AU2016335968B2 - Resetting biological pathways for defending against and repairing deterioration from human aging - Google Patents
Resetting biological pathways for defending against and repairing deterioration from human aging Download PDFInfo
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- AU2016335968B2 AU2016335968B2 AU2016335968A AU2016335968A AU2016335968B2 AU 2016335968 B2 AU2016335968 B2 AU 2016335968B2 AU 2016335968 A AU2016335968 A AU 2016335968A AU 2016335968 A AU2016335968 A AU 2016335968A AU 2016335968 B2 AU2016335968 B2 AU 2016335968B2
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/302—Foods, ingredients or supplements having a functional effect on health having a modulating effect on age
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3331894T3 (da) | 2015-08-05 | 2021-03-22 | Metro Int Biotech Llc | Nicotinamidmononukleotidderivater og anvendelser deraf |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| WO2016188091A1 (zh) * | 2015-12-11 | 2016-12-01 | 邦泰生物工程(深圳)有限公司 | 烟酰胺单核苷酸在制备防治动脉硬化、心脑血管疾病的药物中的应用及其药物 |
| WO2016188092A1 (zh) * | 2015-12-11 | 2016-12-01 | 邦泰生物工程(深圳)有限公司 | 烟酰胺单核苷酸在制备防治动脉硬化、心脑血管疾病的保健品中的应用及其保健品 |
| US20190071680A1 (en) * | 2016-03-16 | 2019-03-07 | Dsm Ip Assets B.V. | Microbial production of nicotinic acid riboside |
| EP4049656A1 (en) * | 2017-03-17 | 2022-08-31 | Elysium Health, Inc. | Combination of nicotinamide riboside and pterostilbene for use in treating or preventing liver damage |
| US20180289729A1 (en) * | 2017-04-07 | 2018-10-11 | Robert John Petcavich | Combination therapy for treatment of human neurodegenerative diseases |
| WO2018200357A1 (en) * | 2017-04-26 | 2018-11-01 | Elysium Health, Inc. | Methods and compositions of improving fertility |
| WO2018236814A2 (en) | 2017-06-19 | 2018-12-27 | Gangadhara Ganapati | NICOTINAMIDE RIBOSID DERIVATIVES AND USES THEREOF |
| CN107198232A (zh) * | 2017-06-21 | 2017-09-26 | 浏阳市红杉农业科技发展有限公司 | 一种延年益寿的保健品 |
| US11373732B2 (en) | 2017-07-25 | 2022-06-28 | Deep Longevity Limited | Aging markers of human microbiome and microbiomic aging clock |
| US11260078B2 (en) | 2017-07-25 | 2022-03-01 | Insilico Medicine Ip Limited | Method of treating senescence with multi-stage longevity therapeutics |
| EP3665184A4 (en) * | 2017-08-09 | 2022-03-23 | Intervene Immune, Inc. | MEDICATION AND DOSING DEVICE TO REVERSE HUMAN AGING |
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| US11219590B2 (en) * | 2017-09-14 | 2022-01-11 | Megumi Tanaka | Anti-aging agent and anti-aging method |
| WO2019104065A1 (en) * | 2017-11-22 | 2019-05-31 | Turrinii Pharmaceutical, Llc | Anti-aging methods and compositions |
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| GB2586745B (en) * | 2018-03-13 | 2023-04-05 | Nuchido Ltd | Compositions |
| WO2019209840A1 (en) * | 2018-04-23 | 2019-10-31 | Elysium Health, Inc. | Methods and compositions for treating rheumatoid arthritis |
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| NL1044089B1 (en) * | 2020-08-12 | 2022-07-15 | Dr Jelena Barjaktarovic Md | Combination of Vitamin C, red ginseng, nicotinamide mononucleotide (NMN) and resveratrol as a healthy functional food (food supplement)) |
| NL1044087B1 (en) * | 2020-08-12 | 2022-07-08 | Dr Jelena Barjaktarovic Md | Combination of Vitamin C, red ginseng, nicotinamide mononucleotide (NMN) and resveratrol as a healthy functional food (food supplement)) |
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| US20220088045A1 (en) * | 2020-09-23 | 2022-03-24 | Mo S. Kharazmi | Treatment compositions |
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| WO2022221401A1 (en) * | 2021-04-13 | 2022-10-20 | Animal Biosciences, Inc. | Formulations of nicotinic acid derivatives and flavonoid polyphenols and uses thereof |
| EP4346842A1 (en) | 2021-05-27 | 2024-04-10 | Metro International Biotech, LLC | Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use |
| WO2022269064A1 (en) * | 2021-06-24 | 2022-12-29 | Vestlandets Innovasjonsselskap As (Vis) | Nad-augmentation therapy for parkinson's disease |
| WO2023037173A1 (en) * | 2021-07-12 | 2023-03-16 | Matthias W Rath | A pharmaceutical micronutrient composition for use to simultaneously improve nervous system function, cognitive ability and response to stressors |
