AU2022220512A1 - Bioactive substance conjugate, preparation method therefor and use thereof - Google Patents

Bioactive substance conjugate, preparation method therefor and use thereof Download PDF

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Publication number
AU2022220512A1
AU2022220512A1 AU2022220512A AU2022220512A AU2022220512A1 AU 2022220512 A1 AU2022220512 A1 AU 2022220512A1 AU 2022220512 A AU2022220512 A AU 2022220512A AU 2022220512 A AU2022220512 A AU 2022220512A AU 2022220512 A1 AU2022220512 A1 AU 2022220512A1
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seq
sequence
antibody
antigen
attached
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AU2022220512A
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AU2022220512A9 (en
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Jiaqiang Cai
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Medilink Therapeutics Suzhou Co Ltd
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Medilink Therapeutics Suzhou Co Ltd
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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