PT728218E - Sondas de hibridação para detecção de ácidos nucleicos, troncos universais, métodos e estojos - Google Patents
Sondas de hibridação para detecção de ácidos nucleicos, troncos universais, métodos e estojos Download PDFInfo
- Publication number
- PT728218E PT728218E PT95904104T PT95904104T PT728218E PT 728218 E PT728218 E PT 728218E PT 95904104 T PT95904104 T PT 95904104T PT 95904104 T PT95904104 T PT 95904104T PT 728218 E PT728218 E PT 728218E
- Authority
- PT
- Portugal
- Prior art keywords
- kits
- probes
- target
- nucleic acid
- probe
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15200693A | 1993-11-12 | 1993-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT728218E true PT728218E (pt) | 2008-04-08 |
Family
ID=22541183
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT07075511T PT1921169E (pt) | 1993-11-12 | 1994-11-14 | Sondas de hibridação para detecção de ácidos nucleicos, troncos universais, métodos e estojos |
PT95904104T PT728218E (pt) | 1993-11-12 | 1994-11-14 | Sondas de hibridação para detecção de ácidos nucleicos, troncos universais, métodos e estojos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT07075511T PT1921169E (pt) | 1993-11-12 | 1994-11-14 | Sondas de hibridação para detecção de ácidos nucleicos, troncos universais, métodos e estojos |
Country Status (10)
Country | Link |
---|---|
EP (3) | EP2423322A1 (pt) |
JP (1) | JP4071277B2 (pt) |
AT (2) | ATE382708T1 (pt) |
AU (1) | AU697841B2 (pt) |
CA (1) | CA2176348C (pt) |
DE (1) | DE69435060T2 (pt) |
DK (1) | DK1921169T3 (pt) |
ES (1) | ES2386007T3 (pt) |
PT (2) | PT1921169E (pt) |
WO (1) | WO1995013399A1 (pt) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7273749B1 (en) | 1990-06-04 | 2007-09-25 | University Of Utah Research Foundation | Container for carrying out and monitoring biological processes |
US7081226B1 (en) | 1996-06-04 | 2006-07-25 | University Of Utah Research Foundation | System and method for fluorescence monitoring |
US6576419B1 (en) | 1993-07-23 | 2003-06-10 | University Of Utah Research Foundation | Assay procedure using fluorogenic tracers |
US5925517A (en) * | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
AU693023B2 (en) | 1995-05-05 | 1998-06-18 | Applied Biosystems, Llc | Methods and reagents for combined PCR amplification and hybridization probing assay |
EP0892856B1 (en) * | 1996-03-01 | 2005-11-09 | E.I. Du Pont De Nemours And Company | A method for the amplification and detection of a nucleic acid fragment of interest |
EP0892808B1 (en) * | 1996-04-12 | 2008-05-14 | PHRI Properties, Inc. | Detection probes, kits and assays |
US5955268A (en) * | 1996-04-26 | 1999-09-21 | Abbott Laboratories | Method and reagent for detecting multiple nucleic acid sequences in a test sample |
ATE485397T1 (de) * | 1996-06-04 | 2010-11-15 | Univ Utah Res Found | Vorrichtung zur durchführung von pcr unter zeitnaher beobachtung der fluoreszenz |
CA2658290C (en) | 1996-06-04 | 2012-04-10 | University Of Utah Research Foundation | Monitoring hybridization during pcr using fluorescent dye specific to double-stranded dna |
US6117635A (en) * | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
GB9715522D0 (en) * | 1997-07-24 | 1997-10-01 | Zeneca Ltd | Assays |
US5935791A (en) * | 1997-09-23 | 1999-08-10 | Becton, Dickinson And Company | Detection of nucleic acids by fluorescence quenching |
US6485901B1 (en) | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
AU1366299A (en) | 1997-10-27 | 1999-05-17 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
GB9725237D0 (en) * | 1997-11-29 | 1998-01-28 | Secr Defence | Amplification system |
