BR112018007153A2 - reajuste de caminhos biológicos de defesa contra e reparo de danos causados por envelhecimento humano - Google Patents
reajuste de caminhos biológicos de defesa contra e reparo de danos causados por envelhecimento humanoInfo
- Publication number
- BR112018007153A2 BR112018007153A2 BR112018007153A BR112018007153A BR112018007153A2 BR 112018007153 A2 BR112018007153 A2 BR 112018007153A2 BR 112018007153 A BR112018007153 A BR 112018007153A BR 112018007153 A BR112018007153 A BR 112018007153A BR 112018007153 A2 BR112018007153 A2 BR 112018007153A2
- Authority
- BR
- Brazil
- Prior art keywords
- component
- repair
- combinations
- nicotinamide
- readjustment
- Prior art date
Links
- 230000032683 aging Effects 0.000 title 1
- 230000008236 biological pathway Effects 0.000 title 1
- 230000007123 defense Effects 0.000 title 1
- 239000012190 activator Substances 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 230000006851 antioxidant defense Effects 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- LDHMAVIPBRSVRG-UHFFFAOYSA-O 1-methylnicotinamide Chemical compound C[N+]1=CC=CC(C(N)=O)=C1 LDHMAVIPBRSVRG-UHFFFAOYSA-O 0.000 abstract 1
- XVTDSQJAFPHQGF-UHFFFAOYSA-N 7h-purin-6-amine;pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CC=CN=C1.NC1=NC=NC2=C1NC=N2 XVTDSQJAFPHQGF-UHFFFAOYSA-N 0.000 abstract 1
- 229930024421 Adenine Natural products 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 abstract 1
- UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 abstract 1
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 abstract 1
- DAYLJWODMCOQEW-TURQNECASA-O NMN(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(O)=O)O2)O)=C1 DAYLJWODMCOQEW-TURQNECASA-O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 abstract 1
- LNQVTSROQXJCDD-UHFFFAOYSA-N adenosine monophosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)C(OP(O)(O)=O)C1O LNQVTSROQXJCDD-UHFFFAOYSA-N 0.000 abstract 1
- 230000003679 aging effect Effects 0.000 abstract 1
- 229960003237 betaine Drugs 0.000 abstract 1
- 229960001231 choline Drugs 0.000 abstract 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 abstract 1
- 229940014144 folate Drugs 0.000 abstract 1
- 235000019152 folic acid Nutrition 0.000 abstract 1
- 239000011724 folic acid Substances 0.000 abstract 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 229960004452 methionine Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- JOUIQRNQJGXQDC-AXTSPUMRSA-N namn Chemical compound O1[C@@H](COP(O)([O-])=O)[C@H](O)[C@@H](O)[C@@H]1[N+]1=CC=CC(C(O)=O)=C1 JOUIQRNQJGXQDC-AXTSPUMRSA-N 0.000 abstract 1
- 235000020956 nicotinamide riboside Nutrition 0.000 abstract 1
- 239000011618 nicotinamide riboside Substances 0.000 abstract 1
- JOUIQRNQJGXQDC-ZYUZMQFOSA-L nicotinate D-ribonucleotide(2-) Chemical compound O1[C@H](COP([O-])([O-])=O)[C@@H](O)[C@@H](O)[C@@H]1[N+]1=CC=CC(C([O-])=O)=C1 JOUIQRNQJGXQDC-ZYUZMQFOSA-L 0.000 abstract 1
- 150000008223 ribosides Chemical class 0.000 abstract 1
- RMRCNWBMXRMIRW-WYVZQNDMSA-L vitamin b12 Chemical compound N([C@@H]([C@@]1(C)[C@@](C)(CC(N)=O)[C@H](CCC(N)=O)\C(N1[Co+]C#N)=C(/C)\C1=N\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NCC(C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO RMRCNWBMXRMIRW-WYVZQNDMSA-L 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/13—Nucleic acids or derivatives thereof
