AU2020211461B2 - Detecting endometrial cancer - Google Patents

Detecting endometrial cancer

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Publication number
AU2020211461B2
AU2020211461B2 AU2020211461A AU2020211461A AU2020211461B2 AU 2020211461 B2 AU2020211461 B2 AU 2020211461B2 AU 2020211461 A AU2020211461 A AU 2020211461A AU 2020211461 A AU2020211461 A AU 2020211461A AU 2020211461 B2 AU2020211461 B2 AU 2020211461B2
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AU
Australia
Prior art keywords
methylation
max
dna
sample
markers
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Active
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AU2020211461A
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English (en)
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AU2020211461A1 (en
Inventor
David A. Ahlquist
Hatim T. Allawi
Maria GIAKOUMOPOULOS
John B. Kisiel
Douglas W. Mahoney
William R. Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exact Sciences Corp
Mayo Clinic in Florida
Original Assignee
Mayo Foundation for Medical Education and Research
Exact Sciences Corp
Mayo Clinic in Florida
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Publication of AU2020211461A1 publication Critical patent/AU2020211461A1/en
Assigned to MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, EXACT SCIENCES CORPORATION reassignment MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Request for Assignment Assignors: EXACT SCIENCES DEVELOPMENT COMPANY, LLC, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/20—Screening of libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Library & Information Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Liquid Crystal Substances (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2020211461A 2019-01-24 2020-01-24 Detecting endometrial cancer Active AU2020211461B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962796384P 2019-01-24 2019-01-24
US62/796,384 2019-01-24
PCT/US2020/015059 WO2020154665A1 (en) 2019-01-24 2020-01-24 Detecting endometrial cancer

Publications (2)

Publication Number Publication Date
AU2020211461A1 AU2020211461A1 (en) 2021-08-19
AU2020211461B2 true AU2020211461B2 (en) 2026-03-26

Family

ID=71735383

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020211461A Active AU2020211461B2 (en) 2019-01-24 2020-01-24 Detecting endometrial cancer

Country Status (8)

Country Link
US (1) US12584177B2 (enExample)
EP (1) EP3914733A4 (enExample)
JP (2) JP2022518762A (enExample)
KR (1) KR20210119474A (enExample)
CN (2) CN118910258A (enExample)
AU (1) AU2020211461B2 (enExample)
CA (1) CA3127329A1 (enExample)
WO (1) WO2020154665A1 (enExample)

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CA2902916C (en) 2013-03-14 2018-08-28 Mayo Foundation For Medical Education And Research Detecting neoplasm
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US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
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CN114574585A (zh) 2015-08-31 2022-06-03 梅约医药教育及研究基金会 检测胃肿瘤
CN108350485A (zh) 2015-10-30 2018-07-31 精密科学发展有限责任公司 血浆dna的多重扩增检测测定以及分离和检测
CN109563546B (zh) 2016-05-05 2022-09-09 精密科学发展有限责任公司 通过分析甲基化dna来检测肺肿瘤
KR102892245B1 (ko) 2017-01-27 2025-11-27 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
JP7277460B2 (ja) 2017-11-30 2023-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 乳癌の検出
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
CA3127329A1 (en) 2019-01-24 2020-07-30 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
KR20210146983A (ko) * 2019-04-03 2021-12-06 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 혈장에서 췌장 관상 선암종의 검출
US11702704B2 (en) 2019-10-31 2023-07-18 Mayo Foundation For Medical Education And Research Detecting ovarian cancer
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
US12467096B2 (en) 2020-05-15 2025-11-11 Universal Diagnostics, S.A. Methods and systems for identifying methylation biomarkers
EP4150121A1 (en) 2020-06-30 2023-03-22 Universal Diagnostics, S.A. Systems and methods for detection of multiple cancer types
KR20230150814A (ko) * 2021-01-29 2023-10-31 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 다양한 유형의 암에 대한 존재 또는 부재의 검출
CN114645094B (zh) * 2022-03-21 2023-10-20 武汉凯德维斯生物技术有限公司 一种子宫内膜癌的生物标志物及其应用
CN115725734B (zh) * 2022-08-10 2023-10-13 人和未来生物科技（长沙）有限公司 Znf781基因在制备宫颈癌诊断试剂中的应用
US12606872B2 (en) 2022-11-16 2026-04-21 Universal Diagnostics, S.A. Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers
CN116179698B (zh) * 2022-12-02 2025-08-01 武汉艾米森生命科技有限公司 检测目标区域的甲基化水平的试剂在制备子宫内膜癌诊断产品中的应用
EP4638800A1 (en) * 2022-12-22 2025-10-29 Methylomics B.V. Methylation marker for cancer
CN116162707B (zh) * 2022-12-28 2024-11-29 武汉艾米森生命科技有限公司 检测cyth2基因或/和six3基因中的目标区域的甲基化水平的试剂的新应用
CN116356029B (zh) * 2023-03-29 2023-12-12 北京优迅医疗器械有限公司 Txnrd1基因甲基化水平检测在子宫内膜癌诊断和/或筛查中的应用
CN116790761B (zh) * 2023-08-22 2023-11-17 湖南宏雅基因技术有限公司 一种子宫内膜良恶性病变的生物标志物及其应用
CN118638922B (zh) * 2024-03-15 2025-05-23 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 用于子宫内膜癌早期检测的引物探针组合、甲基化检测试剂盒及其应用

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