GB9804355D0 (en) * | 1998-03-03 | 1998-04-22 | Zeneca Ltd | Method |
DE19811731A1 (de) * | 1998-03-18 | 1999-09-23 | November Ag Molekulare Medizin | Verfahren zum Nachweis einer Nukleotidsequenz |
US6361942B1 (en) | 1998-03-24 | 2002-03-26 | Boston Probes, Inc. | Method, kits and compositions pertaining to detection complexes |
US6468743B1 (en) * | 1998-05-18 | 2002-10-22 | Conagra Grocery Products Company | PCR techniques for detecting microbial contaminants in foodstuffs |
GB9812768D0 (en) | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
ES2330812T3 (es) | 1998-07-02 | 2009-12-15 | Gen-Probe Incorporated | Antorchas moleculares. |
US6037130A (en) * | 1998-07-28 | 2000-03-14 | The Public Health Institute Of The City Of New York, Inc. | Wavelength-shifting probes and primers and their use in assays and kits |
CA2375060A1 (en) | 1999-05-24 | 2000-11-30 | Invitrogen Corporation | Method for deblocking of labeled oligonucleotides |
US6440706B1 (en) * | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
GB2359625B (en) | 1999-12-10 | 2004-10-20 | Molecular Light Tech Res Ltd | Monitoring oligonucleotide binding process using chemiluminescence quenching |
AU1817401A (en) * | 1999-12-14 | 2001-06-25 | Genovo, Incorporated | Methods and compositions for the manufacture of replication incompetent adenovirus |
US6346384B1 (en) * | 2000-03-27 | 2002-02-12 | Dade Behring Inc. | Real-time monitoring of PCR using LOCI |
US6936443B2 (en) | 2000-04-03 | 2005-08-30 | Cytyc Corporation | Detection and typing of human papillomavirus using PNA probes |
JP2003529376A (ja) | 2000-04-03 | 2003-10-07 | サイティック コーポレイション | Pnaプローブを使用するヒトパピローマウイルスの検出およびタイピング |
GB0016813D0 (en) | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (4) |
CN1348096A (zh) | 2000-10-10 | 2002-05-08 | 栾国彦 | 一种均相特异性检测核酸的探针及应用方法 |
AU2002213416A1 (en) * | 2000-10-24 | 2002-05-06 | Yuri Khripin | Detecting specific nucleotide sequences |
US20020102557A1 (en) * | 2001-01-31 | 2002-08-01 | Gentile-Davey Maria C. | Self -complementary molecular probe |
US20020142336A1 (en) * | 2001-02-02 | 2002-10-03 | Genome Therapeutics Corporation | Methods for determining a nucleotide at a specific location within a nucleic acid molecule |
EP1321520A4 (en) * | 2001-03-27 | 2003-09-03 | Nat Inst Of Advanced Ind Scien | NEW NUCLEIC ACID PROBE AND NEW METHOD FOR ANALYZING NUCLEIC ACIDS USING THE SAME |
US20030082547A1 (en) | 2001-08-27 | 2003-05-01 | Ewing Gregory J. | Non-fluorescent quencher compounds and biomolecular assays |
US6852491B2 (en) * | 2001-09-04 | 2005-02-08 | Abbott Laboratories | Amplification and detection reagents for HIV-1 |
EP2267155B2 (en) | 2002-01-07 | 2016-09-07 | Norchip A/S | Method for detecting human papillomavirus mRNA |
WO2003106714A1 (en) | 2002-06-14 | 2003-12-24 | Gen-Probe Incorporated | Compositions and methods for detecting hepatitis b virus |
EP1403382A3 (en) * | 2002-08-06 | 2004-05-06 | Roche Diagnostics GmbH | Improved fluorescent resonance energy transfer probes |
EP1431398A1 (en) | 2002-12-20 | 2004-06-23 | Evotec OAI AG | A method for detecting in a mixture an amount of analytes |
GB0317592D0 (en) | 2003-07-26 | 2003-08-27 | Astrazeneca Ab | Method |
CN103898207B (zh) * | 2003-08-01 | 2016-09-14 | 戴诺生物技术有限公司 | 自杂交多重靶核酸探针及其使用方法 |
US20050123975A1 (en) * | 2003-11-19 | 2005-06-09 | Applera Corporation | Methods for determining the degradation state or concentration of nucleic acids |
US8415298B2 (en) | 2004-06-21 | 2013-04-09 | The Board Of Trustees Of The Leland Stanford Junior University Of Stanford | Administration of FGF2 for treamtent of anxiety |
EP1816130A4 (en) * | 2004-11-08 | 2012-04-25 | Riken | NOVEL NUCLEOSIDE OR NUCLEOTIDE DERIVATIVE AND USE THEREOF |
TW200626729A (en) * | 2004-11-19 | 2006-08-01 | Wakunaga Pharma Co Ltd | Method for producing fermented beverage with beer taste exhibiting excellent brew flavor |
GB0510979D0 (en) * | 2005-05-28 | 2005-07-06 | Kbiosciences Ltd | Detection system for PCR assay |
CA2528222A1 (en) | 2005-10-31 | 2007-04-30 | Centre For Addiction And Mental Health | Slc1a1 marker for anxiety disorder |
DK2564864T3 (en) | 2005-11-12 | 2015-04-07 | Trustees Of The Leland Board Of | FGF-2 related methods for the diagnosis and treatment of depression |
US7759062B2 (en) | 2006-06-09 | 2010-07-20 | Third Wave Technologies, Inc. | T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection |
FR2906532B1 (fr) | 2006-09-28 | 2008-12-12 | Biomerieux Sa | Nouvel oligonucleotide marque |
EP1911852B1 (en) * | 2006-10-12 | 2009-07-29 | Bio-Rad Pasteur | Double-stranded probes for the fluorescent detection of nucleic acids |
EP2212437A4 (en) | 2007-11-07 | 2011-09-28 | Univ British Columbia | MICROFLUIDIC DEVICE AND METHOD OF USING THE DEVICE |
FR2933410B1 (fr) | 2008-07-04 | 2010-08-20 | Biomerieux Sa | Nouvelle sonde de detection |
DE102010012421B4 (de) | 2009-03-23 | 2023-04-20 | Vermicon Ag | Verfahren zum spezifischen Nachweis von Mikroorganismen |
WO2010112033A2 (en) | 2009-03-31 | 2010-10-07 | Østjysk Innovation A/S | Method for estimating the risk of having or developing multiple sclerosis using sequence polymorphisms in a specific region of chromosome x |
US8355927B2 (en) | 2010-11-05 | 2013-01-15 | Genomind, Llc | Neuropsychiatric test reports |
JP5334136B2 (ja) | 2009-09-09 | 2013-11-06 | 独立行政法人産業技術総合研究所 | 電気化学分子認識プローブ及びそれを用いた分子認識センサ並びにそれらを用いた電気化学的検出方法 |
JP6058529B2 (ja) | 2010-04-21 | 2017-01-11 | エリック ベルントルプ, | 血友病aにおけるインヒビターの発達と関連する遺伝因子 |
WO2012052758A1 (en) | 2010-10-22 | 2012-04-26 | Astrazeneca Ab | Response biomarkers for iap antagonists in human cancers |
JP5958034B2 (ja) | 2012-04-11 | 2016-07-27 | 富士レビオ株式会社 | 分子ビーコン型プローブを用いた標的核酸の検出方法 |
CN104995312A (zh) * | 2012-09-17 | 2015-10-21 | 布兰代斯大学 | 用于表征ssdna序列的dsdna结合染料和探针的组合 |
EP2722399A1 (en) | 2012-10-18 | 2014-04-23 | Roche Diagniostics GmbH | Method for preventing high molecular weight products during amplification |
US9816120B2 (en) * | 2013-01-09 | 2017-11-14 | The Penn State Research Foundation | Low sequence bias single-stranded DNA ligation |
MX2016000997A (es) | 2013-07-25 | 2016-04-19 | Dch Molecular Diagnostics Inc | Metodos y composiciones para detectar contaminacion bacteriana. |
WO2015054792A1 (en) | 2013-10-17 | 2015-04-23 | Centre For Addiction And Mental Health | Genetic markers for antipsychotic induced weight gain and methods for use thereof |
EP3096757B1 (en) | 2014-01-24 | 2020-10-21 | AI Therapeutics, Inc. | Apilimod compositions for treating non-hodgkin's b cell lymphoma |
JP6588919B2 (ja) | 2014-02-28 | 2019-10-09 | センター フォー アディクション アンド メンタル ヘルスCentre For Addiction And Mental Health | 抗精神病薬により誘導される体重増加の処置および予防のための組成物および方法 |
ES2741399T3 (es) | 2014-11-07 | 2020-02-10 | Ai Therapeutics Inc | Apilimod para el uso en el tratamiento de cáncer renal |
US9957393B2 (en) | 2015-03-30 | 2018-05-01 | Enzo Biochem, Inc. | Monoazo dyes with cyclic amine as fluorescence quenchers |
WO2018024562A1 (en) | 2016-08-02 | 2018-02-08 | Roche Diagnostics Gmbh | Helper oligonucleotide for improving efficiency of amplification and detection/quantitation of nucleic acids |
EP3687542A1 (en) | 2017-09-27 | 2020-08-05 | AI Therapeutics, Inc. | Therapeutic methods relating to hsp90 inhibitors |
