ECSP21032717A - Compuestos de aminoácidos y métodos de uso - Google Patents
Compuestos de aminoácidos y métodos de usoInfo
- Publication number
- ECSP21032717A ECSP21032717A ECSENADI202132717A ECDI202132717A ECSP21032717A EC SP21032717 A ECSP21032717 A EC SP21032717A EC SENADI202132717 A ECSENADI202132717 A EC SENADI202132717A EC DI202132717 A ECDI202132717 A EC DI202132717A EC SP21032717 A ECSP21032717 A EC SP21032717A
- Authority
- EC
- Ecuador
- Prior art keywords
- methods
- amino acid
- acid compounds
- compounds
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención se refiere a compuestos de la fórmula (I): o una sal de este, en donde R1, G, L1, L2, L3, y Y son como se describen en la presente. Los compuestos de la fórmula (I) y las composiciones farmacéuticas de estos son inhibidores de una o ambas de la integrina αVβ1 y la integrina αVβ6 que son útiles para tratar la fibrosis, tal como en esteatohepatitis no alcohólica (NASH), fibrosis pulmonar idiopática (IPF) y neumonía intersticial inespecífica (NSIP).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862742901P | 2018-10-08 | 2018-10-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP21032717A true ECSP21032717A (es) | 2021-06-30 |
Family
ID=70051340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202132717A ECSP21032717A (es) | 2018-10-08 | 2021-05-07 | Compuestos de aminoácidos y métodos de uso |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US11180494B2 (es) |
| EP (1) | EP3863711A4 (es) |
| JP (1) | JP2022508657A (es) |
| KR (1) | KR20210101205A (es) |
| CN (1) | CN113195053A (es) |
| AU (1) | AU2019358041A1 (es) |
| BR (1) | BR112021006620A2 (es) |
| CA (1) | CA3115643A1 (es) |
| CL (2) | CL2021000863A1 (es) |
| CO (1) | CO2021004279A2 (es) |
| CR (1) | CR20210224A (es) |
| CU (1) | CU24690B1 (es) |
| DO (1) | DOP2021000054A (es) |
| EA (1) | EA202190967A1 (es) |
| EC (1) | ECSP21032717A (es) |
| IL (1) | IL282026A (es) |
| JO (1) | JOP20210056A1 (es) |
| MX (1) | MX2021004015A (es) |
| PE (1) | PE20211463A1 (es) |
| PH (1) | PH12021550784A1 (es) |
| SG (1) | SG11202103283RA (es) |
| TW (1) | TW202028179A (es) |
| WO (1) | WO2020076862A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201823208A (zh) | 2016-09-07 | 2018-07-01 | 美商普萊恩醫療公司 | N－醯基胺基酸化合物及其使用方法 |
| US10696672B2 (en) | 2016-12-23 | 2020-06-30 | Pliant Therapeutics, Inc. | Amino acid compounds and methods of use |
| US11046685B2 (en) | 2017-02-28 | 2021-06-29 | Morphic Therapeutic, Inc. | Inhibitors of (α-v)(β-6) integrin |
| US20180244648A1 (en) | 2017-02-28 | 2018-08-30 | Lazuli, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| WO2019173653A1 (en) | 2018-03-07 | 2019-09-12 | Pliant Therapeutics, Inc. | Amino acid compounds and methods of use |
| EA202190134A1 (ru) | 2018-06-27 | 2021-03-26 | Плайэнт Терапьютикс, Инк. | Соединения аминокислот с неразветвленными линкерами и способы их применения |
| CR20210109A (es) | 2018-08-29 | 2021-06-24 | Morphic Therapeutic Inc | INHIBICIÓN DE LA INTEGRINA av ß6 |
| TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| CA3136745A1 (en) | 2019-04-08 | 2020-10-15 | Pliant Therapeutics, Inc. | Dosage forms and regimens for amino acid compounds |
| GB202010626D0 (en) * | 2020-07-10 | 2020-08-26 | Univ Nottingham | Compound |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048861A (en) * | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
| AR067329A1 (es) | 2007-06-13 | 2009-10-07 | Bristol Myers Squibb Co | Analogos dipeptidos como inhibidores del factor de coagulacion |
| US20120289481A1 (en) * | 2011-05-13 | 2012-11-15 | O'neil Jennifer | Compositions and methods for treating cancer |
| WO2015048819A1 (en) | 2013-09-30 | 2015-04-02 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
| GB201417011D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| CA2981371A1 (en) | 2015-03-10 | 2016-09-15 | The Regents Of The University Of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
| WO2016153054A1 (ja) | 2015-03-25 | 2016-09-29 | 富士フイルム株式会社 | 新規な含窒素化合物またはその塩の製造方法およびそれらの製造中間体 |
| WO2018009501A1 (en) | 2016-07-05 | 2018-01-11 | The Rockefeller University | Tetrahydronaphthyridinepentanamide integrin antagonists |
| TW201823208A (zh) | 2016-09-07 | 2018-07-01 | 美商普萊恩醫療公司 | N－醯基胺基酸化合物及其使用方法 |
| EP3538526B1 (en) | 2016-11-08 | 2024-04-10 | Bristol-Myers Squibb Company | Cyclobutane- and azetidine-containing mono and spirocyclic compounds as alpha v integrin inhibitors |
| US10696672B2 (en) | 2016-12-23 | 2020-06-30 | Pliant Therapeutics, Inc. | Amino acid compounds and methods of use |
| US11046685B2 (en) * | 2017-02-28 | 2021-06-29 | Morphic Therapeutic, Inc. | Inhibitors of (α-v)(β-6) integrin |
| US20180244648A1 (en) | 2017-02-28 | 2018-08-30 | Lazuli, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| WO2019173653A1 (en) | 2018-03-07 | 2019-09-12 | Pliant Therapeutics, Inc. | Amino acid compounds and methods of use |
| TWI741268B (zh) | 2018-03-15 | 2021-10-01 | 美商輝瑞股份有限公司 | 干擾素基因刺激劑（ｓｔｉｎｇ）的環戊烷為主體之調節劑 |
| EA202190134A1 (ru) | 2018-06-27 | 2021-03-26 | Плайэнт Терапьютикс, Инк. | Соединения аминокислот с неразветвленными линкерами и способы их применения |
| CR20210109A (es) | 2018-08-29 | 2021-06-24 | Morphic Therapeutic Inc | INHIBICIÓN DE LA INTEGRINA av ß6 |
| WO2020047208A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| EP3843728A4 (en) | 2018-08-29 | 2022-05-25 | Morphic Therapeutic, Inc. | INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN |
| TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| CA3136745A1 (en) | 2019-04-08 | 2020-10-15 | Pliant Therapeutics, Inc. | Dosage forms and regimens for amino acid compounds |
| EP4146264A1 (en) | 2020-05-07 | 2023-03-15 | Pliant Therapeutics, Inc. | Treatment of respiratory diseases with amino acid compounds |
-
2019
- 2019-10-07 TW TW108136254A patent/TW202028179A/zh unknown
- 2019-10-08 KR KR1020217013781A patent/KR20210101205A/ko unknown
- 2019-10-08 PE PE2021000461A patent/PE20211463A1/es unknown
- 2019-10-08 CN CN201980066146.7A patent/CN113195053A/zh active Pending
- 2019-10-08 BR BR112021006620A patent/BR112021006620A2/pt unknown
- 2019-10-08 CA CA3115643A patent/CA3115643A1/en active Pending
- 2019-10-08 EP EP19870448.8A patent/EP3863711A4/en active Pending
- 2019-10-08 CR CR20210224A patent/CR20210224A/es unknown
- 2019-10-08 SG SG11202103283RA patent/SG11202103283RA/en unknown
- 2019-10-08 WO PCT/US2019/055252 patent/WO2020076862A1/en active Application Filing
- 2019-10-08 AU AU2019358041A patent/AU2019358041A1/en active Pending
- 2019-10-08 JO JOP/2021/0056A patent/JOP20210056A1/ar unknown
- 2019-10-08 JP JP2021544112A patent/JP2022508657A/ja active Pending
- 2019-10-08 US US16/596,649 patent/US11180494B2/en active Active
- 2019-10-08 EA EA202190967A patent/EA202190967A1/ru unknown
- 2019-10-08 CU CU2021000027A patent/CU24690B1/es unknown
- 2019-10-08 MX MX2021004015A patent/MX2021004015A/es unknown
-
2021
- 2021-03-30 DO DO2021000054A patent/DOP2021000054A/es unknown
- 2021-04-04 IL IL282026A patent/IL282026A/en unknown
- 2021-04-07 CL CL2021000863A patent/CL2021000863A1/es unknown
- 2021-04-07 CO CONC2021/0004279A patent/CO2021004279A2/es unknown
- 2021-04-08 PH PH12021550784A patent/PH12021550784A1/en unknown
- 2021-05-07 EC ECSENADI202132717A patent/ECSP21032717A/es unknown
- 2021-10-18 US US17/504,384 patent/US11952376B2/en active Active
-
2023
- 2023-05-08 CL CL2023001331A patent/CL2023001331A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020076862A1 (en) | 2020-04-16 |
| EP3863711A1 (en) | 2021-08-18 |
| TW202028179A (zh) | 2020-08-01 |
| US11952376B2 (en) | 2024-04-09 |
| SG11202103283RA (en) | 2021-04-29 |
| AU2019358041A1 (en) | 2021-05-20 |
| JP2022508657A (ja) | 2022-01-19 |
| CO2021004279A2 (es) | 2021-04-30 |
| PE20211463A1 (es) | 2021-08-05 |
| CR20210224A (es) | 2021-06-08 |
| MX2021004015A (es) | 2021-06-23 |
| CN113195053A (zh) | 2021-07-30 |
| CA3115643A1 (en) | 2020-04-16 |
| EA202190967A1 (ru) | 2021-09-17 |
| US20200109141A1 (en) | 2020-04-09 |
| CU20210027A7 (es) | 2021-11-04 |
| CU24690B1 (es) | 2023-12-07 |
| US20220144829A1 (en) | 2022-05-12 |
| CL2021000863A1 (es) | 2021-09-10 |
| PH12021550784A1 (en) | 2021-10-25 |
| JOP20210056A1 (ar) | 2021-03-24 |
| DOP2021000054A (es) | 2021-08-31 |
| US11180494B2 (en) | 2021-11-23 |
| KR20210101205A (ko) | 2021-08-18 |
| BR112021006620A2 (pt) | 2021-07-06 |
| IL282026A (en) | 2021-05-31 |
| CL2023001331A1 (es) | 2023-10-20 |
| EP3863711A4 (en) | 2022-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP21032717A (es) | Compuestos de aminoácidos y métodos de uso | |
| ECSP20063227A (es) | Compuestos de aminoácidos y métodos de uso | |
| CU20210001A7 (es) | Compuestos de aminoácido con ligadores no ramificados como inhibidores de la integrina y composiciones farmacéuticas que los comprenden | |
| CO2017011172A2 (es) | Compuestos de 1-ciano-pirrolidina como inhibidores de usp30 | |
| CO2018006299A2 (es) | Compuestos novedosos | |
| CY1119489T1 (el) | Υποκατεστημενη πιπεριδυλο-αιθυλο-πυριμιδινη ως αναστολεας της ο-ακυλο τρανσφερασης της γκρελινης | |
| AR107864A1 (es) | ÁCIDO 7a,11b-DIHIDROXI-6a-ETIL-5b-COLAN-24-OICO Y COMPOSICIONES FARMACÉUTICAS | |
| UY37160A (es) | COMPUESTOS DERIVADOS DE PIRROLIDINA CON ACTIVIDAD ANTAGONISTA DE INTEGRINA avß6 | |
| PE20141607A1 (es) | Compuestos heterociclicos, medicamentos que los contienen, uso de aquellos y procesos para su preparacion | |
| MX347692B (es) | Inhibidores del virus de la hepatitis c. | |
| CY1116168T1 (el) | Συγκρυσταλλοι και αλατα αναστολεων toy ccr3 | |
| EA201591499A1 (ru) | Замещенные бисфенилбутановые производные фосфоновой кислоты в качестве ингибиторов nep (нейтральная эндопептидаза) | |
| BR112017000246A2 (pt) | composto, sal farmaceuticamente aceitável de um composto, composição farmacêutica, e, uso de um composto ou de um sal | |
| EA201891506A1 (ru) | Индолиноновые соединения и их применение в лечении фиброзных заболеваний | |
| EA201990765A1 (ru) | Азаиндазольные соединения для применения при повреждениях сухожилий и/или связок | |
| AR080127A1 (es) | Inhibidores de la amida hidrolasa de acidos grasos, composiciones farmaceuticas y sus usos | |
| EA202092110A1 (ru) | Аминокислотные соединения и способы применения | |
| FI10194U1 (fi) | Setilistaattia sisältäviä koostumuksia |