AU516957B2 - Imidazolylalkyl indoles - Google Patents
Imidazolylalkyl indolesInfo
- Publication number
- AU516957B2 AU516957B2 AU56231/80A AU5623180A AU516957B2 AU 516957 B2 AU516957 B2 AU 516957B2 AU 56231/80 A AU56231/80 A AU 56231/80A AU 5623180 A AU5623180 A AU 5623180A AU 516957 B2 AU516957 B2 AU 516957B2
- Authority
- AU
- Australia
- Prior art keywords
- imidazolylalkyl
- indoles
- imidazolylalkyl indoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7908123 | 1979-03-07 | ||
| GB7908123 | 1979-03-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5623180A AU5623180A (en) | 1980-09-11 |
| AU516957B2 true AU516957B2 (en) | 1981-07-02 |
Family
ID=10503707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU56231/80A Ceased AU516957B2 (en) | 1979-03-07 | 1980-03-06 | Imidazolylalkyl indoles |
Country Status (36)
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4414159A (en) * | 1980-09-26 | 1983-11-08 | E. I. Du Pont De Nemours & Co. | Vinyl ether monomers and polymers therefrom |
| US4444775A (en) * | 1981-06-22 | 1984-04-24 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridines |
| KR840000529A (ko) * | 1981-07-07 | 1984-02-25 | 콘스탄틴 루이스 클레멘트 | 인돌 유도체의 제조방법 |
| ZA825413B (en) * | 1981-08-26 | 1983-06-29 | Pfizer | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them |
| US4460777A (en) * | 1981-11-19 | 1984-07-17 | Ciba-Geigy Corporation | N-Substituted-2-pyridylindoles |
| US4478842A (en) * | 1981-11-19 | 1984-10-23 | Ciba-Geigy Corporation | N-Substituted-2-pyridylindoles |
| US4436746A (en) | 1982-09-30 | 1984-03-13 | Ciba-Geigy Corporation | Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles |
| US4539410A (en) * | 1982-09-30 | 1985-09-03 | Ciba-Geigy Corporation | N-Substituted-2-(1-imidazolyl)indoles |
| AT376436B (de) * | 1982-11-05 | 1984-11-26 | Laevosan Gmbh & Co Kg | Verfahren zur herstellung neuer thiophen-2carbons[urederivate und pharmazeutisch vertraeglicher saeure- oder basenadditionssalze davon |
| US4511573A (en) * | 1983-05-17 | 1985-04-16 | Ciba-Geigy Corporation | 3-Substituted-2-(heteroaryl) indoles |
| ATE90076T1 (de) | 1986-03-27 | 1993-06-15 | Merck Frosst Canada Inc | Tetrahydrocarbazole ester. |
| JPH0832679B2 (ja) * | 1986-09-05 | 1996-03-29 | 理化学研究所 | Ｎ―フタルイシド誘導体及びその製造法 |
| GR871809B (en) * | 1986-11-28 | 1988-03-07 | Glaxo Group Ltd | Process for the preparation of tricyclic ketones |
| EP0427860A1 (en) * | 1989-03-31 | 1991-05-22 | Kyoto Pharmaceutical Industries, Ltd. | New imidazole derivatives, production thereof, and uses thereof as medicines |
| PT97888B (pt) * | 1990-06-07 | 1998-12-31 | Zeneca Ltd | Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem |
| DE4023215A1 (de) * | 1990-07-21 | 1992-01-23 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung |
| IE913204A1 (en) * | 1990-09-13 | 1992-02-25 | Beecham Group Plc | Novel compounds |
| US5162337A (en) * | 1990-10-05 | 1992-11-10 | Merck & Co., Inc. | Animal growth promotion |
| US5120749A (en) * | 1991-02-20 | 1992-06-09 | Abbott Laboratories | Platelet activating antagonists |
| US5463074A (en) * | 1991-12-18 | 1995-10-31 | Schering Corporation | Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring |
| WO1993020065A1 (fr) * | 1992-03-27 | 1993-10-14 | Kyoto Pharmaceutical Industries, Ltd. | Nouveau derive d'imidazole, son utilisation pharmaceutique, et intermediaire associe |