AU2019309923A1 (en) * | 2018-07-24 | 2021-02-04 | The Regents Of The University Of Michigan | Intramolecular kinetic probes |
CN113614245B (zh) * | 2019-02-12 | 2024-08-27 | 10X基因组学有限公司 | 用于加工核酸分子的方法 |
GB201915346D0 (en) | 2019-06-21 | 2019-12-04 | Lumiradx Tech Ltd | Improvements in or relating to nicking enzymes |
WO2021051135A1 (en) | 2019-09-12 | 2021-03-18 | AI Therapeutics, Inc. | Pikfyve inhibitors for cancer therapy |
US20230212702A1 (en) * | 2020-06-04 | 2023-07-06 | Logicink Corporation | Multi-sensing of nucleic acid and small molecule markers |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1190838A (en) | 1981-07-17 | 1985-07-23 | Cavit Akin | Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer |
US4766062A (en) | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay method and polynucleotide complex reagent therefor |
US4822733A (en) | 1985-05-28 | 1989-04-18 | Amoco Corporation | Lifetime-resolved assay procedures |
CA1273552A (en) * | 1985-12-23 | 1990-09-04 | Michael J. Heller | Fluorescent stokes shift probes for polynucleotide hybridization assays |
EP0232967B1 (en) * | 1986-01-10 | 1993-04-28 | Amoco Corporation | Competitive homogeneous assay |
US4868103A (en) * | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
US5118801A (en) * | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
EP0428000A1 (en) * | 1989-11-03 | 1991-05-22 | Abbott Laboratories | Fluorogenic substrates for the detection of proteolytic enzyme activity |
WO1992014845A1 (en) * | 1991-02-26 | 1992-09-03 | Worcester Foundation For Experimental Biology | Diagnosing cystic fibrosis and other genetic diseases using fluorescence resonance energy transfer (fret) |
JP3085756B2 (ja) * | 1991-10-30 | 2000-09-11 | 株式会社日立製作所 | 核酸の検出方法 |
EP0601889A2 (en) * | 1992-12-10 | 1994-06-15 | Maine Medical Center Research Institute | Nucleic acid probes |
-
1994
- 1994-11-14 EP EP10184995A patent/EP2423322A1/en not_active Withdrawn
- 1994-11-14 EP EP95904104A patent/EP0728218B1/en not_active Expired - Lifetime
- 1994-11-14 AU AU12921/95A patent/AU697841B2/en not_active Expired
- 1994-11-14 PT PT07075511T patent/PT1921169E/pt unknown
- 1994-11-14 EP EP07075511A patent/EP1921169B1/en not_active Expired - Lifetime
- 1994-11-14 AT AT95904104T patent/ATE382708T1/de not_active IP Right Cessation
- 1994-11-14 CA CA002176348A patent/CA2176348C/en not_active Expired - Lifetime
- 1994-11-14 DK DK07075511.1T patent/DK1921169T3/da active
- 1994-11-14 WO PCT/US1994/013415 patent/WO1995013399A1/en active IP Right Grant
- 1994-11-14 AT AT07075511T patent/ATE545711T1/de active
- 1994-11-14 JP JP51407995A patent/JP4071277B2/ja not_active Expired - Lifetime
- 1994-11-14 ES ES07075511T patent/ES2386007T3/es not_active Expired - Lifetime
- 1994-11-14 PT PT95904104T patent/PT728218E/pt unknown
- 1994-11-14 DE DE69435060T patent/DE69435060T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0728218A4 (en) | 1998-06-17 |
EP2423322A1 (en) | 2012-02-29 |
WO1995013399A1 (en) | 1995-05-18 |
DE69435060T2 (de) | 2009-01-02 |
AU1292195A (en) | 1995-05-29 |
ES2386007T3 (es) | 2012-08-07 |
EP1921169B1 (en) | 2012-02-15 |
JPH09504950A (ja) | 1997-05-20 |
CA2176348C (en) | 2004-11-02 |
DK1921169T3 (da) | 2012-06-04 |
EP0728218A1 (en) | 1996-08-28 |
JP4071277B2 (ja) | 2008-04-02 |
AU697841B2 (en) | 1998-10-15 |
ATE382708T1 (de) | 2008-01-15 |
EP1921169A1 (en) | 2008-05-14 |
CA2176348A1 (en) | 1995-05-18 |
ATE545711T1 (de) | 2012-03-15 |
EP0728218B1 (en) | 2008-01-02 |
DE69435060D1 (de) | 2008-02-14 |
PT1921169E (pt) | 2012-05-23 |
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