AU3767472A - Basically substituted benzyl phthalazone derivatives, acid salts thereof and process forthe production thereof - Google Patents

Basically substituted benzyl phthalazone derivatives, acid salts thereof and process forthe production thereof

Info

Publication number
AU3767472A
AU3767472A AU37674/72A AU3767472A AU3767472A AU 3767472 A AU3767472 A AU 3767472A AU 37674/72 A AU37674/72 A AU 37674/72A AU 3767472 A AU3767472 A AU 3767472A AU 3767472 A AU3767472 A AU 3767472A
Authority
AU
Australia
Prior art keywords
acid salts
substituted benzyl
process forthe
forthe production
basically substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU37674/72A
Other languages
English (en)
Inventor
DR. GERHARD SCHEFFLER PROF. DR. NORBERT BROCK and PROF. DR. DIETER LENKE DR. DIETRICH VOGELSANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Werke AG Chemische Fabrik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Werke AG Chemische Fabrik filed Critical Asta Werke AG Chemische Fabrik
Publication of AU3767472A publication Critical patent/AU3767472A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
AU37674/72A 1971-01-22 1972-01-06 Basically substituted benzyl phthalazone derivatives, acid salts thereof and process forthe production thereof Expired AU3767472A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH101271A CH572914A5 (nl) 1971-01-22 1971-01-22
CHCH001012/7 1971-01-22

Publications (1)

Publication Number Publication Date
AU3767472A true AU3767472A (en) 1973-07-12

Family

ID=4200381

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37674/72A Expired AU3767472A (en) 1971-01-22 1972-01-06 Basically substituted benzyl phthalazone derivatives, acid salts thereof and process forthe production thereof

Country Status (21)

Country Link
AR (1) AR197293A1 (nl)
AT (1) AT313288B (nl)
AU (1) AU3767472A (nl)
BE (1) BE778269A (nl)
CA (1) CA1010041A (nl)
CH (1) CH572914A5 (nl)
DE (1) DE2164058C3 (nl)
DK (1) DK136981B (nl)
ES (1) ES398949A1 (nl)
FI (1) FI53704C (nl)
FR (1) FR2122517B1 (nl)
GB (1) GB1377231A (nl)
HK (1) HK62577A (nl)
HU (1) HU163979B (nl)
IL (1) IL38496A (nl)
NL (1) NL177116C (nl)
OA (1) OA04087A (nl)
PL (1) PL88930B1 (nl)
SE (1) SE404604B (nl)
YU (1) YU35361B (nl)
ZA (1) ZA718712B (nl)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU622022B2 (en) * 1989-05-05 1992-03-26 Asta Medica Aktiengesellschaft Salts of azelastine having improved solubility
US8071073B2 (en) 2004-11-24 2011-12-06 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US10064817B2 (en) 2004-11-24 2018-09-04 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3575135D1 (de) * 1984-09-14 1990-02-08 Asta Pharma Ag Substituierte benzylphthalazinon-derivate.
DE3836579A1 (de) * 1987-11-13 1989-05-24 Asta Pharma Ag Azelastin enthaltende arzneimittel zur anwendung in der nase und/oder am auge
ES2053679T3 (es) * 1987-11-13 1994-08-01 Asta Medica Ag Embonato de azelastina, procedimiento para su preparacion y preparados farmaceuticos que contienen embonato de azelastina como principio activo.
AU609210B2 (en) * 1987-11-13 1991-04-26 Viatris Gmbh & Co. Kg Azelastine embonate, processes for its preparation and pharmaceutical formulations which contain azelastine embonate as active substance
DE3877904D1 (de) * 1987-11-13 1993-03-11 Asta Pharma Ag Azelastin enthaltende arzneimittel zur anwendung in der nase und/oder am auge.
DE3912292A1 (de) * 1988-04-20 1989-11-09 Asta Pharma Ag Azelastin enthaltende arzneimittel mit kontrollierter wirkstoffabgabe
US5110814A (en) * 1989-01-11 1992-05-05 Asta Pharma Ag Azelastine and its salts used to combat psoriasis
DE4207234A1 (de) * 1992-03-07 1993-09-09 Asta Medica Ag Neue aminocarbonsaeure-derivate mit antiallergischer/antiasthmatischer wirkung und verfahren zu deren herstellung
DE4343409C2 (de) * 1993-12-18 1997-03-20 Asta Medica Ag Verbessertes Verfahren zur Herstellung von Hexahydroazepinonen und Hexahydroazepinolen
DE4345224C2 (de) * 1993-12-18 1999-07-01 Asta Medica Ag Verfahren zur Herstellung von Säureadditionssalzen des Azelastins und Flezelastins
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
CA2649029A1 (en) * 2006-04-20 2007-11-01 Glaxo Group Limited 2-substituted 4-benzylphthalazinone derivatives as histamine h1 and h3 antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1046625B (de) * 1957-08-15 1958-12-18 Hydrierwerk Rodleben Veb Verfahren zur Herstellung basisch substituierter Phthalazone
GB1100911A (en) * 1963-08-20 1968-01-24 Benger Lab Ltd Phthalazine derivatives
FR1512879A (fr) * 1966-10-28 1968-02-09 Hydrierwerk Rodleben Veb Procédé pour la fabrication de phtalazones avec substituants basiques

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU622022B2 (en) * 1989-05-05 1992-03-26 Asta Medica Aktiengesellschaft Salts of azelastine having improved solubility
US8071073B2 (en) 2004-11-24 2011-12-06 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US8518919B2 (en) 2004-11-24 2013-08-27 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US9919050B2 (en) 2004-11-24 2018-03-20 Meda Pharmaceuticals Inc. Compositions comprising azelastine
US10064817B2 (en) 2004-11-24 2018-09-04 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof

Also Published As

Publication number Publication date
DK136981C (nl) 1978-06-05
DE2164058C3 (de) 1981-08-13
HU163979B (nl) 1973-12-28
PL88930B1 (nl) 1976-10-30
SE404604B (sv) 1978-10-16
YU11272A (en) 1980-06-30
NL7200400A (nl) 1972-07-25
NL177116B (nl) 1985-03-01
CA1010041A (en) 1977-05-10
IL38496A0 (en) 1972-03-28
FI53704B (nl) 1978-03-31
ES398949A1 (es) 1975-06-01
YU35361B (en) 1980-12-31
FR2122517A1 (nl) 1972-09-01
OA04087A (fr) 1979-10-30
AT313288B (de) 1974-02-11
DK136981B (da) 1977-12-27
ZA718712B (en) 1972-09-27
DE2164058B2 (de) 1980-10-23
SU440838A3 (nl) 1974-08-25
AR197293A1 (es) 1974-03-29
FI53704C (fi) 1978-07-10
FR2122517B1 (nl) 1975-08-01
NL177116C (nl) 1985-08-01
DE2164058A1 (de) 1972-07-27
GB1377231A (en) 1974-12-11
BE778269A (fr) 1972-07-19
HK62577A (en) 1977-12-30
CH572914A5 (nl) 1976-02-27
IL38496A (en) 1975-05-22

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