AU2018250206A1 - Compositions and methods for treating parkinson's disease (PD) and related disorders - Google Patents

Info

Publication number

AU2018250206A1

AU2018250206A1 AU2018250206A AU2018250206A AU2018250206A1 AU 2018250206 A1 AU2018250206 A1 AU 2018250206A1 AU 2018250206 A AU2018250206 A AU 2018250206A AU 2018250206 A AU2018250206 A AU 2018250206A AU 2018250206 A1 AU2018250206 A1 AU 2018250206A1

Authority

AU

Australia

Prior art keywords

fecal

therapeutic composition

administered

dose

patient

Prior art date

2017-04-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 title claims abstract description 179
• 239000000203 mixture Substances 0.000 title claims abstract description 179
• 208000018737 Parkinson disease Diseases 0.000 title claims abstract description 127
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract description 30
• 230000002550 fecal effect Effects 0.000 claims abstract description 202
• 239000000706 filtrate Substances 0.000 claims abstract description 34
• 230000001717 pathogenic effect Effects 0.000 claims abstract description 30
• 230000001225 therapeutic effect Effects 0.000 claims description 141
• 241000736262 Microbiota Species 0.000 claims description 95
• 241000894006 Bacteria Species 0.000 claims description 55
• 239000002775 capsule Substances 0.000 claims description 49
• 230000033001 locomotion Effects 0.000 claims description 48
• 208000024891 symptom Diseases 0.000 claims description 45
• 230000003442 weekly effect Effects 0.000 claims description 38
• 239000000463 material Substances 0.000 claims description 34
• 230000001771 impaired effect Effects 0.000 claims description 28
• 230000001413 cellular effect Effects 0.000 claims description 27
• 206010044565 Tremor Diseases 0.000 claims description 25
• 241000282414 Homo sapiens Species 0.000 claims description 22
• 230000003115 biocidal effect Effects 0.000 claims description 22
• 239000002253 acid Substances 0.000 claims description 21
• 239000003242 anti bacterial agent Substances 0.000 claims description 19
• 239000007788 liquid Substances 0.000 claims description 18
• 238000012423 maintenance Methods 0.000 claims description 16
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
• 208000006083 Hypokinesia Diseases 0.000 claims description 13
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 12
• 239000000843 powder Substances 0.000 claims description 12
• 206010006100 Bradykinesia Diseases 0.000 claims description 10
• 210000003205 muscle Anatomy 0.000 claims description 8
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 7
• 230000003111 delayed effect Effects 0.000 claims description 7
• 239000008101 lactose Substances 0.000 claims description 7
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
• 239000002202 Polyethylene glycol Substances 0.000 claims description 6
• 239000002577 cryoprotective agent Substances 0.000 claims description 6
• 229920001223 polyethylene glycol Polymers 0.000 claims description 6
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 5
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 5
• 239000000600 sorbitol Substances 0.000 claims description 5
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
• 229930006000 Sucrose Natural products 0.000 claims description 4
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
• 239000005720 sucrose Substances 0.000 claims description 4
• HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 3
• HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 claims description 3
• HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims description 3
• 239000004386 Erythritol Substances 0.000 claims description 3
• UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 3
• 239000005715 Fructose Substances 0.000 claims description 3
• 229930091371 Fructose Natural products 0.000 claims description 3
• 239000004471 Glycine Substances 0.000 claims description 3
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 3
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 3
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 3
• PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims description 3
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 3
• 235000004279 alanine Nutrition 0.000 claims description 3
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 3
• HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims description 3
• UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 3
• 235000019414 erythritol Nutrition 0.000 claims description 3
• 229940009714 erythritol Drugs 0.000 claims description 3
• 239000008103 glucose Substances 0.000 claims description 3
• HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
• 235000020183 skimmed milk Nutrition 0.000 claims description 3
• 238000011282 treatment Methods 0.000 abstract description 79
• 201000010099 disease Diseases 0.000 abstract description 18
• 239000008194 pharmaceutical composition Substances 0.000 abstract description 8
• 241000124008 Mammalia Species 0.000 abstract description 2
• 244000005700 microbiome Species 0.000 description 37
• 210000004027 cell Anatomy 0.000 description 35
• 238000002560 therapeutic procedure Methods 0.000 description 31
• 241000192031 Ruminococcus Species 0.000 description 23
• 241000606124 Bacteroides fragilis Species 0.000 description 20
• 230000009467 reduction Effects 0.000 description 19
• 241000606125 Bacteroides Species 0.000 description 18
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 18
• 230000000694 effects Effects 0.000 description 18
• 241000193403 Clostridium Species 0.000 description 17
• 230000001580 bacterial effect Effects 0.000 description 16
• 241001464948 Coprococcus Species 0.000 description 15
• 241000186394 Eubacterium Species 0.000 description 15
• 210000004215 spore Anatomy 0.000 description 15
• 241001531188 [Eubacterium] rectale Species 0.000 description 14
• 239000003094 microcapsule Substances 0.000 description 14
• 239000000047 product Substances 0.000 description 14
• 239000003826 tablet Substances 0.000 description 14
• 239000004480 active ingredient Substances 0.000 description 13
• 238000002360 preparation method Methods 0.000 description 13
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
• 238000001802 infusion Methods 0.000 description 12
• 241001143779 Dorea Species 0.000 description 11
• 208000035475 disorder Diseases 0.000 description 11
• 238000001914 filtration Methods 0.000 description 11
• 235000013305 food Nutrition 0.000 description 11
• 241001464956 Collinsella Species 0.000 description 10
• 206010010774 Constipation Diseases 0.000 description 10
• 241000792859 Enema Species 0.000 description 10
• 241000588724 Escherichia coli Species 0.000 description 10
• WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 10
• WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 10
• 230000006735 deficit Effects 0.000 description 10
• 239000003814 drug Substances 0.000 description 10
• 229940079593 drug Drugs 0.000 description 10
• 239000007920 enema Substances 0.000 description 10
• 229940095399 enema Drugs 0.000 description 10
• 229960004502 levodopa Drugs 0.000 description 10
• -1 oligofructoses Polymers 0.000 description 10
• 239000006187 pill Substances 0.000 description 10
• 241001185600 Gemmiger Species 0.000 description 9
• 241000186660 Lactobacillus Species 0.000 description 9
• 241000191992 Peptostreptococcus Species 0.000 description 9
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
• 229940088710 antibiotic agent Drugs 0.000 description 9
• 229960003638 dopamine Drugs 0.000 description 9
• 210000001035 gastrointestinal tract Anatomy 0.000 description 9
• 230000006698 induction Effects 0.000 description 9
• 229940039696 lactobacillus Drugs 0.000 description 9
• 241001464894 Blautia producta Species 0.000 description 8
• 241001262170 Collinsella aerofaciens Species 0.000 description 8
• 241000186588 Erysipelatoclostridium ramosum Species 0.000 description 8
• 241001531192 Eubacterium ventriosum Species 0.000 description 8
• 241000605956 Fusobacterium mortiferum Species 0.000 description 8
• 241000206591 Peptococcus Species 0.000 description 8
• 230000009471 action Effects 0.000 description 8
• 230000000648 anti-parkinson Effects 0.000 description 8
• 239000000939 antiparkinson agent Substances 0.000 description 8
• 244000052769 pathogen Species 0.000 description 8
• 229940023488 pill Drugs 0.000 description 8
• 241000894007 species Species 0.000 description 8
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 8
• 239000000725 suspension Substances 0.000 description 8
• 108010062877 Bacteriocins Proteins 0.000 description 7
• 229920002472 Starch Polymers 0.000 description 7
