AU2017216900A1 - Methods for stabilizing collagen-containing tissue products against enzymatic degradation - Google Patents
Methods for stabilizing collagen-containing tissue products against enzymatic degradation Download PDFInfo
- Publication number
- AU2017216900A1 AU2017216900A1 AU2017216900A AU2017216900A AU2017216900A1 AU 2017216900 A1 AU2017216900 A1 AU 2017216900A1 AU 2017216900 A AU2017216900 A AU 2017216900A AU 2017216900 A AU2017216900 A AU 2017216900A AU 2017216900 A1 AU2017216900 A1 AU 2017216900A1
- Authority
- AU
- Australia
- Prior art keywords
- tissue
- collagen
- matrix
- tissue matrix
- crosslinked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000008186 Collagen Human genes 0.000 title claims abstract description 32
- 108010035532 Collagen Proteins 0.000 title claims abstract description 32
- 229920001436 collagen Polymers 0.000 title claims abstract description 32
- 238000000034 method Methods 0.000 title claims abstract 24
- 230000007515 enzymatic degradation Effects 0.000 title 1
- 230000000087 stabilizing effect Effects 0.000 title 1
- 239000011159 matrix material Substances 0.000 claims abstract description 57
- 230000001678 irradiating effect Effects 0.000 claims abstract 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 26
- 239000004971 Cross linker Substances 0.000 claims description 16
- 239000002953 phosphate buffered saline Substances 0.000 claims description 15
- 239000004228 Riboflavin-5'-Phosphate Substances 0.000 claims description 14
- 230000002500 effect on skin Effects 0.000 claims description 14
- 239000011768 flavin mononucleotide Substances 0.000 claims description 14
- FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical group OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 claims description 14
- 235000019231 riboflavin-5'-phosphate Nutrition 0.000 claims description 14
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 13
- 235000019192 riboflavin Nutrition 0.000 claims description 13
- 239000002151 riboflavin Substances 0.000 claims description 13
- 229960002477 riboflavin Drugs 0.000 claims description 13
- 239000000243 solution Substances 0.000 claims description 10
- 102000029816 Collagenase Human genes 0.000 claims description 5
- 108060005980 Collagenase Proteins 0.000 claims description 5
- 229960002424 collagenase Drugs 0.000 claims description 5
- 230000029087 digestion Effects 0.000 claims description 3
- 238000011282 treatment Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims 78
- 239000007864 aqueous solution Substances 0.000 claims 3
- 241001269524 Dura Species 0.000 claims 2
- 210000002808 connective tissue Anatomy 0.000 claims 2
- 210000003195 fascia Anatomy 0.000 claims 2
- 210000003709 heart valve Anatomy 0.000 claims 2
- 230000000968 intestinal effect Effects 0.000 claims 2
- 210000003041 ligament Anatomy 0.000 claims 2
- 230000001537 neural effect Effects 0.000 claims 2
- 210000005059 placental tissue Anatomy 0.000 claims 2
- 210000002435 tendon Anatomy 0.000 claims 2
- 210000003954 umbilical cord Anatomy 0.000 claims 2
- 210000000626 ureter Anatomy 0.000 claims 2
- 210000003932 urinary bladder Anatomy 0.000 claims 2
- 206010019909 Hernia Diseases 0.000 claims 1
- 238000007605 air drying Methods 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 239000011261 inert gas Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002791 soaking Methods 0.000 claims 1
- 238000001291 vacuum drying Methods 0.000 claims 1
- 239000000872 buffer Substances 0.000 description 14
- 210000004207 dermis Anatomy 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 10
- 239000012591 Dulbecco’s Phosphate Buffered Saline Substances 0.000 description 6
- 239000007836 KH2PO4 Substances 0.000 description 6
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 6
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 5
- 230000036425 denaturation Effects 0.000 description 3
- 238000004925 denaturation Methods 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 3
- 238000000113 differential scanning calorimetry Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/044—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