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
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- A—HUMAN NECESSITIES
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
composições para resolver um ou mais dos efeitos de envelhecimento são descritas. as composições compreendem um primeiro componente que compreende ativador (s) de sistema de reparo tal como nicotinamida adenina dinucleotídeo (nad+), nicotinamida mononucleotídeo (nmn), nicotinamida ribosídeo (nr) , ácido nicotínico mononucleotídeo adenina (namn), ácido nicotínico adenina (naad), ácido nicotínico ribosídeo (nar) , 1-metilnicotinamide (mnm), monofosfato de adenosina (camp) e combinações dos mesmos ; um segundo componente compreendendo doador de metila (s) tal como s -5'- ade-nosil-l-metionina (sam), metionina, betaína, colina, folato, vitamina b12, ou combinações dos mesmos; e um terceiro componente compreendendo ativadores de defesa antioxidante tais como h2o2, n2s, nash, na2s, e vários outros, incluindo combinações dos mesmos. métodos de administrar as composições reveladas ou formulações separadas de ativador de sistema de reparo, doadores de metila, e ativadores de defesa antioxidante são também descritos
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562238338P | 2015-10-07 | 2015-10-07 | |
PCT/US2016/055173 WO2017062311A1 (en) | 2015-10-07 | 2016-10-03 | Resetting biological pathways for defending against and repairing deterioration from human aging |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018007153A2 true BR112018007153A2 (pt) | 2018-11-06 |
Family
ID=58488381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018007153A BR112018007153A2 (pt) | 2015-10-07 | 2016-10-03 | reajuste de caminhos biológicos de defesa contra e reparo de danos causados por envelhecimento humano |
Country Status (14)
Country | Link |
---|---|
US (2) | US20190060336A1 (pt) |
EP (1) | EP3359259B1 (pt) |
JP (2) | JP2018530614A (pt) |
KR (1) | KR20180063179A (pt) |
CN (1) | CN108290059A (pt) |
AU (2) | AU2016335968B2 (pt) |
BR (1) | BR112018007153A2 (pt) |
CA (2) | CA3118834A1 (pt) |
HK (1) | HK1258406A1 (pt) |
IL (3) | IL299824B2 (pt) |
MX (2) | MX2018004358A (pt) |
RU (1) | RU2768936C2 (pt) |
SG (1) | SG11201802933YA (pt) |
WO (1) | WO2017062311A1 (pt) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2018001363A (es) | 2015-08-05 | 2018-11-29 | Metro Int Biotech Llc | Derivados del mononucleotido de nicotinamida y sus usos. |
GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
WO2016188092A1 (zh) * | 2015-12-11 | 2016-12-01 | 邦泰生物工程(深圳)有限公司 | 烟酰胺单核苷酸在制备防治动脉硬化、心脑血管疾病的保健品中的应用及其保健品 |
WO2016188091A1 (zh) * | 2015-12-11 | 2016-12-01 | 邦泰生物工程(深圳)有限公司 | 烟酰胺单核苷酸在制备防治动脉硬化、心脑血管疾病的药物中的应用及其药物 |
CN108884483A (zh) * | 2016-03-16 | 2018-11-23 | 帝斯曼知识产权资产管理有限公司 | 烟酸核糖苷的微生物生产 |
US11389468B2 (en) * | 2017-03-17 | 2022-07-19 | Elysium Health, Inc. | Nicotinamide riboside for use in treating or preventing liver damage |
US20180289729A1 (en) * | 2017-04-07 | 2018-10-11 | Robert John Petcavich | Combination therapy for treatment of human neurodegenerative diseases |
