AU2017235545A1 - Combination therapy using a LIV1-ADC and a chemotherapeutic - Google Patents

Combination therapy using a LIV1-ADC and a chemotherapeutic Download PDF

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Publication number
AU2017235545A1
AU2017235545A1 AU2017235545A AU2017235545A AU2017235545A1 AU 2017235545 A1 AU2017235545 A1 AU 2017235545A1 AU 2017235545 A AU2017235545 A AU 2017235545A AU 2017235545 A AU2017235545 A AU 2017235545A AU 2017235545 A1 AU2017235545 A1 AU 2017235545A1
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Australia
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ser
leu
gly
ala
glu
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Abandoned
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AU2017235545A
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English (en)
Inventor
Ana Kostic
Fu LI
Django Sussman
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Seagen Inc
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Seagen Inc
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Application filed by Seagen Inc filed Critical Seagen Inc
Publication of AU2017235545A1 publication Critical patent/AU2017235545A1/en
Assigned to SEAGEN INC. reassignment SEAGEN INC. Amend patent request/document other than specification (104) Assignors: SEATTLE GENETICS, INC.
Priority to AU2024201856A priority Critical patent/AU2024201856A1/en
Abandoned legal-status Critical Current

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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/3015—Breast
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
AU2017235545A 2016-03-15 2017-03-15 Combination therapy using a LIV1-ADC and a chemotherapeutic Abandoned AU2017235545A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024201856A AU2024201856A1 (en) 2016-03-15 2024-03-21 Combination therapy using a LIV1-ADC and a chemotherapeutic

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662308639P 2016-03-15 2016-03-15
US62/308,639 2016-03-15
US201662317792P 2016-04-04 2016-04-04
US62/317,792 2016-04-04
US201662367510P 2016-07-27 2016-07-27
US62/367,510 2016-07-27
PCT/US2017/022541 WO2017161007A1 (en) 2016-03-15 2017-03-15 Combination therapy using a liv1-adc and a chemotherapeutic

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2024201856A Division AU2024201856A1 (en) 2016-03-15 2024-03-21 Combination therapy using a LIV1-ADC and a chemotherapeutic

Publications (1)

Publication Number Publication Date
AU2017235545A1 true AU2017235545A1 (en) 2018-10-25

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ID=59852409

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2017235545A Abandoned AU2017235545A1 (en) 2016-03-15 2017-03-15 Combination therapy using a LIV1-ADC and a chemotherapeutic
AU2024201856A Abandoned AU2024201856A1 (en) 2016-03-15 2024-03-21 Combination therapy using a LIV1-ADC and a chemotherapeutic

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2024201856A Abandoned AU2024201856A1 (en) 2016-03-15 2024-03-21 Combination therapy using a LIV1-ADC and a chemotherapeutic

Country Status (14)

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US (2) US11325980B2 (OSRAM)
EP (1) EP3429626A4 (OSRAM)
JP (3) JP2019508433A (OSRAM)
KR (3) KR20230169462A (OSRAM)
CN (1) CN108697801A (OSRAM)
AU (2) AU2017235545A1 (OSRAM)
BR (1) BR112018068129A2 (OSRAM)
CA (1) CA3016485A1 (OSRAM)
EA (1) EA201891968A1 (OSRAM)
IL (1) IL261505A (OSRAM)
MA (1) MA45324A (OSRAM)
MX (2) MX2018010847A (OSRAM)
SG (2) SG11201807526SA (OSRAM)
WO (1) WO2017161007A1 (OSRAM)

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Publication number Priority date Publication date Assignee Title
CA2819038C (en) 2010-12-06 2023-10-17 Seattle Genetics, Inc. Humanized antibodies to liv-1 and use of same to treat cancer
US20200283540A1 (en) * 2017-12-01 2020-09-10 Seattle Genetics, Inc. Humanized anti-liv1 antibodies for the treatment of breast cancer
JP7471289B2 (ja) * 2018-11-07 2024-04-19 クリスパー セラピューティクス アクチェンゲゼルシャフト 抗ｌｉｖ１免疫細胞癌療法
CA3164124A1 (en) 2019-12-09 2021-06-17 Seagen Inc. Combination therapy with liv1-adc and pd-1 antagonist
AU2021349385A1 (en) * 2020-09-28 2023-05-25 Seagen Inc. Humanized anti-liv1 antibodies for the treatment of cancer
US12036286B2 (en) 2021-03-18 2024-07-16 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds
WO2024188339A1 (zh) * 2023-03-15 2024-09-19 浙江博锐生物制药有限公司 抗liv-1抗体和抗liv-1抗体药物偶联物及其药物用途
WO2025162207A1 (zh) * 2024-01-31 2025-08-07 上海复宏汉霖生物技术股份有限公司 抗liv1抗体及使用方法

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