IL276706A - Transplantation of cultured thymus tissue promoting donor-specific resistance to allogeneic solid organ transplants - Google Patents

Transplantation of cultured thymus tissue promoting donor-specific resistance to allogeneic solid organ transplants

Info

Publication number
IL276706A
IL276706A IL276706A IL27670620A IL276706A IL 276706 A IL276706 A IL 276706A IL 276706 A IL276706 A IL 276706A IL 27670620 A IL27670620 A IL 27670620A IL 276706 A IL276706 A IL 276706A
Authority
IL
Israel
Prior art keywords
solid organ
organ transplants
tissue transplantation
specific tolerance
thymus tissue
Prior art date
Application number
IL276706A
Other languages
English (en)
Hebrew (he)
Original Assignee
Duke Univ & Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke Univ & Medical Center filed Critical Duke Univ & Medical Center
Publication of IL276706A publication Critical patent/IL276706A/en

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
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    • A01N1/162—Temperature processes, e.g. following predefined temperature changes over time
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/065—Thymocytes
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
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    • A61L2430/00—Materials or treatment for tissue regeneration
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    • A61L2430/00—Materials or treatment for tissue regeneration
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • G01N2800/24—Immunology or allergic disorders
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Transplantation (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
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  • Oral & Maxillofacial Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
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IL276706A 2018-02-23 2020-08-13 Transplantation of cultured thymus tissue promoting donor-specific resistance to allogeneic solid organ transplants IL276706A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862634377P 2018-02-23 2018-02-23
PCT/US2019/019137 WO2019165197A1 (en) 2018-02-23 2019-02-22 Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants

Publications (1)

Publication Number Publication Date
IL276706A true IL276706A (en) 2020-09-30

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ID=67687403

Family Applications (1)

Application Number Title Priority Date Filing Date
IL276706A IL276706A (en) 2018-02-23 2020-08-13 Transplantation of cultured thymus tissue promoting donor-specific resistance to allogeneic solid organ transplants

Country Status (12)

Country Link
US (2) US12064452B2 (https=)
EP (2) EP3755346B1 (https=)
JP (2) JP7499178B2 (https=)
KR (2) KR102805282B1 (https=)
CN (1) CN112074277A (https=)
AU (1) AU2019225151B2 (https=)
BR (1) BR112020016614A2 (https=)
CA (1) CA3089593A1 (https=)
IL (1) IL276706A (https=)
MX (1) MX2020008590A (https=)
SG (1) SG11202007498YA (https=)
WO (1) WO2019165197A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021034650A1 (en) 2019-08-19 2021-02-25 Duke University & Medical Center Methods of determining the suitability of cultured thymus tissue for implantation into humans and associated methods of use
CN115287262B (zh) * 2022-01-28 2024-04-02 浙江中医药大学 一种胸腺类器官微球及其制备方法与应用
WO2024042488A1 (en) 2022-08-24 2024-02-29 Enzyvant Therapeutics Gmbh Thymic exosome assays, and methods of producing t cell depleted thymus tissue and uses thereof
WO2025068989A1 (en) 2023-09-29 2025-04-03 Enzyvant Therapeutics Gmbh Device for cultivating and transporting biological tissue
JP7627920B1 (ja) 2023-12-11 2025-02-07 浩 宮内 移植材料の評価方法
CN118203653A (zh) * 2024-02-06 2024-06-18 同济大学 一种利用胸腺疫苗降低或消除同种异体移植排斥的方法
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