KR102805282B1 - 동종이계 고형 장기 이식물에 대한 공여자-특이적 내성을 증진시키는 배양된 융선 조직 이식 - Google Patents
동종이계 고형 장기 이식물에 대한 공여자-특이적 내성을 증진시키는 배양된 융선 조직 이식 Download PDFInfo
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- KR102805282B1 KR102805282B1 KR1020207023608A KR20207023608A KR102805282B1 KR 102805282 B1 KR102805282 B1 KR 102805282B1 KR 1020207023608 A KR1020207023608 A KR 1020207023608A KR 20207023608 A KR20207023608 A KR 20207023608A KR 102805282 B1 KR102805282 B1 KR 102805282B1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020257014739A KR20250071282A (ko) | 2018-02-23 | 2019-02-22 | 동종이계 고형 장기 이식물에 대한 공여자-특이적 내성을 증진시키는 배양된 융선 조직 이식 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862634377P | 2018-02-23 | 2018-02-23 | |
| US62/634,377 | 2018-02-23 | ||
| PCT/US2019/019137 WO2019165197A1 (en) | 2018-02-23 | 2019-02-22 | Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257014739A Division KR20250071282A (ko) | 2018-02-23 | 2019-02-22 | 동종이계 고형 장기 이식물에 대한 공여자-특이적 내성을 증진시키는 배양된 융선 조직 이식 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20210005543A KR20210005543A (ko) | 2021-01-14 |
| KR102805282B1 true KR102805282B1 (ko) | 2025-05-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207023608A Active KR102805282B1 (ko) | 2018-02-23 | 2019-02-22 | 동종이계 고형 장기 이식물에 대한 공여자-특이적 내성을 증진시키는 배양된 융선 조직 이식 |
| KR1020257014739A Pending KR20250071282A (ko) | 2018-02-23 | 2019-02-22 | 동종이계 고형 장기 이식물에 대한 공여자-특이적 내성을 증진시키는 배양된 융선 조직 이식 |
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| WO2021034650A1 (en) | 2019-08-19 | 2021-02-25 | Duke University & Medical Center | Methods of determining the suitability of cultured thymus tissue for implantation into humans and associated methods of use |
| CN115287262B (zh) * | 2022-01-28 | 2024-04-02 | 浙江中医药大学 | 一种胸腺类器官微球及其制备方法与应用 |
| WO2024042488A1 (en) | 2022-08-24 | 2024-02-29 | Enzyvant Therapeutics Gmbh | Thymic exosome assays, and methods of producing t cell depleted thymus tissue and uses thereof |
| WO2025068989A1 (en) | 2023-09-29 | 2025-04-03 | Enzyvant Therapeutics Gmbh | Device for cultivating and transporting biological tissue |
| JP7627920B1 (ja) | 2023-12-11 | 2025-02-07 | 浩 宮内 | 移植材料の評価方法 |
| CN118203653A (zh) * | 2024-02-06 | 2024-06-18 | 同济大学 | 一种利用胸腺疫苗降低或消除同种异体移植排斥的方法 |
| WO2025226936A1 (en) * | 2024-04-24 | 2025-10-30 | Revivicor, Inc. | Donor-specific tolerance-inducing regimens for xenotransplantation |
| WO2025240817A1 (en) * | 2024-05-17 | 2025-11-20 | The Trustees Of Columbia University In The City Of New York | Thymoliver and methods of constructing thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060147428A1 (en) | 1992-02-19 | 2006-07-06 | The General Hospital Corporation, A Massachusetts Corporation | Allogeneic and xenogeneic transplantation |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5624823A (en) | 1991-11-22 | 1997-04-29 | The General Hospital Corporation | DNA encoding procine interleukin-10 |
| EP0667792A1 (en) | 1991-11-22 | 1995-08-23 | The General Hospital Corporation | Specific tolerance in transplantation |
| ATE215375T1 (de) | 1992-01-08 | 2002-04-15 | Gen Hospital Corp | Induzierte toleranz gegen transplantate |
| US5658564A (en) | 1992-02-19 | 1997-08-19 | The General Hospital Corporation | Xenograft thymus |
| US5876708A (en) | 1992-02-19 | 1999-03-02 | The General Hospital Corporation | Allogeneic and xenogeneic transplantation |
| US5766944A (en) * | 1996-12-31 | 1998-06-16 | Ruiz; Margaret Eileen | T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments |
| AUPP977899A0 (en) | 1999-04-15 | 1999-05-13 | Monash University | Improvement of t cell mediated immunity |
