AU2018311966A1 - Benzo[b]thiophene sting agonists for cancer treatment - Google Patents

Benzo[b]thiophene sting agonists for cancer treatment Download PDF

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Publication number
AU2018311966A1
AU2018311966A1 AU2018311966A AU2018311966A AU2018311966A1 AU 2018311966 A1 AU2018311966 A1 AU 2018311966A1 AU 2018311966 A AU2018311966 A AU 2018311966A AU 2018311966 A AU2018311966 A AU 2018311966A AU 2018311966 A1 AU2018311966 A1 AU 2018311966A1
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AU
Australia
Prior art keywords
group
alkyl
benzo
cancer
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2018311966A
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English (en)
Inventor
Saso CEMERSKI
Jared N CUMMING
Johnny E. Kopinja
Samanthi A. Perera
Benjamin Wesley TROTTER
Archie Ngai-Chiu TSE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of AU2018311966A1 publication Critical patent/AU2018311966A1/en
Assigned to MERCK SHARP & DOHME LLC reassignment MERCK SHARP & DOHME LLC Amend patent request/document other than specification (104) Assignors: MERCK SHARP & DOHME CORP.
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2018311966A 2017-08-04 2018-07-30 Benzo[b]thiophene sting agonists for cancer treatment Abandoned AU2018311966A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762541174P 2017-08-04 2017-08-04
US62/541,174 2017-08-04
PCT/US2018/044276 WO2019027858A1 (en) 2017-08-04 2018-07-30 BENZO [B] STING THIOPHEN AGONISTS FOR THE TREATMENT OF CANCER

Publications (1)

Publication Number Publication Date
AU2018311966A1 true AU2018311966A1 (en) 2020-02-13

Family

ID=65234123

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018311966A Abandoned AU2018311966A1 (en) 2017-08-04 2018-07-30 Benzo[b]thiophene sting agonists for cancer treatment

Country Status (7)

Country Link
US (1) US11285131B2 (enExample)
EP (1) EP3661498A4 (enExample)
JP (1) JP2020530838A (enExample)
AU (1) AU2018311966A1 (enExample)
CA (1) CA3071538A1 (enExample)
MA (1) MA49772A (enExample)
WO (1) WO2019027858A1 (enExample)

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Also Published As

Publication number Publication date
MA49772A (fr) 2021-04-21
JP2020530838A (ja) 2020-10-29
US11285131B2 (en) 2022-03-29
RU2020109330A (ru) 2021-09-06
EP3661498A1 (en) 2020-06-10
WO2019027858A1 (en) 2019-02-07
RU2020109330A3 (enExample) 2021-09-29
US20200330427A1 (en) 2020-10-22
CA3071538A1 (en) 2019-02-07
EP3661498A4 (en) 2021-04-21

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