AU2019225151B2 - Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants - Google Patents

Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants

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Publication number
AU2019225151B2
AU2019225151B2 AU2019225151A AU2019225151A AU2019225151B2 AU 2019225151 B2 AU2019225151 B2 AU 2019225151B2 AU 2019225151 A AU2019225151 A AU 2019225151A AU 2019225151 A AU2019225151 A AU 2019225151A AU 2019225151 B2 AU2019225151 B2 AU 2019225151B2
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hla
donor
tissue
thymus
thymus tissue
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AU2019225151A
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AU2019225151A1 (en
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Mary Louise MARKERT
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Duke University
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Duke University
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/26Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
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    • AHUMAN NECESSITIES
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    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10Preservation of living parts
    • A01N1/16Physical preservation processes
    • A01N1/162Temperature processes, e.g. following predefined temperature changes over time
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    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • A61L27/3895Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/065Thymocytes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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    • A61K2035/122Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
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AU2019225151A 2018-02-23 2019-02-22 Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants Active AU2019225151B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862634377P 2018-02-23 2018-02-23
US62/634,377 2018-02-23
PCT/US2019/019137 WO2019165197A1 (en) 2018-02-23 2019-02-22 Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants

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AU2019225151A1 AU2019225151A1 (en) 2020-08-20
AU2019225151B2 true AU2019225151B2 (en) 2026-02-05

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US (2) US12064452B2 (https=)
EP (2) EP3755346B1 (https=)
JP (2) JP7499178B2 (https=)
KR (2) KR102805282B1 (https=)
CN (1) CN112074277A (https=)
AU (1) AU2019225151B2 (https=)
BR (1) BR112020016614A2 (https=)
CA (1) CA3089593A1 (https=)
IL (1) IL276706A (https=)
MX (1) MX2020008590A (https=)
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WO2021034650A1 (en) 2019-08-19 2021-02-25 Duke University & Medical Center Methods of determining the suitability of cultured thymus tissue for implantation into humans and associated methods of use
CN115287262B (zh) * 2022-01-28 2024-04-02 浙江中医药大学 一种胸腺类器官微球及其制备方法与应用
WO2024042488A1 (en) 2022-08-24 2024-02-29 Enzyvant Therapeutics Gmbh Thymic exosome assays, and methods of producing t cell depleted thymus tissue and uses thereof
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