• 108010059993 Vancomycin Proteins 0.000 description 7
• 241000700605 Viruses Species 0.000 description 7
• 210000004556 brain Anatomy 0.000 description 7
• 150000001875 compounds Chemical class 0.000 description 7
• 210000003608 fece Anatomy 0.000 description 7
• 108090000623 proteins and genes Proteins 0.000 description 7
• 235000002639 sodium chloride Nutrition 0.000 description 7
• 239000008107 starch Substances 0.000 description 7
• 235000019698 starch Nutrition 0.000 description 7
• 229960003165 vancomycin Drugs 0.000 description 7
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 7
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 7
• 241000220677 Coprococcus catus Species 0.000 description 6
• 241000949098 Coprococcus comes Species 0.000 description 6
• 208000004547 Hallucinations Diseases 0.000 description 6
• 241000186561 [Clostridium] clostridioforme Species 0.000 description 6
• 241001531273 [Eubacterium] eligens Species 0.000 description 6
• 241001531197 [Eubacterium] hallii Species 0.000 description 6
• 241001464870 [Ruminococcus] torques Species 0.000 description 6
• DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 6
• 229960003805 amantadine Drugs 0.000 description 6
• 239000012620 biological material Substances 0.000 description 6
• 235000013365 dairy product Nutrition 0.000 description 6
• 239000003085 diluting agent Substances 0.000 description 6
• 239000012634 fragment Substances 0.000 description 6
• 238000011221 initial treatment Methods 0.000 description 6
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
• 239000000546 pharmaceutical excipient Substances 0.000 description 6
• 230000001144 postural effect Effects 0.000 description 6
• 235000018102 proteins Nutrition 0.000 description 6
• 102000004169 proteins and genes Human genes 0.000 description 6
• 229940032147 starch Drugs 0.000 description 6
• 239000000126 substance Substances 0.000 description 6
• 206010000060 Abdominal distension Diseases 0.000 description 5
• 241000186000 Bifidobacterium Species 0.000 description 5
• 241000605909 Fusobacterium Species 0.000 description 5
• 206010052904 Musculoskeletal stiffness Diseases 0.000 description 5
• 241000186429 Propionibacterium Species 0.000 description 5
• 230000004913 activation Effects 0.000 description 5
• 239000002671 adjuvant Substances 0.000 description 5
• 230000003110 anti-inflammatory effect Effects 0.000 description 5
• 210000004666 bacterial spore Anatomy 0.000 description 5
• 208000024330 bloating Diseases 0.000 description 5
• 239000003599 detergent Substances 0.000 description 5
• 239000002552 dosage form Substances 0.000 description 5
• 210000003527 eukaryotic cell Anatomy 0.000 description 5
• 238000007710 freezing Methods 0.000 description 5
• 230000008014 freezing Effects 0.000 description 5
• 230000005021 gait Effects 0.000 description 5
• 230000006872 improvement Effects 0.000 description 5
• 208000015181 infectious disease Diseases 0.000 description 5
• 229940100691 oral capsule Drugs 0.000 description 5
• 230000004044 response Effects 0.000 description 5
• 239000011780 sodium chloride Substances 0.000 description 5
• 238000000527 sonication Methods 0.000 description 5
• 235000000346 sugar Nutrition 0.000 description 5
• 238000012360 testing method Methods 0.000 description 5
• IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 4
• 241000604450 Acidaminococcus fermentans Species 0.000 description 4
• WZPBZJONDBGPKJ-UHFFFAOYSA-N Antibiotic SQ 26917 Natural products O=C1N(S(O)(=O)=O)C(C)C1NC(=O)C(=NOC(C)(C)C(O)=O)C1=CSC(N)=N1 WZPBZJONDBGPKJ-UHFFFAOYSA-N 0.000 description 4
• 241000193830 Bacillus <bacterium> Species 0.000 description 4
• 108700016166 Bacillus subtilis sboA Proteins 0.000 description 4
• 241001135322 Bacteroides eggerthii Species 0.000 description 4
• 241000186018 Bifidobacterium adolescentis Species 0.000 description 4
• 241001608472 Bifidobacterium longum Species 0.000 description 4
• 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 description 4
• 241000123777 Blautia obeum Species 0.000 description 4
• 241000193174 Butyrivibrio crossotus Species 0.000 description 4
• JSWKNDSDVHJUKY-MNVIWFPGSA-N CC[C@@H](C)[C@@H]1NC(=O)[C@@H]2CS[C@@H](C)[C@@H](NC(=O)[C@@H]3CS[C@@H](C)[C@@H](NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H]4NC(=O)[C@@H]([NH3+])CS[C@H]4C)C(=O)N[C@@H](CC(C)C)C(=O)N4CCC[C@H]4C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N3)C(=O)N[C@@H](CC(C)C)C(=O)NC([C@H](C)S\C=C/NC1=O)C(=O)NC(=C)C(=O)N[C@@H](CCC([O-])=O)C(=O)N2 Chemical compound CC[C@@H](C)[C@@H]1NC(=O)[C@@H]2CS[C@@H](C)[C@@H](NC(=O)[C@@H]3CS[C@@H](C)[C@@H](NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H]4NC(=O)[C@@H]([NH3+])CS[C@H]4C)C(=O)N[C@@H](CC(C)C)C(=O)N4CCC[C@H]4C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N3)C(=O)N[C@@H](CC(C)C)C(=O)NC([C@H](C)S\C=C/NC1=O)C(=O)NC(=C)C(=O)N[C@@H](CCC([O-])=O)C(=O)N2 JSWKNDSDVHJUKY-MNVIWFPGSA-N 0.000 description 4
• 241001147706 Clostridium sardiniense Species 0.000 description 4
• 108010073254 Colicins Proteins 0.000 description 4
• 241001464949 Coprococcus eutactus Species 0.000 description 4
• 241000186427 Cutibacterium acnes Species 0.000 description 4
• 206010012239 Delusion Diseases 0.000 description 4
• 241001531200 Dorea formicigenerans Species 0.000 description 4
• 206010013642 Drooling Diseases 0.000 description 4
• GDSYPXWUHMRTHT-UHFFFAOYSA-N Epidermin Natural products N#CCC(C)(C)OC1OC(CO)C(O)C(O)C1O GDSYPXWUHMRTHT-UHFFFAOYSA-N 0.000 description 4
• 241000186398 Eubacterium limosum Species 0.000 description 4
• 241001531190 Eubacterium ramulus Species 0.000 description 4
• 241000143590 Eubacterium ruminantium Species 0.000 description 4
• 241000605980 Faecalibacterium prausnitzii Species 0.000 description 4
• 241001531275 Faecalitalea cylindroides Species 0.000 description 4
• 241001617393 Finegoldia Species 0.000 description 4
• 241001303074 Fusobacterium naviforme Species 0.000 description 4
• 241000605986 Fusobacterium nucleatum Species 0.000 description 4
• 241000605978 Fusobacterium russii Species 0.000 description 4
• 241001147749 Gemella morbillorum Species 0.000 description 4
• 241001223495 Gemmiger formicilis Species 0.000 description 4
• 229940122957 Histamine H2 receptor antagonist Drugs 0.000 description 4
• 241000186399 Holdemanella biformis Species 0.000 description 4
• 241001134654 Lactobacillus leichmannii Species 0.000 description 4
• 241001363490 Monilia Species 0.000 description 4
• 208000002740 Muscle Rigidity Diseases 0.000 description 4
• 229930193140 Neomycin Natural products 0.000 description 4
• NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 description 4
• 108010053775 Nisin Proteins 0.000 description 4
• 241001135232 Odoribacter splanchnicus Species 0.000 description 4
• 241000604373 Ovatus Species 0.000 description 4
• 208000002193 Pain Diseases 0.000 description 4
• 241000606210 Parabacteroides distasonis Species 0.000 description 4
• UOZODPSAJZTQNH-UHFFFAOYSA-N Paromomycin II Natural products NC1C(O)C(O)C(CN)OC1OC1C(O)C(OC2C(C(N)CC(N)C2O)OC2C(C(O)C(O)C(CO)O2)N)OC1CO UOZODPSAJZTQNH-UHFFFAOYSA-N 0.000 description 4
• 241001135261 Prevotella oralis Species 0.000 description 4
• 241001528479 Pseudoflavonifractor capillosus Species 0.000 description 4
• 241000192029 Ruminococcus albus Species 0.000 description 4
• 241000123753 Ruminococcus bromii Species 0.000 description 4
• 241000123754 Ruminococcus callidus Species 0.000 description 4
• 241000192026 Ruminococcus flavefaciens Species 0.000 description 4
• 241000202356 Ruminococcus lactaris Species 0.000 description 4
• 208000008630 Sialorrhea Diseases 0.000 description 4
• 241000191963 Staphylococcus epidermidis Species 0.000 description 4
• 241000194046 Streptococcus intermedius Species 0.000 description 4
• 241001648295 Succinivibrio Species 0.000 description 4
• ZWBTYMGEBZUQTK-PVLSIAFMSA-N [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,32-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23-dioxospiro[8,33-dioxa-24,27,29-triazapentacyclo[23.6.1.14,7.05,31.026,30]tritriaconta-1(32),2,4,9,19,21,24,26,30-nonaene-28,4'-piperidine]-13-yl] acetate Chemical compound CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c4NC5(CCN(CC(C)C)CC5)N=c4c(=NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C ZWBTYMGEBZUQTK-PVLSIAFMSA-N 0.000 description 4
• 241000204291 [Bacteroides] coagulans Species 0.000 description 4
• 241000193462 [Clostridium] innocuum Species 0.000 description 4
• 241000186569 [Clostridium] leptum Species 0.000 description 4
• 241001531189 [Eubacterium] siraeum Species 0.000 description 4
• 241000186397 [Eubacterium] tenue Species 0.000 description 4
• 230000002159 abnormal effect Effects 0.000 description 4