| US5538973A (en) * | 1992-03-27 | 1996-07-23 | Kyoto Pharmaceutical Industries, Ltd. | Imidazole derivative, pharmaceutical use thereof, and intermediate therefor |
| JPH0632913U (ja) * | 1992-09-18 | 1994-04-28 | 三洋電機株式会社 | 床暖房用パネル |
| US6214991B1 (en) * | 1998-03-31 | 2001-04-10 | The Institute For Pharmaceutical Discovery, Inc. | Substituted indolealkanoic acids |
| RU2296759C2 (ru) * | 2002-09-12 | 2007-04-10 | Ф.Хоффманн-Ля Рош Аг | N-замещенные 1н-индол-5-пропионовые кислоты, фармацевтическая композиция, содержащая эти соединения, и их применение (варианты) |
| RU2315767C2 (ru) * | 2002-11-25 | 2008-01-27 | Ф.Хоффманн-Ля Рош Аг | Индолилпроизводные, способ их получения, фармацевтическая композиция, способ лечения и/или профилактики заболеваний |
| CA2509170A1 (en) * | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| GB0324763D0 (en) * | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| DE602005015962D1 (de) * | 2004-05-03 | 2009-09-24 | Hoffmann La Roche | Indolylderivate als liver-x-rezeptormodulatoren |
| DE602005026553D1 (de) * | 2004-10-12 | 2011-04-07 | Decode Genetics Ehf | Peri-substituierte bicyclische sulfonamide gegen arterielle verschlusskrankheit |
| RU2008110908A (ru) * | 2005-08-25 | 2009-09-27 | Шеринг Корпорейшн (US) | Производные имидазола в качестве функционально селективных агонистов альфа2с адренорецепторов |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| US8399666B2 (en) * | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| CA2652152A1 (en) * | 2006-05-16 | 2007-11-29 | Decode Genetics Ehf | Process for preparing 7-(acryloyl)indoles |
| CA2658496A1 (en) | 2006-07-22 | 2008-01-31 | Oxagen Limited | 2-{5-fluoro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1h-indol-yl} acetic acid derivatives and esters thereof having crth2 antagonist activity |
| TW200920369A (en) * | 2007-10-26 | 2009-05-16 | Amira Pharmaceuticals Inc | 5-lipoxygenase activating protein (flap) inhibitor |
| JP2011517313A (ja) | 2007-12-11 | 2011-06-02 | ビアメト ファーマシューティカルズ，インク． | 金属結合部分を標的化部分と組み合わせて使用する金属酵素阻害剤 |
| US7750027B2 (en) * | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
| CA2712017C (en) | 2008-01-18 | 2016-08-09 | Oxagen Limited | Compounds having crth2 antagonist activity |
| JP2011509991A (ja) * | 2008-01-22 | 2011-03-31 | オキサジェン リミテッド | Ｃｒｔｈ２アンタゴニスト活性を有する化合物 |
| EP2265581A1 (en) * | 2008-01-22 | 2010-12-29 | Oxagen Limited | Compounds having crth2 antagonist activity |
| MX2010012814A (es) * | 2008-05-23 | 2010-12-20 | Amira Pharmaceuticals Inc | Inhibidor de proteina activadora de 5-lipoxigenasa. |
| US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| EP2739144A4 (en) * | 2011-06-20 | 2015-04-01 | Alzheimer S Inst Of America Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
| GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
| GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| US11530186B2 (en) * | 2018-03-29 | 2022-12-20 | H. Lee Moffitt Cancer Center and Research Center Institute, Inc. | Inhibitors for the β-catenin / T-cell factor protein-protein interaction |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL125443C (enExample) * | 1963-06-06 | |||
