AU542861B2 - Carbacyclin analogs - Google Patents

Carbacyclin analogs

Info

Publication number
AU542861B2
AU542861B2 AU66606/81A AU6660681A AU542861B2 AU 542861 B2 AU542861 B2 AU 542861B2 AU 66606/81 A AU66606/81 A AU 66606/81A AU 6660681 A AU6660681 A AU 6660681A AU 542861 B2 AU542861 B2 AU 542861B2
Authority
AU
Australia
Prior art keywords
carbacyclin analogs
carbacyclin
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU66606/81A
Other languages
English (en)
Other versions
AU6660681A (en
Inventor
Paul Adrian Aristoff
Robert Charles Kelly
Norman Allan Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/125,608 external-priority patent/US4338457A/en
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AU6660681A publication Critical patent/AU6660681A/en
Application granted granted Critical
Publication of AU542861B2 publication Critical patent/AU542861B2/en
Assigned to PHARMACIA & UPJOHN COMPANY reassignment PHARMACIA & UPJOHN COMPANY Request to Amend Deed and Register Assignors: UPJOHN COMPANY, THE
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Indole Compounds (AREA)
AU66606/81A 1980-02-28 1981-01-23 Carbacyclin analogs Expired AU542861B2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US125608 1980-02-28
US06/125,608 US4338457A (en) 1980-02-28 1980-02-28 Composition and process
US13505580A 1980-03-28 1980-03-28
US135055 1980-03-28
US14054680A 1980-04-15 1980-04-15
US140546 1980-04-15
US14295380A 1980-04-23 1980-04-23
US142953 1980-04-23

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU38207/85A Division AU560955B2 (en) 1980-02-28 1985-01-30 Carbacyclin intermediates
AU38208/85A Division AU567392B2 (en) 1980-02-28 1985-01-30 Carbacyclin analogs

Publications (2)

Publication Number Publication Date
AU6660681A AU6660681A (en) 1981-09-03
AU542861B2 true AU542861B2 (en) 1985-03-21

Family

ID=27494588

Family Applications (2)

Application Number Title Priority Date Filing Date
AU66606/81A Expired AU542861B2 (en) 1980-02-28 1981-01-23 Carbacyclin analogs
AU38208/85A Expired AU567392B2 (en) 1980-02-28 1985-01-30 Carbacyclin analogs

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU38208/85A Expired AU567392B2 (en) 1980-02-28 1985-01-30 Carbacyclin analogs

Country Status (12)

Country Link
JP (2) JPH02167248A (sv)
AU (2) AU542861B2 (sv)
CA (1) CA1201712A (sv)
CH (2) CH648017A5 (sv)
DE (4) DE3153460C2 (sv)
FR (1) FR2484413B1 (sv)
GB (1) GB2070596B (sv)
HK (1) HK6989A (sv)
IL (1) IL61936A (sv)
IT (1) IT1144901B (sv)
NL (1) NL8100959A (sv)
SE (6) SE453594B (sv)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU576477B2 (en) * 1982-10-05 1988-09-01 Schering Aktiengesellschaft 5-fluoro-carbacyclins