• 235000001014 amino acid Nutrition 0.000 description 4
• 150000001413 amino acids Chemical class 0.000 description 4
• 229960003644 aztreonam Drugs 0.000 description 4
• WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 description 4
• 229960001081 benzatropine Drugs 0.000 description 4
• GIJXKZJWITVLHI-PMOLBWCYSA-N benzatropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(C=1C=CC=CC=1)C1=CC=CC=C1 GIJXKZJWITVLHI-PMOLBWCYSA-N 0.000 description 4
• 229940004120 bifidobacterium infantis Drugs 0.000 description 4
• 229940009291 bifidobacterium longum Drugs 0.000 description 4
• 229960002802 bromocriptine Drugs 0.000 description 4
• OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 description 4
• 238000005119 centrifugation Methods 0.000 description 4
• 230000008859 change Effects 0.000 description 4
• RKLXDNHNLPUQRB-TVJUEJKUSA-N chembl564271 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]2C(C)SC[C@H](N[C@@H](CC(N)=O)C(=O)NC(=O)[C@@H](NC2=O)CSC1C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NC(=C)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@H]1NC(=O)C(=C\C)/NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H]3N[C@@H](CC(C)C)C(=O)NC(=O)C(=C)NC(=O)CC[C@H](NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=4C5=CC=CC=C5NC=4)CSC3)C(O)=O)C(C)SC2)C(C)C)C(C)SC1)C1=CC=CC=C1 RKLXDNHNLPUQRB-TVJUEJKUSA-N 0.000 description 4
• 239000003795 chemical substances by application Substances 0.000 description 4
• 238000004587 chromatography analysis Methods 0.000 description 4
• 108010063293 cinnamycin Proteins 0.000 description 4
• QJDWKBINWOWJNZ-OURZNGJWSA-N cinnamycin Chemical compound CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H]3CCCN3C(=O)CNC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H]3CNCCCC[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CSC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CS[C@H]4C)C(=O)N[C@@H](CS[C@H]2C)C(=O)N3)NC1=O)[C@@H](O)C(O)=O)C(O)=O QJDWKBINWOWJNZ-OURZNGJWSA-N 0.000 description 4
• 229960002626 clarithromycin Drugs 0.000 description 4
• AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 description 4
• 230000007423 decrease Effects 0.000 description 4
• 230000003247 decreasing effect Effects 0.000 description 4
• 231100000868 delusion Toxicity 0.000 description 4
• 239000003136 dopamine receptor stimulating agent Substances 0.000 description 4
• 239000003937 drug carrier Substances 0.000 description 4
• JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 description 4
• 229960003337 entacapone Drugs 0.000 description 4
• 108010064962 epidermin Proteins 0.000 description 4
• CXTXHTVXPMOOSW-JUEJINBGSA-N epidermin Chemical compound C([C@H]1C(=O)N[C@H](C(=O)N[C@@H](CSC[C@H](C(N[C@@H](CCCCN)C(=O)N1)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@H]1C(N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](CS[C@H]1C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N\C(=C/C)C(=O)NCC(=O)N[C@H]1C(N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@H](C(N\C=C/SC2)=O)CSC1)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 CXTXHTVXPMOOSW-JUEJINBGSA-N 0.000 description 4
• 230000008921 facial expression Effects 0.000 description 4
• 235000013373 food additive Nutrition 0.000 description 4
• 239000002778 food additive Substances 0.000 description 4
• 238000009472 formulation Methods 0.000 description 4
• 108010070411 gardimycin Proteins 0.000 description 4
• LAWKVNVCUPIOMG-HWWYPGLISA-N gardimycin Chemical compound C1=CC=C2C(C[C@H](C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C)C(=O)NCC(=O)N[C@H](CC)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(O)=O)C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](CC)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)N)[C@@H](C)CC)C(C)C)=CNC2=C1 LAWKVNVCUPIOMG-HWWYPGLISA-N 0.000 description 4
• 230000002496 gastric effect Effects 0.000 description 4
• 238000010438 heat treatment Methods 0.000 description 4
• 239000004615 ingredient Substances 0.000 description 4
• 239000003112 inhibitor Substances 0.000 description 4
• 229910052500 inorganic mineral Inorganic materials 0.000 description 4
• 235000015110 jellies Nutrition 0.000 description 4
• 239000008274 jelly Substances 0.000 description 4
• 108010067215 mersacidin Proteins 0.000 description 4
• 229960000282 metronidazole Drugs 0.000 description 4
• VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 4
• 108010079904 microcin Proteins 0.000 description 4
• 239000011707 mineral Chemical class 0.000 description 4
• 235000010755 mineral Nutrition 0.000 description 4
• SUJOIPVTNUVDCB-UHFFFAOYSA-N mutactin Natural products CC1=CC(O)=C2C(=O)CC(O)CC2=C1C1=CC(O)=CC(=O)O1 SUJOIPVTNUVDCB-UHFFFAOYSA-N 0.000 description 4
• 229960004927 neomycin Drugs 0.000 description 4
• 229960000808 netilmicin Drugs 0.000 description 4
• ZBGPYVZLYBDXKO-HILBYHGXSA-N netilmycin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@]([C@H](NC)[C@@H](O)CO1)(C)O)NCC)[C@H]1OC(CN)=CC[C@H]1N ZBGPYVZLYBDXKO-HILBYHGXSA-N 0.000 description 4
• 239000004309 nisin Substances 0.000 description 4
• 235000010297 nisin Nutrition 0.000 description 4
• 229960001914 paromomycin Drugs 0.000 description 4
• UOZODPSAJZTQNH-LSWIJEOBSA-N paromomycin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO UOZODPSAJZTQNH-LSWIJEOBSA-N 0.000 description 4
• 229960003089 pramipexole Drugs 0.000 description 4
• FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 description 4
• 229940055019 propionibacterium acne Drugs 0.000 description 4
• 239000000612 proton pump inhibitor Substances 0.000 description 4
• 229940126409 proton pump inhibitor Drugs 0.000 description 4
• 229960000885 rifabutin Drugs 0.000 description 4
• JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 4
• 229960001225 rifampicin Drugs 0.000 description 4
• 229960001879 ropinirole Drugs 0.000 description 4
• UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 description 4
• 229960003179 rotigotine Drugs 0.000 description 4
• KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 description 4
• MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 description 4
• 229960003946 selegiline Drugs 0.000 description 4
• 238000000926 separation method Methods 0.000 description 4
• 239000007787 solid Substances 0.000 description 4
• 235000010356 sorbitol Nutrition 0.000 description 4
• 229960005322 streptomycin Drugs 0.000 description 4
• 108010082567 subtilin Proteins 0.000 description 4
• NRQODXJXWWUXFE-LYQFAKRDSA-N subtilosin a Chemical compound OC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]1N(C(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CN)[C@@H](C)O)[C@@H](C)CC)C(C)C)CCC1 NRQODXJXWWUXFE-LYQFAKRDSA-N 0.000 description 4
• 108010067167 thuricin Proteins 0.000 description 4
• MIQPIUSUKVNLNT-UHFFFAOYSA-N tolcapone Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 description 4
• 229960004603 tolcapone Drugs 0.000 description 4
• 235000013618 yogurt Nutrition 0.000 description 4
• 208000000044 Amnesia Diseases 0.000 description 3
• 241000203069 Archaea Species 0.000 description 3
• 241000283690 Bos taurus Species 0.000 description 3
• KORNTPPJEAJQIU-KJXAQDMKSA-N Cabaser Chemical compound C1=CC([C@H]2C[C@H](CN(CC=C)[C@@H]2C2)C(=O)N(CCCN(C)C)C(=O)NCC)=C3C2=CNC3=C1 KORNTPPJEAJQIU-KJXAQDMKSA-N 0.000 description 3
• 108090000565 Capsid Proteins Proteins 0.000 description 3
• 241000193155 Clostridium botulinum Species 0.000 description 3
• 206010009657 Clostridium difficile colitis Diseases 0.000 description 3
• 206010013887 Dysarthria Diseases 0.000 description 3
• 208000012661 Dyskinesia Diseases 0.000 description 3
• 208000026139 Memory disease Diseases 0.000 description 3
• 241001465754 Metazoa Species 0.000 description 3
• 102000010909 Monoamine Oxidase Human genes 0.000 description 3
• 108010062431 Monoamine oxidase Proteins 0.000 description 3
• 208000027089 Parkinsonian disease Diseases 0.000 description 3
• 206010034010 Parkinsonism Diseases 0.000 description 3
• 241000605860 Prevotella ruminicola Species 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• 208000028017 Psychotic disease Diseases 0.000 description 3
• 229940069428 antacid Drugs 0.000 description 3
• 239000003159 antacid agent Substances 0.000 description 3
• 239000002260 anti-inflammatory agent Substances 0.000 description 3
• 230000000845 anti-microbial effect Effects 0.000 description 3
• 230000006399 behavior Effects 0.000 description 3
• 230000004397 blinking Effects 0.000 description 3
• 229960004596 cabergoline Drugs 0.000 description 3
• 239000001913 cellulose Substances 0.000 description 3
• 229920002678 cellulose Polymers 0.000 description 3
• 230000001684 chronic effect Effects 0.000 description 3
• 229940052760 dopamine agonists Drugs 0.000 description 3
