AU2019358041A1 - Amino acid compounds and methods of use - Google Patents
Amino acid compounds and methods of use Download PDFInfo
- Publication number
- AU2019358041A1 AU2019358041A1 AU2019358041A AU2019358041A AU2019358041A1 AU 2019358041 A1 AU2019358041 A1 AU 2019358041A1 AU 2019358041 A AU2019358041 A AU 2019358041A AU 2019358041 A AU2019358041 A AU 2019358041A AU 2019358041 A1 AU2019358041 A1 AU 2019358041A1
- Authority
- AU
- Australia
- Prior art keywords
- tetrahydro
- naphthyridin
- homoserine
- compound
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862742901P | 2018-10-08 | 2018-10-08 | |
| US62/742,901 | 2018-10-08 | ||
| PCT/US2019/055252 WO2020076862A1 (fr) | 2018-10-08 | 2019-10-08 | Composés d'acides aminés et procédés d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2019358041A1 true AU2019358041A1 (en) | 2021-05-20 |
Family
ID=70051340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019358041A Pending AU2019358041A1 (en) | 2018-10-08 | 2019-10-08 | Amino acid compounds and methods of use |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US11180494B2 (fr) |
| EP (1) | EP3863711A4 (fr) |
| JP (1) | JP2022508657A (fr) |
| KR (1) | KR20210101205A (fr) |
| CN (1) | CN113195053A (fr) |
| AU (1) | AU2019358041A1 (fr) |
| BR (1) | BR112021006620A2 (fr) |
| CA (1) | CA3115643A1 (fr) |
| CL (2) | CL2021000863A1 (fr) |
| CO (1) | CO2021004279A2 (fr) |
| CR (1) | CR20210224A (fr) |
| CU (1) | CU24690B1 (fr) |
| DO (1) | DOP2021000054A (fr) |
| EA (1) | EA202190967A1 (fr) |
| EC (1) | ECSP21032717A (fr) |
| IL (1) | IL282026A (fr) |
| JO (1) | JOP20210056A1 (fr) |
| MX (1) | MX2021004015A (fr) |
| PE (1) | PE20211463A1 (fr) |
| PH (1) | PH12021550784A1 (fr) |
| SG (1) | SG11202103283RA (fr) |
| TW (1) | TW202028179A (fr) |
| WO (1) | WO2020076862A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3509590A4 (fr) | 2016-09-07 | 2020-12-02 | Pliant Therapeutics, Inc. | Composés d'acides aminés n-acyle et méthodes d'utilisation |
| EP3558303A4 (fr) | 2016-12-23 | 2020-07-29 | Pliant Therapeutics, Inc. | Composés acides aminés et leurs procédés d'utilisation |
| US11046685B2 (en) | 2017-02-28 | 2021-06-29 | Morphic Therapeutic, Inc. | Inhibitors of (α-v)(β-6) integrin |
| EP3589627A4 (fr) | 2017-02-28 | 2020-08-05 | Morphic Therapeutic, Inc. | Inhibiteurs de l'(alpha-v)(bêta-6) intégrine |
| DK3761980T3 (da) | 2018-03-07 | 2024-01-29 | Pliant Therapeutics Inc | Aminosyreforbindelser og fremgangsmåder til anvendelse |
| CU24693B1 (es) | 2018-06-27 | 2024-02-07 | Pliant Therapeutics Inc | Compuestos de aminoácido con enlazadores no ramificados como inhibidores de la integrina |
| PE20211640A1 (es) | 2018-08-29 | 2021-08-24 | Morphic Therapeutic Inc | INHIBICION DE LA INTEGRINA xvß6 |
| TW202028179A (zh) * | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| JP2022526818A (ja) | 2019-04-08 | 2022-05-26 | プライアント・セラピューティクス・インコーポレイテッド | アミノ酸化合物の剤形およびレジメン |
| GB202010626D0 (en) * | 2020-07-10 | 2020-08-26 | Univ Nottingham | Compound |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
| CN101784516B (zh) * | 2007-06-13 | 2014-07-02 | 百时美施贵宝公司 | 作为凝血因子抑制剂的二肽类似物 |
