AU2021266715A1 - Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof - Google Patents

Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof Download PDF

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Publication number
AU2021266715A1
AU2021266715A1 AU2021266715A AU2021266715A AU2021266715A1 AU 2021266715 A1 AU2021266715 A1 AU 2021266715A1 AU 2021266715 A AU2021266715 A AU 2021266715A AU 2021266715 A AU2021266715 A AU 2021266715A AU 2021266715 A1 AU2021266715 A1 AU 2021266715A1
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Prior art keywords
compound
formula
crystalline form
catalyst
thf
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Inventor
Matthew M. Bio
Serge Henri Boyer
Yuanqing Fang
Angela GONZALES DE CASTRO
Scott J. Hecker
Laurent Lefort
Thomas Linder
Zuolin Zhu
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Qpex Biopharma Inc
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Qpex Biopharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
    • B01J23/74—Iron group metals
    • B01J23/755—Nickel
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2021266715A 2020-05-05 2021-05-04 Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof Pending AU2021266715A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063020494P 2020-05-05 2020-05-05
US63/020,494 2020-05-05
PCT/US2021/030690 WO2021226114A1 (en) 2020-05-05 2021-05-04 Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
AU2021266715A1 true AU2021266715A1 (en) 2022-11-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021266715A Pending AU2021266715A1 (en) 2020-05-05 2021-05-04 Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof

Country Status (12)

Country Link
US (1) US12552815B2 (https=)
EP (1) EP4149949A4 (https=)
JP (1) JP2023524525A (https=)
KR (1) KR20230020419A (https=)
CN (1) CN115996933A (https=)
AU (1) AU2021266715A1 (https=)
BR (1) BR112022022367A2 (https=)
CA (1) CA3180499A1 (https=)
IL (1) IL297458A (https=)
MX (1) MX2022013890A (https=)
TW (1) TW202207945A (https=)
WO (1) WO2021226114A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2894251T3 (es) 2016-06-30 2022-02-14 Qpex Biopharma Inc Derivados de ácido borónico y usos terapéuticos de los mismos
CN114539305B (zh) * 2022-02-24 2023-10-31 川北医学院 一种通过对苯并呋喃去芳构化制备双键有机化合物的方法
CN119118844B (zh) * 2023-06-13 2025-12-19 中国科学院兰州化学物理研究所 一种咪唑类化合物结构重整制备n-苯基苯二胺类化合物的方法
WO2025247268A1 (zh) * 2024-05-28 2025-12-04 江苏恒瑞医药股份有限公司 作为β-内酰胺酶抑制剂的硼酸衍生物的制备方法

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EP4149949A4 (en) 2024-05-15
MX2022013890A (es) 2022-11-30
US20250002508A1 (en) 2025-01-02
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