AU2016378480A1 - Endothelium-specific nucleic acid regulatory elements and methods and use thereof - Google Patents
Endothelium-specific nucleic acid regulatory elements and methods and use thereof Download PDFInfo
- Publication number
- AU2016378480A1 AU2016378480A1 AU2016378480A AU2016378480A AU2016378480A1 AU 2016378480 A1 AU2016378480 A1 AU 2016378480A1 AU 2016378480 A AU2016378480 A AU 2016378480A AU 2016378480 A AU2016378480 A AU 2016378480A AU 2016378480 A1 AU2016378480 A1 AU 2016378480A1
- Authority
- AU
- Australia
- Prior art keywords
- nucleic acid
- dna
- othd
- eolf
- homo sapiens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/23—Parvoviridae, e.g. feline panleukopenia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2015/081075 | 2015-12-22 | ||
| EP2015081075 | 2015-12-22 | ||
| PCT/EP2016/082314 WO2017109039A1 (en) | 2015-12-22 | 2016-12-22 | Endothelium-specific nucleic acid regulatory elements and methods and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2016378480A1 true AU2016378480A1 (en) | 2018-07-12 |
Family
ID=57821918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016378480A Abandoned AU2016378480A1 (en) | 2015-12-22 | 2016-12-22 | Endothelium-specific nucleic acid regulatory elements and methods and use thereof |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11446375B2 (enExample) |
| EP (1) | EP3393523B9 (enExample) |
| JP (2) | JP2018538003A (enExample) |
| AU (1) | AU2016378480A1 (enExample) |
| CA (1) | CA3009264A1 (enExample) |
| WO (1) | WO2017109039A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111534541A (zh) * | 2020-05-07 | 2020-08-14 | 西南大学 | 一种真核生物CRISPR-Cas9双gRNA载体及构建方法 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201700086403A1 (it) * | 2017-07-27 | 2019-01-27 | Univ Del Piemonte Orientale | Endothelial-specific promoter sequences and uses thereof |
| WO2020084161A1 (en) | 2018-10-26 | 2020-04-30 | Vrije Universiteit Brussel | New tools for improving gene therapy and use thereof |
| WO2020152653A1 (en) * | 2019-01-24 | 2020-07-30 | Excellgene Sa | Methods of producing and using recombinant alpha 1-antitrypsin (aat) and compositions thereof |
| WO2020168362A1 (en) | 2019-02-15 | 2020-08-20 | Crispr Therapeutics Ag | Gene editing for hemophilia a with improved factor viii expression |
| JP7585217B2 (ja) * | 2019-06-05 | 2024-11-18 | クリスパー セラピューティクス アクチェンゲゼルシャフト | 改善された第viii因子発現による血友病aのための遺伝子編集 |
| US20230272422A1 (en) * | 2020-08-05 | 2023-08-31 | Spacecraft Seven, Llc | Adeno-associated viral vector for glut1 expression and uses thereof |
| US20220233714A1 (en) * | 2021-01-27 | 2022-07-28 | Vanderbilt University | Nanogold-dna bioconjugates and methods of use thereof |
| CN114032239B (zh) * | 2021-10-28 | 2024-06-21 | 北京美康基免生物科技有限公司 | 一种组织特异启动子及其应用 |
| EP4368209A1 (en) | 2022-11-09 | 2024-05-15 | Vrije Universiteit Brussel | Cardiac vascular endothelial cell-derived nucleic acid regulatory elements and methods and use thereof |
| CN117925624B (zh) * | 2024-03-22 | 2024-05-31 | 上海凌医生物科技有限公司 | 一种金属响应调控元件 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656454A (en) * | 1994-10-04 | 1997-08-12 | President And Fellows Of Harvard College | Endothelial cell-specific enhancer |
| FR2756570B1 (fr) * | 1996-12-03 | 2002-09-27 | Commissariat Energie Atomique | Promoteur de la ve-cadherine et ses utilisations |
| AU2003222427B8 (en) | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
| ITMI20011138A1 (it) * | 2001-05-29 | 2002-11-29 | Uni Di Torino | Vettore e metodi di impiego per l'espressione selettiva di geni in siti di angiogenesi in vivo |
| JP2005204549A (ja) * | 2004-01-21 | 2005-08-04 | Hubit Genomix Inc | C型肝炎ウイルス感染者の経過に関する遺伝子およびその利用 |
