AU2016340989B2 - Anti-IL-2 antibodies and compositions and uses thereof - Google Patents

Anti-IL-2 antibodies and compositions and uses thereof Download PDF

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Publication number
AU2016340989B2
AU2016340989B2 AU2016340989A AU2016340989A AU2016340989B2 AU 2016340989 B2 AU2016340989 B2 AU 2016340989B2 AU 2016340989 A AU2016340989 A AU 2016340989A AU 2016340989 A AU2016340989 A AU 2016340989A AU 2016340989 B2 AU2016340989 B2 AU 2016340989B2
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AU
Australia
Prior art keywords
seq
antibody
antigen
binding portion
antibodies
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AU2016340989A
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English (en)
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AU2016340989A1 (en
Inventor
Paul Bessette
Jeffrey A. Bluestone
Natasha CRELLIN
Lauren K. Ely
Kenan Christopher GARCIA
Isaac J. Rondon
Eleonora TROTTA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
University of California San Diego UCSD
Leland Stanford Junior University
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
University of California Berkeley
University of California San Diego UCSD
Leland Stanford Junior University
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Application filed by Pfizer Corp Belgium, Pfizer Corp SRL, University of California Berkeley, University of California San Diego UCSD, Leland Stanford Junior University filed Critical Pfizer Corp Belgium
Publication of AU2016340989A1 publication Critical patent/AU2016340989A1/en
Priority to AU2023219940A priority Critical patent/AU2023219940A1/en
Application granted granted Critical
Publication of AU2016340989B2 publication Critical patent/AU2016340989B2/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/246—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2016340989A 2015-10-23 2016-10-21 Anti-IL-2 antibodies and compositions and uses thereof Active AU2016340989B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023219940A AU2023219940A1 (en) 2015-10-23 2023-08-24 Anti-IL-2 antibodies and compositions and uses thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562245600P 2015-10-23 2015-10-23
US62/245,600 2015-10-23
US201662408360P 2016-10-14 2016-10-14
US62/408,360 2016-10-14
PCT/US2016/058249 WO2017070561A1 (en) 2015-10-23 2016-10-21 Anti-il-2 antibodies and compositions and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2023219940A Division AU2023219940A1 (en) 2015-10-23 2023-08-24 Anti-IL-2 antibodies and compositions and uses thereof

Publications (2)

Publication Number Publication Date
AU2016340989A1 AU2016340989A1 (en) 2018-04-26
AU2016340989B2 true AU2016340989B2 (en) 2023-09-14

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AU2023219940A Pending AU2023219940A1 (en) 2015-10-23 2023-08-24 Anti-IL-2 antibodies and compositions and uses thereof

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Country Status (9)

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US (4) US10138298B2 (OSRAM)
EP (1) EP3365369A1 (OSRAM)
JP (1) JP7030689B2 (OSRAM)
KR (2) KR20250154564A (OSRAM)
CN (2) CN115636880A (OSRAM)
AU (2) AU2016340989B2 (OSRAM)
CA (1) CA2946113A1 (OSRAM)
TW (1) TW201722989A (OSRAM)
WO (1) WO2017070561A1 (OSRAM)

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CN115636880A (zh) 2015-10-23 2023-01-24 辉瑞有限公司 抗il-2抗体及其组合物和用途
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EP3448874A4 (en) 2016-04-29 2020-04-22 Voyager Therapeutics, Inc. COMPOSITIONS FOR TREATING A DISEASE
MX2019003543A (es) * 2016-09-28 2019-06-17 Xoma Us Llc Anticuerpos que se fijan al interleucina-2 y sus usos.
AR110564A1 (es) * 2016-12-23 2019-04-10 Cephalon Inc Anticuerpos anti-il-5
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CN111010866A (zh) 2017-05-24 2020-04-14 潘迪恩治疗公司 靶向免疫耐受性
JP7057980B2 (ja) * 2017-05-25 2022-04-21 インスティテュート フォー ベーシック サイエンス 抗－ヒトインターロイキン－２抗体及びその用途
PH12020550661A1 (en) 2017-11-21 2021-04-19 Univ Leland Stanford Junior Partial agonists of interleukin-2
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
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CN120157765A (zh) * 2019-02-01 2025-06-17 瑞泽恩制药公司 抗IL2受体γ抗原结合蛋白
CN114126637A (zh) * 2019-03-29 2022-03-01 居里研究所 具有经修饰的生物活性的白介素-2变体
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CN115768483A (zh) 2020-01-13 2023-03-07 西纳福克斯股份有限公司 抗体与免疫细胞衔接器的缀合物
JP7303391B2 (ja) 2020-01-14 2023-07-04 シンセカイン インコーポレイテッド バイアス型ｉｌ２ムテイン、方法、および組成物
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
TW202140563A (zh) * 2020-02-21 2021-11-01 大陸商江蘇恆瑞醫藥股份有限公司 抗ｉｌ－２抗體、其抗原結合片段及其醫藥用途
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AU2021327147A1 (en) * 2020-08-18 2023-04-06 Universität Zürich A CD25-biased anti-IL-2 antibody
CN117157107A (zh) 2021-02-08 2023-12-01 西纳福克斯股份有限公司 多功能抗体
EP4130038A1 (en) * 2021-08-03 2023-02-08 Institut national de recherche pour l'agriculture, l'alimentation et l'environnement Anti-il-2 antibody, complex comprising it, and uses thereof
TW202327642A (zh) * 2021-08-25 2023-07-16 大陸商江蘇恆瑞醫藥股份有限公司 一種含融合蛋白的醫藥組成物
PE20240727A1 (es) * 2021-08-27 2024-04-15 Janssen Biotech Inc Anticuerpos anti-psma y usos de estos
JP2024539749A (ja) * 2021-10-14 2024-10-29 ラッティコン （スージョウ） バイオファーマシューティカルズ カンパニー リミテッド 新規な抗体－サイトカイン融合タンパク質及びその製造方法と使用
WO2023122653A1 (en) * 2021-12-23 2023-06-29 Arizona Board Of Regents On Behalf Of Arizona State University Compositions and methods for delivery of il-2 and anti-il-2 for treatment of rheumatoid arthritis
CN115850471A (zh) * 2022-10-13 2023-03-28 深圳市百士通科技开发有限公司 一种抗人il-2单克隆抗体及其应用
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CN120329440A (zh) * 2024-01-18 2025-07-18 烁微生物医药(上海)有限公司 特异性结合hEGFR的单克隆抗体及双特异性抗体
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