- A61F2002/0068—Implantable repair or support meshes, e.g. hernia meshes having a special mesh pattern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662294042P | 2016-02-11 | 2016-02-11 | |
| US62/294,042 | 2016-02-11 | ||
| PCT/US2017/015067 WO2017139102A1 (en) | 2016-02-11 | 2017-01-26 | Methods for stabilizing collagen-containing tissue products against enzymatic degradation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2017216900A1 true AU2017216900A1 (en) | 2018-08-09 |
Family
ID=57966216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017216900A Abandoned AU2017216900A1 (en) | 2016-02-11 | 2017-01-26 | Methods for stabilizing collagen-containing tissue products against enzymatic degradation |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11179505B2 (https=) |
| EP (1) | EP3413943A1 (https=) |
| JP (1) | JP2019504708A (https=) |
| CN (1) | CN108697828A (https=) |
| AU (1) | AU2017216900A1 (https=) |
| CA (1) | CA3013296A1 (https=) |
| WO (1) | WO2017139102A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9622911B2 (en) | 2010-09-30 | 2017-04-18 | Cxl Ophthalmics, Llc | Ophthalmic treatment device, system, and method of use |
| WO2013149075A1 (en) | 2012-03-29 | 2013-10-03 | Cxl Ophthalmics, Llc | Compositions and methods for treating or preventing diseases associated with oxidative stress |
| EP4420725A3 (en) | 2012-03-29 | 2025-04-16 | Epion Therapeutics, Inc. | Ocular treatment solutions, delivery devices and delivery augmentation methods |
| CN109527192B (zh) * | 2018-12-05 | 2023-01-31 | 大连工业大学 | 一种基于uva照射诱导核黄素氧化增强鱼肌原纤维蛋白制品凝胶特性的方法 |
| CN109821069A (zh) * | 2019-01-16 | 2019-05-31 | 华中科技大学同济医学院附属协和医院 | 一种光交联型去细胞瓣膜及其制备方法和其应用 |
| MX2021014654A (es) * | 2019-05-30 | 2022-03-11 | Lifecell Corp | Implante de mama biologico. |
| CN112175039B (zh) * | 2019-12-08 | 2021-08-31 | 兰州大学 | 一种绿色、广谱的蛋白质交联方法 |
| CN113425910A (zh) * | 2021-07-30 | 2021-09-24 | 中南大学湘雅二医院 | 一种复合交联生物瓣膜及其制备方法 |
| CN116392637A (zh) * | 2023-04-23 | 2023-07-07 | 成都纽脉生物科技有限公司 | 对生物材料进行交联的方法 |
| CN118178730A (zh) * | 2024-03-27 | 2024-06-14 | 上海茂摩生物科技有限公司 | 真皮脱细胞基质补片及其制备方法和应用 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1073243A (en) | 1963-12-13 | 1967-06-21 | Ethicon Inc | Twisted collagen ribbon |
| GB8413319D0 (en) | 1984-05-24 | 1984-06-27 | Oliver Roy Frederick | Biological material |
| US4865602A (en) | 1986-11-06 | 1989-09-12 | Collagen Corporation | Gamma irradiation of collagen/mineral mixtures |
| US4978352A (en) | 1989-06-07 | 1990-12-18 | Fedorov Svjatoslav N | Process for producing collagen-based cross-linked biopolymer, an implant from said biopolymer, method for producing said implant, and method for hermetization of corneal or scleral wounds involved in eye injuries, using said implant |
| US8067149B2 (en) | 1990-09-12 | 2011-11-29 | Lifecell Corporation | Acellular dermal matrix and method of use thereof for grafting |
| CA2051092C (en) | 1990-09-12 | 2002-07-23 | Stephen A. Livesey | Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions |
| US5336616A (en) | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
| US5709934A (en) * | 1994-11-22 | 1998-01-20 | Tissue Engineering, Inc. | Bipolymer foams having extracellular matrix particulates |
| JP3471967B2 (ja) | 1995-03-28 | 2003-12-02 | カネボウ株式会社 | ハイブリッド型人工歯根 |
| US6166288A (en) | 1995-09-27 | 2000-12-26 | Nextran Inc. | Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor |
| US5843084A (en) | 1995-11-17 | 1998-12-01 | Innovasive Devices, Inc. | Surgical fastening system and method for using the same |
| JP3567451B2 (ja) | 1997-06-24 | 2004-09-22 | 住友電気工業株式会社 | 光増幅器 |
| JPH1147258A (ja) * | 1997-07-30 | 1999-02-23 | Menicon Co Ltd | ゼラチンとコラーゲンとを含有する医用基材 |
| US6734018B2 (en) | 1999-06-07 | 2004-05-11 | Lifenet | Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced |
| FR2786400B1 (fr) | 1998-11-30 | 2002-05-10 | Imedex Biomateriaux | Procede de preparation d'un materiau collagenique a vitesse de biodegradation in vivo controlee et materiaux obtenus |
| US6203570B1 (en) | 1999-11-24 | 2001-03-20 | John L. Baeke | Breast implant with position lock |
| AU9109201A (en) * | 2000-09-18 | 2002-03-26 | Organogenesis Inc | Methods for treating a patient using a bioengineered flat sheet graft prostheses |
| US20030003157A1 (en) | 2001-06-06 | 2003-01-02 | University Of Medicine & Dentistry Of New Jersey | Collagen compositions and methods for making and using the same |