• 239000000835 fiber Substances 0.000 description 3
• 210000003811 finger Anatomy 0.000 description 3
• 210000002683 foot Anatomy 0.000 description 3
• 210000004247 hand Anatomy 0.000 description 3
• 239000003485 histamine H2 receptor antagonist Substances 0.000 description 3
• 230000003483 hypokinetic effect Effects 0.000 description 3
• 230000000977 initiatory effect Effects 0.000 description 3
• 208000002551 irritable bowel syndrome Diseases 0.000 description 3
• 230000000670 limiting effect Effects 0.000 description 3
• 235000019359 magnesium stearate Nutrition 0.000 description 3
• 238000004519 manufacturing process Methods 0.000 description 3
• 230000006984 memory degeneration Effects 0.000 description 3
• 208000023060 memory loss Diseases 0.000 description 3
• 244000000010 microbial pathogen Species 0.000 description 3
• 230000036651 mood Effects 0.000 description 3
• 235000015097 nutrients Nutrition 0.000 description 3
• 239000002245 particle Substances 0.000 description 3
• 239000008188 pellet Substances 0.000 description 3
• 238000002203 pretreatment Methods 0.000 description 3
• 108090000765 processed proteins & peptides Proteins 0.000 description 3
• 210000001236 prokaryotic cell Anatomy 0.000 description 3
• 230000002829 reductive effect Effects 0.000 description 3
• 230000000284 resting effect Effects 0.000 description 3
• 210000003296 saliva Anatomy 0.000 description 3
• 208000019116 sleep disease Diseases 0.000 description 3
• 230000000638 stimulation Effects 0.000 description 3
• 210000002784 stomach Anatomy 0.000 description 3
• 150000008163 sugars Chemical class 0.000 description 3
• 239000006228 supernatant Substances 0.000 description 3
• 238000001356 surgical procedure Methods 0.000 description 3
• 230000009747 swallowing Effects 0.000 description 3
• XUSXOPRDIDWMFO-CTMSJIKGSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[[(2s,3r)-3-amino-6-[(1s)-1-aminoethyl]-3,4-dihydro-2h-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(O2)[C@H](C)N)N)[C@@H](N)C[C@H]1N XUSXOPRDIDWMFO-CTMSJIKGSA-N 0.000 description 2
• RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 description 2
• YZEUHQHUFTYLPH-UHFFFAOYSA-N 2-nitroimidazole Chemical compound [O-][N+](=O)C1=NC=CN1 YZEUHQHUFTYLPH-UHFFFAOYSA-N 0.000 description 2
• 229920001817 Agar Polymers 0.000 description 2
• 241001584951 Anaerostipes hadrus Species 0.000 description 2
• 206010002942 Apathy Diseases 0.000 description 2
• 241001147785 Asaccharospora irregularis Species 0.000 description 2
• 241000304886 Bacilli Species 0.000 description 2
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
• 102000006378 Catechol O-methyltransferase Human genes 0.000 description 2
• 108020002739 Catechol O-methyltransferase Proteins 0.000 description 2
• 208000017667 Chronic Disease Diseases 0.000 description 2
• 208000037384 Clostridium Infections Diseases 0.000 description 2
• 241001147768 Clostridium argentinense Species 0.000 description 2
• 241000186542 Clostridium baratii Species 0.000 description 2
• 241000193455 Clostridium cadaveris Species 0.000 description 2
• 241001509496 Clostridium celatum Species 0.000 description 2
• 241000206044 Clostridium chauvoei Species 0.000 description 2
• 241000193167 Clostridium cochlearium Species 0.000 description 2
• 206010054236 Clostridium difficile infection Diseases 0.000 description 2
• 241000186571 Clostridium fallax Species 0.000 description 2
• 241001509499 Clostridium felsineum Species 0.000 description 2
• 241001656807 Clostridium haemolyticum Species 0.000 description 2
• 241000186565 Clostridium malenominatum Species 0.000 description 2
• 241000186581 Clostridium novyi Species 0.000 description 2
• 241000193468 Clostridium perfringens Species 0.000 description 2
• 241000408944 Clostridium putrefaciens Species 0.000 description 2
• 241001656793 Clostridium sartagoforme Species 0.000 description 2
• 241000193466 Clostridium septicum Species 0.000 description 2
• 241000193470 Clostridium sporogenes Species 0.000 description 2
• 241000186524 Clostridium subterminale Species 0.000 description 2
• 241000186528 Clostridium tertium Species 0.000 description 2
• 241000193449 Clostridium tetani Species 0.000 description 2
• 102000004127 Cytokines Human genes 0.000 description 2
• 108090000695 Cytokines Proteins 0.000 description 2
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
• 206010012289 Dementia Diseases 0.000 description 2
• 241000605716 Desulfovibrio Species 0.000 description 2
• 206010012735 Diarrhoea Diseases 0.000 description 2
• 241000016537 Dorea longicatena Species 0.000 description 2
• 208000027244 Dysbiosis Diseases 0.000 description 2
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
• 241000186589 Faecalicatena orotica Species 0.000 description 2
• 241001147710 Filifactor villosus Species 0.000 description 2
• 208000014540 Functional gastrointestinal disease Diseases 0.000 description 2
• 241000233866 Fungi Species 0.000 description 2
• 208000018522 Gastrointestinal disease Diseases 0.000 description 2
• 108010010803 Gelatin Proteins 0.000 description 2
• 229930182566 Gentamicin Natural products 0.000 description 2
• CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 2
• 241000193159 Hathewaya histolytica Species 0.000 description 2
• 241000186568 Hathewaya limosa Species 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• 208000001953 Hypotension Diseases 0.000 description 2
• 206010061598 Immunodeficiency Diseases 0.000 description 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 description 2
• 102000015696 Interleukins Human genes 0.000 description 2
• 108010063738 Interleukins Proteins 0.000 description 2
• 229930195725 Mannitol Natural products 0.000 description 2
• 206010057333 Micrographia Diseases 0.000 description 2
• 206010028813 Nausea Diseases 0.000 description 2
• 239000004677 Nylon Substances 0.000 description 2
• 241001147789 Paeniclostridium ghonii Species 0.000 description 2
• 241000193465 Paeniclostridium sordellii Species 0.000 description 2
• 241000605861 Prevotella Species 0.000 description 2
• ZVGNESXIJDCBKN-WUIGKKEISA-N R-Tiacumicin B Natural products O([C@@H]1[C@@H](C)O[C@H]([C@H]([C@H]1O)OC)OCC1=CC=CC[C@H](O)C(C)=C[C@@H]([C@H](C(C)=CC(C)=CC[C@H](OC1=O)[C@@H](C)O)O[C@H]1[C@H]([C@@H](O)[C@H](OC(=O)C(C)C)C(C)(C)O1)O)CC)C(=O)C1=C(O)C(Cl)=C(O)C(Cl)=C1CC ZVGNESXIJDCBKN-WUIGKKEISA-N 0.000 description 2
• URWAJWIAIPFPJE-UHFFFAOYSA-N Rickamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N URWAJWIAIPFPJE-UHFFFAOYSA-N 0.000 description 2
• 241000282849 Ruminantia Species 0.000 description 2
• 206010040030 Sensory loss Diseases 0.000 description 2
• 201000001880 Sexual dysfunction Diseases 0.000 description 2
• 229930192786 Sisomicin Natural products 0.000 description 2
• 241001509489 Terrisporobacter glycolicus Species 0.000 description 2
• 241000167944 Tissierella praeacuta Species 0.000 description 2
• XUSXOPRDIDWMFO-UHFFFAOYSA-N Verdamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(O2)C(C)N)N)C(N)CC1N XUSXOPRDIDWMFO-UHFFFAOYSA-N 0.000 description 2
• 241000985249 [Clostridium] indolis Species 0.000 description 2
• 241000193460 [Clostridium] piliforme Species 0.000 description 2
• 241001147801 [Clostridium] scindens Species 0.000 description 2
• 241001147717 [Clostridium] sphenoides Species 0.000 description 2
• 241001147796 [Clostridium] spiroforme Species 0.000 description 2
• 241000193450 [Clostridium] symbiosum Species 0.000 description 2
• 206010000059 abdominal discomfort Diseases 0.000 description 2
• 230000005856 abnormality Effects 0.000 description 2
• 239000002250 absorbent Substances 0.000 description 2
• 230000002745 absorbent Effects 0.000 description 2
• 150000007513 acids Chemical class 0.000 description 2
• 239000008272 agar Substances 0.000 description 2
• 235000010443 alginic acid Nutrition 0.000 description 2
• 229920000615 alginic acid Polymers 0.000 description 2
• 229960004821 amikacin Drugs 0.000 description 2
• LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 description 2
• 229940126575 aminoglycoside Drugs 0.000 description 2
• 230000001458 anti-acid effect Effects 0.000 description 2
• 229940124599 anti-inflammatory drug Drugs 0.000 description 2
• 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 description 2
• 239000004599 antimicrobial Substances 0.000 description 2
• 229950006334 apramycin Drugs 0.000 description 2
• XZNUGFQTQHRASN-XQENGBIVSA-N apramycin Chemical compound O([C@H]1O[C@@H]2[C@H](O)[C@@H]([C@H](O[C@H]2C[C@H]1N)O[C@@H]1[C@@H]([C@@H](O)[C@H](N)[C@@H](CO)O1)O)NC)[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O XZNUGFQTQHRASN-XQENGBIVSA-N 0.000 description 2
• 229960005397 arbekacin Drugs 0.000 description 2