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1201712A (en) * 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3142733A1 (de) * 1981-10-23 1983-05-05 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von carbacyclin-zwischenprodukten
DE3146278C2 (de) * 1981-11-21 1984-10-31 Grünenthal GmbH, 5190 Stolberg cis-Bicyclo[3.3.0]octanderivate, diese enthaltende Arzneimittel und Verfahren zur Herstellung dieser Verbindungen
IL67332A (en) * 1981-12-01 1985-12-31 Chinoin Gyogyszer Es Vegyeszet Inter-m-phenylene-prostacyclin analogues,process for the preparation thereof and pharmaceutical compositions containing them
DE3204443A1 (de) * 1982-02-08 1983-08-18 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4533749A (en) * 1982-02-16 1985-08-06 The Upjohn Company 9-Substituted carbacyclin analogs
US4487961A (en) * 1982-02-16 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
US4490555A (en) * 1982-03-19 1984-12-25 The Upjohn Company 9-Substituted carbacyclin analogs
US4487960A (en) * 1982-04-19 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
DE3225288A1 (de) * 1982-07-02 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4668814A (en) * 1984-03-08 1987-05-26 The Upjohn Company Interphenylene carbacyclin derivatives
DE3408699A1 (de) * 1984-03-08 1985-09-12 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4683330A (en) * 1984-03-08 1987-07-28 The Upjohn Company Interphenylene carbacyclin derivatives
EP0175450B1 (en) * 1984-07-18 1989-03-22 The Upjohn Company An interphenylene-carbacyclin compound
DE3428266A1 (de) * 1984-07-27 1986-01-30 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE19722849A1 (de) * 1997-05-23 1998-11-26 Schering Ag Leukotrien-B¶4¶-Antagonisten, insbesondere 3-Oxa-Tetra-hydronaphthalin-LTB¶4¶-Antagonisten
US6700025B2 (en) * 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
CN100558351C (zh) 2003-05-22 2009-11-11 联合治疗公司 化合物和释放前列环素类似物的方法
US20090124697A1 (en) 2003-12-16 2009-05-14 United Therapeutics Corporation Inhalation formulations of treprostinil
CN1917866B (zh) * 2003-12-16 2010-12-15 联合治疗公司 曲前列环素或它的衍生物，或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途
CA2710725C (en) 2010-07-22 2017-08-01 Alphora Research Inc. Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation
CA2726599C (en) 2010-12-30 2017-07-25 Alphora Research Inc. Process for treprostinil salt preparation
US9822057B2 (en) 2013-03-14 2017-11-21 United Therapeutics Corporation Solid forms of treprostinil
KR101830693B1 (ko) * 2016-04-28 2018-02-21 연성정밀화학(주) 트레프로스티닐의 제조방법 및 이를 위한 중간체
HU231212B1 (hu) 2018-04-16 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás iloprost előállítására

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5495552A (en) * 1978-01-06 1979-07-28 Sankyo Co Ltd Prostacyline derivative and its preparation
JPS54119441A (en) * 1978-03-09 1979-09-17 Sumitomo Chem Co Ltd Novel bicyclooctane derivative
IT1113341B (it) * 1978-03-31 1986-01-20 Ono Pharmaceutical Co Analoghi della 6,9-metano-pgi2
US4180657A (en) * 1978-08-14 1979-12-25 The Upjohn Company Acyl-substituted phenyl esters of prostacyclin-type compounds
US4192891A (en) * 1979-04-25 1980-03-11 E. R. Squibb & Sons, Inc. Prostacyclin analogs and their use in inhibition of arachidonic acid-induced platelet aggregation and bronchoconstriction
US4338457A (en) * 1980-02-28 1982-07-06 The Upjohn Company Composition and process
CA1201712A (en) * 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
DE3121155A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU576477B2 (en) * 1982-10-05 1988-09-01 Schering Aktiengesellschaft 5-fluoro-carbacyclins

Also Published As

Publication number Publication date
CH648017A5 (de) 1985-02-28
IT1144901B (it) 1986-10-29
GB2070596A (en) 1981-09-09
DE3153390C2 (sv) 1989-09-14
SE8504616L (sv) 1985-10-04
IT8120019A0 (it) 1981-02-26
AU3820885A (en) 1985-06-20
SE8504617L (sv) 1985-10-04
FR2484413B1 (fr) 1986-05-23
AU6660681A (en) 1981-09-03
FR2484413A1 (fr) 1981-12-18
JPH02167248A (ja) 1990-06-27
SE453594B (sv) 1988-02-15
SE8504619D0 (sv) 1985-10-04
SE8504615D0 (sv) 1985-10-04
GB2070596B (en) 1984-02-08
SE8504618L (sv) 1985-10-04
SE8504615L (sv) 1985-10-04
SE8504617D0 (sv) 1985-10-04
SE8504616D0 (sv) 1985-10-04
CA1201712A (en) 1986-03-11
AU567392B2 (en) 1987-11-19
IL61936A0 (en) 1981-02-27
DE3153474C2 (sv) 1990-05-31
SE8504618D0 (sv) 1985-10-04
DE3105588C2 (sv) 1989-04-13
DE3153460C2 (sv) 1990-08-16
DE3153460A1 (sv) 1988-08-11
IL61936A (en) 1986-08-31
SE8100564L (sv) 1981-08-29
JPH048427B2 (sv) 1992-02-17
SE8504619L (sv) 1985-10-04
DE3105588A1 (de) 1981-12-10
HK6989A (en) 1989-01-27
NL8100959A (nl) 1981-10-01
CH655308A5 (de) 1986-04-15
JPH06145085A (ja) 1994-05-24

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired