MX2020003959A - Metodos terapeuticos relacionados con los inhibidores de hsp90. - Google Patents

Metodos terapeuticos relacionados con los inhibidores de hsp90.

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Publication number
MX2020003959A
MX2020003959A MX2020003959A MX2020003959A MX2020003959A MX 2020003959 A MX2020003959 A MX 2020003959A MX 2020003959 A MX2020003959 A MX 2020003959A MX 2020003959 A MX2020003959 A MX 2020003959A MX 2020003959 A MX2020003959 A MX 2020003959A
Authority
MX
Mexico
Prior art keywords
inhibitors
therapeutic methods
methods relating
hsp90 inhibitors
limited
Prior art date
Application number
MX2020003959A
Other languages
English (en)
Spanish (es)
Inventor
Henri Lichenstein
Sophia Gayle
Sean Landrette
Jonathan M Rothberg
Marylens Hernandez
Neil Beeharry
Jeff Grotzke
Peter R Young
Original Assignee
Ai Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ai Therapeutics Inc filed Critical Ai Therapeutics Inc
Publication of MX2020003959A publication Critical patent/MX2020003959A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A—HUMAN NECESSITIES
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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MX2020003959A 2017-09-27 2018-09-27 Metodos terapeuticos relacionados con los inhibidores de hsp90. MX2020003959A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762563991P 2017-09-27 2017-09-27
US201762587886P 2017-11-17 2017-11-17
US201862688079P 2018-06-21 2018-06-21
PCT/US2018/053025 WO2019067666A1 (en) 2017-09-27 2018-09-27 THERAPEUTIC METHODS RELATING TO HSP90 INHIBITORS

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MX2020003959A true MX2020003959A (es) 2020-08-03

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US (2) US20190091229A1 (enExample)
EP (1) EP3687542A1 (enExample)
JP (1) JP2020535173A (enExample)
KR (1) KR20200077518A (enExample)
CN (1) CN111372588A (enExample)
AU (1) AU2018341571A1 (enExample)
BR (1) BR112020006009A2 (enExample)
CA (1) CA3076915A1 (enExample)
IL (1) IL273585A (enExample)
MX (1) MX2020003959A (enExample)
RU (1) RU2020114632A (enExample)
TW (1) TW201919634A (enExample)
WO (1) WO2019067666A1 (enExample)

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JP2020505433A (ja) 2017-02-03 2020-02-20 エイアイ・セラピューティクス・インコーポレーテッド Ｈｓｐ９０阻害剤を使用してがんを治療するための方法
WO2020176686A1 (en) * 2019-02-26 2020-09-03 Oregon Health & Science University Methods of treating venetoclax-resistant acute myeloid leukemia
MX2021011948A (es) * 2019-03-29 2022-01-04 Univ Texas Compuestos con actividad antitumoral contra células cancerígenas que llevan inserciones de exon 20 effr o her2.
EP3771469A1 (en) * 2019-07-30 2021-02-03 Amgen, Inc Formulations and dosages for administering a compound that inhibits mcl1 protein
US11471451B2 (en) * 2019-08-19 2022-10-18 Arog Pharmaceuticals, Inc. Uses of crenolanib
WO2021035168A1 (en) * 2019-08-22 2021-02-25 Thomas Jefferson University Methods for reprogramming cancer cells
CN114641292A (zh) * 2019-08-23 2022-06-17 光谱制药有限公司 波齐替尼与vegfr2抑制剂的组合及其用途
TW202126302A (zh) * 2019-09-30 2021-07-16 大陸商江蘇恆瑞醫藥股份有限公司 Ｅｚｈ２抑制劑與免疫檢查點抑制劑、酪胺酸激酶抑制劑聯合在製備治療腫瘤藥物中的用途
US20230040125A1 (en) * 2019-12-24 2023-02-09 The Regents Of The University Of California Targeting the intrinsic apoptotic machinery in glioblastoma
WO2021148396A1 (en) * 2020-01-20 2021-07-29 Astrazeneca Ab Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
JP2023526228A (ja) * 2020-05-12 2023-06-21 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 膠芽腫を処置するための方法
WO2022090547A1 (en) 2020-10-30 2022-05-05 Dsm Ip Assets B.V. Production of carotenoids by fermentation
US11969420B2 (en) 2020-10-30 2024-04-30 Arog Pharmaceuticals, Inc. Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders
EP4313029A4 (en) * 2021-04-02 2024-12-11 The Regents of The University of Michigan COMBINATION THERAPY FOR CANCER TREATMENT
US20240390379A1 (en) * 2021-09-29 2024-11-28 University Of Massachusetts EZH2 Inhibition in Pancreatic Cancer
PE20242008A1 (es) 2021-12-30 2024-10-03 Biomea Fusion Inc Compuestos de pirazina como inhibidores de flt3
CN114796503B (zh) * 2022-05-05 2024-05-24 安徽省立医院(中国科学技术大学附属第一医院) Kdm6a抑制剂和酪氨酸激酶抑制剂联合在制备抗肿瘤的药物中的用途

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