AU2016367536B2 - Thrombin microcapsules - Google Patents

Thrombin microcapsules Download PDF

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Publication number
AU2016367536B2
AU2016367536B2 AU2016367536A AU2016367536A AU2016367536B2 AU 2016367536 B2 AU2016367536 B2 AU 2016367536B2 AU 2016367536 A AU2016367536 A AU 2016367536A AU 2016367536 A AU2016367536 A AU 2016367536A AU 2016367536 B2 AU2016367536 B2 AU 2016367536B2
Authority
AU
Australia
Prior art keywords
thrombin
spray
powder
dried
drying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2016367536A
Other languages
English (en)
Other versions
AU2016367536A1 (en
Inventor
Assaf GERSHONOVITCH
Erez Ilan
Rivka KAUFMAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omrix Biopharmaceuticals Ltd
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Publication of AU2016367536A1 publication Critical patent/AU2016367536A1/en
Application granted granted Critical
Publication of AU2016367536B2 publication Critical patent/AU2016367536B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
AU2016367536A 2015-12-08 2016-12-01 Thrombin microcapsules Ceased AU2016367536B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562264432P 2015-12-08 2015-12-08
IL242984A IL242984A0 (en) 2015-12-08 2015-12-08 Thrombin microcapsules, their preparation and how to use them
IL242984 2015-12-08
US62/264,432 2015-12-08
PCT/IL2016/000024 WO2017098493A1 (en) 2015-12-08 2016-12-01 Thrombin microcapsules

Publications (2)

Publication Number Publication Date
AU2016367536A1 AU2016367536A1 (en) 2018-05-17
AU2016367536B2 true AU2016367536B2 (en) 2021-12-02

Family

ID=59012760

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016367536A Ceased AU2016367536B2 (en) 2015-12-08 2016-12-01 Thrombin microcapsules

Country Status (9)

Country Link
EP (1) EP3386487A1 (pt)
JP (1) JP6918799B2 (pt)
KR (1) KR20180091035A (pt)
CN (1) CN108366967B (pt)
AU (1) AU2016367536B2 (pt)
BR (1) BR112018011504A2 (pt)
CA (1) CA3007900A1 (pt)
IL (2) IL242984A0 (pt)
WO (1) WO2017098493A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2865349C (en) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
CA2874290C (en) 2012-06-12 2020-02-25 Ferrosan Medical Devices A/S Dry haemostatic composition
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
CA2928963C (en) 2013-12-11 2020-10-27 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
CN106999621B (zh) 2014-10-13 2020-07-03 弗罗桑医疗设备公司 用于止血和伤口愈合的干组合物
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
EP3316930B1 (en) 2015-07-03 2019-07-31 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
CN111787958A (zh) 2017-12-29 2020-10-16 巴克斯特国际公司 喷雾干燥凝血酶以及使用和制造喷雾干燥凝血酶的方法
KR20210008479A (ko) 2018-05-09 2021-01-22 훼로산 메디칼 디바이스 에이/에스 지혈 조성물을 제조하는 방법
IL263679A (en) * 2018-12-12 2019-03-31 Omrix Biopharmaceuticals Ltd Kits, methods, and ingredients for preventing tissue adhesion

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6113948A (en) * 1996-05-17 2000-09-05 Quadrant Healthcare Microparticles and their use in wound therapy
US20100150900A1 (en) * 2008-12-12 2010-06-17 Nicola Whitfield Dry Powder Fibrin Sealant
WO2011151386A1 (en) * 2010-06-01 2011-12-08 Baxter International Inc. Process for making dry and stable hemostatic compositions
US20120315305A1 (en) * 2010-01-08 2012-12-13 Profibrix Bv Dry Powder Fibrin Sealant
US20150147312A1 (en) * 2013-11-26 2015-05-28 Omrix Biopharmaceuticals Ltd. Dry pad comprising thrombin and pectin
US9084728B2 (en) * 2010-06-01 2015-07-21 Baxter International Inc. Process for making dry and stable hemostatic compositions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
DE69418334T2 (de) 1993-08-06 2000-01-27 Opperbas Holding B.V., Amsterdam Verfahren zur hohen beladung von vesikeln mit biopolymeren substanzen
EP0856317A1 (en) 1997-01-31 1998-08-05 Omrix Biopharmaceuticals S.A. A stabilized mixture comprising fibrinogen
US6121232A (en) 1997-01-31 2000-09-19 Omrix Biopharmaceuticals Sa Stabilized mixture comprising fibrinogen
GB9727102D0 (en) 1997-12-22 1998-02-25 Andaris Ltd Microparticles and their therapeutic use
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
ATE342353T1 (de) 2001-05-21 2006-11-15 Omrix Biopharm Sa Abtrennung von plasmin(ogen) aus proteinlösungen
BRPI0621537B8 (pt) 2006-04-10 2021-05-25 Ethicon Inc curativo hemostático de múltiplas camadas absorvível e reforçado para curativo, e método de fabricação
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
KR20100134078A (ko) * 2008-04-16 2010-12-22 잇빤 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 트롬빈 고정화 생체 흡수성 시트 제제의 제조방법
US9212357B2 (en) * 2012-12-03 2015-12-15 Omrix Biopharmaceuticals Ltd. Thrombin solution and methods of use thereof
JP2016510059A (ja) 2013-03-07 2016-04-04 プロフィブリックス・ベーフェー 粉末製剤

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6113948A (en) * 1996-05-17 2000-09-05 Quadrant Healthcare Microparticles and their use in wound therapy
US20100150900A1 (en) * 2008-12-12 2010-06-17 Nicola Whitfield Dry Powder Fibrin Sealant
US20120315305A1 (en) * 2010-01-08 2012-12-13 Profibrix Bv Dry Powder Fibrin Sealant
WO2011151386A1 (en) * 2010-06-01 2011-12-08 Baxter International Inc. Process for making dry and stable hemostatic compositions
US9084728B2 (en) * 2010-06-01 2015-07-21 Baxter International Inc. Process for making dry and stable hemostatic compositions
US20150147312A1 (en) * 2013-11-26 2015-05-28 Omrix Biopharmaceuticals Ltd. Dry pad comprising thrombin and pectin

Also Published As

Publication number Publication date
BR112018011504A2 (pt) 2018-12-04
EP3386487A1 (en) 2018-10-17
IL242984A0 (en) 2016-02-29
IL259185B (en) 2021-07-29
WO2017098493A1 (en) 2017-06-15
IL259185A (en) 2018-07-31
CN108366967B (zh) 2021-03-12
KR20180091035A (ko) 2018-08-14
CN108366967A (zh) 2018-08-03
JP6918799B2 (ja) 2021-08-11
JP2019501893A (ja) 2019-01-24
CA3007900A1 (en) 2017-06-15
AU2016367536A1 (en) 2018-05-17

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired