AU4905000A - Methods and compounds for inhibiting amyloid deposits - Google Patents
Methods and compounds for inhibiting amyloid deposits Download PDFInfo
- Publication number
- AU4905000A AU4905000A AU49050/00A AU4905000A AU4905000A AU 4905000 A AU4905000 A AU 4905000A AU 49050/00 A AU49050/00 A AU 49050/00A AU 4905000 A AU4905000 A AU 4905000A AU 4905000 A AU4905000 A AU 4905000A
- Authority
- AU
- Australia
- Prior art keywords
- iapp
- independently
- hydrogen
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Battery Electrode And Active Subsutance (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2005203635A AU2005203635B2 (en) | 1999-05-24 | 2005-08-15 | Methods and compounds for inhibiting amyloid deposits |
| AU2008229759A AU2008229759A1 (en) | 1999-05-24 | 2008-10-02 | Methods and compounds for inhibiting amyloid deposits |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13554599P | 1999-05-24 | 1999-05-24 | |
| US60135545 | 1999-05-24 | ||
| US14312399P | 1999-07-09 | 1999-07-09 | |
| US60143123 | 1999-07-09 | ||
| US09576677 | 2000-05-23 | ||
| US09/576,677 US6562836B1 (en) | 1999-05-24 | 2000-05-23 | Methods and compounds for inhibiting amyloid deposits |
| PCT/CA2000/000607 WO2000071101A2 (en) | 1999-05-24 | 2000-05-24 | Methods and compounds for inhibiting amyloid deposits |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005203635A Division AU2005203635B2 (en) | 1999-05-24 | 2005-08-15 | Methods and compounds for inhibiting amyloid deposits |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU4905000A true AU4905000A (en) | 2000-12-12 |
Family
ID=27384726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU49050/00A Abandoned AU4905000A (en) | 1999-05-24 | 2000-05-24 | Methods and compounds for inhibiting amyloid deposits |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6562836B1 (https=) |
| EP (1) | EP1227803B1 (https=) |
| JP (1) | JP2003500350A (https=) |
| CN (1) | CN100435785C (https=) |
| AT (1) | ATE466571T1 (https=) |
| AU (1) | AU4905000A (https=) |
| CA (2) | CA2684016A1 (https=) |
| DE (1) | DE60044365D1 (https=) |
| HK (1) | HK1050133A1 (https=) |
| IL (3) | IL146681A0 (https=) |
| MX (1) | MXPA01011989A (https=) |
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Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040208875A1 (en) * | 1995-03-15 | 2004-10-21 | Queen's University At Kingston | Method for treating amyloidosis |
| CA2369997C (en) * | 1999-04-28 | 2009-11-17 | Queen's University At Kingston | Compositions and methods for treating amyloidosis |
| US6562836B1 (en) * | 1999-05-24 | 2003-05-13 | Queen's University Of Kingston | Methods and compounds for inhibiting amyloid deposits |
| AU5994900A (en) * | 1999-07-09 | 2001-01-30 | Isis Innovation Limited | Compounds for inhibiting diseases and preparing cells for transplantation |
| CA2462851A1 (en) | 2001-10-04 | 2003-04-10 | Elan Pharmaceuticals, Inc. | Hydroxypropylamines |
| US7345068B2 (en) | 2002-02-07 | 2008-03-18 | Hitoshi Endou | Aromatic amino acid derivatives and medicinal compositions |
| WO2004058686A1 (en) | 2002-04-30 | 2004-07-15 | Elan Pharmaceuticals, Inc. | Hydroxypropyl amides for the treatment of alzheimer’s disease |
| PT2527315E (pt) * | 2002-05-31 | 2014-06-24 | Proteotech Inc | Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson |
| US20050154011A1 (en) * | 2003-02-20 | 2005-07-14 | The Procter & Gamble Company | Tetrahydroisoquinolnyl sulfamic acids |
| CA2521189A1 (en) * | 2003-04-11 | 2004-10-28 | Gabor Tigyi | Lysophosphatidic acid analogs and inhibition of neointima formation |
| ZA200509647B (en) * | 2003-06-23 | 2008-04-30 | Neurochem Int Ltd | Methods and compositions for treating amyloid-related diseases |
| US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| US7244764B2 (en) * | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| AU2011250847B2 (en) * | 2003-06-23 | 2013-06-20 | Bhi Limited Partnership | Methods and compositions for treating amyloid-related diseases |
| SI1646659T1 (sl) * | 2003-06-23 | 2014-07-31 | Kiacta Sarl | Postopek za pripravo spojin 1,3-propan disulfonske kisline |
| JP5146714B2 (ja) * | 2003-06-23 | 2013-02-20 | ビーエイチアイ リミテッド パートナーシップ | アミロイド関連疾患を治療するための方法および組成物 |
| US7253306B2 (en) * | 2003-06-23 | 2007-08-07 | Neurochem (International) Limited | Pharmaceutical drug candidates and methods for preparation thereof |
| US7414076B2 (en) * | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US20080004211A1 (en) * | 2004-02-23 | 2008-01-03 | Paul Fraser | Inhibitors of Amyloid Fibril Formation and Uses Thereof |
| UA91341C2 (ru) | 2004-07-15 | 2010-07-26 | Амр Текнолоджи, Інк. | Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина |
| US20060183800A1 (en) * | 2004-11-12 | 2006-08-17 | Xianqi Kong | Methods and fluorinated compositions for treating amyloid-related diseases |
| US20060167057A1 (en) * | 2004-11-16 | 2006-07-27 | Xianqi Kong | Compounds for the treatment of CNS and amyloid associated diseases |
| WO2006085149A2 (en) * | 2004-12-22 | 2006-08-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| ATE452632T1 (de) * | 2005-04-07 | 2010-01-15 | Astrum Therapeutics Pty Ltd | Verbindungen zur behandlung von amyloidose und verhinderung des tods von beta-zellen bei diabetes mellitus typ 2 |
| WO2006110491A2 (en) * | 2005-04-07 | 2006-10-19 | Astrum Therapeutics Pty. Ltd. | Complementary compositions to reduce blood glucose levels and treat diabetes |
| TW200716088A (en) * | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
| EP1893576A4 (en) * | 2005-05-27 | 2010-03-17 | Univ Kingston | TREATMENT OF PROTEIN DISORDERING |
| US20070049638A1 (en) * | 2005-07-21 | 2007-03-01 | Neurochem (International) Limited | Polymorphic forms of 3-amino-1-propanesulfonic acid |
| EP1968561B8 (en) * | 2005-12-22 | 2010-10-20 | Kiacta Sàrl | Treatment of diabetic nephropathy |
| PT2089417E (pt) | 2006-10-12 | 2015-04-14 | Bhi Ltd Partnership | Métodos, compostos, composições e veículos para administrar o ácido 3-amino-1-propanossulfónico |
| ATE554769T1 (de) * | 2006-12-06 | 2012-05-15 | Cornell Res Foundation Inc | Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon |
| WO2008078176A1 (en) * | 2006-12-22 | 2008-07-03 | Bellus Health (International) Limited | Methods, compounds, and compositions for treating metabolic disorders and diabetes |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| US20110313040A1 (en) * | 2008-11-14 | 2011-12-22 | Bellus Health Inc. | Organic nutrient salts, methods of preparation and uses |
| US8592451B2 (en) | 2009-03-17 | 2013-11-26 | Cornell University | Reversible nondepolarizing neuromuscular blockade agents and methods for their use |
| AU2010247763B2 (en) * | 2009-05-12 | 2015-12-24 | Albany Molecular Research, Inc. | 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof |
| EP2429295B1 (en) * | 2009-05-12 | 2013-12-25 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
| US8815894B2 (en) * | 2009-05-12 | 2014-08-26 | Bristol-Myers Squibb Company | Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
| IN2012DN00352A (https=) * | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
| WO2011017800A1 (en) | 2009-08-10 | 2011-02-17 | Bellus Health (International) Limited | Methods, compounds, and compositions for delivering 1,3-propan ed isulfonic acid |
| US9220700B2 (en) | 2009-08-19 | 2015-12-29 | Cornell University | Cysteine for physiological injection |