| WO2003032735A1 (en) | 2001-10-18 | 2003-04-24 | Lifecell Corporation | Remodeling of tissues and organs |
| JPWO2003094985A1 (ja) * | 2002-05-14 | 2005-09-08 | 北海道ティー・エル・オー株式会社 | 人工細胞外マトリックス及びその製造方法 |
| US20030229394A1 (en) | 2002-06-06 | 2003-12-11 | Ogle Matthew F. | Processed tissue for medical device formation |
| CA2533259C (en) | 2003-07-21 | 2014-01-28 | Lifecell Corporation | Acellular tissue matrices made from galactose .alpha.-1,3-galactose-deficient tissue |
| GB0415080D0 (en) | 2004-07-05 | 2004-08-04 | Ucl Biomedica Plc | Methods for preparing tissue equivalent implants and products thereof |
| WO2006029571A1 (en) * | 2004-09-14 | 2006-03-23 | The University Of Hong Kong | Photochemically crosslinked collagen scaffolds and methods for their preparation |
| US20060073592A1 (en) | 2004-10-06 | 2006-04-06 | Wendell Sun | Methods of storing tissue matrices |
| JP5478884B2 (ja) | 2005-09-26 | 2014-04-23 | ライフセル コーポレーション | 乾燥血小板組成物 |
| US20070248575A1 (en) | 2006-04-19 | 2007-10-25 | Jerome Connor | Bone graft composition |
| EP2015707B1 (en) | 2006-05-09 | 2019-01-23 | LifeCell Corporation | Reinforced biological tissue |
| WO2008070848A2 (en) * | 2006-12-07 | 2008-06-12 | Priavision, Inc. | Method and material for in situ corneal structural augmentation |
| US20080195229A1 (en) | 2007-02-09 | 2008-08-14 | Quijano Rodolfo C | Decellularized pericardial tissue |
| TW200916069A (en) | 2007-06-24 | 2009-04-16 | Gary Pierre Lauryssen | Human mammary prosthetic support |
| CZ301086B6 (cs) | 2007-10-17 | 2009-11-04 | Bio-Skin, A. S. | Sterilní autologní, allogenní nebo xenogenní implantát a zpusob jeho výroby |
| JP5388090B2 (ja) * | 2008-05-29 | 2014-01-15 | 国立大学法人東北大学 | 強膜透明化による角膜移植材料調製方法 |
| CA2726350C (en) | 2008-06-06 | 2016-07-19 | Lifecell Corporation | Elastase treatment of tissue matrices |
| JP2011525140A (ja) | 2008-06-20 | 2011-09-15 | クック・バイオテック・インコーポレイテッド | 複合細胞外マトリックス材料およびそれらから形成される医療製品 |
| CN103751842A (zh) | 2008-07-30 | 2014-04-30 | 米辛瑟斯有限公司 | 衍生自前胃胞外基质的组织支架 |
| EP2349089A4 (en) | 2008-11-21 | 2014-01-15 | Lifecell Corp | REINFORCED BIOLOGICAL MATERIAL |
| IT1413578B1 (it) | 2008-12-05 | 2015-01-30 | Frullini | Metodo per ristrutturare un tessuto biologico comprendente fibrille di collagene e relativi usi |
| GB0908927D0 (en) | 2009-05-22 | 2009-07-01 | Univ Reading The | Synthetic graft |
| US8986377B2 (en) | 2009-07-21 | 2015-03-24 | Lifecell Corporation | Graft materials for surgical breast procedures |
| US9987225B2 (en) | 2009-09-30 | 2018-06-05 | Ottawa Hospital Research Institute | Crosslinked hydrogels and related method of preparation |
| WO2011074208A1 (ja) * | 2009-12-18 | 2011-06-23 | 国立大学法人東北大学 | 皮膚真皮又は羊膜透明化による角膜移植材料調製法 |
| AU2011276246B2 (en) * | 2010-07-08 | 2014-12-04 | Lifecell Corporation | Method for shaping tissue matrices |
| EP2663281B1 (en) | 2011-01-12 | 2016-08-10 | Sooft Italia Spa | Corneal delivery of cross-linking agents by iontophoresis for the treatment of keratoconus and related ophthalmic compositions |
| WO2014089548A1 (en) * | 2012-12-07 | 2014-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Oculoplasty grafts |
| CN103520772B (zh) | 2013-10-24 | 2015-05-20 | 北京积水潭医院 | 一种制备皮肤移植用脱细胞真皮材料的改进工艺 |
| JP2015110537A (ja) * | 2013-12-06 | 2015-06-18 | 大日本印刷株式会社 | 貼付用シートおよびその製造方法 |
-
2017
- 2017-01-26 AU AU2017216900A patent/AU2017216900A1/en not_active Abandoned
- 2017-01-26 EP EP17703619.1A patent/EP3413943A1/en not_active Withdrawn
- 2017-01-26 CN CN201780010120.1A patent/CN108697828A/zh active Pending
- 2017-01-26 JP JP2018541695A patent/JP2019504708A/ja active Pending
- 2017-01-26 WO PCT/US2017/015067 patent/WO2017139102A1/en not_active Ceased
- 2017-01-26 CA CA3013296A patent/CA3013296A1/en not_active Abandoned
- 2017-01-26 US US16/077,143 patent/US11179505B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA3013296A1 (en) | 2017-08-17 |
| CN108697828A (zh) | 2018-10-23 |
| WO2017139102A1 (en) | 2017-08-17 |
| EP3413943A1 (en) | 2018-12-19 |
| US11179505B2 (en) | 2021-11-23 |
| US20190255226A1 (en) | 2019-08-22 |
| JP2019504708A (ja) | 2019-02-21 |
| WO2017139102A8 (en) | 2017-10-19 |
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