IT201700086403A1 - Endothelial-specific promoter sequences and uses thereof - Google Patents

Endothelial-specific promoter sequences and uses thereof

Info

Publication number
IT201700086403A1
IT201700086403A1 IT102017000086403A IT201700086403A IT201700086403A1 IT 201700086403 A1 IT201700086403 A1 IT 201700086403A1 IT 102017000086403 A IT102017000086403 A IT 102017000086403A IT 201700086403 A IT201700086403 A IT 201700086403A IT 201700086403 A1 IT201700086403 A1 IT 201700086403A1
Authority
IT
Italy
Prior art keywords
endothelial
specific promoter
promoter sequences
sequences
specific
Prior art date
Application number
IT102017000086403A
Other languages
English (en)
Inventor
Antonia Follenzi
Simone Merlin
Ester Borroni
Chiara Borsotti
Valentina Bruscaggin
Silvia Zucchelli
Original Assignee
Univ Del Piemonte Orientale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Del Piemonte Orientale filed Critical Univ Del Piemonte Orientale
Priority to IT102017000086403A priority Critical patent/IT201700086403A1/it
Priority to US16/634,432 priority patent/US20200165631A1/en
Priority to EP18756292.1A priority patent/EP3658676B1/en
Priority to PCT/IB2018/055603 priority patent/WO2019021238A1/en
Publication of IT201700086403A1 publication Critical patent/IT201700086403A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT102017000086403A 2017-07-27 2017-07-27 Endothelial-specific promoter sequences and uses thereof IT201700086403A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT102017000086403A IT201700086403A1 (it) 2017-07-27 2017-07-27 Endothelial-specific promoter sequences and uses thereof
US16/634,432 US20200165631A1 (en) 2017-07-27 2018-07-26 Endothelial-specific promoter sequences and uses thereof
EP18756292.1A EP3658676B1 (en) 2017-07-27 2018-07-26 Endothelial-specific promoter sequences and uses thereof
PCT/IB2018/055603 WO2019021238A1 (en) 2017-07-27 2018-07-26 SPECIFIC PROMOTER SEQUENCES OF ENDOTHELIAL CELLS AND USES THEREOF

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102017000086403A IT201700086403A1 (it) 2017-07-27 2017-07-27 Endothelial-specific promoter sequences and uses thereof

Publications (1)

Publication Number Publication Date
IT201700086403A1 true IT201700086403A1 (it) 2019-01-27

Family

ID=60628059

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102017000086403A IT201700086403A1 (it) 2017-07-27 2017-07-27 Endothelial-specific promoter sequences and uses thereof

Country Status (4)

Country Link
US (1) US20200165631A1 (it)
EP (1) EP3658676B1 (it)
IT (1) IT201700086403A1 (it)
WO (1) WO2019021238A1 (it)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005052171A2 (en) * 2003-10-30 2005-06-09 Oxford Biomedica (Uk) Limited Retroviral and lentiviral vectors
WO2007000668A2 (en) * 2005-05-27 2007-01-04 Fondazione Centro San Raffaele Del Monte Tabor Gene vector comprising mi-rna
US20160244837A1 (en) * 2010-11-02 2016-08-25 Celera Corporation Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
WO2017109039A1 (en) * 2015-12-22 2017-06-29 Vrije Universiteit Brussel Endothelium-specific nucleic acid regulatory elements and methods and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1958648A4 (en) * 2005-10-28 2009-12-30 Dnavec Corp THERAPEUTIC PROCESS FOR BLOOD CLEANING DISORDER
BRPI1010873B1 (pt) * 2009-04-30 2020-04-14 Fond Centro San Raffaele Del Monte Tabor usos de um vetor de genes, de uma composição farmacêutica e de uma célula
ITUA20164289A1 (it) * 2016-06-10 2017-12-10 Univ Del Piemonte Orientale Promoter for cell-specific gene expression and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005052171A2 (en) * 2003-10-30 2005-06-09 Oxford Biomedica (Uk) Limited Retroviral and lentiviral vectors
WO2007000668A2 (en) * 2005-05-27 2007-01-04 Fondazione Centro San Raffaele Del Monte Tabor Gene vector comprising mi-rna
US20160244837A1 (en) * 2010-11-02 2016-08-25 Celera Corporation Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
WO2017109039A1 (en) * 2015-12-22 2017-06-29 Vrije Universiteit Brussel Endothelium-specific nucleic acid regulatory elements and methods and use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CYRILL GÉRAUD ET AL: "GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis", JOURNAL OF CLINICAL INVESTIGATION, vol. 127, no. 3, March 2017 (2017-03-01), US, pages 1099 - 1114, XP055444378, ISSN: 0021-9738, DOI: 10.1172/JCI90086 *
JAMES D. PERKINS: "Liver sinusoidal endothelial cells: Their unique role in immune tolerance", LIVER TRANSPLANTATION, vol. 12, no. 12, December 2006 (2006-12-01), US, pages 1900 - 1903, XP055444522, ISSN: 1527-6465, DOI: 10.1002/lt.21017 *
MARINA E. FOMIN ET AL: "Production of Factor VIII by Human Liver Sinusoidal Endothelial Cells Transplanted in Immunodeficient uPA Mice", PLOS ONE, vol. 8, no. 10, 22 October 2013 (2013-10-22), pages e77255, XP055444533, DOI: 10.1371/journal.pone.0077255 *
MEGAN S. ROST ET AL: "Hyaluronic Acid Receptor Stabilin-2 Regulates Erk Phosphorylation and Arterial - Venous Differentiation in Zebrafish", PLOS ONE, vol. 9, no. 2, 28 February 2014 (2014-02-28), pages e88614, XP055444397, DOI: 10.1371/journal.pone.0088614 *

Also Published As

Publication number Publication date
EP3658676A1 (en) 2020-06-03
EP3658676B1 (en) 2023-02-22
WO2019021238A1 (en) 2019-01-31
US20200165631A1 (en) 2020-05-28

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