• MKKYBZZTJQGVCD-XTCKQBCOSA-N arbekacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)CC[C@H]1N MKKYBZZTJQGVCD-XTCKQBCOSA-N 0.000 description 2
• 229960004099 azithromycin Drugs 0.000 description 2
• MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 2
• 244000052616 bacterial pathogen Species 0.000 description 2
• 230000008901 benefit Effects 0.000 description 2
• 229950007558 bicozamycin Drugs 0.000 description 2
• WOUDXEYYJPOSNE-VKZDFBPFSA-N bicozamycin Chemical compound N1C(=O)[C@@]2(O)NC(=O)[C@]1([C@@H](O)[C@@](O)(CO)C)OCCC2=C WOUDXEYYJPOSNE-VKZDFBPFSA-N 0.000 description 2
• WOUDXEYYJPOSNE-UHFFFAOYSA-N bicyclomycin Natural products N1C(=O)C2(O)NC(=O)C1(C(O)C(O)(CO)C)OCCC2=C WOUDXEYYJPOSNE-UHFFFAOYSA-N 0.000 description 2
• 239000011230 binding agent Substances 0.000 description 2
• 230000015572 biosynthetic process Effects 0.000 description 2
• 229960000782 bismuth subsalicylate Drugs 0.000 description 2
• ZREIPSZUJIFJNP-UHFFFAOYSA-K bismuth subsalicylate Chemical compound C1=CC=C2O[Bi](O)OC(=O)C2=C1 ZREIPSZUJIFJNP-UHFFFAOYSA-K 0.000 description 2
• 201000007637 bowel dysfunction Diseases 0.000 description 2
• 239000000872 buffer Substances 0.000 description 2
• 239000006172 buffering agent Substances 0.000 description 2
• 244000309466 calf Species 0.000 description 2
• 150000001720 carbohydrates Chemical class 0.000 description 2
• 235000014633 carbohydrates Nutrition 0.000 description 2
• 229960005091 chloramphenicol Drugs 0.000 description 2
• WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 2
• 239000000812 cholinergic antagonist Substances 0.000 description 2
• MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
• 229960004287 clofazimine Drugs 0.000 description 2
• WDQPAMHFFCXSNU-BGABXYSRSA-N clofazimine Chemical compound C12=CC=CC=C2N=C2C=C(NC=3C=CC(Cl)=CC=3)C(=N/C(C)C)/C=C2N1C1=CC=C(Cl)C=C1 WDQPAMHFFCXSNU-BGABXYSRSA-N 0.000 description 2
• 238000011260 co-administration Methods 0.000 description 2
• 229960001338 colchicine Drugs 0.000 description 2
• 210000001072 colon Anatomy 0.000 description 2
• 238000002052 colonoscopy Methods 0.000 description 2
• 230000006866 deterioration Effects 0.000 description 2
• 238000011161 development Methods 0.000 description 2
• 230000018109 developmental process Effects 0.000 description 2
• 235000015872 dietary supplement Nutrition 0.000 description 2
• 208000010643 digestive system disease Diseases 0.000 description 2
• 229960004100 dirithromycin Drugs 0.000 description 2
• WLOHNSSYAXHWNR-NXPDYKKBSA-N dirithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H]2O[C@H](COCCOC)N[C@H]([C@@H]2C)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 WLOHNSSYAXHWNR-NXPDYKKBSA-N 0.000 description 2
• 230000007140 dysbiosis Effects 0.000 description 2
• 150000002066 eicosanoids Chemical class 0.000 description 2
• 239000002702 enteric coating Substances 0.000 description 2
• 239000012055 enteric layer Substances 0.000 description 2
• 230000007613 environmental effect Effects 0.000 description 2
• 210000003414 extremity Anatomy 0.000 description 2
• 239000003925 fat Substances 0.000 description 2
• 235000019197 fats Nutrition 0.000 description 2
• 229960000628 fidaxomicin Drugs 0.000 description 2
• ZVGNESXIJDCBKN-UUEYKCAUSA-N fidaxomicin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@H]([C@H]1O)OC)OCC\1=C/C=C/C[C@H](O)/C(C)=C/[C@@H]([C@H](/C(C)=C/C(/C)=C/C[C@H](OC/1=O)[C@@H](C)O)O[C@H]1[C@H]([C@@H](O)[C@H](OC(=O)C(C)C)C(C)(C)O1)O)CC)C(=O)C1=C(O)C(Cl)=C(O)C(Cl)=C1CC ZVGNESXIJDCBKN-UUEYKCAUSA-N 0.000 description 2
• 238000011049 filling Methods 0.000 description 2
• 235000021255 galacto-oligosaccharides Nutrition 0.000 description 2
• 150000003271 galactooligosaccharides Chemical class 0.000 description 2
• 244000000036 gastrointestinal pathogen Species 0.000 description 2
• 208000018685 gastrointestinal system disease Diseases 0.000 description 2
• 239000008273 gelatin Substances 0.000 description 2
• 229920000159 gelatin Polymers 0.000 description 2
• 235000019322 gelatine Nutrition 0.000 description 2
• 235000011852 gelatine desserts Nutrition 0.000 description 2
• BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
• 210000000987 immune system Anatomy 0.000 description 2
• 230000002458 infectious effect Effects 0.000 description 2
• 230000002401 inhibitory effect Effects 0.000 description 2
• 229960000318 kanamycin Drugs 0.000 description 2
• 229930027917 kanamycin Natural products 0.000 description 2
• SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 2
• 229930182823 kanamycin A Natural products 0.000 description 2
• 150000002617 leukotrienes Chemical class 0.000 description 2
• 238000011068 loading method Methods 0.000 description 2
• 230000007774 longterm Effects 0.000 description 2
• 208000012866 low blood pressure Diseases 0.000 description 2
• 239000000314 lubricant Substances 0.000 description 2
• 239000003120 macrolide antibiotic agent Substances 0.000 description 2
• ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 2
• 239000001095 magnesium carbonate Substances 0.000 description 2
• 229910000021 magnesium carbonate Inorganic materials 0.000 description 2
• 239000000594 mannitol Substances 0.000 description 2
• 235000010355 mannitol Nutrition 0.000 description 2
• 239000012528 membrane Substances 0.000 description 2
• 230000002503 metabolic effect Effects 0.000 description 2
• 230000000813 microbial effect Effects 0.000 description 2
• 244000005706 microflora Species 0.000 description 2
• 239000011785 micronutrient Substances 0.000 description 2
• 235000013369 micronutrients Nutrition 0.000 description 2
• 230000008450 motivation Effects 0.000 description 2
• 230000004973 motor coordination Effects 0.000 description 2
• 230000008693 nausea Effects 0.000 description 2
• 210000002569 neuron Anatomy 0.000 description 2
• 239000002858 neurotransmitter agent Substances 0.000 description 2
• 229920001778 nylon Polymers 0.000 description 2
• 230000036961 partial effect Effects 0.000 description 2
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
• 102000004196 processed proteins & peptides Human genes 0.000 description 2
• 230000035755 proliferation Effects 0.000 description 2
• 230000002035 prolonged effect Effects 0.000 description 2
• 229940100618 rectal suppository Drugs 0.000 description 2
• 239000006215 rectal suppository Substances 0.000 description 2
• 230000011514 reflex Effects 0.000 description 2
• 230000000717 retained effect Effects 0.000 description 2
• 229930184609 rhodostreptomycin Natural products 0.000 description 2
• 229950005007 rifalazil Drugs 0.000 description 2
• SGHWBDUXKUSFOP-KYALZUAASA-N rifalazil Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)N=C2C(=O)C=3C(O)=C4C)C)OC)C4=C1C=3C(NC1=C(O)C=3)=C2OC1=CC=3N1CCN(CC(C)C)CC1 SGHWBDUXKUSFOP-KYALZUAASA-N 0.000 description 2
• HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical class OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 description 2
• 229960002599 rifapentine Drugs 0.000 description 2
• WDZCUPBHRAEYDL-GZAUEHORSA-N rifapentine Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C(O)=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N(CC1)CCN1C1CCCC1 WDZCUPBHRAEYDL-GZAUEHORSA-N 0.000 description 2
• 229960003040 rifaximin Drugs 0.000 description 2
• NZCRJKRKKOLAOJ-XRCRFVBUSA-N rifaximin Chemical compound OC1=C(C(O)=C2C)C3=C4N=C5C=C(C)C=CN5C4=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O NZCRJKRKKOLAOJ-XRCRFVBUSA-N 0.000 description 2
• 229960005224 roxithromycin Drugs 0.000 description 2
• 150000003839 salts Chemical class 0.000 description 2
• 230000028327 secretion Effects 0.000 description 2
• 238000007873 sieving Methods 0.000 description 2
• 229960005456 sisomicin Drugs 0.000 description 2
• URWAJWIAIPFPJE-YFMIWBNJSA-N sisomycin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-YFMIWBNJSA-N 0.000 description 2
• 208000020685 sleep-wake disease Diseases 0.000 description 2
• 208000026473 slurred speech Diseases 0.000 description 2
• 239000002904 solvent Substances 0.000 description 2
• 210000003523 substantia nigra Anatomy 0.000 description 2
• 239000004094 surface-active agent Substances 0.000 description 2
• 230000008961 swelling Effects 0.000 description 2
• 230000009885 systemic effect Effects 0.000 description 2
• 239000000454 talc Substances 0.000 description 2
• 229910052623 talc Inorganic materials 0.000 description 2
• 229960003250 telithromycin Drugs 0.000 description 2
• LJVAJPDWBABPEJ-PNUFFHFMSA-N telithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]([C@]2(OC(=O)N(CCCCN3C=C(N=C3)C=3C=NC=CC=3)[C@@H]2[C@@H](C)C(=O)[C@H](C)C[C@@]1(C)OC)C)CC)[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O LJVAJPDWBABPEJ-PNUFFHFMSA-N 0.000 description 2
