AU2018341571A1 - Therapeutic methods relating to HSP90 inhibitors - Google Patents

Therapeutic methods relating to HSP90 inhibitors Download PDF

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Publication number
AU2018341571A1
AU2018341571A1 AU2018341571A AU2018341571A AU2018341571A1 AU 2018341571 A1 AU2018341571 A1 AU 2018341571A1 AU 2018341571 A AU2018341571 A AU 2018341571A AU 2018341571 A AU2018341571 A AU 2018341571A AU 2018341571 A1 AU2018341571 A1 AU 2018341571A1
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AU
Australia
Prior art keywords
mpc
inhibitor
flt3
cancer
aml
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Abandoned
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AU2018341571A
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English (en)
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AU2018341571A8 (en
Inventor
Neil BEEHARRY
Sophia GAYLE
Jeff Grotzke
Marylens HERNANDEZ
Sean LANDRETTE
Henri Lichenstein
Jonathan M. Rothberg
Peter R. Young
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OrphAI Therapeutics Inc
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AI Therapeutics Inc
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Publication of AU2018341571A1 publication Critical patent/AU2018341571A1/en
Publication of AU2018341571A8 publication Critical patent/AU2018341571A8/en
Abandoned legal-status Critical Current

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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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AU2018341571A 2017-09-27 2018-09-27 Therapeutic methods relating to HSP90 inhibitors Abandoned AU2018341571A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762563991P 2017-09-27 2017-09-27
US62/563,991 2017-09-27
US201762587886P 2017-11-17 2017-11-17
US62/587,886 2017-11-17
US201862688079P 2018-06-21 2018-06-21
US62/688,079 2018-06-21
PCT/US2018/053025 WO2019067666A1 (en) 2017-09-27 2018-09-27 THERAPEUTIC METHODS RELATING TO HSP90 INHIBITORS

Publications (2)

Publication Number Publication Date
AU2018341571A1 true AU2018341571A1 (en) 2020-04-23
AU2018341571A8 AU2018341571A8 (en) 2020-05-28

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AU2018341571A Abandoned AU2018341571A1 (en) 2017-09-27 2018-09-27 Therapeutic methods relating to HSP90 inhibitors

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US (2) US20190091229A1 (enExample)
EP (1) EP3687542A1 (enExample)
JP (1) JP2020535173A (enExample)
KR (1) KR20200077518A (enExample)
CN (1) CN111372588A (enExample)
AU (1) AU2018341571A1 (enExample)
BR (1) BR112020006009A2 (enExample)
CA (1) CA3076915A1 (enExample)
IL (1) IL273585A (enExample)
MX (1) MX2020003959A (enExample)
RU (1) RU2020114632A (enExample)
TW (1) TW201919634A (enExample)
WO (1) WO2019067666A1 (enExample)

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US11471451B2 (en) * 2019-08-19 2022-10-18 Arog Pharmaceuticals, Inc. Uses of crenolanib
US20220362254A1 (en) * 2019-08-22 2022-11-17 Thomas Jefferson University Methods for reprogramming cancer cells
CN114641292A (zh) * 2019-08-23 2022-06-17 光谱制药有限公司 波齐替尼与vegfr2抑制剂的组合及其用途
WO2021063340A1 (zh) * 2019-09-30 2021-04-08 江苏恒瑞医药股份有限公司 Ezh2抑制剂与免疫检查点抑制剂、酪氨酸激酶抑制剂联合在制备治疗肿瘤药物中的用途
WO2021133862A1 (en) * 2019-12-24 2021-07-01 The Regents Of The University Of California Targeting the intrinsic apoptotic machinery in glioblastoma
JP2023510426A (ja) * 2020-01-20 2023-03-13 アストラゼネカ・アクチエボラーグ 癌を治療するための上皮細胞増殖因子受容体チロシンキナーゼ阻害剤
EP4149512A4 (en) * 2020-05-12 2024-06-05 Board of Regents, The University of Texas System METHODS OF TREATMENT OF GLIOBLASTOMA
WO2022090547A1 (en) 2020-10-30 2022-05-05 Dsm Ip Assets B.V. Production of carotenoids by fermentation
US11969420B2 (en) * 2020-10-30 2024-04-30 Arog Pharmaceuticals, Inc. Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders
US20240197711A1 (en) * 2021-04-02 2024-06-20 The Regents Of The University Of Michigan Combination Therapy for Cancer Treatment
WO2023055885A2 (en) * 2021-09-29 2023-04-06 University Of Massachusetts Ezh2 inhibition in pancreatic cancer
AU2022426699A1 (en) 2021-12-30 2024-07-11 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of flt3
CN114796503B (zh) * 2022-05-05 2024-05-24 安徽省立医院(中国科学技术大学附属第一医院) Kdm6a抑制剂和酪氨酸激酶抑制剂联合在制备抗肿瘤的药物中的用途

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KR20200077518A (ko) 2020-06-30
US20190091229A1 (en) 2019-03-28
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CA3076915A1 (en) 2019-04-04
US20200253979A1 (en) 2020-08-13
RU2020114632A (ru) 2021-10-28
WO2019067666A1 (en) 2019-04-04
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