KR20220070232A - 망막의 변성을 치료하기 위한 약물가능성 표적 - Google Patents

망막의 변성을 치료하기 위한 약물가능성 표적 Download PDF

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KR20220070232A
KR20220070232A KR1020227012050A KR20227012050A KR20220070232A KR 20220070232 A KR20220070232 A KR 20220070232A KR 1020227012050 A KR1020227012050 A KR 1020227012050A KR 20227012050 A KR20227012050 A KR 20227012050A KR 20220070232 A KR20220070232 A KR 20220070232A
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compound
retina
disease
rpe
treating
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카필 바티
사바네로 칼라 야디라 바르보사
저스틴 런 위엔 창
발렌두 쉐하르 자
루치 샤마
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더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈
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Application filed by 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 filed Critical 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7505912B2 (ja) * 2020-04-30 2024-06-25 小林製薬株式会社 オートファジー活性化剤
WO2022023956A1 (en) * 2020-07-31 2022-02-03 The Joan and Irwin Jacobs Technion-Cornell Institute System and method for on-phase microscopy
KR102629963B1 (ko) * 2021-09-23 2024-01-29 순천향대학교 산학협력단 mTOR 활성화제를 포함하는 안질환 치료용 조성물 및 이의 용도
CN115969844B (zh) * 2021-12-28 2024-04-02 首都医科大学附属北京同仁医院 Nox2特异性抑制剂在制备视网膜变性药物中的应用
US20250170143A1 (en) * 2022-04-14 2025-05-29 Mayo Foundation For Medical Education And Research Methods of treating ocular fibrotic pathologies
CN115068456A (zh) * 2022-05-18 2022-09-20 中山大学中山眼科中心 二甲双胍在制备预防、治疗眼部疾病的药物中的用途及其剂型和制备方法
WO2023229993A1 (en) * 2022-05-25 2023-11-30 Curative Biotechnology, Inc. Ophthalmic formulation capable of delivering metformin to choroid rpe and retina
WO2024196814A1 (en) 2023-03-17 2024-09-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for treatment of age-related macular degeneration
EP4559900A1 (en) * 2023-11-21 2025-05-28 Opus Genetics, Inc. Phentolamine mesylate and therapeutic uses thereof

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
CN1704048A (zh) * 2004-05-25 2005-12-07 孙明杰 复方羟苯磺酸钙
US20060257391A1 (en) * 2005-05-11 2006-11-16 Bausch & Lomb Incorporated Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions
WO2008022256A2 (en) * 2006-08-16 2008-02-21 Blagosklonny Mikhail V Methods and compositions for preventing or treating age-related diseases
JP2010047567A (ja) * 2008-07-24 2010-03-04 Santen Pharmaceut Co Ltd 加齢黄斑変性の予防又は治療剤
KR101498665B1 (ko) * 2013-01-10 2015-03-05 한국 한의학 연구원 천연 추출물을 포함하는 당뇨합병증 또는 혈관부종의 예방 또는 치료용 약학적 조성물 및 건강기능식품 조성물
WO2014152661A1 (en) * 2013-03-14 2014-09-25 Panoptica, Inc. Ocular formulations for drug-delivery to the posterior segment of the eye
WO2015103480A1 (en) * 2014-01-02 2015-07-09 Massachusetts Eye & Ear Infirmary Treating ocular neovascularization
CA2976632A1 (en) * 2015-02-13 2016-08-18 Stealth Biotherapeutics Corp Therapeutic compositions including mitochondrial fission inhibitor peptides, variants thereof and methods of using the same
US20200056186A1 (en) * 2016-09-22 2020-02-20 Rsem, Limited Partnership Compositions comprising sasp modulators and senescence attenuators and uses thereof for modulating cellular senescence
WO2019033119A1 (en) * 2017-08-11 2019-02-14 Unity Biotechnology, Inc. TREATMENT OF OPHTHALMIC CONDITIONS SUCH AS MACULAR DEGENERATION, GLAUCOMA AND DIABETIC RETINOPATHY USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS
WO2019108602A1 (en) * 2017-11-28 2019-06-06 University Of Florida Research Foundation Methods and compositions for retinal drug delivery

Cited By (1)

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