AU2019259112B2 - Compounds having a tubulin-polymerisation-inhibiting activity and immunomodulatory properties - Google Patents

Compounds having a tubulin-polymerisation-inhibiting activity and immunomodulatory properties Download PDF

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Publication number
AU2019259112B2
AU2019259112B2 AU2019259112A AU2019259112A AU2019259112B2 AU 2019259112 B2 AU2019259112 B2 AU 2019259112B2 AU 2019259112 A AU2019259112 A AU 2019259112A AU 2019259112 A AU2019259112 A AU 2019259112A AU 2019259112 B2 AU2019259112 B2 AU 2019259112B2
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Australia
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group
alkyl group
hydrogen atom
compound
representing
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AU2019259112A
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AU2019259112A1 (en
Inventor
Mouad Alami
Sébastien APCHER
Romain DARRIGRAND
Abdallah Hamze
Ilhem KHELIFI
Timothée NARET
Olivier Provot
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Centre National de la Recherche Scientifique CNRS
Institut Gustave Roussy (IGR)
Institut National de la Sante et de la Recherche Medicale INSERM
Universite Paris Saclay
Original Assignee
Centre National de la Recherche Scientifique CNRS
Institut Gustave Roussy (IGR)
Institut National de la Sante et de la Recherche Medicale INSERM
Universite Paris Saclay
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
AU2019259112A 2018-04-27 2019-04-26 Compounds having a tubulin-polymerisation-inhibiting activity and immunomodulatory properties Active AU2019259112B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1853709A FR3080620B1 (fr) 2018-04-27 2018-04-27 Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices
FR1853709 2018-04-27
PCT/FR2019/050982 WO2019207257A1 (fr) 2018-04-27 2019-04-26 Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices

Publications (2)

Publication Number Publication Date
AU2019259112A1 AU2019259112A1 (en) 2020-11-26
AU2019259112B2 true AU2019259112B2 (en) 2024-02-08

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AU2019259112A Active AU2019259112B2 (en) 2018-04-27 2019-04-26 Compounds having a tubulin-polymerisation-inhibiting activity and immunomodulatory properties

Country Status (9)

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US (2) US11634405B2 (https=)
EP (1) EP3784662B1 (https=)
JP (1) JP7408894B2 (https=)
AU (1) AU2019259112B2 (https=)
CA (1) CA3097622A1 (https=)
DK (1) DK3784662T3 (https=)
ES (1) ES2932370T3 (https=)
FR (1) FR3080620B1 (https=)
WO (1) WO2019207257A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111825610B (zh) * 2020-06-24 2023-03-31 中国药科大学 一种具有抗肿瘤活性的2-甲基喹啉类衍生物及其合成方法和用途
CN115417860B (zh) * 2020-08-03 2023-10-20 中国药科大学 一种具有抗肿瘤活性的喹唑啉类衍生物及其合成方法和用途
CN113173915B (zh) * 2021-03-29 2022-12-09 中南大学湘雅医院 抗皮肤肿瘤化合物及其应用
CN113620874B (zh) * 2021-08-10 2024-02-06 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 2-三氟甲基-4-氨基-喹啉衍生物及其用途
CN114436975B (zh) * 2022-01-26 2023-10-31 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 2-三氟甲基-4-氨基喹唑啉类化合物及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9323290D0 (en) * 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
GB9514265D0 (en) * 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
SK288365B6 (sk) * 1999-02-10 2016-07-01 Astrazeneca Ab Medziprodukty pre chinazolínové deriváty ako inhibítory angiogenézy
JP2003535867A (ja) 2000-06-06 2003-12-02 ファイザー プロダクツ インコーポレイテッド 抗癌剤として有用なチオフェン誘導体
GB0126433D0 (en) 2001-11-03 2002-01-02 Astrazeneca Ab Compounds
AU2004289303A1 (en) * 2003-11-10 2005-05-26 Synta Pharmaceuticals, Corp. Fused heterocyclic compounds
EA009994B1 (ru) * 2003-12-23 2008-06-30 Пфайзер Инк. Новые хинолиновые производные
KR20070117547A (ko) 2005-01-03 2007-12-12 미리어드 제네틱스, 인크. 뇌암 치료방법
GB0508717D0 (en) 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
JP2009508917A (ja) * 2005-09-20 2009-03-05 アストラゼネカ アクチボラグ 抗癌剤としてのキナゾリン誘導体
FR2914640B1 (fr) 2007-04-04 2012-11-16 Centre Nat Rech Scient Iso ca-4 et analogues : puissants cytotoxiques, inhibiteurs de polymerisation de la tubuline

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MAHAL K. ET AL.: CHEMMEDCHEM, vol. 9, no. 4, 1 January 2014 (2014-01-01), pages 847 - 854, XP002784057 *

Also Published As

Publication number Publication date
US11634405B2 (en) 2023-04-25
US20210230140A1 (en) 2021-07-29
JP7408894B2 (ja) 2024-01-09
CA3097622A1 (fr) 2019-10-31
AU2019259112A1 (en) 2020-11-26
US12371417B2 (en) 2025-07-29
WO2019207257A8 (fr) 2019-11-21
EP3784662A1 (fr) 2021-03-03
EP3784662B1 (fr) 2022-11-09
WO2019207257A1 (fr) 2019-10-31
ES2932370T3 (es) 2023-01-18
DK3784662T3 (da) 2022-12-19
FR3080620B1 (fr) 2021-11-12
US20230203005A1 (en) 2023-06-29
JP2021522244A (ja) 2021-08-30
FR3080620A1 (fr) 2019-11-01

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