AU2018382530B2 - Anti-alpha-synuclein antibodies - Google Patents

Anti-alpha-synuclein antibodies Download PDF

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Publication number
AU2018382530B2
AU2018382530B2 AU2018382530A AU2018382530A AU2018382530B2 AU 2018382530 B2 AU2018382530 B2 AU 2018382530B2 AU 2018382530 A AU2018382530 A AU 2018382530A AU 2018382530 A AU2018382530 A AU 2018382530A AU 2018382530 B2 AU2018382530 B2 AU 2018382530B2
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seq
antibody
antigen
cdr
binding fragment
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AU2018382530A1 (en
Inventor
Ralph Adams
Terence Seward Baker
Lorenzo DE LICHTERVELDE
Patrick Downey
Daniel John Lightwood
David James MCMILLAN
Kerry Louise Tyson
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UCB Biopharma SRL
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UCB Biopharma SRL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Psychology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2018382530A 2017-12-15 2018-12-13 Anti-alpha-synuclein antibodies Active AU2018382530B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1720975.0 2017-12-15
GBGB1720975.0A GB201720975D0 (en) 2017-12-15 2017-12-15 Anti-alpha synuclein antibodies
PCT/EP2018/084697 WO2019115674A1 (en) 2017-12-15 2018-12-13 Anti-alpha-synuclein antibodies

Publications (2)

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AU2018382530A1 AU2018382530A1 (en) 2020-06-18
AU2018382530B2 true AU2018382530B2 (en) 2025-04-17

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US (2) US11261242B2 (enExample)
EP (1) EP3724224A1 (enExample)
JP (2) JP7292279B2 (enExample)
KR (1) KR102789446B1 (enExample)
CN (1) CN111479826B (enExample)
AR (1) AR115192A1 (enExample)
AU (1) AU2018382530B2 (enExample)
BR (1) BR112020010504A2 (enExample)
CA (1) CA3083199A1 (enExample)
CL (1) CL2020001605A1 (enExample)
EA (1) EA202091478A1 (enExample)
EC (1) ECSP20039623A (enExample)
GB (1) GB201720975D0 (enExample)
IL (1) IL275187A (enExample)
MA (1) MA51135A (enExample)
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PE (1) PE20201061A1 (enExample)
PH (1) PH12020551007A1 (enExample)
SG (1) SG11202004502SA (enExample)
TN (2) TN2020000069A1 (enExample)
TW (2) TWI801469B (enExample)
UA (1) UA126295C2 (enExample)
UY (1) UY38010A (enExample)
WO (1) WO2019115674A1 (enExample)
ZA (2) ZA202003542B (enExample)

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WO2021113464A1 (en) * 2019-12-04 2021-06-10 Friedman Simon Protein blocking assembly and methods of making and using
KR20240176098A (ko) * 2023-06-14 2024-12-24 경상국립대학교산학협력단 알파 시누클레인 에피토프를 유효성분으로 포함하는 파킨슨병의 예방 또는 치료용 조성물

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MY205948A (en) 2024-11-21
TW201930354A (zh) 2019-08-01
TW202332692A (zh) 2023-08-16
CA3083199A1 (en) 2019-06-20
ZA202003542B (en) 2022-12-21
AR115192A1 (es) 2020-12-09
CN111479826B (zh) 2024-10-29
JP2023127585A (ja) 2023-09-13
ZA202103456B (en) 2023-01-25
IL275187A (en) 2020-07-30
JP7627300B2 (ja) 2025-02-05
PE20201061A1 (es) 2020-10-16
BR112020010504A2 (pt) 2020-11-24
GB201720975D0 (en) 2018-01-31
WO2019115674A1 (en) 2019-06-20
CN111479826A (zh) 2020-07-31
MX2024013356A (es) 2024-12-06
TN2021000169A1 (en) 2023-04-04
UY38010A (es) 2019-07-31
MX2020005691A (es) 2020-08-20
US20220220192A1 (en) 2022-07-14
TN2020000069A1 (en) 2022-01-06
KR102789446B1 (ko) 2025-04-01
CL2020001605A1 (es) 2020-08-28
EP3724224A1 (en) 2020-10-21
RU2020123274A3 (enExample) 2022-01-17
AU2018382530A1 (en) 2020-06-18
US20210107971A1 (en) 2021-04-15
UA126295C2 (uk) 2022-09-14
TWI801469B (zh) 2023-05-11
US11261242B2 (en) 2022-03-01
JP2021509012A (ja) 2021-03-18
JP7292279B2 (ja) 2023-06-16
MA51135A (fr) 2021-03-24
RU2020123274A (ru) 2022-01-17
ECSP20039623A (es) 2020-08-31
KR20200099160A (ko) 2020-08-21
EA202091478A1 (ru) 2020-09-04
SG11202004502SA (en) 2020-06-29
PH12020551007A1 (en) 2021-08-16

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