| US3370063A (en) * | 1964-10-05 | 1968-02-20 | Mcneilab Inc | Substituted dimethoxy indoles and method of making the same |
| US3621027A (en) * | 1968-03-18 | 1971-11-16 | Endo Lab | 1-aminoalkyl-2,6-diaryl 4,5,6,7 tetrahydro-4-oxindales |
| US3931229A (en) * | 1973-08-23 | 1976-01-06 | Warner-Lambert Company | 3-Thiomethyl-2[2-(dialkylamino)ethyl]indoles |
| US4059583A (en) * | 1975-11-13 | 1977-11-22 | Mcneil Laboratories, Incorporated | Substituted indoles |
| AU523536B2 (en) * | 1977-08-26 | 1982-08-05 | Wellcome Foundation Limited, The | Imidazoles and methods of preparing them |
| US4140858A (en) * | 1977-12-19 | 1979-02-20 | Warner-Lambert Company | 3-(1H-imidazol-1-ylmethyl)-2-(disubstitutedaminomethyl)indoles and a method for their production |
| EP0003901B1 (en) * | 1978-02-24 | 1981-08-05 | Pfizer Limited | 3-(imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them |
-
1980
- 1980-01-31 DK DK042580A patent/DK151884C/da active
- 1980-03-04 CS CS801492A patent/CS253702B2/cs unknown
- 1980-03-04 HU HU80498A patent/HU184727B/hu not_active IP Right Cessation
- 1980-03-05 FI FI800672A patent/FI66860C/fi not_active IP Right Cessation
- 1980-03-05 NZ NZ193052A patent/NZ193052A/en unknown
- 1980-03-05 ES ES489220A patent/ES8104278A1/es not_active Expired
- 1980-03-05 YU YU614/80A patent/YU41911B/xx unknown
- 1980-03-05 PH PH23726A patent/PH15198A/en unknown
- 1980-03-05 IL IL59524A patent/IL59524A/xx unknown
- 1980-03-05 PL PL1980222470A patent/PL128296B1/pl unknown
- 1980-03-05 LU LU82224A patent/LU82224A1/fr unknown
- 1980-03-05 SE SE8001736A patent/SE440778B/sv not_active IP Right Cessation
- 1980-03-05 GR GR61368A patent/GR67237B/el unknown
- 1980-03-05 SU SU802891745A patent/SU1277894A3/ru active
- 1980-03-05 US US06/127,298 patent/US4273782A/en not_active Expired - Lifetime
- 1980-03-06 ZA ZA00801328A patent/ZA801328B/xx unknown
- 1980-03-06 BE BE0/199699A patent/BE882113A/fr not_active IP Right Cessation
- 1980-03-06 IE IE453/80A patent/IE49542B1/en not_active IP Right Cessation
- 1980-03-06 DE DE19803008632 patent/DE3008632A1/de active Granted
- 1980-03-06 IT IT20399/80A patent/IT1218420B/it active
- 1980-03-06 AU AU56231/80A patent/AU516957B2/en not_active Ceased
- 1980-03-06 CA CA000347143A patent/CA1120479A/en not_active Expired
- 1980-03-06 AT AT0125780A patent/AT375366B/de not_active IP Right Cessation
- 1980-03-06 NO NO800650A patent/NO152217C/no unknown
- 1980-03-06 NL NLAANVRAGE8001351,A patent/NL182959C/xx not_active IP Right Cessation
- 1980-03-06 FR FR8005054A patent/FR2450832A1/fr active Granted
- 1980-03-06 KR KR1019800000931A patent/KR850000760B1/ko not_active Expired
- 1980-03-06 DD DD80219495A patent/DD149525A5/de not_active IP Right Cessation
- 1980-03-06 CH CH1781/80A patent/CH649546A5/de not_active IP Right Cessation
- 1980-03-06 PT PT70914A patent/PT70914A/pt not_active IP Right Cessation
- 1980-03-06 AR AR280198A patent/AR227015A1/es active
- 1980-03-06 JP JP2856380A patent/JPS55133380A/ja active Granted
- 1980-11-14 ES ES496889A patent/ES496889A0/es active Granted
-
1984
- 1984-09-21 SG SG67284A patent/SG67284G/en unknown
- 1984-10-05 KE KE3467A patent/KE3467A/xx unknown
- 1984-11-15 HK HK898/84A patent/HK89884A/xx unknown
-
1985
- 1985-12-30 MY MY285/85A patent/MY8500285A/xx unknown
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