AU2017210042B2 - Compositions and methods for inhibiting Factor D - Google Patents

Compositions and methods for inhibiting Factor D Download PDF

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Publication number
AU2017210042B2
AU2017210042B2 AU2017210042A AU2017210042A AU2017210042B2 AU 2017210042 B2 AU2017210042 B2 AU 2017210042B2 AU 2017210042 A AU2017210042 A AU 2017210042A AU 2017210042 A AU2017210042 A AU 2017210042A AU 2017210042 B2 AU2017210042 B2 AU 2017210042B2
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aptamer
cases
aptamers
dna
artificial sequence
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AU2017210042A1 (en
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Carl ERICKSON
Kevin G. Mclure
Christopher P. Rusconi
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396419 BC Ltd
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396419 B C Ltd
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Priority to AU2021202392A priority Critical patent/AU2021202392B2/en
Priority to AU2023202548A priority patent/AU2023202548A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2017210042A 2016-01-20 2017-01-20 Compositions and methods for inhibiting Factor D Active AU2017210042B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021202392A AU2021202392B2 (en) 2016-01-20 2021-04-20 Compositions and methods for inhibiting Factor D
AU2023202548A AU2023202548A1 (en) 2016-01-20 2023-04-27 Compositions and methods for inhibiting factor d

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662281092P 2016-01-20 2016-01-20
US62/281,092 2016-01-20
US201662297095P 2016-02-18 2016-02-18
US62/297,095 2016-02-18
PCT/US2017/014458 WO2017127761A1 (en) 2016-01-20 2017-01-20 Compositions and methods for inhibiting factor d

Related Child Applications (1)

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AU2021202392A Division AU2021202392B2 (en) 2016-01-20 2021-04-20 Compositions and methods for inhibiting Factor D

Publications (2)

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AU2017210042A1 AU2017210042A1 (en) 2018-07-26
AU2017210042B2 true AU2017210042B2 (en) 2021-01-21

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AU2017210042A Active AU2017210042B2 (en) 2016-01-20 2017-01-20 Compositions and methods for inhibiting Factor D
AU2021202392A Active AU2021202392B2 (en) 2016-01-20 2021-04-20 Compositions and methods for inhibiting Factor D
AU2023202548A Abandoned AU2023202548A1 (en) 2016-01-20 2023-04-27 Compositions and methods for inhibiting factor d

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AU2021202392A Active AU2021202392B2 (en) 2016-01-20 2021-04-20 Compositions and methods for inhibiting Factor D
AU2023202548A Abandoned AU2023202548A1 (en) 2016-01-20 2023-04-27 Compositions and methods for inhibiting factor d

Country Status (8)

Country Link
US (4) US10174325B2 (cg-RX-API-DMAC7.html)
EP (1) EP3405577B8 (cg-RX-API-DMAC7.html)
JP (3) JP2019506159A (cg-RX-API-DMAC7.html)
CN (1) CN108934169A (cg-RX-API-DMAC7.html)
AU (3) AU2017210042B2 (cg-RX-API-DMAC7.html)
CA (1) CA3011819A1 (cg-RX-API-DMAC7.html)
GB (1) GB2553252B (cg-RX-API-DMAC7.html)
WO (1) WO2017127761A1 (cg-RX-API-DMAC7.html)

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EP3340983B1 (en) 2015-08-26 2023-10-04 Achillion Pharmaceuticals, Inc. Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
WO2017035401A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amide compounds for treatment of immune and inflammatory disorders
AU2017210042B2 (en) 2016-01-20 2021-01-21 396419 B.C. Ltd. Compositions and methods for inhibiting Factor D
WO2018136831A1 (en) * 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Pseudoknot compositions and methods for inhibiting factor d
WO2018136827A1 (en) 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Stem-loop compositions and methods for inhibiting factor d
MX2019010381A (es) 2017-03-01 2020-01-21 Achillion Pharmaceuticals Inc Compuestos farmaceuticos de arilo, heteroarilo y heterociclicos para el tratamiento de trastornos medicos.
WO2018160891A1 (en) 2017-03-01 2018-09-07 Achillion Pharmaceutical, Inc. Pharmaceutical compounds for treatment of medical disorders
WO2019022986A1 (en) * 2017-07-24 2019-01-31 Vitrisa Therapeutics, Inc. NUCLEIC ACID COMPOSITIONS AND METHODS OF INHIBITING D-FACTOR
WO2019028284A1 (en) 2017-08-02 2019-02-07 Achillion Pharmaceuticals, Inc. THERAPEUTIC REGIMES FOR THE TREATMENT OF NOCTURNAL PAROXYSTIC HEMOGLOBINURIA
WO2019210194A1 (en) * 2018-04-26 2019-10-31 Vitrisa Therapeutics, Inc. Pegylated compositions for ocular use, and methods thereof
MX2021002640A (es) 2018-09-06 2021-07-16 Achillion Pharmaceuticals Inc Formas morficas de los inhibidores del factor d del complemento.
US11814391B2 (en) 2018-09-06 2023-11-14 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for the treatment of medical disorders
MX2021003425A (es) 2018-09-25 2021-07-16 Achillion Pharmaceuticals Inc Formas morficas de los inhibidores del factor d del complemento.
AU2019406830A1 (en) 2018-12-17 2021-07-08 Achillion Pharmaceuticals, Inc. Targeted dosing for the treatment of complement mediated disorders
WO2020146731A1 (en) * 2019-01-11 2020-07-16 Drive Therapeutics Llc Compositions and methods for inhibiting vascular endothelial growth factor
WO2020198062A1 (en) 2019-03-22 2020-10-01 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement mediated disorders
US20220395557A1 (en) * 2019-10-23 2022-12-15 Gemini Therapeutics Sub, Inc. Methods for treating patients having cfh mutations with recombinant cfh proteins
CN114686481B (zh) * 2020-12-31 2023-08-15 北京键凯科技股份有限公司 一种抑制cfd表达的干扰rna及其制备方法和应用
US20250129371A1 (en) * 2023-10-11 2025-04-24 Regeneron Pharmaceuticals, Inc. Treatment Of Macular Degeneration With Complement Factor D (CFD) Inhibitors

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Publication number Publication date
HK1251610A1 (zh) 2019-02-01
JP2022078283A (ja) 2022-05-24
CN108934169A (zh) 2018-12-04
US20180051287A1 (en) 2018-02-22
AU2023202548A1 (en) 2023-06-01
EP3405577A1 (en) 2018-11-28
AU2021202392A1 (en) 2021-05-20
WO2017127761A1 (en) 2017-07-27
EP3405577B8 (en) 2023-02-15
US10174325B2 (en) 2019-01-08
GB201718801D0 (en) 2017-12-27
AU2017210042A1 (en) 2018-07-26
US11274307B2 (en) 2022-03-15
GB2553252A (en) 2018-02-28
JP2024029136A (ja) 2024-03-05
US20190161755A1 (en) 2019-05-30
GB2553252A8 (en) 2018-03-14
EP3405577B1 (en) 2022-12-14
EP3405577A4 (en) 2019-09-11
AU2021202392B2 (en) 2023-02-02
US20200392502A1 (en) 2020-12-17
US20250197868A1 (en) 2025-06-19
GB2553252B (en) 2019-07-31
CA3011819A1 (en) 2017-07-27
JP2019506159A (ja) 2019-03-07

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