JP7030689B2 - 抗ｉｌ－２抗体ならびにその組成物及び使用 - Google Patents

抗ｉｌ－２抗体ならびにその組成物及び使用 Download PDF

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JP7030689B2
JP7030689B2 JP2018520536A JP2018520536A JP7030689B2 JP 7030689 B2 JP7030689 B2 JP 7030689B2 JP 2018520536 A JP2018520536 A JP 2018520536A JP 2018520536 A JP2018520536 A JP 2018520536A JP 7030689 B2 JP7030689 B2 JP 7030689B2
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seq
antibody
antigen
binding
antibodies
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JP2018537962A (ja
JP2018537962A5 (OSRAM
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アイザック ジェイ． ロンドン
ナターシャ クレリン
ポール ベセッテ
エレノラ トロッタ
ジェフリー エイ． ブルーストーン
ローレン ケイ． イーリー
ケナン クリストファー ガルシア
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University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/246—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2018520536A 2015-10-23 2016-10-21 抗ｉｌ－２抗体ならびにその組成物及び使用 Active JP7030689B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562245600P 2015-10-23 2015-10-23
US62/245,600 2015-10-23
US201662408360P 2016-10-14 2016-10-14
US62/408,360 2016-10-14
PCT/US2016/058249 WO2017070561A1 (en) 2015-10-23 2016-10-21 Anti-il-2 antibodies and compositions and uses thereof

Publications (3)

Publication Number Publication Date
JP2018537962A JP2018537962A (ja) 2018-12-27
JP2018537962A5 JP2018537962A5 (OSRAM) 2019-11-28
JP7030689B2 true JP7030689B2 (ja) 2022-03-07

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JP2018520536A Active JP7030689B2 (ja) 2015-10-23 2016-10-21 抗ｉｌ－２抗体ならびにその組成物及び使用

Country Status (9)

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US (4) US10138298B2 (OSRAM)
EP (1) EP3365369A1 (OSRAM)
JP (1) JP7030689B2 (OSRAM)
KR (2) KR20250154564A (OSRAM)
CN (2) CN109071648B (OSRAM)
AU (2) AU2016340989B2 (OSRAM)
CA (1) CA2946113A1 (OSRAM)
TW (1) TW201722989A (OSRAM)
WO (1) WO2017070561A1 (OSRAM)

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WO2017070561A1 (en) 2015-10-23 2017-04-27 Pfizer Inc. Anti-il-2 antibodies and compositions and uses thereof
WO2017189964A2 (en) 2016-04-29 2017-11-02 Voyager Therapeutics, Inc. Compositions for the treatment of disease
WO2017189959A1 (en) 2016-04-29 2017-11-02 Voyager Therapeutics, Inc. Compositions for the treatment of disease
JP2019534710A (ja) * 2016-09-28 2019-12-05 ゾーマ （ユーエス） リミテッド ライアビリティ カンパニー インターロイキン２に結合する抗体およびその使用
CA3048186A1 (en) * 2016-12-23 2018-06-28 Cephalon, Inc. Anti-il-5 antibodies
CA3056630A1 (en) 2017-03-15 2018-09-20 Pandion Therapeutics, Inc. Targeted immunotolerance
JP2020521452A (ja) 2017-05-24 2020-07-27 パンディオン・セラピューティクス・インコーポレイテッド 標的化免疫寛容
RU2745451C1 (ru) * 2017-05-25 2021-03-25 Инститьют Фор Бейсик Сайенс Антитела к человеческому интерлейкину-2 и их применение
EP3713592A4 (en) 2017-11-21 2022-01-12 The Board of Trustees of the Leland Stanford Junior University INTERLEUKIN-2 PARTIAL AGONISTS
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
EP3765505B1 (en) * 2018-03-13 2023-09-27 Tusk Therapeutics Ltd Anti-cd25 for tumour specific cell depletion
SG11202107272SA (en) * 2019-02-01 2021-07-29 Regeneron Pharma Anti-il2 receptor gamma antigen-binding proteins
AU2020252119B2 (en) * 2019-03-29 2025-09-04 Centre National De La Recherche Scientifique - Cnrs Interleukin-2 variants with modified biological activity
EP3952913A4 (en) * 2019-04-12 2023-05-10 The Johns Hopkins University Tolerogenic artificial antigen-presenting cells
CA3141327A1 (en) 2019-05-20 2020-11-26 Pandion Operations, Inc. Madcam targeted immunotolerance
KR20220034133A (ko) * 2019-06-26 2022-03-17 더 존스 홉킨스 유니버시티 조절 t 세포의 표적화된 확장을 위한 방법 및 재료
CN118307669A (zh) * 2019-07-12 2024-07-09 国立大学法人京都大学 靶向usag-1分子的用于牙齿再生治疗的中和抗体
CN115768483A (zh) 2020-01-13 2023-03-07 西纳福克斯股份有限公司 抗体与免疫细胞衔接器的缀合物
CN115362168A (zh) 2020-01-14 2022-11-18 辛德凯因股份有限公司 偏向化il2突变蛋白方法和组合物
WO2021168079A1 (en) 2020-02-21 2021-08-26 Pandion Operations, Inc. Tissue targeted immunotolerance with a cd39 effector
CN115210257A (zh) * 2020-02-21 2022-10-18 江苏恒瑞医药股份有限公司 抗il-2抗体、其抗原结合片段及其医药用途
EP4139354A4 (en) * 2020-04-24 2024-05-29 University of Central Florida Research Foundation, Inc. IL-2 TARGETING CD25 TO INCREASE CD4 T CELL FORMATION AND TREATMENT OF INFECTIONS
CA3189257A1 (en) 2020-08-18 2022-02-24 Universitat Zurich A cd25-biased anti-il-2 antibody
US20250262314A1 (en) 2021-02-08 2025-08-21 Synaffix B.V. Multifunctional antibodies
EP4130038A1 (en) * 2021-08-03 2023-02-08 Institut national de recherche pour l'agriculture, l'alimentation et l'environnement Anti-il-2 antibody, complex comprising it, and uses thereof
CA3229503A1 (en) * 2021-08-25 2023-03-02 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition containing fusion protein
IL311070A (en) * 2021-08-27 2024-04-01 Janssen Biotech Inc Anti-PSMA antibodies and uses thereof
JP2024539749A (ja) * 2021-10-14 2024-10-29 ラッティコン （スージョウ） バイオファーマシューティカルズ カンパニー リミテッド 新規な抗体－サイトカイン融合タンパク質及びその製造方法と使用
US20250082571A1 (en) * 2021-12-23 2025-03-13 Arizona Board Of Regents On Behalf Of Arizona State University Compositions and methods for delivery of il-2 and anti-il-2 for treatment of rheumatoid arthritis
CN115850471A (zh) * 2022-10-13 2023-03-28 深圳市百士通科技开发有限公司 一种抗人il-2单克隆抗体及其应用
WO2025032158A1 (en) 2023-08-08 2025-02-13 Institut National de la Santé et de la Recherche Médicale Method to treat tauopathies
CN120329440A (zh) * 2024-01-18 2025-07-18 烁微生物医药(上海)有限公司 特异性结合hEGFR的单克隆抗体及双特异性抗体
CN118515762B (zh) * 2024-07-23 2024-11-01 北京百普赛斯生物科技股份有限公司 特异性结合il-2的抗体及其应用

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