| WO2011156389A2 (en) * | 2010-06-07 | 2011-12-15 | The Regents Of The University Of California | The islet amyloid polypeptide toxic oligomer is a biomarker of heart or kidney failure in type-2 diabetes mellitus |
| AU2011292233B2 (en) * | 2010-08-16 | 2015-05-21 | Cognoptix, Inc. | System and method for detecting amyloid proteins |
| US9095631B2 (en) | 2011-05-24 | 2015-08-04 | Universita Degli Studi Di Bari “Aldo Moro” | Tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases |
| AU2012346214B2 (en) | 2011-11-30 | 2017-09-14 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
| EP3363800A1 (en) * | 2013-10-03 | 2018-08-22 | Kura Oncology, Inc. | Heterocyclic inhibitors of erk and methods of use |
| WO2016196569A1 (en) * | 2015-06-01 | 2016-12-08 | Indiana University Research & Technology Corporation | Small molecule inhibitors of protein tyrosine phosphatases and uses thereof |
| WO2018009854A1 (en) * | 2016-07-08 | 2018-01-11 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Indoline derivatives and method for using and producing the same |
| CN115361866B (zh) * | 2020-03-31 | 2025-07-18 | 株式会社Lg化学 | 用于保护胰岛移植的组合物 |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3872125A (en) | 1973-03-03 | 1975-03-18 | Sandoz Ag | 3-substituted-4-aryl isoquinolines |
| FR2384751A1 (fr) | 1977-03-23 | 1978-10-20 | Francaise Coop Pharma | Nouveaux derives de la taurine a activite neuro-musculaire renforcee |
| CA1144937A (en) | 1977-12-22 | 1983-04-19 | Dke J.E. Helgstrand | Aromatic derivatives, pharmaceutical compositions and methods for combatting virus infections |
| FR2457281A1 (fr) | 1979-05-23 | 1980-12-19 | Meram Lab | Nouveaux derives de l'acide 3-aminopropanesulfonique ayant une activite membranaire renforcee |
| US5087618A (en) | 1982-05-18 | 1992-02-11 | University Of Florida | Redox carriers for brain-specific drug delivery |
| US4540564A (en) | 1982-05-18 | 1985-09-10 | University Of Florida | Brain-specific drug delivery |
| FR2529546A1 (fr) | 1982-07-05 | 1984-01-06 | Meram Lab | Nouveaux sels d'amino-(et imino-)acides a, o-sulfoniques n-substitues, vecteurs cationiques de haute penetration cellulaire |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| IT1193590B (it) | 1983-01-07 | 1988-07-08 | Loris Jacopo Bononi | Derivati amino-alchil-solfonici,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
| US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
| MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
| FR2595356B1 (fr) | 1986-03-05 | 1991-05-24 | Pasteur Strasbourg Universite | Derives des nitro ou aminobenzyltetrahydroisoquinoleines, procedes d'obtention, compositions pharmaceutiques les contenant, proprietes pharmacologiques et applications |
| SE454299B (sv) * | 1986-10-08 | 1988-04-18 | Westermark P | Sats innehallande polypeptid som finns i pankreasoamyloid och/eller antikroppar riktade mot polypeptiden |
| US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5194654A (en) | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
| US5463092A (en) | 1989-11-22 | 1995-10-31 | Vestar, Inc. | Lipid derivatives of phosphonacids for liposomal incorporation and method of use |
| DE3940410A1 (de) | 1989-12-04 | 1991-06-06 | Schering Ag | Neue verwendung von nmda-rezeptor-antagonisten |
| FR2657164B1 (fr) | 1990-01-16 | 1992-04-03 | Cit Alcatel | Installation de detection de fuite a pompe holweck a prise intermediaire. |
| US5385915A (en) | 1990-05-16 | 1995-01-31 | The Rockefeller University | Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation |
| US5242932A (en) | 1991-12-17 | 1993-09-07 | The Rockefeller University | Treatment of amyloidosis associated with alzheimer disease |