| US20070161031A1 (en) | 2005-12-16 | 2007-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Functional arrays for high throughput characterization of gene expression regulatory elements |
| EP2097538A4 (en) * | 2006-12-07 | 2011-11-30 | Switchgear Genomics | TRANSCRIPTION REAGULATION ELEMENTS OF BIOLOGICAL PATHS, TOOLS AND METHODS |
| US8815779B2 (en) * | 2009-09-16 | 2014-08-26 | SwitchGear Genomics, Inc. | Transcription biomarkers of biological responses and methods |
| CA2785677C (en) * | 2009-12-29 | 2019-06-25 | Cornell University | Methods for developing endothelial cells from pluripotent cells and endothelial cells derived therefrom |
| CN103492576A (zh) * | 2011-02-14 | 2014-01-01 | 雷维维科公司 | 用于血管化异种移植物及其衍生物的异种移植的遗传修饰的猪 |
| JP2015109833A (ja) * | 2013-11-08 | 2015-06-18 | 学校法人慶應義塾 | 線維芽細胞から血管内皮細胞を製造する方法 |
-
2016
- 2016-12-22 AU AU2016378480A patent/AU2016378480A1/en not_active Abandoned
- 2016-12-22 JP JP2018533200A patent/JP2018538003A/ja active Pending
- 2016-12-22 EP EP16826729.2A patent/EP3393523B9/en active Active
- 2016-12-22 US US16/065,629 patent/US11446375B2/en active Active
- 2016-12-22 CA CA3009264A patent/CA3009264A1/en active Pending
- 2016-12-22 WO PCT/EP2016/082314 patent/WO2017109039A1/en not_active Ceased
-
2021
- 2021-03-12 JP JP2021040766A patent/JP7376018B2/ja active Active
-
2022
- 2022-07-26 US US17/815,136 patent/US12558416B2/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111534541A (zh) * | 2020-05-07 | 2020-08-14 | 西南大学 | 一种真核生物CRISPR-Cas9双gRNA载体及构建方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3393523B1 (en) | 2023-06-07 |
| US11446375B2 (en) | 2022-09-20 |
| JP2021097701A (ja) | 2021-07-01 |
| CA3009264A1 (en) | 2017-06-29 |
| JP2018538003A (ja) | 2018-12-27 |
| US20200237900A1 (en) | 2020-07-30 |
| EP3393523B9 (en) | 2023-10-04 |
| EP3393523A1 (en) | 2018-10-31 |
| JP7376018B2 (ja) | 2023-11-08 |
| US12558416B2 (en) | 2026-02-24 |
| WO2017109039A1 (en) | 2017-06-29 |
| US20230051499A1 (en) | 2023-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102319845B1 (ko) | 조류 숙주 세포에 대한 crispr-cas 시스템 | |
| AU2016378480A1 (en) | Endothelium-specific nucleic acid regulatory elements and methods and use thereof | |
| ES2819976T3 (es) | Composiciones y usos médicos para la reprogramación de TCR con proteínas de fusión | |
| KR102007061B1 (ko) | 다중 면역 스크리닝 분석 | |
| KR20180048743A (ko) | 2a 펩타이드를 포함하는 재조합 벡터 | |
| CN113396222A (zh) | 腺相关病毒(aav)生产细胞系和相关方法 | |
| KR20100087303A (ko) | 생물치료학적 분자를 발현시키기 위한 치료학적 유전자-스위치 작제물 및 생물반응기, 및 이의 용도 | |
| KR20210105382A (ko) | 단백질을 코딩하는 rna | |
| KR20230019063A (ko) | C9orf72 연관 질환의 치료를 위한 삼중 기능 아데노-연관 바이러스 (aav) 벡터 | |
| KR20230054840A (ko) | rAAV 비리온의 유도 생산을 위한 안정화된 세포주 | |
| US12421524B2 (en) | Expression vectors for eukaryotic expression systems | |
| CN115968300A (zh) | 用于体内转导的载体和方法 | |
| AU2017352591B2 (en) | A two-part device for T-cell receptor synthesis and stable genomic integration to TCR-presenting cells | |
| KR20230056630A (ko) | 신규의 omni-59, 61, 67, 76, 79, 80, 81 및 82 crispr 뉴클레아제 | |
| CN114026242A (zh) | 具有髓鞘蛋白零启动子的aav载体及其用于治疗雪旺细胞相关疾病如charcot-marie-tooth疾病的用途 | |
| KR20240021906A (ko) | 발현 벡터, 박테리아 서열-무함유 벡터, 및 이를 제조하고 사용하는 방법 | |
| KR100880509B1 (ko) | 재조합 단백질의 대량 생산을 위한 신규한 벡터, 발현세포주 및 이를 이용한 재조합 단백질의 생산 방법 | |
| AU2017233862B2 (en) | Methods and compositions for increased double stranded RNA production | |
| KR20230117327A (ko) | 가용성 알칼리성 포스파타제 작제물 및 가용성 알칼리성 포스파타제 작제물을 인코딩하는 폴리뉴클레오티드를 포함하는 발현 벡터 | |
| KR20240022571A (ko) | Rna-가이드된 이펙터 동원을 위한 시스템, 방법 및 성분 | |
| CN117881788A (zh) | 表达载体、无细菌序列载体及其制备和使用方法 | |
| CN101180082A (zh) | 利用siv-pedf载体治疗伴随眼组织细胞凋亡变性的疾患的药物 | |
| CN112063655A (zh) | 一种端粒基因治疗产品和哺乳动物广泛性启动子的用途 | |
| HK40111561A (zh) | 表达载体、无细菌序列载体及其制备和使用方法 | |
| HK40091834A (zh) | 增加双链rna产生的方法和组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |