FR3080620B1 - Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices - Google Patents

Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices Download PDF

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Publication number
FR3080620B1
FR3080620B1 FR1853709A FR1853709A FR3080620B1 FR 3080620 B1 FR3080620 B1 FR 3080620B1 FR 1853709 A FR1853709 A FR 1853709A FR 1853709 A FR1853709 A FR 1853709A FR 3080620 B1 FR3080620 B1 FR 3080620B1
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FR
France
Prior art keywords
compounds
polymerization inhibitor
inhibitor activity
tubulin polymerization
immunomodulatory properties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1853709A
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English (en)
French (fr)
Other versions
FR3080620A1 (fr
Inventor
Mouad Alami
Olivier Provot
Abdallah Hamze
Ilhem Khelifi
Timothee Naret
Sebastien Apcher
Romain Darrigrand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Gustave Roussy Fr
Centre National de la Recherche Scientifique CNRS
Institut National de la Sante et de la Recherche Medicale INSERM
Universite Paris Saclay
Original Assignee
Centre National de la Recherche Scientifique CNRS
Institut Gustave Roussy (IGR)
Institut National de la Sante et de la Recherche Medicale INSERM
Universite Paris Sud
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1853709A priority Critical patent/FR3080620B1/fr
Application filed by Centre National de la Recherche Scientifique CNRS, Institut Gustave Roussy (IGR), Institut National de la Sante et de la Recherche Medicale INSERM, Universite Paris Sud filed Critical Centre National de la Recherche Scientifique CNRS
Priority to CA3097622A priority patent/CA3097622A1/fr
Priority to PCT/FR2019/050982 priority patent/WO2019207257A1/fr
Priority to EP19733845.2A priority patent/EP3784662B1/fr
Priority to AU2019259112A priority patent/AU2019259112B2/en
Priority to US17/050,772 priority patent/US11634405B2/en
Priority to DK19733845.2T priority patent/DK3784662T3/da
Priority to ES19733845T priority patent/ES2932370T3/es
Priority to JP2020559423A priority patent/JP7408894B2/ja
Publication of FR3080620A1 publication Critical patent/FR3080620A1/fr
Application granted granted Critical
Publication of FR3080620B1 publication Critical patent/FR3080620B1/fr
Priority to US18/117,847 priority patent/US12371417B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
FR1853709A 2018-04-27 2018-04-27 Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices Active FR3080620B1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR1853709A FR3080620B1 (fr) 2018-04-27 2018-04-27 Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices
JP2020559423A JP7408894B2 (ja) 2018-04-27 2019-04-26 チューブリン重合阻害活性及び免疫調節特性を有する化合物
EP19733845.2A EP3784662B1 (fr) 2018-04-27 2019-04-26 Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices
AU2019259112A AU2019259112B2 (en) 2018-04-27 2019-04-26 Compounds having a tubulin-polymerisation-inhibiting activity and immunomodulatory properties
US17/050,772 US11634405B2 (en) 2018-04-27 2019-04-26 Compounds with tubulin polymerisation inhibitory activity and immunomodulatory properties
DK19733845.2T DK3784662T3 (da) 2018-04-27 2019-04-26 Forbindelser med en tubulin-polymerisationshæmmende aktivitet og immunomodulatoriske egenskaber
CA3097622A CA3097622A1 (fr) 2018-04-27 2019-04-26 Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices
PCT/FR2019/050982 WO2019207257A1 (fr) 2018-04-27 2019-04-26 Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices
ES19733845T ES2932370T3 (es) 2018-04-27 2019-04-26 Compuestos con actividad inhibidora de la polimerización de la tubulina y con propiedades inmunomoduladoras
US18/117,847 US12371417B2 (en) 2018-04-27 2023-03-06 Compounds with tubulin polymerisation inhibitory activity and immunomodulatory properties

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1853709A FR3080620B1 (fr) 2018-04-27 2018-04-27 Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices
FR1853709 2018-04-27

Publications (2)

Publication Number Publication Date
FR3080620A1 FR3080620A1 (fr) 2019-11-01
FR3080620B1 true FR3080620B1 (fr) 2021-11-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
FR1853709A Active FR3080620B1 (fr) 2018-04-27 2018-04-27 Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices

Country Status (9)

Country Link
US (2) US11634405B2 (https=)
EP (1) EP3784662B1 (https=)
JP (1) JP7408894B2 (https=)
AU (1) AU2019259112B2 (https=)
CA (1) CA3097622A1 (https=)
DK (1) DK3784662T3 (https=)
ES (1) ES2932370T3 (https=)
FR (1) FR3080620B1 (https=)
WO (1) WO2019207257A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111825610B (zh) * 2020-06-24 2023-03-31 中国药科大学 一种具有抗肿瘤活性的2-甲基喹啉类衍生物及其合成方法和用途
CN115417860B (zh) * 2020-08-03 2023-10-20 中国药科大学 一种具有抗肿瘤活性的喹唑啉类衍生物及其合成方法和用途
CN113173915B (zh) * 2021-03-29 2022-12-09 中南大学湘雅医院 抗皮肤肿瘤化合物及其应用
CN113620874B (zh) * 2021-08-10 2024-02-06 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 2-三氟甲基-4-氨基-喹啉衍生物及其用途
CN114436975B (zh) * 2022-01-26 2023-10-31 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 2-三氟甲基-4-氨基喹唑啉类化合物及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9323290D0 (en) * 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
GB9514265D0 (en) * 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
SK288365B6 (sk) * 1999-02-10 2016-07-01 Astrazeneca Ab Medziprodukty pre chinazolínové deriváty ako inhibítory angiogenézy
JP2003535867A (ja) 2000-06-06 2003-12-02 ファイザー プロダクツ インコーポレイテッド 抗癌剤として有用なチオフェン誘導体
GB0126433D0 (en) 2001-11-03 2002-01-02 Astrazeneca Ab Compounds
AU2004289303A1 (en) * 2003-11-10 2005-05-26 Synta Pharmaceuticals, Corp. Fused heterocyclic compounds
EA009994B1 (ru) * 2003-12-23 2008-06-30 Пфайзер Инк. Новые хинолиновые производные
KR20070117547A (ko) 2005-01-03 2007-12-12 미리어드 제네틱스, 인크. 뇌암 치료방법
GB0508717D0 (en) 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
JP2009508917A (ja) * 2005-09-20 2009-03-05 アストラゼネカ アクチボラグ 抗癌剤としてのキナゾリン誘導体
FR2914640B1 (fr) 2007-04-04 2012-11-16 Centre Nat Rech Scient Iso ca-4 et analogues : puissants cytotoxiques, inhibiteurs de polymerisation de la tubuline

Also Published As

Publication number Publication date
US11634405B2 (en) 2023-04-25
US20210230140A1 (en) 2021-07-29
JP7408894B2 (ja) 2024-01-09
CA3097622A1 (fr) 2019-10-31
AU2019259112A1 (en) 2020-11-26
US12371417B2 (en) 2025-07-29
WO2019207257A8 (fr) 2019-11-21
EP3784662A1 (fr) 2021-03-03
EP3784662B1 (fr) 2022-11-09
WO2019207257A1 (fr) 2019-10-31
ES2932370T3 (es) 2023-01-18
DK3784662T3 (da) 2022-12-19
US20230203005A1 (en) 2023-06-29
AU2019259112B2 (en) 2024-02-08
JP2021522244A (ja) 2021-08-30
FR3080620A1 (fr) 2019-11-01

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