• 229960000707 tobramycin Drugs 0.000 description 2
• NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 2
• 239000003053 toxin Substances 0.000 description 2
• 231100000765 toxin Toxicity 0.000 description 2
• 108700012359 toxins Proteins 0.000 description 2
• 239000011573 trace mineral Chemical class 0.000 description 2
• 235000013619 trace mineral Nutrition 0.000 description 2
• 235000013343 vitamin Nutrition 0.000 description 2
• 239000011782 vitamin Substances 0.000 description 2
• 229940088594 vitamin Drugs 0.000 description 2
• 229930003231 vitamin Natural products 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
• 230000004580 weight loss Effects 0.000 description 2
• WYDUSKDSKCASEF-LJQANCHMSA-N (1s)-1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol Chemical compound C([C@](O)(C1CCCCC1)C=1C=CC=CC=1)CN1CCCC1 WYDUSKDSKCASEF-LJQANCHMSA-N 0.000 description 1
• QWWVBNODQCWBAZ-WHFBIAKZSA-N (2r)-2-amino-3-[(2r)-2-carboxy-2-(methylamino)ethyl]sulfanylpropanoic acid Chemical compound CN[C@H](C(O)=O)CSC[C@H](N)C(O)=O QWWVBNODQCWBAZ-WHFBIAKZSA-N 0.000 description 1
• LITBAYYWXZOHAW-XDZRHBBOSA-N (2s,5r,6r)-6-[[(2r)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;(2s,3s,5r)-3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4$l^{6}-thia-1-azabicyclo[3.2.0]hept Chemical compound C([C@]1(C)S([C@H]2N(C(C2)=O)[C@H]1C(O)=O)(=O)=O)N1C=CN=N1.O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 LITBAYYWXZOHAW-XDZRHBBOSA-N 0.000 description 1
• FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 description 1
• WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 description 1
• SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
• 206010050013 Abulia Diseases 0.000 description 1
• 206010072413 Action tremor Diseases 0.000 description 1
• 206010001497 Agitation Diseases 0.000 description 1
• 206010001540 Akathisia Diseases 0.000 description 1
• 206010001541 Akinesia Diseases 0.000 description 1
• 208000019901 Anxiety disease Diseases 0.000 description 1
• 235000017060 Arachis glabrata Nutrition 0.000 description 1
• 244000105624 Arachis hypogaea Species 0.000 description 1
• 235000010777 Arachis hypogaea Nutrition 0.000 description 1
• 235000018262 Arachis monticola Nutrition 0.000 description 1
• 208000035143 Bacterial infection Diseases 0.000 description 1
• 241000605059 Bacteroidetes Species 0.000 description 1
• 206010050012 Bradyphrenia Diseases 0.000 description 1
• 108010074051 C-Reactive Protein Proteins 0.000 description 1
• 102100032752 C-reactive protein Human genes 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• 241000283707 Capra Species 0.000 description 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
• 229930186147 Cephalosporin Natural products 0.000 description 1
• 206010008874 Chronic Fatigue Syndrome Diseases 0.000 description 1
• HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 description 1
• 241001112696 Clostridia Species 0.000 description 1
• 241000193163 Clostridioides difficile Species 0.000 description 1
• 241000186562 Clostridium carnis Species 0.000 description 1
• 241001147791 Clostridium paraputrificum Species 0.000 description 1
• 206010009944 Colon cancer Diseases 0.000 description 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
• 208000035473 Communicable disease Diseases 0.000 description 1
• 206010011224 Cough Diseases 0.000 description 1
• UQBOJOOOTLPNST-UHFFFAOYSA-N Dehydroalanine Chemical compound NC(=C)C(O)=O UQBOJOOOTLPNST-UHFFFAOYSA-N 0.000 description 1
• 229920001353 Dextrin Polymers 0.000 description 1
• 239000004375 Dextrin Substances 0.000 description 1
• 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
• 239000001836 Dioctyl sodium sulphosuccinate Substances 0.000 description 1
• 206010013700 Drug hypersensitivity Diseases 0.000 description 1
• 208000014094 Dystonic disease Diseases 0.000 description 1
• 241000196324 Embryophyta Species 0.000 description 1
• 102000004190 Enzymes Human genes 0.000 description 1
• 108090000790 Enzymes Proteins 0.000 description 1
• 206010015137 Eructation Diseases 0.000 description 1
• 241000206602 Eukaryota Species 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• 241000192125 Firmicutes Species 0.000 description 1
• 241000287828 Gallus gallus Species 0.000 description 1
• 241000192128 Gammaproteobacteria Species 0.000 description 1
• 206010019233 Headaches Diseases 0.000 description 1
• 208000005176 Hepatitis C Diseases 0.000 description 1
• 208000029462 Immunodeficiency disease Diseases 0.000 description 1
• 206010021567 Impulsive behaviour Diseases 0.000 description 1
• 206010061217 Infestation Diseases 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 229920001202 Inulin Polymers 0.000 description 1
• 208000015592 Involuntary movements Diseases 0.000 description 1
• 206010023509 Kyphosis Diseases 0.000 description 1
• DWPCPZJAHOETAG-IMJSIDKUSA-N L-lanthionine Chemical compound OC(=O)[C@@H](N)CSC[C@H](N)C(O)=O DWPCPZJAHOETAG-IMJSIDKUSA-N 0.000 description 1
• GSDSWSVVBLHKDQ-JTQLQIEISA-N Levofloxacin Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-JTQLQIEISA-N 0.000 description 1
• 208000032443 Masked facies Diseases 0.000 description 1
• 208000001145 Metabolic Syndrome Diseases 0.000 description 1
• 208000034819 Mobility Limitation Diseases 0.000 description 1
• 208000019022 Mood disease Diseases 0.000 description 1
• 208000016285 Movement disease Diseases 0.000 description 1
• 208000001089 Multiple system atrophy Diseases 0.000 description 1
• 241000699670 Mus sp. Species 0.000 description 1
• 206010058483 Nuchal rigidity Diseases 0.000 description 1
• 208000008589 Obesity Diseases 0.000 description 1
• 206010031127 Orthostatic hypotension Diseases 0.000 description 1
• FTLDJPRFCGDUFH-UHFFFAOYSA-N Oxethazaine Chemical compound C=1C=CC=CC=1CC(C)(C)N(C)C(=O)CN(CCO)CC(=O)N(C)C(C)(C)CC1=CC=CC=C1 FTLDJPRFCGDUFH-UHFFFAOYSA-N 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 208000037581 Persistent Infection Diseases 0.000 description 1
• 241000286209 Phasianidae Species 0.000 description 1
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
• 229920001100 Polydextrose Polymers 0.000 description 1
• 206010073211 Postural tremor Diseases 0.000 description 1
• 241000288906 Primates Species 0.000 description 1
• 208000001431 Psychomotor Agitation Diseases 0.000 description 1
• 208000025535 REM sleep behavior disease Diseases 0.000 description 1
• 241000700159 Rattus Species 0.000 description 1
• 241000283984 Rodentia Species 0.000 description 1
• 206010039424 Salivary hypersecretion Diseases 0.000 description 1
• 229920001800 Shellac Polymers 0.000 description 1
• 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
• 208000032140 Sleepiness Diseases 0.000 description 1
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
• 206010041349 Somnolence Diseases 0.000 description 1
• 235000021355 Stearic acid Nutrition 0.000 description 1
• 208000003028 Stuttering Diseases 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• 206010042674 Swelling Diseases 0.000 description 1
• WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 description 1
• HWHLPVGTWGOCJO-UHFFFAOYSA-N Trihexyphenidyl Chemical group C1CCCCC1C(C=1C=CC=CC=1)(O)CCN1CCCCC1 HWHLPVGTWGOCJO-UHFFFAOYSA-N 0.000 description 1
• 208000003443 Unconsciousness Diseases 0.000 description 1
• 241001148134 Veillonella Species 0.000 description 1
• 241001430183 Veillonellaceae Species 0.000 description 1
• 206010047513 Vision blurred Diseases 0.000 description 1
• 206010047700 Vomiting Diseases 0.000 description 1
• 238000010521 absorption reaction Methods 0.000 description 1
• 230000001133 acceleration Effects 0.000 description 1
• 229940081735 acetylcellulose Drugs 0.000 description 1
• 230000009858 acid secretion Effects 0.000 description 1
• 238000013019 agitation Methods 0.000 description 1
• 239000000783 alginic acid Substances 0.000 description 1
• 229960001126 alginic acid Drugs 0.000 description 1
• 150000004781 alginic acids Chemical class 0.000 description 1
• 229940043312 ampicillin / sulbactam Drugs 0.000 description 1
• 239000003674 animal food additive Substances 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• 210000003423 ankle Anatomy 0.000 description 1
• 208000022531 anorexia Diseases 0.000 description 1
• 230000001078 anti-cholinergic effect Effects 0.000 description 1
• 229940121363 anti-inflammatory agent Drugs 0.000 description 1
• 238000011203 antimicrobial therapy Methods 0.000 description 1
• 230000036506 anxiety Effects 0.000 description 1
• 229960004046 apomorphine Drugs 0.000 description 1
• VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 230000002238 attenuated effect Effects 0.000 description 1
