AU2021212262A1

AU2021212262A1 - Methods of preparing lipid nanoparticles

Methods of preparing lipid nanoparticles Download PDF

Info

Publication number: AU2021212262A1
Authority: AU; Australia
Prior art keywords: lnp; empty; solution; mol; lipid
Prior art date: 2020-01-31
Legal status : Abandoned

Application number

AU2021212262A

Other languages

English (en)

Inventor

Jason Auer

Brie SKINNER

Mike Smith

Current Assignee

ModernaTx Inc

Original Assignee

ModernaTx Inc

Priority date

2020-01-31

Filing date

2021-01-29

Publication date

2022-09-22

2021-01-29 Application filed by ModernaTx Inc filed Critical ModernaTx Inc

2022-09-22 Publication of AU2021212262A1 publication Critical patent/AU2021212262A1/en

Status Abandoned legal-status Critical Current

Links

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238000000034 method Methods 0.000 title claims abstract description 293
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238000009472 formulation Methods 0.000 claims abstract description 142
230000001225 therapeutic effect Effects 0.000 claims abstract description 81
239000000243 solution Substances 0.000 claims description 430
229920001223 polyethylene glycol Polymers 0.000 claims description 199
108700011259 MicroRNAs Proteins 0.000 claims description 155
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 56
229920002477 rna polymer Polymers 0.000 claims description 50
239000007983 Tris buffer Substances 0.000 claims description 48
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238000002360 preparation method Methods 0.000 claims description 48
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