| CN115414375B (zh) * | 2022-11-03 | 2023-03-24 | 卡瑞济(北京)生命科技有限公司 | 烟酰胺单核苷酸延长car-t细胞寿命的用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060127506A1 (en) * | 2004-12-10 | 2006-06-15 | Hebert Rolland F | Compositions of S-adenosyl-L-methionine |
| US20090003275A1 (en) * | 2003-09-17 | 2009-01-01 | Research In Motion Limited | System and Method for Asynchronous Wireless Services Using Reverse Service Schema Generation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9920351D0 (en) * | 1999-08-28 | 1999-11-03 | Strachen John S | Sparse constructive node stimulation of cell surface molecular resonance in vivo |
| JP2003171325A (ja) * | 2001-11-30 | 2003-06-20 | Sumitomo Chem Co Ltd | 固体有機化合物の製造方法 |
| WO2003084485A1 (en) * | 2002-04-09 | 2003-10-16 | Otsuka Pharmaceutical Co., Ltd. | Composition for cell proliferation |
| US20090035275A1 (en) * | 2003-10-31 | 2009-02-05 | John Geoffrey Pickering | Methods and formulations for protecting cells, and for treating diseases and conditions by optimizing the intracellular concentration of NAD |
| CN1299688C (zh) * | 2004-04-29 | 2007-02-14 | 路宁 | 氨基酸溶液及其制备方法 |
| ES2747926T3 (es) * | 2004-09-27 | 2020-03-12 | Special Water Patents B V | Métodos y composiciones para el tratamiento de agua |
| KR101312422B1 (ko) * | 2004-12-22 | 2013-09-30 | 시바 홀딩 인코포레이티드 | 항라디칼제 |
| EP3730507A1 (en) * | 2005-11-18 | 2020-10-28 | Cornell Research Foundation, Inc. | Nicotinoyl riboside and nicotinamide riboside compositions for use in reducing toxicity induced by hmg-coa reductase inhibitors |
| US9649513B2 (en) * | 2006-03-24 | 2017-05-16 | Colgate—Palmolive Company | Aerosol dispenser |
| CN101926459A (zh) * | 2009-11-20 | 2010-12-29 | 张小夫 | 一种能提升学习记忆力预防考试焦虑的制剂及制备方法 |
| US20140065099A1 (en) * | 2011-02-15 | 2014-03-06 | Ecole Polytechnique Federale De Lausanne (Epfl) | Methods of Treating Mitochondrial Dysfunction |
| RU2488376C1 (ru) * | 2012-01-26 | 2013-07-27 | Екатерина Александровна Диброва | Способ лечения и оздоровления организма человека |
| US20140004097A1 (en) * | 2012-06-29 | 2014-01-02 | Shire Human Genetic Therapies, Inc. | Method of producing recombinant iduronate-2-sulfatase |
| CN104814974A (zh) * | 2015-03-16 | 2015-08-05 | 邦泰生物工程(深圳)有限公司 | 烟酰胺单核苷酸在制备抗衰老药物或保健品的应用 |
| WO2016158212A1 (ja) | 2015-03-31 | 2016-10-06 | 新興和製薬株式会社 | レスベラトロールとニコチンアミドモノヌクレオチドを含む食品組成物 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090003275A1 (en) * | 2003-09-17 | 2009-01-01 | Research In Motion Limited | System and Method for Asynchronous Wireless Services Using Reverse Service Schema Generation |
| US20060127506A1 (en) * | 2004-12-10 | 2006-06-15 | Hebert Rolland F | Compositions of S-adenosyl-L-methionine |
Non-Patent Citations (5)
| Title |
|---|
| ALARCON DE LA LASTRA CATALINA ET AL, "RESVERATROL AS AN ANTI-INFLAMMATORY AND ANTI-AGING AGENT: MECHANISMS AND CLINICAL IMPLICATIONS", MOLECULAR NUTRITION & FOOD RESEARCH, (2005), vol. 49, no. 5, pages 405 - 430 * |
| E. K. GO ET AL, JOURNALS OF GERONTOLOGY, SERIES A, BIOLOGICAL SCIENCES ANDMEDICAL SCIENCES, (2005), vol. 60, no. 10, pages 1252 - 1264 * |
| LIANG-JUN YAN, 'Positive oxidative stress in aging and aging-related disease tolerance', REDOX BIOLOGY, (2014), pages 165-169 * |
| MARIA GIULIA BACALINI ET AL, "Present and future of anti-ageing epigenetic diets", MECHANISMS OF AGEING AND DEVELOPMENT., CH, (2014-03-01), vol. 136-137, doi:10.1016/j.mad.2013.12.006, ISSN 0047-6374, pages 101 - 115 * |
| Sue Dunlevy, news.com.au/lifestyle/health, (2013-12-19), pages 1 - 2, URL: https://www.news.com.au/lifestyle/health/university-of-nsw-research-finds-compound-that-can-reverse-ageing/news-story/2db52e293fb786faf08acf57da7d0bb7, (2019-03-15) * |
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| IL258541B (en) | 2022-05-01 |
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| CA3001483A1 (en) | 2017-04-13 |
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| EP3359259A1 (en) | 2018-08-15 |
| SG11201802933YA (en) | 2018-05-30 |
| CN108290059A (zh) | 2018-07-17 |
| EP3359259C0 (en) | 2023-11-15 |
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| JP2018530614A (ja) | 2018-10-18 |
| RU2018114520A (ru) | 2019-11-07 |
| IL292414A (en) | 2022-06-01 |
| IL258541A (en) | 2018-05-31 |
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