| DE4021066A1 (de) | 1990-07-03 | 1992-01-09 | Hoechst Ag | Langzeitprophylaxe gegen erkrankungen, die durch viren oder durch unkonventionelle viren verursacht werden |
| ATE231723T1 (de) | 1991-02-22 | 2003-02-15 | Howard K Shapiro | Verwendung von pharmazeutischen wirkstoffen zur behandlung von krankheitssymptomen neurologischer erkrankungen und etiologisch verwandter symptomenkomplexe |
| US5164295A (en) | 1991-03-06 | 1992-11-17 | The Upjohn Company | Method for identifying amyloid protein-extracellular matrix protein affinity altering compounds |
| IT1245907B (it) * | 1991-05-17 | 1994-10-25 | Alfa Wassermann Spa | Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica. |
| US5276059A (en) | 1992-07-10 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of diseases associated with amyloid formation |
| EP0611966A1 (en) * | 1993-02-19 | 1994-08-24 | Bayer Corporation | Method, composition and device for measuring the ionic strength or specific gravity of a test sample |
| DE69434571T2 (de) | 1993-03-29 | 2006-08-03 | Queen's University At Kingston, Kingston | Propan-1,3-disulphonsäure und deren pharmazeutisch akzeptable Salze zur Behandlung von Amyloidosis |
| US5840294A (en) | 1993-03-29 | 1998-11-24 | Queen's University At Kingston | Method for treating amyloidosis |
| US5972328A (en) * | 1993-03-29 | 1999-10-26 | Queen's University At Kingston | Method for treating amyloidosis |
| US5643562A (en) | 1993-03-29 | 1997-07-01 | Queen's University Of Kingston | Method for treating amyloidosis |
| DE4313118A1 (de) | 1993-04-22 | 1994-10-27 | Hoechst Ag | Verwendung von 1,2,3,4-Tetrahydroisochinolin-Derivaten als Antimykotika |
| WO1994027602A1 (en) | 1993-06-01 | 1994-12-08 | Cortex Pharmaceuticals, Inc. | Use of metabotropic receptor agonists in progressive neurodegenerative deseases |
| US5576419A (en) * | 1993-06-30 | 1996-11-19 | Regents Of The University Of Minnesota | Mild solid-phase synthesis of aligned branched triple-helical peptides |
| WO1995006477A1 (en) | 1993-08-31 | 1995-03-09 | Gliatech, Inc. | Inhibition of beta amyloid binding to glycosaminoglycans for treatment of alzheimer's disease |
| US6187991B1 (en) | 1995-05-23 | 2001-02-13 | Pfizer Inc | Transgenic animal models for type II diabetes mellitus |
| US5858326A (en) * | 1995-06-06 | 1999-01-12 | Neurochem, Inc. | Methods of increasing amyloid deposition |
| WO1997007402A1 (en) | 1995-08-17 | 1997-02-27 | The Ontario Cancer Institute | Protein fibril assembly assay |
| WO1997009976A2 (en) | 1995-09-01 | 1997-03-20 | Washington University | Method of reducing neurotoxic injury with zinc chelators |
| JPH0995444A (ja) * | 1995-10-02 | 1997-04-08 | Teijin Ltd | アミロイド蛋白凝集阻害剤 |
| WO1997016191A1 (en) | 1995-11-02 | 1997-05-09 | Warner-Lambert Company | Inhibition of amyloidosis by 9-acridinones |
| AU703540B2 (en) | 1996-03-26 | 1999-03-25 | Meddiss, Incorporated | Methods for inducing analgesia or anesthesia and treating or preventing ischemic injury of tissues in general |
| US6043283A (en) | 1996-09-20 | 2000-03-28 | Baylor College Of Medicine | Tyramine compounds and their neuronal effects |
| US5927328A (en) * | 1996-09-26 | 1999-07-27 | Masco Corporation | Self closing faucet with timing mechanism |
| PL332413A1 (en) | 1996-09-27 | 1999-09-13 | Guilford Pharm Inc | Compositions containing inhibitors of naaladase as well as methods of treating glutamatic anomaly and influencing neuronic functions among animals |
| SE9604582D0 (sv) | 1996-12-13 | 1996-12-13 | Astra Ab | Novel compounds |
| NZ550116A (en) * | 1997-08-18 | 2008-03-28 | Neurochem Int Ltd | Phosphono-carboxylate compounds for treating amyloidosis |
| US5869469A (en) | 1997-08-18 | 1999-02-09 | Queen's University At Kingston | Phosphonocarboxylate compounds for treating amyloidosis |