• 230000005784 autoimmunity Effects 0.000 description 1
• 208000022362 bacterial infectious disease Diseases 0.000 description 1
• 239000003899 bactericide agent Substances 0.000 description 1
• 235000013361 beverage Nutrition 0.000 description 1
• 230000002146 bilateral effect Effects 0.000 description 1
• 229960003003 biperiden Drugs 0.000 description 1
• YSXKPIUOCJLQIE-UHFFFAOYSA-N biperiden Chemical compound C1C(C=C2)CC2C1C(C=1C=CC=CC=1)(O)CCN1CCCCC1 YSXKPIUOCJLQIE-UHFFFAOYSA-N 0.000 description 1
• 230000036471 bradycardia Effects 0.000 description 1
• 208000006218 bradycardia Diseases 0.000 description 1
• 230000001680 brushing effect Effects 0.000 description 1
• 230000001612 cachectic effect Effects 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• 229960004205 carbidopa Drugs 0.000 description 1
• TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
• 239000003543 catechol methyltransferase inhibitor Substances 0.000 description 1
• 229960004261 cefotaxime Drugs 0.000 description 1
• AZZMGZXNTDTSME-JUZDKLSSSA-M cefotaxime sodium Chemical compound [Na+].N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 AZZMGZXNTDTSME-JUZDKLSSSA-M 0.000 description 1
• 229960004755 ceftriaxone Drugs 0.000 description 1
• VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 description 1
• 210000002421 cell wall Anatomy 0.000 description 1
• 229920002301 cellulose acetate Polymers 0.000 description 1
• 229940124587 cephalosporin Drugs 0.000 description 1
• 150000001780 cephalosporins Chemical class 0.000 description 1
• 229960000541 cetyl alcohol Drugs 0.000 description 1
• 238000002512 chemotherapy Methods 0.000 description 1
• 235000013330 chicken meat Nutrition 0.000 description 1
• 208000019902 chronic diarrheal disease Diseases 0.000 description 1
• 229960003405 ciprofloxacin Drugs 0.000 description 1
• 229940087211 ciprofloxacin and metronidazole Drugs 0.000 description 1
• 229960003324 clavulanic acid Drugs 0.000 description 1
• HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 description 1
• 230000008045 co-localization Effects 0.000 description 1
• 229940047766 co-trimoxazole Drugs 0.000 description 1
• 238000000576 coating method Methods 0.000 description 1
• 230000001149 cognitive effect Effects 0.000 description 1
• 230000000112 colonic effect Effects 0.000 description 1
• 230000001332 colony forming effect Effects 0.000 description 1
• 238000004891 communication Methods 0.000 description 1
• 230000001010 compromised effect Effects 0.000 description 1
• 208000012696 congenital leptin deficiency Diseases 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 238000010276 construction Methods 0.000 description 1
• 230000001054 cortical effect Effects 0.000 description 1
• 238000011461 current therapy Methods 0.000 description 1
• 238000005520 cutting process Methods 0.000 description 1
• 230000009089 cytolysis Effects 0.000 description 1
• 239000000824 cytostatic agent Substances 0.000 description 1
• 230000001085 cytostatic effect Effects 0.000 description 1
• 231100000433 cytotoxic Toxicity 0.000 description 1
• 230000001472 cytotoxic effect Effects 0.000 description 1
• 206010061428 decreased appetite Diseases 0.000 description 1
• 230000013872 defecation Effects 0.000 description 1
• 230000001934 delay Effects 0.000 description 1
• 235000019425 dextrin Nutrition 0.000 description 1
• 239000008121 dextrose Substances 0.000 description 1
• 206010012601 diabetes mellitus Diseases 0.000 description 1
• NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
• 229940038472 dicalcium phosphate Drugs 0.000 description 1
• 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
• 235000005911 diet Nutrition 0.000 description 1
• 230000037213 diet Effects 0.000 description 1
• 230000003292 diminished effect Effects 0.000 description 1
• 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
• 238000002845 discoloration Methods 0.000 description 1
• NWOYIVRVSJDTLK-YSDBFZIDSA-L disodium;(2s,5r,6r)-6-[[(2r)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;(1r,4s)-3,3-dimethyl-2,2,6-trioxo-2$l^{6}-thiabicyclo[3.2.0]heptane-4-carboxylate Chemical compound [Na+].[Na+].O=S1(=O)C(C)(C)[C@H](C([O-])=O)C2C(=O)C[C@H]21.C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=CC=C1 NWOYIVRVSJDTLK-YSDBFZIDSA-L 0.000 description 1
• 239000002270 dispersing agent Substances 0.000 description 1
• 208000002173 dizziness Diseases 0.000 description 1
• 229940005501 dopaminergic agent Drugs 0.000 description 1
• 230000035622 drinking Effects 0.000 description 1
• 206010013781 dry mouth Diseases 0.000 description 1
• 210000001198 duodenum Anatomy 0.000 description 1
• 230000004064 dysfunction Effects 0.000 description 1
• 208000010118 dystonia Diseases 0.000 description 1
• 239000003995 emulsifying agent Substances 0.000 description 1
• 239000002158 endotoxin Substances 0.000 description 1
• 238000009505 enteric coating Methods 0.000 description 1
• 210000000981 epithelium Anatomy 0.000 description 1
• 210000003743 erythrocyte Anatomy 0.000 description 1
• 235000020774 essential nutrients Nutrition 0.000 description 1
• 229940011871 estrogen Drugs 0.000 description 1
• 239000000262 estrogen Substances 0.000 description 1
• 230000007717 exclusion Effects 0.000 description 1
• 230000001747 exhibiting effect Effects 0.000 description 1
• 206010016256 fatigue Diseases 0.000 description 1
• 238000010304 firing Methods 0.000 description 1
• 206010016766 flatulence Diseases 0.000 description 1
• 229940124307 fluoroquinolone Drugs 0.000 description 1
• 239000006260 foam Substances 0.000 description 1
• 230000037406 food intake Effects 0.000 description 1
• 210000005224 forefinger Anatomy 0.000 description 1
• 238000004108 freeze drying Methods 0.000 description 1
• 230000006870 function Effects 0.000 description 1
• 210000004211 gastric acid Anatomy 0.000 description 1
• 210000005095 gastrointestinal system Anatomy 0.000 description 1
• 239000000499 gel Substances 0.000 description 1
• 239000007903 gelatin capsule Substances 0.000 description 1
• 230000035784 germination Effects 0.000 description 1
• 150000002334 glycols Chemical class 0.000 description 1
• 230000005484 gravity Effects 0.000 description 1
• 244000005709 gut microbiome Species 0.000 description 1
• 231100000869 headache Toxicity 0.000 description 1
• 208000005252 hepatitis A Diseases 0.000 description 1
• 208000002672 hepatitis B Diseases 0.000 description 1
• 239000004009 herbicide Substances 0.000 description 1
• 239000008240 homogeneous mixture Substances 0.000 description 1
• 244000005702 human microbiome Species 0.000 description 1
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
• 235000015243 ice cream Nutrition 0.000 description 1
• 229960002182 imipenem Drugs 0.000 description 1
• ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 description 1
• 230000036039 immunity Effects 0.000 description 1
• 230000007813 immunodeficiency Effects 0.000 description 1
• 239000002955 immunomodulating agent Substances 0.000 description 1
• 229940121354 immunomodulator Drugs 0.000 description 1
• 239000007943 implant Substances 0.000 description 1
• 238000002513 implantation Methods 0.000 description 1
• 230000002779 inactivation Effects 0.000 description 1
• 230000001524 infective effect Effects 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 238000002347 injection Methods 0.000 description 1
• 239000007924 injection Substances 0.000 description 1
• 206010022437 insomnia Diseases 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 230000000968 intestinal effect Effects 0.000 description 1
• 210000000936 intestine Anatomy 0.000 description 1
• 230000001788 irregular Effects 0.000 description 1
• BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• 238000009533 lab test Methods 0.000 description 1
• 150000002605 large molecules Chemical class 0.000 description 1
• 239000008141 laxative Substances 0.000 description 1
• 229940125722 laxative agent Drugs 0.000 description 1
• 229960003376 levofloxacin Drugs 0.000 description 1
• 238000009630 liquid culture Methods 0.000 description 1
• 244000144972 livestock Species 0.000 description 1
• 229920002521 macromolecule Polymers 0.000 description 1
• 238000011418 maintenance treatment Methods 0.000 description 1
• 238000002483 medication Methods 0.000 description 1
• 210000005060 membrane bound organelle Anatomy 0.000 description 1
• 206010027175 memory impairment Diseases 0.000 description 1
• 229960002260 meropenem Drugs 0.000 description 1
• DMJNNHOOLUXYBV-PQTSNVLCSA-N meropenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](C(=O)N(C)C)C1 DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 description 1