| US20120289481A1 (en) | 2011-05-13 | 2012-11-15 | O'neil Jennifer | Compositions and methods for treating cancer |
| AU2014324426A1 (en) | 2013-09-30 | 2016-04-21 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
| GB201417011D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| US10214522B2 (en) | 2015-03-10 | 2019-02-26 | The Regents Of The University Of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
| SI3275883T1 (sl) | 2015-03-25 | 2021-09-30 | Fujifilm Corporation | Postopek za pripravo nove dušik-vsebujoče spojine ali njene soli in proizvodni intermediat le-te |
| WO2018009501A1 (fr) | 2016-07-05 | 2018-01-11 | The Rockefeller University | Antagonistes de l'intégrine tetrahydronaphthyridinepentanamide |
| EP3509590A4 (fr) | 2016-09-07 | 2020-12-02 | Pliant Therapeutics, Inc. | Composés d'acides aminés n-acyle et méthodes d'utilisation |
| JP7264810B2 (ja) | 2016-11-08 | 2023-04-25 | ブリストル－マイヤーズ スクイブ カンパニー | アルファｖインテグリン阻害剤としてのシクロブタン－およびアゼチジン－含有の単環およびスピロ環式化合物 |
| EP3558303A4 (fr) | 2016-12-23 | 2020-07-29 | Pliant Therapeutics, Inc. | Composés acides aminés et leurs procédés d'utilisation |
| US11046685B2 (en) | 2017-02-28 | 2021-06-29 | Morphic Therapeutic, Inc. | Inhibitors of (α-v)(β-6) integrin |
| EP3589627A4 (fr) | 2017-02-28 | 2020-08-05 | Morphic Therapeutic, Inc. | Inhibiteurs de l'(alpha-v)(bêta-6) intégrine |
| DK3761980T3 (da) | 2018-03-07 | 2024-01-29 | Pliant Therapeutics Inc | Aminosyreforbindelser og fremgangsmåder til anvendelse |
| US10538542B2 (en) | 2018-03-15 | 2020-01-21 | Pfizer Inc. | Cyclopentane-based modulators of STING (stimulator of interferon genes) |
| CU24693B1 (es) | 2018-06-27 | 2024-02-07 | Pliant Therapeutics Inc | Compuestos de aminoácido con enlazadores no ramificados como inhibidores de la integrina |
| PE20211640A1 (es) | 2018-08-29 | 2021-08-24 | Morphic Therapeutic Inc | INHIBICION DE LA INTEGRINA xvß6 |
| WO2020047207A1 (fr) | 2018-08-29 | 2020-03-05 | Morphic Therapeutics, Inc. | Inhibiteurs de l'intégrine (alpha-v)(bêta -6) |
| EP3843727A4 (fr) | 2018-08-29 | 2022-08-17 | Morphic Therapeutic, Inc. | Inhibiteurs de l'intégrine (alpha-v)(bêta-6) |
| TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| JP2022526818A (ja) | 2019-04-08 | 2022-05-26 | プライアント・セラピューティクス・インコーポレイテッド | アミノ酸化合物の剤形およびレジメン |
| CA3173761A1 (fr) | 2020-05-07 | 2021-11-11 | Eric Lefebvre | Traitement de maladies respiratoires avec des composes acides amines |
-
2019
- 2019-10-07 TW TW108136254A patent/TW202028179A/zh unknown
- 2019-10-08 EA EA202190967A patent/EA202190967A1/ru unknown
- 2019-10-08 AU AU2019358041A patent/AU2019358041A1/en active Pending
- 2019-10-08 JO JOP/2021/0056A patent/JOP20210056A1/ar unknown
- 2019-10-08 WO PCT/US2019/055252 patent/WO2020076862A1/fr active Application Filing
- 2019-10-08 EP EP19870448.8A patent/EP3863711A4/fr active Pending
- 2019-10-08 KR KR1020217013781A patent/KR20210101205A/ko unknown
- 2019-10-08 MX MX2021004015A patent/MX2021004015A/es unknown
- 2019-10-08 SG SG11202103283RA patent/SG11202103283RA/en unknown