WO2018200357A1 (en) * | 2017-04-26 | 2018-11-01 | Elysium Health, Inc. | Methods and compositions of improving fertility |
US11286274B2 (en) | 2017-06-19 | 2022-03-29 | Mitopower Llc | Nicotinamide riboside derivatives and their uses |
CN107198232A (zh) * | 2017-06-21 | 2017-09-26 | 浏阳市红杉农业科技发展有限公司 | 一种延年益寿的保健品 |
US11373732B2 (en) | 2017-07-25 | 2022-06-28 | Deep Longevity Limited | Aging markers of human microbiome and microbiomic aging clock |
US11260078B2 (en) | 2017-07-25 | 2022-03-01 | Insilico Medicine Ip Limited | Method of treating senescence with multi-stage longevity therapeutics |
WO2019032627A1 (en) * | 2017-08-09 | 2019-02-14 | Intervene Immune, Inc. | PHARMACEUTICAL PRODUCTS AND MEANS FOR REVERSE INVERSION OF HUMAN AGING |
JP2020530460A (ja) | 2017-08-10 | 2020-10-22 | ワシントン・ユニバーシティWashington University | ニコチンアミドモノヌクレオチドを使用する治療の組成物および方法 |
EP3682746A4 (en) * | 2017-09-14 | 2021-03-10 | Megumi Tanaka | AGING PROTECTION AGENTS AND AGING PROTECTION PROCEDURES |
WO2019104065A1 (en) * | 2017-11-22 | 2019-05-31 | Turrinii Pharmaceutical, Llc | Anti-aging methods and compositions |
CN107875171A (zh) * | 2017-12-08 | 2018-04-06 | 深圳市莱利赛生物科技有限公司 | 一种脐带间充质干细胞药物在促进皮肤伤口愈合中的应用 |
WO2019133815A1 (en) | 2017-12-28 | 2019-07-04 | Kansas State University Research Foundation | Nicotinamide riboside treatments of domesticated meat animals |
US11180521B2 (en) | 2018-01-30 | 2021-11-23 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
AU2019233807A1 (en) * | 2018-03-13 | 2020-10-22 | Nuchido Limited | Compositions |
WO2019209840A1 (en) * | 2018-04-23 | 2019-10-31 | Elysium Health, Inc. | Methods and compositions for treating rheumatoid arthritis |
WO2019242982A2 (en) * | 2018-06-21 | 2019-12-26 | Societe Des Produits Nestle S.A. | Compositions and methods using a nicotinamide adenine dinucleotide (nad+) precursor and at least one ketone or ketone precursor |
WO2020054795A1 (ja) * | 2018-09-14 | 2020-03-19 | めぐみ 田中 | 老化防止剤及び老化防止方法 |
CN109566826A (zh) * | 2018-10-15 | 2019-04-05 | 河南省锐达医药科技有限公司 | 一种抗衰老提高免疫力美容的组合物 |
US11767314B2 (en) | 2018-11-02 | 2023-09-26 | Conopco, Inc. | Bioenergetic nicotinic acid glycerol esters, compositions and methods of using same |
EP3897666A2 (en) | 2018-12-17 | 2021-10-27 | Mitopower LLC | Nicotinyl riboside compounds and their uses |
CN109884007B (zh) * | 2019-02-18 | 2020-10-27 | 西安交通大学 | 一体化同步dna纳米器件及其活细胞多靶标成像应用和成像方法 |
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MX2018004358A (es) | 2018-05-23 |
WO2017062311A1 (en) | 2017-04-13 |
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CN108290059A (zh) | 2018-07-17 |
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AU2023200040A1 (en) | 2023-02-09 |
SG11201802933YA (en) | 2018-05-30 |
IL258541A (en) | 2018-05-31 |
JP2018530614A (ja) | 2018-10-18 |
US20220023323A1 (en) | 2022-01-27 |
RU2768936C2 (ru) | 2022-03-25 |
US20190060336A1 (en) | 2019-02-28 |
AU2016335968B2 (en) | 2022-10-27 |
IL292414B2 (en) | 2023-06-01 |
KR20180063179A (ko) | 2018-06-11 |
MX2022013626A (es) | 2022-11-16 |
CA3118834A1 (en) | 2017-04-13 |
EP3359259A4 (en) | 2019-04-24 |
AU2016335968A1 (en) | 2018-05-10 |
IL299824B2 (en) | 2024-02-01 |
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