AU2021207653A1 - Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases - Google Patents

Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases Download PDF

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Publication number
AU2021207653A1
AU2021207653A1 AU2021207653A AU2021207653A AU2021207653A1 AU 2021207653 A1 AU2021207653 A1 AU 2021207653A1 AU 2021207653 A AU2021207653 A AU 2021207653A AU 2021207653 A AU2021207653 A AU 2021207653A AU 2021207653 A1 AU2021207653 A1 AU 2021207653A1
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AU
Australia
Prior art keywords
pen
lys
phe
seq
aminoethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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AU2021207653A
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English (en)
Inventor
Ashok Bhandari
Elisabetta Bianchi
Gregory Thomas Bourne
Danila Branca
Roberto COSTANTE
Brian Troy FREDERICK
Raffaele Ingenito
Raymond Patch
Sandeep Somani
Chengzao Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biotech Inc
Protagonist Therapeutics Inc
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Janssen Biotech Inc
Protagonist Therapeutics Inc
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Application filed by Janssen Biotech Inc, Protagonist Therapeutics Inc filed Critical Janssen Biotech Inc
Publication of AU2021207653A1 publication Critical patent/AU2021207653A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
AU2021207653A 2020-01-15 2021-01-14 Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases Pending AU2021207653A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062961624P 2020-01-15 2020-01-15
US62/961,624 2020-01-15
PCT/US2021/013463 WO2021146441A1 (en) 2020-01-15 2021-01-14 Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases

Publications (1)

Publication Number Publication Date
AU2021207653A1 true AU2021207653A1 (en) 2022-08-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021207653A Pending AU2021207653A1 (en) 2020-01-15 2021-01-14 Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases

Country Status (32)

Country Link
US (2) US11845808B2 (enExample)
EP (2) EP4090670B1 (enExample)
JP (2) JP7441955B2 (enExample)
KR (1) KR20220141807A (enExample)
CN (5) CN118063554A (enExample)
AR (1) AR121070A1 (enExample)
AU (1) AU2021207653A1 (enExample)
CA (1) CA3167751A1 (enExample)
CL (2) CL2022001893A1 (enExample)
CO (1) CO2022009931A2 (enExample)
CR (1) CR20220332A (enExample)
DK (1) DK4090670T3 (enExample)
DO (1) DOP2022000147A (enExample)
EC (1) ECSP22063238A (enExample)
ES (1) ES3036287T3 (enExample)
FI (1) FI4090670T3 (enExample)
HR (1) HRP20250769T1 (enExample)
HU (1) HUE072238T2 (enExample)
IL (1) IL294680A (enExample)
JO (1) JOP20220169A1 (enExample)
LT (1) LT4090670T (enExample)
MA (1) MA58373B1 (enExample)
MX (1) MX2022008741A (enExample)
PE (1) PE20230370A1 (enExample)
PH (1) PH12022551750A1 (enExample)
PL (1) PL4090670T3 (enExample)
PT (1) PT4090670T (enExample)
RS (1) RS66991B1 (enExample)
SI (1) SI4090670T1 (enExample)
SM (1) SMT202500254T1 (enExample)
TW (2) TWI882061B (enExample)
WO (1) WO2021146441A1 (enExample)

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WO2021146441A1 (en) 2020-01-15 2021-07-22 Janssen Biotech, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
WO2021146454A1 (en) 2020-01-15 2021-07-22 Janssen Biotech, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
EP4247403A4 (en) 2020-11-20 2024-12-11 JANSSEN Pharmaceutica NV COMPOSITIONS OF PEPTIDE INHIBITORS OF THE INTERLEUKIN-23 RECEPTOR
JP2024525732A (ja) 2021-07-14 2024-07-12 ヤンセン バイオテツク，インコーポレーテツド インターロイキン－２３受容体の脂質化ペプチド阻害剤
MX2024000762A (es) * 2021-07-14 2024-04-18 Janssen Biotech Inc Inhibidores peptidicos del receptor de interleucina-23.
WO2023004414A1 (en) * 2021-07-23 2023-01-26 Colorado Chromatography, Llc A method for preparing hexahydrocannabinol
IL313185A (en) 2021-12-01 2024-07-01 Zealand Pharma As Peptide inhibitors of the interleukin-23 receptor
JP2025506374A (ja) 2022-02-01 2025-03-11 ヤンセン ファーマシューティカ エヌ．ベー． インターロイキン－２３受容体のペプチド阻害剤及びその医薬組成物
US20250206692A1 (en) * 2022-03-14 2025-06-26 Colorado Chromatography, Llc Hydrogenation of cannabigerol and cannabichromene
CA3260606A1 (en) 2022-06-30 2024-01-04 Sanofi NEW PEPTIDES FOR USE AS SELECTIVE IL-23 RECEPTOR ANTAGONISTS
EP4622991A2 (en) * 2022-11-21 2025-10-01 Janssen Pharmaceutica NV Synthesis of a cyclic peptide
KR20250111134A (ko) * 2022-11-30 2025-07-22 상하이 한서 바이오메디컬 컴퍼니 리미티드 폴리펩티드 억제제, 이의 제조 방법 및 응용
EP4652180A2 (en) * 2023-01-16 2025-11-26 Janssen Pharmaceutica NV Peptide inhibitors of interleukin-23 receptor
EP4652179A1 (en) * 2023-01-16 2025-11-26 Janssen Pharmaceutica NV Lipidated peptide inhibitors of interleukin-23 receptor
EP4652182A1 (en) * 2023-01-16 2025-11-26 Janssen Pharmaceutica NV Peptide inhibitors of interleukin-23 receptor
KR20250139359A (ko) 2023-01-31 2025-09-23 얀센 파마슈티카 엔브이 인터류킨-23 수용체의 결정질 펩티드 억제제의 제조 방법
KR20250156781A (ko) * 2023-03-03 2025-11-03 얀센 파마슈티카 엔브이 건선의 치료에 사용하기 위한 인터루킨-23 수용체 길항제 펩티드
WO2024227437A1 (zh) * 2023-05-04 2024-11-07 西藏海思科制药有限公司 白介素-23受体的肽抑制剂制备及其用途
EP4471049A1 (en) 2023-06-01 2024-12-04 Zealand Pharma A/S Peptide inhibitors of interleukin-23 receptor
EP4471048A1 (en) 2023-06-01 2024-12-04 Zealand Pharma A/S Peptide inhibitors of interleukin-23 receptor
WO2025051912A1 (en) * 2023-09-08 2025-03-13 Sanofi New peptides as selective il-23 receptor inhibitors
WO2025163534A1 (en) 2024-01-31 2025-08-07 Janssen Pharmaceutica Nv Crystal form of a peptide inhibitor of interleukin-23 receptor
WO2025243217A1 (en) * 2024-05-22 2025-11-27 Janssen Pharmaceutica Nv Crystal forms of peptide molecules
CN120905324A (zh) * 2025-10-10 2025-11-07 北京元延医药科技股份有限公司 白细胞介素-23受体肽抑制剂及其手性中间体的制法

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