| US6037327A (en) * | 1997-08-28 | 2000-03-14 | University Of Washington | Specific saccharide compositions and methods for treating Alzheimer's disease and other amyloidoses |
| US5952389A (en) | 1998-01-13 | 1999-09-14 | Synchroneuron | Methods of treating tardive dyskinesia and other movement disorders |
| US6166320A (en) * | 1998-03-19 | 2000-12-26 | Toyota Jidosha Kabushiki Kaisha | Tandem solar cell |
| US6310073B1 (en) | 1998-07-28 | 2001-10-30 | Queen's University At Kingston | Methods and compositions to treat glycosaminoglycan-associated molecular interactions |
| AU3886200A (en) | 1999-03-15 | 2000-10-16 | Proteotech, Inc. | Methods of treating alzheimer's disease and other amyloidoses using hypericum perforatum and derivatives thereof |
| CA2369997C (en) | 1999-04-28 | 2009-11-17 | Queen's University At Kingston | Compositions and methods for treating amyloidosis |
| US6562836B1 (en) * | 1999-05-24 | 2003-05-13 | Queen's University Of Kingston | Methods and compounds for inhibiting amyloid deposits |
| AU5994900A (en) | 1999-07-09 | 2001-01-30 | Isis Innovation Limited | Compounds for inhibiting diseases and preparing cells for transplantation |
-
2000
- 2000-05-23 US US09/576,677 patent/US6562836B1/en not_active Expired - Fee Related
- 2000-05-24 HK HK03100829.4A patent/HK1050133A1/zh unknown
- 2000-05-24 MX MXPA01011989A patent/MXPA01011989A/es not_active Application Discontinuation
- 2000-05-24 CN CNB008107203A patent/CN100435785C/zh not_active Expired - Fee Related
- 2000-05-24 JP JP2000619408A patent/JP2003500350A/ja active Pending
- 2000-05-24 DE DE60044365T patent/DE60044365D1/de not_active Expired - Lifetime
- 2000-05-24 CA CA002684016A patent/CA2684016A1/en not_active Abandoned
- 2000-05-24 IL IL14668100A patent/IL146681A0/xx active IP Right Grant
- 2000-05-24 NZ NZ541238A patent/NZ541238A/en not_active IP Right Cessation
- 2000-05-24 NZ NZ566739A patent/NZ566739A/en not_active IP Right Cessation
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- 2000-05-24 NZ NZ552354A patent/NZ552354A/en not_active IP Right Cessation
- 2000-05-24 EP EP00930923A patent/EP1227803B1/en not_active Expired - Lifetime
- 2000-05-24 CA CA002373093A patent/CA2373093C/en not_active Expired - Fee Related
- 2000-05-24 WO PCT/CA2000/000607 patent/WO2000071101A2/en not_active Ceased
- 2000-05-24 AU AU49050/00A patent/AU4905000A/en not_active Abandoned
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- 2001-11-22 IL IL146681A patent/IL146681A/en not_active IP Right Cessation
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- 2003-05-02 US US10/429,198 patent/US7393875B2/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
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| NZ541238A (en) | 2007-02-23 |
| ATE466571T1 (de) | 2010-05-15 |
| US7393875B2 (en) | 2008-07-01 |
| DE60044365D1 (de) | 2010-06-17 |
| EP1227803B1 (en) | 2010-05-05 |
| US20040248876A1 (en) | 2004-12-09 |
| WO2000071101A2 (en) | 2000-11-30 |
| CA2373093A1 (en) | 2000-11-30 |
| CN1377260A (zh) | 2002-10-30 |
| EP1227803A2 (en) | 2002-08-07 |
| US6562836B1 (en) | 2003-05-13 |
| IL146681A (en) | 2007-12-03 |
| CA2373093C (en) | 2010-01-19 |
| MXPA01011989A (es) | 2002-05-06 |
| IL180523A0 (en) | 2009-02-11 |
| IL146681A0 (en) | 2002-07-25 |
| JP2003500350A (ja) | 2003-01-07 |
| CA2684016A1 (en) | 2000-11-30 |
| NZ566739A (en) | 2009-10-30 |
| US7786174B2 (en) | 2010-08-31 |
| NZ552354A (en) | 2008-04-30 |
| CN100435785C (zh) | 2008-11-26 |
| WO2000071101A3 (en) | 2001-12-06 |
| US20080227767A1 (en) | 2008-09-18 |
| HK1050133A1 (zh) | 2003-06-13 |
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