- 2019-10-08 CU CU2021000027A patent/CU24690B1/es unknown
- 2019-10-08 CA CA3115643A patent/CA3115643A1/fr active Pending
- 2019-10-08 BR BR112021006620A patent/BR112021006620A2/pt unknown
- 2019-10-08 US US16/596,649 patent/US11180494B2/en active Active
- 2019-10-08 CR CR20210224A patent/CR20210224A/es unknown
- 2019-10-08 CN CN201980066146.7A patent/CN113195053A/zh active Pending
- 2019-10-08 PE PE2021000461A patent/PE20211463A1/es unknown
- 2019-10-08 JP JP2021544112A patent/JP2022508657A/ja active Pending
-
2021
- 2021-03-30 DO DO2021000054A patent/DOP2021000054A/es unknown
- 2021-04-04 IL IL282026A patent/IL282026A/en unknown
- 2021-04-07 CL CL2021000863A patent/CL2021000863A1/es unknown
- 2021-04-07 CO CONC2021/0004279A patent/CO2021004279A2/es unknown
- 2021-04-08 PH PH12021550784A patent/PH12021550784A1/en unknown
- 2021-05-07 EC ECSENADI202132717A patent/ECSP21032717A/es unknown
- 2021-10-18 US US17/504,384 patent/US11952376B2/en active Active
-
2023
- 2023-05-08 CL CL2023001331A patent/CL2023001331A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JOP20210056A1 (ar) | 2021-03-24 |
| CO2021004279A2 (es) | 2021-04-30 |
| CU24690B1 (es) | 2023-12-07 |
| PE20211463A1 (es) | 2021-08-05 |
| CA3115643A1 (fr) | 2020-04-16 |
| US20200109141A1 (en) | 2020-04-09 |
| CL2023001331A1 (es) | 2023-10-20 |
| IL282026A (en) | 2021-05-31 |
| KR20210101205A (ko) | 2021-08-18 |
| BR112021006620A2 (pt) | 2021-07-06 |
| US11952376B2 (en) | 2024-04-09 |
| CN113195053A (zh) | 2021-07-30 |
| EP3863711A1 (fr) | 2021-08-18 |
| SG11202103283RA (en) | 2021-04-29 |
| PH12021550784A1 (en) | 2021-10-25 |
| US20220144829A1 (en) | 2022-05-12 |
| TW202028179A (zh) | 2020-08-01 |
| DOP2021000054A (es) | 2021-08-31 |
| US11180494B2 (en) | 2021-11-23 |
| CU20210027A7 (es) | 2021-11-04 |
| CR20210224A (es) | 2021-06-08 |
| WO2020076862A1 (fr) | 2020-04-16 |
| EA202190967A1 (ru) | 2021-09-17 |
| ECSP21032717A (es) | 2021-06-30 |
| CL2021000863A1 (es) | 2021-09-10 |
| MX2021004015A (es) | 2021-06-23 |
| JP2022508657A (ja) | 2022-01-19 |
| EP3863711A4 (fr) | 2022-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2019358041A1 (en) | Amino acid compounds and methods of use | |
| AU2019295769B2 (en) | Amino acid compounds with unbranched linkers and methods of use | |
| AU2019230209B2 (en) | Amino acid compounds and methods of use | |
| JP4523281B2 (ja) | Ｈｉｖインテグラーゼ阻害薬として有用なヒドロキシナフチリジノンカルボキサミド類 | |
| WO2020210404A1 (fr) | Formes posologiques et schémas de traitement pour des composés d'acides aminés | |
| AU2015323380B2 (en) | Methyl-and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof | |
| CA3173761A1 (fr) | Traitement de maladies respiratoires avec des composes acides amines | |
| CA2938186C (fr) | Derive d'azaindole | |
| BR122023025996A2 (pt) | Compostos de aminoácidos, composição farmacêutica e kit compreendendo os mesmos, seus usos, e seu método de produção | |
| TWI841573B (zh) | 具有未分支連接子之胺基酸化合物及使用方法 | |
| OA20261A (en) | Amino acid compounds and methods of use. | |
| OA18254A (en) | Methyl-and trifluoromethyl-substituted pyrrolopyridine modulators of rorc2 and methods of use thereof. |