| US20040096971A1 (en) * | 2000-12-22 | 2004-05-20 | Blackburn Catherine Clare | Thymic epithelial progenitor cells and uses thereof |
| US20040086508A1 (en) * | 2001-06-05 | 2004-05-06 | Advanced Biotherapy, Inc. | Treatment of organ transplant rejection |
| US7037900B2 (en) | 2001-10-12 | 2006-05-02 | Supergen, Inc. | Composition and method for treating graft-versus-host disease |
| US7402432B2 (en) * | 2003-12-12 | 2008-07-22 | The Brigham And Women's Hospital, Inc. | Process for producing T lymphocytes |
| CA2580271A1 (en) * | 2004-10-05 | 2006-04-20 | Genentech, Inc. | Method for treating vasculitis |
| WO2006107601A2 (en) * | 2005-04-06 | 2006-10-12 | Duke University | Parathyroid and thymus transplantation in digeorge syndrome subjects |
| EP1993573A2 (en) * | 2006-01-13 | 2008-11-26 | Renovar, Inc. | Systems and methods for monitoring immune responses and predicting outcomes in transplant recipients |
| US20080131441A1 (en) | 2006-09-26 | 2008-06-05 | Manikkam Suthanthiran | Methods of Using FOXP3 Levels to Predict the Outcome of Organs Undergoing Acute Rejection |
| US9176122B2 (en) | 2008-03-24 | 2015-11-03 | University Of South Florida | Biomarkers for predicting response to immunosuppressive therapy |
| JP2013511554A (ja) | 2009-11-23 | 2013-04-04 | パラティン テクノロジーズ,インコーポレイテッド | メラノコルチン−1受容体特異的線状ペプチド |
| JP2014503217A (ja) * | 2010-12-31 | 2014-02-13 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | マウスにおける自己t細胞の生成 |
| US8637038B2 (en) * | 2011-04-12 | 2014-01-28 | Rigel Pharmaceuticals, Inc. | Methods for inhibiting allograft rejection |
| WO2015056103A2 (en) * | 2013-10-15 | 2015-04-23 | Regeneron Pharmaceuticals, Inc. | High resolution allele identification |
| US12090142B2 (en) | 2018-02-22 | 2024-09-17 | Board Of Regents, The University Of Texas System | Combination therapy for the treatment of cancer |
| WO2020010067A1 (en) | 2018-07-06 | 2020-01-09 | Enzyvant Therapeutics, Inc. | Tissue potency determination through quantitative histomorphology analysis |
-
2019
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060147428A1 (en) | 1992-02-19 | 2006-07-06 | The General Hospital Corporation, A Massachusetts Corporation | Allogeneic and xenogeneic transplantation |
Non-Patent Citations (2)
| Title |
|---|
| 2001 Fiscal Year Final Research Report Summary, A Trial to Obtain a Donor-Specific Immunotorelance Using a Vascularized Thymus Allograft after Host Thymectomy andHost Lymphocyte Depletion(2003.09.17.)* |
| Bin Li et al., Thymic microenvironment reconstitution after postnatal human thymus transplantation, Clinical Immunology (2011) 140, 244-259* |
Also Published As
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| CA3089593A1 (en) | 2019-08-29 |
| AU2019225151B2 (en) | 2026-02-05 |
| AU2019225151A1 (en) | 2020-08-20 |
| JP2024041955A (ja) | 2024-03-27 |
| US20220079989A1 (en) | 2022-03-17 |
| BR112020016614A2 (pt) | 2020-12-22 |
| MX2020008590A (es) | 2020-09-21 |
| EP4545145A2 (en) | 2025-04-30 |
| WO2019165197A1 (en) | 2019-08-29 |
| US12064452B2 (en) | 2024-08-20 |
| CN112074277A (zh) | 2020-12-11 |
| JP2021516224A (ja) | 2021-07-01 |
| SG11202007498YA (en) | 2020-09-29 |
| EP4545145A3 (en) | 2025-07-02 |
| JP7499178B2 (ja) | 2024-06-13 |
| EP3755346B1 (en) | 2024-12-04 |
| US20250114402A1 (en) | 2025-04-10 |
| KR20210005543A (ko) | 2021-01-14 |
| KR20250071282A (ko) | 2025-05-21 |
| EP3755346A1 (en) | 2020-12-30 |
| EP3755346A4 (en) | 2022-03-09 |
| RU2020124312A (ru) | 2022-03-23 |
| IL276706A (en) | 2020-09-30 |
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