AU2020346064A1 - Druggable target to treat retinal degeneration - Google Patents

Druggable target to treat retinal degeneration Download PDF

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Publication number
AU2020346064A1
AU2020346064A1 AU2020346064A AU2020346064A AU2020346064A1 AU 2020346064 A1 AU2020346064 A1 AU 2020346064A1 AU 2020346064 A AU2020346064 A AU 2020346064A AU 2020346064 A AU2020346064 A AU 2020346064A AU 2020346064 A1 AU2020346064 A1 AU 2020346064A1
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Australia
Prior art keywords
compound
retinal
rpe
disease
treating
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AU2020346064A
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Inventor
Karla Yadira BARBOSA SABANERO
Kapil BHARTI
Justin Ren Yuan CHANG
Balendu Shekhar Jha
Ruchi Sharma
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US Department of Health and Human Services
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Government of the United States of America
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    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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JP7505912B2 (ja) * 2020-04-30 2024-06-25 小林製薬株式会社 オートファジー活性化剤
WO2022023956A1 (en) * 2020-07-31 2022-02-03 The Joan and Irwin Jacobs Technion-Cornell Institute System and method for on-phase microscopy
KR102629963B1 (ko) * 2021-09-23 2024-01-29 순천향대학교 산학협력단 mTOR 활성화제를 포함하는 안질환 치료용 조성물 및 이의 용도
CN115969844B (zh) * 2021-12-28 2024-04-02 首都医科大学附属北京同仁医院 Nox2特异性抑制剂在制备视网膜变性药物中的应用
US20250170143A1 (en) * 2022-04-14 2025-05-29 Mayo Foundation For Medical Education And Research Methods of treating ocular fibrotic pathologies
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WO2023229993A1 (en) * 2022-05-25 2023-11-30 Curative Biotechnology, Inc. Ophthalmic formulation capable of delivering metformin to choroid rpe and retina
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EP4559900A1 (en) * 2023-11-21 2025-05-28 Opus Genetics, Inc. Phentolamine mesylate and therapeutic uses thereof

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US20060257391A1 (en) * 2005-05-11 2006-11-16 Bausch & Lomb Incorporated Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions
WO2008022256A2 (en) * 2006-08-16 2008-02-21 Blagosklonny Mikhail V Methods and compositions for preventing or treating age-related diseases
JP2010047567A (ja) * 2008-07-24 2010-03-04 Santen Pharmaceut Co Ltd 加齢黄斑変性の予防又は治療剤
KR101498665B1 (ko) * 2013-01-10 2015-03-05 한국 한의학 연구원 천연 추출물을 포함하는 당뇨합병증 또는 혈관부종의 예방 또는 치료용 약학적 조성물 및 건강기능식품 조성물
WO2014152661A1 (en) * 2013-03-14 2014-09-25 Panoptica, Inc. Ocular formulations for drug-delivery to the posterior segment of the eye
WO2015103480A1 (en) * 2014-01-02 2015-07-09 Massachusetts Eye & Ear Infirmary Treating ocular neovascularization
CA2976632A1 (en) * 2015-02-13 2016-08-18 Stealth Biotherapeutics Corp Therapeutic compositions including mitochondrial fission inhibitor peptides, variants thereof and methods of using the same
US20200056186A1 (en) * 2016-09-22 2020-02-20 Rsem, Limited Partnership Compositions comprising sasp modulators and senescence attenuators and uses thereof for modulating cellular senescence
WO2019033119A1 (en) * 2017-08-11 2019-02-14 Unity Biotechnology, Inc. TREATMENT OF OPHTHALMIC CONDITIONS SUCH AS MACULAR DEGENERATION, GLAUCOMA AND DIABETIC RETINOPATHY USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS
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