AU2017235462B2 - Bridged bicyclic inhibitors of menin-MLL and methods of use - Google Patents

Bridged bicyclic inhibitors of menin-MLL and methods of use Download PDF

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Publication number
AU2017235462B2
AU2017235462B2 AU2017235462A AU2017235462A AU2017235462B2 AU 2017235462 B2 AU2017235462 B2 AU 2017235462B2 AU 2017235462 A AU2017235462 A AU 2017235462A AU 2017235462 A AU2017235462 A AU 2017235462A AU 2017235462 B2 AU2017235462 B2 AU 2017235462B2
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Prior art keywords
compound
optionally substituted
hnc
cancer
menin
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AU2017235462A
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AU2017235462A1 (en
Inventor
Dmitry Borkin
Tomasz Cierpicki
Jolanta Grembecka
Szymon Klossowski
Liansheng Li
Jonathan Pollock
Pingda Ren
Yi Wang
Tao Wu
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University of Michigan System
Kura Oncology Inc
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University of Michigan System
Kura Oncology Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2017235462A 2016-03-16 2017-03-15 Bridged bicyclic inhibitors of menin-MLL and methods of use Active AU2017235462B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662309362P 2016-03-16 2016-03-16
US62/309,362 2016-03-16
US201662431387P 2016-12-07 2016-12-07
US62/431,387 2016-12-07
PCT/US2017/022535 WO2017161002A1 (en) 2016-03-16 2017-03-15 Bridged bicyclic inhibitors of menin-mll and methods of use

Publications (2)

Publication Number Publication Date
AU2017235462A1 AU2017235462A1 (en) 2018-09-27
AU2017235462B2 true AU2017235462B2 (en) 2021-07-01

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Family Applications (1)

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AU2017235462A Active AU2017235462B2 (en) 2016-03-16 2017-03-15 Bridged bicyclic inhibitors of menin-MLL and methods of use

Country Status (17)

Country Link
US (3) US10752639B2 (https=)
EP (1) EP3429585B1 (https=)
JP (1) JP7000333B2 (https=)
KR (1) KR102419524B1 (https=)
CN (1) CN109640987B (https=)
AU (1) AU2017235462B2 (https=)
BR (1) BR112018068702A2 (https=)
CA (1) CA3015845A1 (https=)
IL (1) IL261625B (https=)
MA (1) MA43823A (https=)
MX (1) MX387806B (https=)
MY (1) MY199965A (https=)
PH (1) PH12018501955B1 (https=)
SG (1) SG11201807834WA (https=)
TW (1) TWI743096B (https=)
WO (1) WO2017161002A1 (https=)
ZA (1) ZA201805845B (https=)

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CN109152784B (zh) 2016-03-16 2021-12-28 库拉肿瘤学公司 经取代的menin-mll抑制剂及使用方法
WO2017192543A1 (en) 2016-05-02 2017-11-09 Regents Of The University Of Michigan Piperidines as menin inhibitors
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US12084462B2 (en) 2016-09-14 2024-09-10 Janssen Pharmaceutica Nv Spiro bicyclic inhibitors of menin-MLL interaction
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