4 (en) 2019-01-18 2022-10-26 Astrazeneca AB PCSK9 INHIBITORS AND METHODS OF USE THEREOF

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2848117A1 (de) * 1978-11-06 1980-05-14 Bayer Ag Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB2064527B (en) * 1979-12-08 1984-05-02 Nippon Shinyaku Co Ltd Moranoline derivatives and process for preparation thereof
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.

Also Published As

Publication number Publication date
HU194263B (en) 1988-01-28
CN85109548A (zh) 1986-07-09
CN1016784B (zh) 1992-05-27
ES550060A0 (es) 1987-06-01
KR860004921A (ko) 1986-07-16
EP0186103A2 (en) 1986-07-02
FI854944A0 (fi) 1985-12-13
NO855087L (no) 1986-06-19
PH23660A (en) 1989-09-27
ES8706164A1 (es) 1987-06-01
PT81689A (en) 1986-01-01
ATE62249T1 (de) 1991-04-15
EP0186103B1 (en) 1991-04-03
FI854944A (fi) 1986-06-19
KR900005607B1 (ko) 1990-07-31
AU574246B2 (en) 1988-06-30
FI80707C (fi) 1990-07-10
DE3582420D1 (de) 1991-05-08
DK587085A (da) 1986-06-19
GR853032B (pt) 1986-04-18
EP0186103A3 (en) 1988-02-03
NO162387B (no) 1989-09-11
AU5081085A (en) 1986-06-26
HUT40137A (en) 1986-11-28
NZ214570A (en) 1988-03-30
CA1240989A (en) 1988-08-23
DK587085D0 (da) 1985-12-17
IE58186B1 (en) 1993-07-28
IE853179L (en) 1986-06-18
JPS61158994A (ja) 1986-07-18
US4634765A (en) 1987-01-06
FI80707B (fi) 1990-03-30
ZA859573B (en) 1986-08-27
JPH0565519B2 (pt) 1993-09-17

Similar Documents

Publication Publication Date Title
PT81689B (pt) Processo para a preparacao de agentes hipoglicemicos homodissacarios, designadamente, glicosidos da 2,6-imino-2,6-didesoxi-d-glicero-1-gulo-heptidol (homonojirimicina)
DE3587943D1 (de) Verbinder für Hochleistungsstrahl.
DE3681468D1 (de) Staubfreie koernige enzymzusammensetzung.
BR8505093A (pt) Combinada(ceifadeira/trilhadeira),e transportador de alimpaduras
DE3485210D1 (de) Immobilisierte enzymzusammensetzungen.
IT8520090A0 (it) Procedimento di purificazione di un enzima.
IT8519862A0 (it) Composizione di policarbonato autoestinguente.
ES8704934A1 (es) Un procedimiento para producir un compuesto analogo a estreptonigrina
IT1215310B (it) Carbammato di cellulosa. procedimento per precipitare
IT8422517A0 (it) Composizione di policarbonato autoestinguente.
IT8422516A0 (it) Composizione di policarbonato autoestinguente.
IT8320426A0 (it) Composizione di policarbonato autoestinguente.
IT8320903A0 (it) Composizione di policarbonato autoestinguente.
ATE52536T1 (de) Geschuetzte enzymsysteme.
ATE38050T1 (de) Selbstloeschende polycarbonatzusammensetzung.
IT8222968A0 (it) Composizione di policarbonato autoestinguente.
IT8222987A0 (it) Composizione di policarbonato autoestinguente.
IT8222964A0 (it) Composizione di policarbonato autoestinguente.
IT8221699A0 (it) Composizione di policarbonato autoestinguente.
IT8222965A0 (it) Composizione di policarbonato autoestinguente.
SU1162191A1 (ru) 1,1-Этилиденди-(5-бром-2-фуроиламин), проявляющий противовоспалительную активность
FI915516A0 (fi) Foerfarande foer framstaellning av farmaceutiskt aktiva 2-pyridylalkensulfinyl) benzimidazoler.
IT8448711A1 (it) Composti 1,2,4 - triazolici procedimento per produrli e composizioni farmaceutiche che li contengono.
MX9203113A (es) Composiciones farmaceuticas que contienen glicosidos de antraciclina.
SU1557961A1 (ru) П-хлорфениламид 3-дифенилметил-4-(п-хлорфенил)-2,4-диоксобутановой кислоты, проявляющий противогипоксическую активность

Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19941130