• DWPCPZJAHOETAG-UHFFFAOYSA-N meso-lanthionine Natural products OC(=O)C(N)CSCC(N)C(O)=O DWPCPZJAHOETAG-UHFFFAOYSA-N 0.000 description 1
• 230000004060 metabolic process Effects 0.000 description 1
• 239000002207 metabolite Substances 0.000 description 1
• 229910052751 metal Inorganic materials 0.000 description 1
• 239000002184 metal Substances 0.000 description 1
• 238000001471 micro-filtration Methods 0.000 description 1
• 230000003278 mimic effect Effects 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 230000037230 mobility Effects 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 150000002772 monosaccharides Chemical class 0.000 description 1
• 208000001022 morbid obesity Diseases 0.000 description 1
• 238000010172 mouse model Methods 0.000 description 1
• 229960003702 moxifloxacin Drugs 0.000 description 1
• FABPRXSRWADJSP-MEDUHNTESA-N moxifloxacin Chemical compound COC1=C(N2C[C@H]3NCCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 FABPRXSRWADJSP-MEDUHNTESA-N 0.000 description 1
• 230000017311 musculoskeletal movement, spinal reflex action Effects 0.000 description 1
• 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 1
• 229940039506 mylanta Drugs 0.000 description 1
• PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
• 210000005036 nerve Anatomy 0.000 description 1
• 210000000653 nervous system Anatomy 0.000 description 1
• 208000015122 neurodegenerative disease Diseases 0.000 description 1
• 231100000252 nontoxic Toxicity 0.000 description 1
• 230000003000 nontoxic effect Effects 0.000 description 1
• 102000039446 nucleic acids Human genes 0.000 description 1
• 108020004707 nucleic acids Proteins 0.000 description 1
• 150000007523 nucleic acids Chemical class 0.000 description 1
• 231100000862 numbness Toxicity 0.000 description 1
• 230000000474 nursing effect Effects 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
• 230000009965 odorless effect Effects 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 235000019198 oils Nutrition 0.000 description 1
• 229960000381 omeprazole Drugs 0.000 description 1
• 210000003463 organelle Anatomy 0.000 description 1
• 229960003941 orphenadrine Drugs 0.000 description 1
• QVYRGXJJSLMXQH-UHFFFAOYSA-N orphenadrine Chemical compound C=1C=CC=C(C)C=1C(OCCN(C)C)C1=CC=CC=C1 QVYRGXJJSLMXQH-UHFFFAOYSA-N 0.000 description 1
• 230000003204 osmotic effect Effects 0.000 description 1
• 229940052740 other dopaminergic agent in atc Drugs 0.000 description 1
• 239000006179 pH buffering agent Substances 0.000 description 1
• 239000012188 paraffin wax Substances 0.000 description 1
• 244000045947 parasite Species 0.000 description 1
• 239000013618 particulate matter Substances 0.000 description 1
• 230000008506 pathogenesis Effects 0.000 description 1
• 230000007918 pathogenicity Effects 0.000 description 1
• 230000001575 pathological effect Effects 0.000 description 1
• 235000020232 peanut Nutrition 0.000 description 1
• 201000005354 penicillin allergy Diseases 0.000 description 1
• 239000000575 pesticide Substances 0.000 description 1
• 239000008024 pharmaceutical diluent Substances 0.000 description 1
• 239000002504 physiological saline solution Substances 0.000 description 1
• 229940104641 piperacillin / tazobactam Drugs 0.000 description 1
• 125000003367 polycyclic group Chemical group 0.000 description 1
• 235000013856 polydextrose Nutrition 0.000 description 1
• 229920005862 polyol Polymers 0.000 description 1
• 150000003077 polyols Chemical class 0.000 description 1
• 208000022131 polyp of large intestine Diseases 0.000 description 1
• 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
• 229920001282 polysaccharide Polymers 0.000 description 1
• 239000005017 polysaccharide Substances 0.000 description 1
• 150000004804 polysaccharides Chemical class 0.000 description 1
• 229920001296 polysiloxane Polymers 0.000 description 1
• 229920000136 polysorbate Polymers 0.000 description 1
• 230000036544 posture Effects 0.000 description 1
• DWHGNUUWCJZQHO-ZVDZYBSKSA-M potassium;(2s,5r,6r)-6-[[(2r)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;(2r,3z,5r)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate Chemical compound [K+].[O-]C(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21.C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 DWHGNUUWCJZQHO-ZVDZYBSKSA-M 0.000 description 1
• 235000008476 powdered milk Nutrition 0.000 description 1
• 235000013406 prebiotics Nutrition 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 230000008569 process Effects 0.000 description 1
• 229960005253 procyclidine Drugs 0.000 description 1
• 208000037821 progressive disease Diseases 0.000 description 1
• 230000000770 proinflammatory effect Effects 0.000 description 1
• 230000000069 prophylactic effect Effects 0.000 description 1
• 238000011321 prophylaxis Methods 0.000 description 1
• VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical group [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
• 229960000620 ranitidine Drugs 0.000 description 1
• 229960000245 rasagiline Drugs 0.000 description 1
• RUOKEQAAGRXIBM-GFCCVEGCSA-N rasagiline Chemical compound C1=CC=C2[C@H](NCC#C)CCC2=C1 RUOKEQAAGRXIBM-GFCCVEGCSA-N 0.000 description 1
• CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
• 208000026451 salivation Diseases 0.000 description 1
• 230000003248 secreting effect Effects 0.000 description 1
• 238000004062 sedimentation Methods 0.000 description 1
• 230000035807 sensation Effects 0.000 description 1
• 230000001953 sensory effect Effects 0.000 description 1
• 230000008786 sensory perception of smell Effects 0.000 description 1
• 239000008159 sesame oil Substances 0.000 description 1
• 235000011803 sesame oil Nutrition 0.000 description 1
• 208000018316 severe headache Diseases 0.000 description 1
• 230000009329 sexual behaviour Effects 0.000 description 1
• 231100000872 sexual dysfunction Toxicity 0.000 description 1
• 239000004208 shellac Substances 0.000 description 1
• 229940113147 shellac Drugs 0.000 description 1
• ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
• 235000013874 shellac Nutrition 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 230000005808 skin problem Effects 0.000 description 1
• 230000007958 sleep Effects 0.000 description 1
• 208000022925 sleep disturbance Diseases 0.000 description 1
• 230000037321 sleepiness Effects 0.000 description 1
• 239000000344 soap Substances 0.000 description 1
• APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
• 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
• 229940080313 sodium starch Drugs 0.000 description 1
• 235000021058 soft food Nutrition 0.000 description 1
• 239000011343 solid material Substances 0.000 description 1
• 239000008247 solid mixture Substances 0.000 description 1
• 238000001228 spectrum Methods 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 230000000087 stabilizing effect Effects 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 239000008117 stearic acid Substances 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1
• 239000000375 suspending agent Substances 0.000 description 1
• 230000002459 sustained effect Effects 0.000 description 1
• 230000035900 sweating Effects 0.000 description 1
• 230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 description 1
• 238000002636 symptomatic treatment Methods 0.000 description 1
• 208000006379 syphilis Diseases 0.000 description 1
• 235000012222 talc Nutrition 0.000 description 1
• 230000002123 temporal effect Effects 0.000 description 1
• 239000002562 thickening agent Substances 0.000 description 1
• 150000003568 thioethers Chemical class 0.000 description 1
• 210000003813 thumb Anatomy 0.000 description 1
• OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 description 1
• 229960004659 ticarcillin Drugs 0.000 description 1
• 229960004089 tigecycline Drugs 0.000 description 1
• FPZLLRFZJZRHSY-HJYUBDRYSA-N tigecycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=C(NC(=O)CNC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O FPZLLRFZJZRHSY-HJYUBDRYSA-N 0.000 description 1
• 238000004448 titration Methods 0.000 description 1
• 238000012546 transfer Methods 0.000 description 1
• 238000002054 transplantation Methods 0.000 description 1
• 229960001032 trihexyphenidyl Drugs 0.000 description 1
• 241001515965 unidentified phage Species 0.000 description 1
• 210000001364 upper extremity Anatomy 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 230000035899 viability Effects 0.000 description 1
• 230000008673 vomiting Effects 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 230000004584 weight gain Effects 0.000 description 1
• 208000016261 weight loss Diseases 0.000 description 1
• 238000009736 wetting Methods 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1